{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:11:57Z","timestamp":1790190717501,"version":"4.1.0"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T00:00:00Z","timestamp":1343174400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0039837","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T21:56:41Z","timestamp":1343253401000},"page":"e39837","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":85,"title":["Weight Cycling Enhances Adipose Tissue Inflammatory Responses in Male Mice"],"prefix":"10.1371","volume":"7","author":[{"given":"Sandra","family":"Barbosa-da-Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"Fraulob-Aquino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Mandarim-de-Lacerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia B.","family":"Aguila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,7,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin resistance.","volume":"72","author":"JM Olefsky","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/13550280601094563","article-title":"JC virus viremia in interferon-beta -treated and untreated Italian multiple sclerosis patients and healthy controls.","volume":"13","author":"S Delbue","year":"2007","journal-title":"J Neurovirol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1136\/hrt.2009.171447","article-title":"Anthropometric assessment of abdominal obesity and coronary heart disease risk in men: the PRIME study.","volume":"96","author":"E Gruson","year":"2010","journal-title":"Heart"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2265.2009.03727.x","article-title":"Relationship of abdominal obesity with cardiovascular disease, diabetes and hyperlipidaemia in Spain.","volume":"73","author":"FF Casanueva","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/oby.2009.223","article-title":"Excess weight and the risk of incident coronary heart disease among men and women.","volume":"18","author":"AJ Flint","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/ajcn\/49.5.1105","article-title":"Weight cycling: the experience of human dieters.","volume":"49","author":"GL Blackburn","year":"1989","journal-title":"Am J Clin Nutr"},{"key":"ref7","first-page":"98","article-title":"Influence of obesity, physical inactivity, and weight cycling on chronic inflammation.","volume":"2","author":"K Strohacker","year":"2010","journal-title":"Front Biosci (Elite Ed)"},{"key":"ref8","article-title":"Effect of the Timing of Weight Cycling During Adulthood on Mortality Risk in Overweight and Obese Postmenopausal Women","author":"KY Taing","year":"2011"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1001\/archinternmed.2009.67","article-title":"Weight cycling and mortality among middle-aged or older women.","volume":"169","author":"AE Field","year":"2009","journal-title":"Arch Intern Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1093\/jn\/123.11.1923","article-title":"Development and testing of the AIN-93 purified diets for rodents: results on growth, kidney calcification and bone mineralization in rats and mice.","volume":"123","author":"PG Reeves","year":"1993","journal-title":"J Nutr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2818.2010.03481.x","article-title":"A simple tool for stereological assessment of digital images: the STEPanizer.","volume":"243","author":"SA Tschanz","year":"2011","journal-title":"J Microsc"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2818.1977.tb00062.x","article-title":"Notes on the estimation of the numerical density of arbitrary profiles: the edge effect.","volume":"111","author":"HJ Gundersen","year":"1977","journal-title":"J Microsc"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"785","DOI":"10.2307\/2530693","article-title":"Log-normal variation belts for growth curves.","volume":"42","author":"P Jolicoeur","year":"1986","journal-title":"Biometrics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1056\/NEJM199503093321001","article-title":"Changes in energy expenditure resulting from altered body weight.","volume":"332","author":"RL Leibel","year":"1995","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1093\/ajcn\/69.6.1117","article-title":"Meta-analysis of resting metabolic rate in formerly obese subjects.","volume":"69","author":"A Astrup","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.jada.2008.12.026","article-title":"Anthropometric, metabolic, psychosocial, and dietary characteristics of overweight\/obese postmenopausal women with a history of weight cycling: a MONET (Montreal Ottawa New Emerging Team) study.","volume":"109","author":"I Strychar","year":"2009","journal-title":"J Am Diet Assoc"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/ajcn\/70.6.965","article-title":"Weight-loss attempts and risk of major weight gain: a prospective study in Finnish adults.","volume":"70","author":"M Korkeila","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/ajcn\/45.1.296","article-title":"Dietary fat, carbohydrate balance, and weight maintenance: effects of exercise.","volume":"45","author":"JP Flatt","year":"1987","journal-title":"Am J Clin Nutr"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/ajcn\/59.3.560","article-title":"Effects of cycles of food restriction followed by ad libitum refeeding on body composition and energy expenditure in obese rats.","volume":"59","author":"R Rozen","year":"1994","journal-title":"The American journal of clinical nutrition"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1590\/S0100-879X2010007500030","article-title":"Beneficial effects of exercise training (treadmill) on insulin resistance and nonalcoholic fatty liver disease in high-fat fed C57BL\/6 mice.","volume":"43","author":"CM Marques","year":"2010","journal-title":"Braz J Med Biol Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0002-9343(74)90006-0","article-title":"Reappraisal of the role of insulin in hypertriglyceridemia.","volume":"57","author":"JM Olefsky","year":"1974","journal-title":"Am J Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/S0006-291X(03)00664-8","article-title":"Diet-dependent obesity and hypercholesterolemia in the New Zealand obese mouse: identification of a quantitative trait locus for elevated serum cholesterol on the distal mouse chromosome 5.","volume":"304","author":"K Giesen","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1507\/endocrj.K09E-046","article-title":"Shifts in diet from high fat to high carbohydrate improved levels of adipokines and pro-inflammatory cytokines in mice fed a high-fat diet.","volume":"57","author":"IS Lee","year":"2010","journal-title":"Endocrine journal"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1172\/JCI107115","article-title":"Effect of age, sex, and sites on the cellularity of the adipose tissue in mice and rats rendered obese by a high-fat diet.","volume":"51","author":"D Lemonnier","year":"1972","journal-title":"J Clin Invest"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1749-6632.2000.tb06482.x","article-title":"Body fat content influences the body composition response to nutrition and exercise.","volume":"904","author":"GB Forbes","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1093\/ajcn\/75.5.840","article-title":"Composition (lean and fat tissue) of weight changes in adult Danes.","volume":"75","author":"BL Heitmann","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/CS20050110","article-title":"The adipocyte life cycle hypothesis.","volume":"110","author":"J Smith","year":"2006","journal-title":"Clin Sci (Lond)"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1194\/jlr.M500294-JLR200","article-title":"Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans.","volume":"46","author":"S Cinti","year":"2005","journal-title":"J Lipid Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.2337\/db07-0767","article-title":"Adipocyte death, adipose tissue remodeling, and obesity complications.","volume":"56","year":"2007","journal-title":"Diabetes"},{"key":"ref30","first-page":"E279","article-title":"Diet-induced adipocyte number increase in adult rats: a new model of obesity.","volume":"235","author":"IM Faust","year":"1978","journal-title":"Am J Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1074\/jbc.M109.074252","article-title":"Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis.","volume":"285","author":"N Alkhouri","year":"2010","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"242S","DOI":"10.1038\/oby.2006.317","article-title":"Adipose tissue as an endocrine organ.","volume":"14","author":"RS Ahima","year":"2006","journal-title":"Obesity (Silver Spring)"},{"key":"ref33","first-page":"115","article-title":"The effects of weight cycling on serum leptin levels and lipogenic enzyme activities in adipose tissue.","volume":"57","author":"Z Kochan","year":"2006","journal-title":"J Physiol Pharmacol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1530\/eje.1.01978","article-title":"The metabolism of isoforms of human adiponectin: studies in human subjects and in experimental animals.","volume":"153","author":"PW Peake","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.2337\/diabetes.53.4.1150","article-title":"Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study.","volume":"53","author":"F Fumeron","year":"2004","journal-title":"Diabetes"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1743-7075-7-27","article-title":"Circulating omentin concentration increases after weight loss.","volume":"7","author":"JM Moreno-Navarrete","year":"2010","journal-title":"Nutr Metab (Lond)"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"258S","DOI":"10.3945\/ajcn.2009.28449C","article-title":"Adiponectin in insulin resistance: lessons from translational research.","volume":"91","author":"F Ziemke","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1210\/jc.2003-031826","article-title":"Adiponectin, inflammation, and the expression of the metabolic syndrome in obese individuals: the impact of rapid weight loss through caloric restriction.","volume":"89","author":"AM Xydakis","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1210\/jc.2006-1055","article-title":"Relationship between adipocyte size and adipokine expression and secretion.","volume":"92","author":"T Skurk","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1111\/j.1572-0241.2006.00848.x","article-title":"The evolving role of leptin and adiponectin in chronic liver diseases.","volume":"101","author":"E Tsochatzis","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1189\/jlb.68.4.437","article-title":"Leptin in the regulation of immunity, inflammation, and hematopoiesis.","volume":"68","author":"G Fantuzzi","year":"2000","journal-title":"J Leukoc Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"R226","DOI":"10.1152\/ajpregu.00392.2001","article-title":"Determinants of leptin gene expression in fat depots of lean mice.","volume":"282","author":"Y Zhang","year":"2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref43","first-page":"3647","article-title":"Effects of weight change on plasma leptin concentrations and energy expenditure.","volume":"82","author":"M Rosenbaum","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"270624","DOI":"10.4061\/2011\/270624","article-title":"Obesity hypertension: the regulatory role of leptin.","volume":"2011","author":"S Kshatriya","year":"2011","journal-title":"Int J Hypertens"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"E316","DOI":"10.1152\/ajpendo.00710.2006","article-title":"Sexually dimorphic responses to fat loss after caloric restriction or surgical lipectomy.","volume":"293","author":"H Shi","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/nm1195-1155","article-title":"Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects.","volume":"1","author":"M Maffei","year":"1995","journal-title":"Nat Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/377527a0","article-title":"Transient increase in obese gene expression after food intake or insulin administration.","volume":"377","author":"R Saladin","year":"1995","journal-title":"Nature"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S1043-2760(01)00522-7","article-title":"Resistin and obesity-associated insulin resistance.","volume":"13","author":"CM Steppan","year":"2002","journal-title":"Trends Endocrinol Metab"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1530\/EJE-08-0427","article-title":"Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese.","volume":"159","author":"Q Qi","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35053000","article-title":"The hormone resistin links obesity to diabetes.","volume":"409","author":"CM Steppan","year":"2001","journal-title":"Nature"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/oby.2003.137","article-title":"Correlation between serum resistin level and adiposity in obese individuals.","volume":"11","author":"K Azuma","year":"2003","journal-title":"Obes Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1210\/jcem.87.5.8627","article-title":"Increased resistin gene and protein expression in human abdominal adipose tissue.","volume":"87","author":"PG McTernan","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.metabol.2003.11.022","article-title":"Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines.","volume":"53","author":"G Valsamakis","year":"2004","journal-title":"Metabolism"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.2337\/db07-1062","article-title":"Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle.","volume":"57","author":"I Nieto-Vazquez","year":"2008","journal-title":"Diabetes"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1507\/endocrj.K09E-046","article-title":"Shifts in diet from high fat to high carbohydrate improved levels of adipokines and pro-inflammatory cytokines in mice fed a high-fat diet.","volume":"57","author":"IS Lee","year":"2010","journal-title":"Endocr J"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1172\/JCI117936","article-title":"Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.","volume":"95","author":"GS Hotamisligil","year":"1995","journal-title":"J Clin Invest"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000289203","article-title":"TNF-alpha and obesity.","volume":"11","author":"T Tzanavari","year":"2010","journal-title":"Curr Dir Autoimmun"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1210\/endo.138.11.5519","article-title":"High fat diets elevate adipose tissue-derived tumor necrosis factor-alpha activity.","volume":"138","author":"CL Morin","year":"1997","journal-title":"Endocrinology"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.2337\/diacare.26.8.2442","article-title":"Adiponectin: more than just another fat cell hormone?","volume":"26","author":"M Chandran","year":"2003","journal-title":"Diabetes Care"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/hep.20282","article-title":"Adiponectin protects LPS-induced liver injury through modulation of TNF-alpha in KK-Ay obese mice.","volume":"40","author":"T Masaki","year":"2004","journal-title":"Hepatology"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2174\/157489009789152230","article-title":"Targeting MCP-1 to reduce vascular complications of obesity.","volume":"4","author":"MK Ohman","year":"2009","journal-title":"Recent Pat Cardiovasc Drug Discov"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.nut.2011.05.011","article-title":"Modulation of cytokines, resistin, and distribution of adipose tissue in C57BL\/6 mice by different high-fat diets.","volume":"28","author":"M Catta-Preta","year":"2012","journal-title":"Nutrition"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"25445","DOI":"10.1074\/jbc.M701549200","article-title":"Role of MAPK phosphatase-1 in the induction of monocyte chemoattractant protein-1 during the course of adipocyte hypertrophy.","volume":"282","author":"A Ito","year":"2007","journal-title":"J Biol Chem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/1476-511X-10-198","article-title":"Apoptosis, mastocytosis, and diminished adipocytokine gene expression accompany reduced epididymal fat mass in long-standing diet-induced obese mice.","volume":"10","author":"MM Altintas","year":"2011","journal-title":"Lipids Health Dis"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0039837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T13:05:22Z","timestamp":1714223122000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0039837"}},"subtitle":[],"editor":[{"given":"Massimo","family":"Federici","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,25]]},"references-count":64,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0039837","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,25]]}}}