{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:42:57Z","timestamp":1793054577620,"version":"4.5.0"},"reference-count":100,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T00:00:00Z","timestamp":1341273600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0039871","type":"journal-article","created":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T16:41:53Z","timestamp":1341333713000},"page":"e39871","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":214,"title":["Monocytes Induce STAT3 Activation in Human Mesenchymal Stem Cells to Promote Osteoblast Formation"],"prefix":"10.1371","volume":"7","author":[{"given":"Vicky","family":"Nicolaidou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Mei","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andia N.","family":"Redpath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Ersek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilair F.","family":"Baban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn M.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Cope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole J.","family":"Horwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.beem.2008.06.001","article-title":"Epidemiology of osteoporosis.","volume":"22","author":"C Holroyd","year":"2008","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00223-010-9420-x","article-title":"Impact of treatments for postmenopausal osteoporosis (bisphosphonates, parathyroid hormone, strontium ranelate, and denosumab) on bone quality: a systematic review.","volume":"87","author":"SJ Gallacher","year":"2010","journal-title":"Calcif Tissue Int"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cytogfr.2009.10.003","article-title":"Bone morphogenetic proteins in orthopaedic surgery.","volume":"20","author":"TW Axelrad","year":"2009","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref4","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD006950.pub2","article-title":"Bone morphogenetic protein (BMP) for fracture healing in adults.","author":"KR Garrison","year":"2010"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1210\/jc.2011-2332","article-title":"Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives.","volume":"97","author":"R Baron","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"ref6","first-page":"19","article-title":"Stromal mechanisms of bone marrow: cloning in vitro and retransplantation in vivo.","volume":"25","author":"AJ Friedenstein","year":"1980","journal-title":"Haematol Blood Transfus"},{"key":"ref7","first-page":"42","article-title":"Stromal stem cells: marrow-derived osteogenic precursors.","volume":"136","author":"M Owen","year":"1988","journal-title":"Ciba Found Symp"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells.","volume":"284","author":"MF Pittenger","year":"1999","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0092-8674(00)80257-3","article-title":"Osf2\/Cbfa1: a transcriptional activator of osteoblast differentiation.","volume":"89","author":"P Ducy","year":"1997","journal-title":"Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0092-8674(00)80258-5","article-title":"Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts.","volume":"89","author":"T Komori","year":"1997","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(01)00622-5","article-title":"The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation.","volume":"108","author":"K Nakashima","year":"2002","journal-title":"Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.cellsig.2009.02.012","article-title":"PTH and PTHrP signaling in osteoblasts.","volume":"21","author":"NS Datta","year":"2009","journal-title":"Cell Signal"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nrm3254","article-title":"Building strong bones: molecular regulation of the osteoblast lineage.","volume":"13","author":"F Long","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/jb\/mvs004","article-title":"Regulation of bone and cartilage development by network between BMP signalling and transcription factors.","volume":"151","author":"R Nishimura","year":"2012","journal-title":"J Biochem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.devcel.2005.03.016","article-title":"Wnt\/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis.","volume":"8","author":"TF Day","year":"2005","journal-title":"Dev Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"19185","DOI":"10.1074\/jbc.M414275200","article-title":"Developmental regulation of Wnt\/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification.","volume":"280","author":"Y Tamamura","year":"2005","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1093\/emboj\/cdg599","article-title":"Osteocyte control of bone formation via sclerostin, a novel BMP antagonist.","volume":"22","author":"DG Winkler","year":"2003","journal-title":"EMBO J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.bone.2006.03.017","article-title":"Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia.","volume":"39","author":"J Li","year":"2006","journal-title":"Bone"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nm1538","article-title":"Dickkopf-1 is a master regulator of joint remodeling.","volume":"13","author":"D Diarra","year":"2007","journal-title":"Nat Med"},{"key":"ref20","article-title":"U.S. National Institutes of Health Clinical Trials website."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev.immunol.24.021605.090646","article-title":"Osteoimmunology: interplay between the immune system and bone metabolism.","volume":"24","author":"MC Walsh","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1080\/08916930701694766","article-title":"Lymphocyte-derived cytokines in inflammatory arthritis.","volume":"41","author":"N Horwood","year":"2008","journal-title":"Autoimmunity"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1210\/er.2007-0038","article-title":"Osteoimmunology: interactions of the bone and immune system.","volume":"29","author":"J Lorenzo","year":"2008","journal-title":"Endocr Rev"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nrrheum.2009.217","article-title":"Osteoimmunology and the effects of the immune system on bone.","volume":"5","author":"H Takayanagi","year":"2009","journal-title":"Nat Rev Rheumatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.4049\/jimmunol.181.2.1232","article-title":"Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo.","volume":"181","author":"MK Chang","year":"2008","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/jbmr.354","article-title":"Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model.","volume":"26","author":"KA Alexander","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev.iy.08.040190.000551","article-title":"Regulation of hemopoiesis by bone marrow stromal cells and their products.","volume":"8","author":"K Dorshkind","year":"1990","journal-title":"Annu Rev Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nature02040","article-title":"Osteoblastic cells regulate the haematopoietic stem cell niche.","volume":"425","author":"LM Calvi","year":"2003","journal-title":"Nature"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.blre.2005.11.002","article-title":"The role of mesenchymal stem cells in haemopoiesis.","volume":"20","author":"F Dazzi","year":"2006","journal-title":"Blood Rev"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1182\/blood.V99.10.3838","article-title":"Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli.","volume":"99","author":"M Di Nicola","year":"2002","journal-title":"Blood"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1182\/blood-2003-04-1193","article-title":"Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals.","volume":"102","author":"F Djouad","year":"2003","journal-title":"Blood"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1097\/01.TP.0000082540.43730.80","article-title":"Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells.","volume":"76","author":"I Rasmusson","year":"2003","journal-title":"Transplantation"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/01.TP.0000045055.63901.A9","article-title":"Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation.","volume":"75","author":"WT Tse","year":"2003","journal-title":"Transplantation"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1089\/ten.2006.12.2263","article-title":"Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves.","volume":"12","author":"P Batten","year":"2006","journal-title":"Tissue Eng"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.exphem.2005.05.002","article-title":"Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells.","volume":"33","author":"ME Groh","year":"2005","journal-title":"Exp Hematol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.stem.2007.11.014","article-title":"Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide.","volume":"2","author":"G Ren","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1182\/blood-2004-04-1559","article-title":"Human mesenchymal stem cells modulate allogeneic immune cell responses.","volume":"105","author":"S Aggarwal","year":"2005","journal-title":"Blood"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nm.1905","article-title":"Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production.","volume":"15","author":"K Nemeth","year":"2009","journal-title":"Nat Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/BF02571314","article-title":"Effect of interleukin 1 beta on osteoblastic clone MC3T3-E1 cells.","volume":"43","author":"E Ikeda","year":"1988","journal-title":"Calcif Tissue Int"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF00298724","article-title":"Proliferative responses to estradiol, IL-1 alpha and TGF beta by cells expressing alkaline phosphatase in human osteoblast-like cell cultures.","volume":"52","author":"DJ Rickard","year":"1993","journal-title":"Calcif Tissue Int"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/cr.2010.159","article-title":"Role of NF-kappaB in the skeleton.","volume":"21","author":"DV Novack","year":"2011","journal-title":"Cell Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"9645","DOI":"10.1074\/jbc.275.13.9645","article-title":"Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase.","volume":"275","author":"RK Jaiswal","year":"2000","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.bbrc.2011.10.097","article-title":"Osterix is regulated by Erk1\/2 during osteoblast differentiation.","volume":"415","author":"YH Choi","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"ref44","article-title":"Interactions between extracellular signal-regulated kinase 1\/2 and P38 map kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity.","author":"C Ge","year":"2011"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0006-291X(02)03071-1","article-title":"Cloning and characterization of a functional promoter of the human SOCS-3 gene.","volume":"301","author":"B He","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1128\/MCB.16.7.3490","article-title":"The lipopolysaccharide-binding protein is a secretory class 1 acute-phase protein whose gene is transcriptionally activated by APRF\/STAT\/3 and other cytokine-inducible nuclear proteins.","volume":"16","author":"RR Schumann","year":"1996","journal-title":"Mol Cell Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1006\/bbrc.1994.2053","article-title":"Transcriptional activation of the IL-6 response element in the junB promoter is mediated by multiple Stat family proteins.","volume":"202","author":"Y Fujitani","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.1073\/pnas.131568898","article-title":"Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis.","volume":"98","author":"T Bowman","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1158\/1541-7786.MCR-07-2177","article-title":"Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells.","volume":"6","author":"G Niu","year":"2008","journal-title":"Mol Cancer Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1002\/stem.110","article-title":"Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog.","volume":"27","author":"PY Bourillot","year":"2009","journal-title":"Stem Cells"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.1038\/sj.onc.1208719","article-title":"Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways.","volume":"24","author":"Q Xu","year":"2005","journal-title":"Oncogene"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1038\/sj.onc.1208469","article-title":"Stat3 regulates genes common to both wound healing and cancer.","volume":"24","author":"DJ Dauer","year":"2005","journal-title":"Oncogene"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"823","DOI":"10.18632\/aging.100232","article-title":"A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction.","volume":"2","author":"M Demaria","year":"2010","journal-title":"Aging (Albany NY)"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1172\/JCI40568","article-title":"Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice.","volume":"120","author":"EC Walker","year":"2010","journal-title":"J Clin Invest"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/jcb.20933","article-title":"T-cell cytokine induction of BMP-2 regulates human mesenchymal stromal cell differentiation and mineralization.","volume":"98","author":"L Rifas","year":"2006","journal-title":"J Cell Biochem"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/jcb.10436","article-title":"Inflammatory T cells rapidly induce differentiation of human bone marrow stromal cells into mature osteoblasts.","volume":"88","author":"L Rifas","year":"2003","journal-title":"J Cell Biochem"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1634\/stemcells.2008-0149","article-title":"Hematopoietic stem cells regulate mesenchymal stromal cell induction into osteoblasts thereby participating in the formation of the stem cell niche.","volume":"26","author":"Y Jung","year":"2008","journal-title":"Stem Cells"},{"key":"ref58","doi-asserted-by":"crossref","DOI":"10.1002\/stem.1040","article-title":"Induction of Osteogenesis in Mesenchymal Stem Cells by Activated Monocytes\/Macrophages Depends on Oncostatin M Signaling.","author":"P Guihard","year":"2012"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1182\/blood-2004-07-2921","article-title":"Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness.","volume":"105","author":"S Beyth","year":"2005","journal-title":"Blood"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.exphem.2009.09.004","article-title":"Mesenchymal stem cell-educated macrophages: a novel type of alternatively activated macrophages.","volume":"37","author":"J Kim","year":"2009","journal-title":"Exp Hematol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/endo.138.9.5364","article-title":"Activation of the Janus kinase\/STAT (signal transducer and activator of transcription) signal transduction pathway by interleukin-6-type cytokines promotes osteoblast differentiation.","volume":"138","author":"T Bellido","year":"1997","journal-title":"Endocrinology"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1359\/jbmr.1998.13.5.777","article-title":"Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells.","volume":"13","author":"R Nishimura","year":"1998","journal-title":"J Bone Miner Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.exphem.2006.11.001","article-title":"Contact-dependent induction of regulatory antigen-presenting cells by human mesenchymal stem cells is mediated via STAT3 signaling.","volume":"35","author":"D Gur-Wahnon","year":"2007","journal-title":"Exp Hematol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bone.2006.02.074","article-title":"A critical role for interleukin-6 family-mediated Stat3 activation in osteoblast differentiation and bone formation.","volume":"39","author":"S Itoh","year":"2006","journal-title":"Bone"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/jcp.22017","article-title":"Bone morphogenetic protein 2 and dexamethasone synergistically increase alkaline phosphatase levels through JAK\/STAT signaling in C3H10T1\/2 cells.","volume":"223","author":"Y Mikami","year":"2010","journal-title":"J Cell Physiol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/j.biocel.2010.07.017","article-title":"Highly efficient osteogenic differentiation of human mesenchymal stem cells by eradication of STAT3 signaling.","volume":"42","author":"O Levy","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"8520","DOI":"10.1038\/sj.onc.1207892","article-title":"DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin\/TCF pathway.","volume":"23","author":"A Niida","year":"2004","journal-title":"Oncogene"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/PRS.0b013e3181da8858","article-title":"Regulation of human adipose-derived stromal cell osteogenic differentiation by insulin-like growth factor-1 and platelet-derived growth factor-alpha.","volume":"126","author":"B Levi","year":"2010","journal-title":"Plast Reconstr Surg"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/jcb.21472","article-title":"Expression of serum amyloid A transcripts in human bone tissues, differentiated osteoblast-like stem cells and human osteosarcoma cell lines.","volume":"103","author":"A Kovacevic","year":"2008","journal-title":"J Cell Biochem"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1242\/dev.126.10.2033","article-title":"Eph receptors and ephrins: effectors of morphogenesis.","volume":"126","author":"N Holder","year":"1999","journal-title":"Development"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"14637","DOI":"10.1074\/jbc.M807598200","article-title":"Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis.","volume":"284","author":"N Irie","year":"2009","journal-title":"J Biol Chem"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.bone.2010.10.180","article-title":"EphB\/ephrin-B interactions mediate human MSC attachment, migration and osteochondral differentiation.","volume":"48","author":"A Arthur","year":"2011","journal-title":"Bone"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/jcp.20312","article-title":"GP130\/OSMR is the only LIF\/IL-6 family receptor complex to promote osteoblast differentiation of calvaria progenitors.","volume":"204","author":"L Malaval","year":"2005","journal-title":"J Cell Physiol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1172\/JCI118432","article-title":"Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal\/osteoblastic cells.","volume":"97","author":"T Bellido","year":"1996","journal-title":"J Clin Invest"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/jcb.240540113","article-title":"Regulation of bone marrow stromal cell differentiation by cytokines whose receptors share the gp130 protein.","volume":"54","author":"JM Gimble","year":"1994","journal-title":"J Cell Biochem"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/S0002-9440(10)61120-0","article-title":"Adenoviral transfer of murine oncostatin M elicits periosteal bone apposition in knee joints of mice, despite synovial inflammation and up-regulated expression of interleukin-6 and receptor activator of nuclear factor-kappa B ligand.","volume":"160","author":"AS de Hooge","year":"2002","journal-title":"Am J Pathol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1002\/jcb.21245","article-title":"Oncostatin M promotes osteogenesis and suppresses adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells.","volume":"101","author":"HY Song","year":"2007","journal-title":"J Cell Biochem"},{"key":"ref78","first-page":"2349","article-title":"Developmental abnormalities in mice transgenic for bovine oncostatin M. Mol Cell Biol","volume":"15","author":"N Malik","year":"1995"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"9739","DOI":"10.1073\/pnas.83.24.9739","article-title":"Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells.","volume":"83","author":"JM Zarling","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"5334","DOI":"10.1523\/JNEUROSCI.22-13-05334.2002","article-title":"Prostaglandin E2 is a novel inducer of oncostatin-M expression in macrophages and microglia.","volume":"22","author":"P Repovic","year":"2002","journal-title":"J Neurosci"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1210\/endo.137.4.8625884","article-title":"Activation of the JAK-STAT signal transduction pathway by oncostatin-M cultured human and mouse osteoblastic cells.","volume":"137","author":"JB Levy","year":"1996","journal-title":"Endocrinology"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.febslet.2004.07.082","article-title":"Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes.","volume":"573","author":"Y Fujio","year":"2004","journal-title":"FEBS Lett"},{"key":"ref83","first-page":"273","article-title":"STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (Review).","volume":"19","author":"M Katoh","year":"2007","journal-title":"Int J Mol Med"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ab.2004.02.002","article-title":"An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction.","volume":"329","author":"CA Gregory","year":"2004","journal-title":"Anal Biochem"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"567","DOI":"10.4049\/jimmunol.172.1.567","article-title":"Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages.","volume":"172","author":"L Williams","year":"2004","journal-title":"J Immunol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1074\/jbc.M609101200","article-title":"Expression of constitutively active STAT3 can replicate the cytokine-suppressive activity of interleukin-10 in human primary macrophages.","volume":"282","author":"LM Williams","year":"2007","journal-title":"J Biol Chem"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1359\/jbmr.080324","article-title":"EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblasts.","volume":"23","author":"EH Allan","year":"2008","journal-title":"J Bone Miner Res"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"27585","DOI":"10.1074\/jbc.M802453200","article-title":"Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors.","volume":"283","author":"NM Teplyuk","year":"2008","journal-title":"J Biol Chem"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0378-4274(91)90200-P","article-title":"Induction of metallothionein and stimulation of calcification by dexamethasone in cultured clonal osteogenic cells, MC3T3-E1.","volume":"57","author":"T Miyahara","year":"1991","journal-title":"Toxicol Lett"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1002\/jcb.23265","article-title":"Regulation of tenascin expression in bone.","volume":"112","author":"JM Morgan","year":"2011","journal-title":"J Cell Biochem"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1359\/jbmr.091019","article-title":"Parathyroid hormone induction of cyclooxygenase-2 in murine osteoblasts: role of the calcium-calcineurin-NFAT pathway.","volume":"25","author":"H Huang","year":"2010","journal-title":"J Bone Miner Res"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0167-4889(88)90218-2","article-title":"Effects of recombinant human interleukin 1 alpha and interleukin 1 beta on cell growth and alkaline phosphatase of the mouse osteoblastic cell line MC3T3-E1.","volume":"970","author":"Y Ohmori","year":"1988","journal-title":"Biochim Biophys Acta"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/jcp.1041490106","article-title":"Transforming growth factor beta inhibits plasminogen activator (PA) activity and stimulates production of urokinase-type PA, PA inhibitor-1 mRNA, and protein in rat osteoblast-like cells.","volume":"149","author":"EH Allan","year":"1991","journal-title":"J Cell Physiol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0014-5793(84)81015-7","article-title":"Insulin-like growth factor I supports differentiation of cultured osteoblast-like cells.","volume":"173","author":"C Schmid","year":"1984","journal-title":"FEBS Lett"},{"key":"ref95","article-title":"WNT5A is induced by inflammatory mediators in bone marrow stromal cells and regulates cytokine and chemokine production.","author":"M Rauner","year":"2011"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0014-4827(56)90196-3","article-title":"Alkaline phosphatase in osteoblasts and fibroblasts cultivated in vitro.","volume":"11","author":"E Henrichsen","year":"1956","journal-title":"Exp Cell Res"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1359\/jbmr.2003.18.10.1842","article-title":"BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop.","volume":"18","author":"G Rawadi","year":"2003","journal-title":"J Bone Miner Res"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1677\/joe.0.1270391","article-title":"Characterization of insulin-like growth factor-binding proteins in rat serum, lymph, cerebrospinal and amniotic fluids, and in media conditioned by liver, bone and muscle cells.","volume":"127","author":"SE Gargosky","year":"1990","journal-title":"J Endocrinol"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1128\/MCB.18.7.4197","article-title":"Two domains unique to osteoblast-specific transcription factor Osf2\/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfbeta.","volume":"18","author":"K Thirunavukkarasu","year":"1998","journal-title":"Mol Cell Biol"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1210\/endo-125-1-13","article-title":"Platelet-derived growth factor enhances deoxyribonucleic acid and collagen synthesis in osteoblast-enriched cultures from fetal rat parietal bone.","volume":"125","year":"1989","journal-title":"Endocrinology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0039871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T06:26:13Z","timestamp":1714112773000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0039871"}},"subtitle":[],"editor":[{"given":"Dimas Tadeu","family":"Covas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,3]]},"references-count":100,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0039871","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,3]]}}}