{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:13:43Z","timestamp":1792116823759,"version":"4.4.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T00:00:00Z","timestamp":1340582400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0039730","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T06:35:06Z","timestamp":1340778906000},"page":"e39730","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":105,"title":["Long-Term Effects of Pneumococcal Conjugate Vaccine on Nasopharyngeal Carriage of S. pneumoniae, S. aureus, H. influenzae and M. catarrhalis"],"prefix":"10.1371","volume":"7","author":[{"given":"Judith","family":"Spijkerman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine M. P. J.","family":"Prevaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elske J. M.","family":"van Gils","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinier H.","family":"Veenhoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob P.","family":"Bruin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debby","family":"Bogaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alienke J.","family":"Wijmenga-Monsuur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germie P. J. M.","family":"van den Dobbelsteen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth A. M.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,6,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1586\/14760584.5.5.651","article-title":"Nasopharyngeal colonization: a target for pneumococcal vaccination.","volume":"5","author":"H Kayhty","year":"2006","journal-title":"Expert Rev Vaccines"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"584","DOI":"10.3201\/eid1704.101115","article-title":"Carriage of Streptococcus pneumoniae 3 years after start of vaccination program, the Netherlands.","volume":"17","author":"J Spijkerman","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1473-3099(04)00938-7","article-title":"Streptococcus pneumoniae colonisation: the key to pneumococcal disease.","volume":"4","author":"D Bogaert","year":"2004","journal-title":"Lancet Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1586\/14760584.7.1.83","article-title":"Population-based impact of routine infant immunization with pneumococcal conjugate vaccine in the USA.","volume":"7","author":"CG Grijalva","year":"2008","journal-title":"Expert Rev Vaccines"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1586\/erv.09.78","article-title":"Impact of infant immunization programs with pneumococcal conjugate vaccine in Europe.","volume":"8","author":"M Rose","year":"2009","journal-title":"Expert Rev Vaccines"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/S0140-6736(04)16357-5","article-title":"Colonisation by Streptococcus pneumoniae and Staphylococcus aureus in healthy children.","volume":"363","author":"D Bogaert","year":"2004","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/1471-2334-11-175","article-title":"Early acquisition and high nasopharyngeal co-colonisation by Streptococcus pneumoniae and three respiratory pathogens amongst Gambian new-borns and infants.","volume":"11","author":"BA Kwambana","year":"2011","journal-title":"BMC Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1001\/jama.292.6.716","article-title":"Association between carriage of Streptococcus pneumoniae and Staphylococcus aureus in Children.","volume":"292","author":"G Regev-Yochay","year":"2004","journal-title":"JAMA"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJM200102083440602","article-title":"Efficacy of a pneumococcal conjugate vaccine against acute otitis media.","volume":"344","author":"J Eskola","year":"2001","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1086\/378744","article-title":"Protective efficacy of a second pneumococcal conjugate vaccine against pneumococcal acute otitis media in infants and children: randomized, controlled trial of a 7-valent pneumococcal polysaccharide-meningococcal outer membrane protein complex conjugate vaccine in 1666 children.","volume":"37","author":"T Kilpi","year":"2003","journal-title":"Clin Infect Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1016\/S0140-6736(03)13772-5","article-title":"Effect of conjugate pneumococcal vaccine followed by polysaccharide pneumococcal vaccine on recurrent acute otitis media: a randomised study.","volume":"361","author":"R Veenhoven","year":"2003","journal-title":"Lancet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1099\/00222615-46-5-360","article-title":"Moraxella (Branhamella) catarrhalis\u2013clinical and molecular aspects of a rediscovered pathogen.","volume":"46","author":"MC Enright","year":"1997","journal-title":"J Med Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/INF.0b013e318184dba2","article-title":"Nontypeable Haemophilus influenzae as a pathogen in children.","volume":"28","author":"TF Murphy","year":"2009","journal-title":"Pediatr Infect Dis J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1473-3099(05)70295-4","article-title":"The role of nasal carriage in Staphylococcus aureus infections.","volume":"5","author":"HF Wertheim","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e20229","DOI":"10.1371\/journal.pone.0020229","article-title":"Effect of Seven-Valent Pneumococcal Conjugate Vaccine on Staphylococcus aureus Colonisation in a Randomised Controlled Trial.","volume":"6","author":"EJ van Gils","year":"2011","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1086\/652443","article-title":"Transmission of Streptococcus pneumoniae in rural Gambian villages: a longitudinal study.","volume":"50","author":"PC Hill","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/INF.0b013e318217dc6e","article-title":"Crowding and other strong predictors of upper respiratory tract carriage of otitis media-related bacteria in Australian Aboriginal and non-Aboriginal children.","volume":"30","author":"P Jacoby","year":"2011","journal-title":"Pediatr Infect Dis J"},{"key":"ref18","first-page":"950","article-title":"[High vaccination coverage of the National Immunization Programme in the Netherlands].","volume":"153","author":"EA van Lier","year":"2009","journal-title":"Ned Tijdschr Geneeskd"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1001\/jama.2009.975","article-title":"Effect of reduced-dose schedules with 7-valent pneumococcal conjugate vaccine on nasopharyngeal pneumococcal carriage in children: a randomized controlled trial.","volume":"302","author":"EJ van Gils","year":"2009","journal-title":"JAMA"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/00006454-200302000-00010","article-title":"Report from a WHO Working Group: standard method for detecting upper respiratory carriage of Streptococcus pneumoniae.","volume":"22","author":"KL O'Brien","year":"2003","journal-title":"Pediatr Infect Dis J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.1128\/JCM.42.11.4974-4976.2004","article-title":"Nasopharyngeal versus oropharyngeal sampling for detection of pneumococcal carriage in adults.","volume":"42","author":"JP Watt","year":"2004","journal-title":"J Clin Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1128\/JCM.40.7.2659-2661.2002","article-title":"Rapid identification of Staphylococcus aureus and the mecA gene from BacT\/ALERT blood culture bottles by using the LightCycler system.","volume":"40","author":"NK Shrestha","year":"2002","journal-title":"J Clin Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S1473-3099(08)70281-0","article-title":"Impact of conjugate pneumococcal vaccines on antibiotic resistance.","volume":"8","author":"R Dagan","year":"2008","journal-title":"Lancet Infect Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1086\/522164","article-title":"Long-term effect of pneumococcal conjugate vaccine on nasopharyngeal colonization by Streptococcus pneumoniae\u2013and associated interactions with Staphylococcus aureus and Haemophilus influenzae colonization\u2013in HIV-Infected and HIV-uninfected children.","volume":"196","author":"SA Madhi","year":"2007","journal-title":"J Infect Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1086\/505076","article-title":"Lack of association between the nasopharyngeal carriage of Streptococcus pneumoniae and Staphylococcus aureus in HIV-1-infected South African children.","volume":"194","author":"LM McNally","year":"2006","journal-title":"J Infect Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1086\/523734","article-title":"Pneumococcal conjugate vaccine does not influence Staphylococcus aureus carriage in young children with acute otitis media.","volume":"45","author":"R Cohen","year":"2007","journal-title":"Clin Infect Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1471-2334-9-110","article-title":"Epidemiology and risk factors for Staphylococcus aureus colonization in children in the post-PCV7 era.","volume":"9","author":"GM Lee","year":"2009","journal-title":"BMC Infect Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1086\/589573","article-title":"Does pneumococcal conjugate vaccine influence Staphylococcus aureus carriage in children?","volume":"47","author":"G Regev-Yochay","year":"2008","journal-title":"Clin Infect Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1086\/597040","article-title":"The pneumococcal pilus predicts the absence of Staphylococcus aureus co-colonization in pneumococcal carriers.","volume":"48","author":"G Regev-Yochay","year":"2009","journal-title":"Clin Infect Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1128\/JCM.00641-08","article-title":"Dynamics and determinants of Staphylococcus aureus carriage in infancy: the Generation R Study.","volume":"46","author":"A Lebon","year":"2008","journal-title":"J Clin Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJM200101043440102","article-title":"Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group.","volume":"344","author":"C von Eijff","year":"2001","journal-title":"N Engl J Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/01.inf.0000261112.53035.4c","article-title":"Changing epidemiology of pediatric Staphylococcus aureus bacteremia in Denmark from 1971 through 2000.","volume":"26","author":"MS Frederiksen","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1086\/599348","article-title":"Trends in the incidence of methicillin-resistant Staphylococcus aureus infection in children's hospitals in the United States.","volume":"49","author":"JS Gerber","year":"2009","journal-title":"Clin Infect Dis"},{"key":"ref34","article-title":"Trends and Characteristics of Culture-Confirmed Staphylococcus aureus Infections in a Large U.S. Integrated Health Care Organization.","author":"GT Ray","year":"2012"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1001\/jama.2010.1651","article-title":"Diagnosis, microbial epidemiology, and antibiotic treatment of acute otitis media in children: a systematic review.","volume":"304","author":"TR Coker","year":"2010","journal-title":"JAMA"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1542\/peds.2005-1983","article-title":"Effect of pneumococcal conjugate vaccine on nasopharyngeal bacterial colonization during acute otitis media.","volume":"117","author":"K Revai","year":"2006","journal-title":"Pediatrics"},{"key":"ref37","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2011.08.049","article-title":"Effect of 7-valent pneumococcal conjugate vaccine on nasopharyngeal carriage with Haemophilus influenzae and Moraxella catarrhalis in a randomized controlled trial.","author":"EJ van Gils","year":"2011"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1471-2180-10-59","article-title":"The ecology of nasal colonization of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus: the role of competition and interactions with host's immune response.","volume":"10","author":"E Margolis","year":"2010","journal-title":"BMC Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e1001017","DOI":"10.1371\/journal.pmed.1001017","article-title":"Effect of pneumococcal conjugate vaccination on serotype-specific carriage and invasive disease in England: a cross-sectional study.","volume":"8","author":"S Flasche","year":"2011","journal-title":"PLoS Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.vaccine.2010.10.032","article-title":"Serotype specific invasive capacity and persistent reduction in invasive pneumococcal disease.","volume":"29","author":"I Yildirim","year":"2010","journal-title":"Vaccine"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1126\/science.1198545","article-title":"Rapid pneumococcal evolution in response to clinical interventions.","volume":"331","author":"NJ Croucher","year":"2011","journal-title":"Science"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.3201\/eid1411.070467","article-title":"Antimicrobial drug use and resistance in Europe.","volume":"14","author":"N van de Sande-Bruinsma","year":"2008","journal-title":"Emerg Infect Dis"}],"updated-by":[{"DOI":"10.1371\/annotation\/2b5d32c3-808f-4759-8207-0a953e4ad01d","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T00:00:00Z","timestamp":1348704000000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0039730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T16:46:13Z","timestamp":1589042773000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0039730"}},"subtitle":[],"editor":[{"given":"Eliane Namie","family":"Miyaji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,6,25]]},"references-count":42,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,6,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0039730","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/2b5d32c3-808f-4759-8207-0a953e4ad01d","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,25]]}}}