{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:30:25Z","timestamp":1790717425204,"version":"4.1.0"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T00:00:00Z","timestamp":1341532800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0039919","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T16:59:28Z","timestamp":1341593968000},"page":"e39919","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cardioprotection of Controlled and Cardiac-Specific Over-Expression of A2A-Adenosine Receptor in the Pressure Overload"],"prefix":"10.1371","volume":"7","author":[{"given":"Eman A.","family":"Hamad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung O.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhe","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianliang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Y.","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur M.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,7,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"H1797","DOI":"10.1152\/ajpheart.00407.2003","article-title":"Acute adenosinergic cardioprotection in ischemic-reperfused hearts.","volume":"285","author":"HB Headrick JP","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/sj.bjp.0703893","article-title":"Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists.","volume":"132","author":"RJ Sullivan GW","year":"2001","journal-title":"Br J Pharmacol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0008-6363(97)00023-0","article-title":"Adenosine A2 receptor function in rat ventricular myocytes.","volume":"34","author":"JG Dobson Jr","year":"1997","journal-title":"Cardiovasc Res"},{"key":"ref4","first-page":"823","article-title":"Headrick JP WL, Ashton KJ, Holmgren K, Peart J, Matherne GP (2003 ) Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression.","volume":"3)","journal-title":"J of physiol 549 (pt"},{"key":"ref5","first-page":"14","article-title":"Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes.","volume":"217","author":"SV Safran N","year":"2001","journal-title":"Mol Cell Biochem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/0003-4975(96)00495-X","article-title":"Intravascular adenosine at reperfusion reduces infarct size and neutrophil adherence.","volume":"62","author":"J Todd","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1016\/S0003-4975(99)01018-8","article-title":"Broad-spectrum cardioprotection with adenosine.","volume":"68","author":"J Vinten-Johansen","year":"1999","journal-title":"Ann Thorac Surg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1161\/01.CIR.96.8.2656","article-title":"Exogenous and endogenous adenosine inhibits fetal calf serum-induced growth of rat cardiac fibroblasts: role of A2B receptors.","volume":"96","author":"RK Dubey","year":"1997","journal-title":"Circulation"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1161\/01.CIR.97.6.521","article-title":"Adenosine inhibits lipopolysaccharide-induced secretion of tumor necrosis factor-alpha in the failing human heart.","volume":"97","author":"DR Wagner","year":"1998","journal-title":"Circulation"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1097\/00004872-199816120-00015","article-title":"Effects of chronic adenosine uptake blockade on adrenergic responsiveness and left ventricular chamber function in pressure overload hypertrophy in the rat.","volume":"16","author":"ES Chung","year":"1998","journal-title":"J Hypertens"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1161\/01.RES.0000094744.88220.62","article-title":"Activation of adenosine A1 receptor attenuates cardiac hypertrophy and prevents heart failure in murine left ventricular pressure-overload model.","volume":"93","author":"Y Liao","year":"2003","journal-title":"Circ Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1124\/jpet.104.073122","article-title":"Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes.","volume":"312","author":"XT Gan","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1161\/HYPERTENSIONAHA.108.110833","article-title":"Ecto-5\u2032-nucleotidase deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction.","volume":"51","author":"X Xu","year":"2008","journal-title":"Hypertension"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1161\/CIRCULATIONAHA.108.788307","article-title":"Adenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricle.","volume":"118","author":"Z Lu","year":"2008","journal-title":"Circulation"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1161\/CIRCULATIONAHA.106.620211","article-title":"Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function.","volume":"114","author":"H Funakoshi","year":"2006","journal-title":"Circulation"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1056\/NEJM199910213411706","article-title":"Signaling pathways for cardiac hypertrophy and failure.","volume":"341","author":"JJ Hunter","year":"1999","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1056\/NEJMra021498","article-title":"Heart failure.","volume":"348","author":"M Jessup","year":"2003","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1161\/01.CIR.100.20.2093","article-title":"Angiotensin II type 1A receptor knockout mice display less left ventricular remodeling and improved survival after myocardial infarction.","volume":"100","author":"K Harada","year":"1999","journal-title":"Circulation"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5679","DOI":"10.1242\/dev.126.24.5679","article-title":"The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila.","volume":"126","author":"K Gajewski","year":"1999","journal-title":"Development"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1006\/jmcc.2002.2095","article-title":"Release of preformed Ang II from myocytes mediates angiotensinogen and ET-1 gene overexpression in vivo via AT1 receptor.","volume":"34","author":"P Amedeo Modesti","year":"2002","journal-title":"J Mol Cell Cardiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1161\/01.RES.0000065442.64694.9F","article-title":"Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter.","volume":"92","author":"A Sanbe","year":"2003","journal-title":"Circ Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"H1738","DOI":"10.1152\/ajpheart.00688.2009","article-title":"Effects of cardiac-restricted overexpression of the A(2A) adenosine receptor on adriamycin-induced cardiotoxicity.","volume":"298","author":"EA Hamad","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1752-8062.2008.00027.x","article-title":"Cardiac-restricted overexpression of the A(2A)-adenosine receptor in FVB mice transiently increases contractile performance and rescues the heart failure phenotype in mice overexpressing the A(1)-adenosine receptor.","volume":"1","author":"TO Chan","year":"2008","journal-title":"Clin Transl Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1161\/CIRCULATIONAHA.107.694596","article-title":"A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction.","volume":"115","author":"H Funakoshi","year":"2007","journal-title":"Circulation"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00418-008-0541-5","article-title":"Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload.","volume":"131","author":"Y Xia","year":"2009","journal-title":"Histochem Cell Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1161\/HYPERTENSIONAHA.110.158915","article-title":"C-reactive protein overexpression exacerbates pressure overload-induced cardiac remodeling through enhanced inflammatory response.","volume":"57","author":"T Nagai","year":"2011","journal-title":"Hypertension"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"H590","DOI":"10.1152\/ajpheart.00379.2005","article-title":"Cardioprotection afforded by NF-kappaB ablation is associated with activation of Akt in mice overexpressing TNF-alpha.","volume":"290","author":"Y Higuchi","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1189\/jlb.0607359","article-title":"A2A receptors in inflammation and injury: lessons learned from transgenic animals.","volume":"83","author":"G Hasko","year":"2008","journal-title":"J Leukoc Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ejphar.2011.06.049","article-title":"CGS 21680, an agonist of the adenosine (A2A) receptor, decreases acute lung inflammation.","volume":"668","author":"D Impellizzeri","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0002-9440(10)63698-X","article-title":"An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors.","volume":"163","author":"G Pinhal-Enfield","year":"2003","journal-title":"Am J Pathol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1172\/JCI108079","article-title":"Wall stress and patterns of hypertrophy in the human left ventricle.","volume":"56","author":"W Grossman","year":"1975","journal-title":"J Clin Invest"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1161\/01.RES.35.5.793","article-title":"Left ventricular stiffness associated with chronic pressure and volume overloads in man.","volume":"35","author":"W Grossman","year":"1974","journal-title":"Circ Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0140-6736(06)68074-4","article-title":"Controversies in ventricular remodelling.","volume":"367","author":"LH Opie","year":"2006","journal-title":"Lancet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00123828","article-title":"Smooth, cardiac and skeletal muscle myosin force and motion generation assessed by cross-bridge mechanical interactions in vitro.","volume":"15","author":"DE Harris","year":"1994","journal-title":"J Muscle Res Cell Motil"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1161\/01.RES.56.1.78","article-title":"The economy of isometric force development, myosin isoenzyme pattern and myofibrillar ATPase activity in normal and hypothyroid rat myocardium.","volume":"56","author":"C Holubarsch","year":"1985","journal-title":"Circ Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1007\/BF01907857","article-title":"Energetic changes of myocardium as an adaptation to chronic hemodynamic overload and thyroid gland activity.","volume":"80","author":"C Holubarsch","year":"1985","journal-title":"Basic Res Cardiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1016\/j.jacc.2004.09.044","article-title":"Impact of beta-myosin heavy chain expression on cardiac function during stress.","volume":"44","author":"M Krenz","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"ref38","first-page":"H400","article-title":"Myosin heavy chain regulation and myocyte contractile depression after LV hypertrophy in aortic-banded mice.","volume":"267","year":"1994","journal-title":"Am J Physiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"H1274","DOI":"10.1152\/ajpheart.00174.2006","article-title":"Pressure overload-induced hypertrophy in transgenic mice selectively overexpressing AT2 receptors in ventricular myocytes.","volume":"294","author":"X Yan","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1101\/gad.915701","article-title":"Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA.","volume":"15","author":"F Charron","year":"2001","journal-title":"Genes Dev"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"30245","DOI":"10.1074\/jbc.M102174200","article-title":"The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo.","volume":"276","author":"Q Liang","year":"2001","journal-title":"J Biol Chem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejheart.2003.07.007","article-title":"Increased regulatory activity of the calcineurin\/NFAT pathway in human heart failure.","volume":"6","author":"H Diedrichs","year":"2004","journal-title":"Eur J Heart Fail"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1152\/physiolgenomics.00004.2004","article-title":"Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks.","volume":"17","author":"JL Hall","year":"2004","journal-title":"Physiol Genomics"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3892\/mmr_00000287","article-title":"Adrenergic receptor blockade-induced regression of pressure-overload cardiac hypertrophy is associated with inhibition of the calcineurin\/NFAT3\/GATA4 pathway.","volume":"3","author":"D Yang","year":"2010","journal-title":"Mol Med Report"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"34983","DOI":"10.1074\/jbc.M005498200","article-title":"Calcineurin-GATA4 pathway is involved in beta-adrenergic agonist-responsive endothelin-1 transcription in cardiac myocytes.","volume":"276","author":"T Morimoto","year":"2001","journal-title":"J Biol Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"28586","DOI":"10.1074\/jbc.M103166200","article-title":"Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes.","volume":"276","author":"C Morisco","year":"2001","journal-title":"J Biol Chem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/sj.bjp.0702676","article-title":"Expression of immediate early genes, GATA-4, and Nkx-2.5 in adrenergic-induced cardiac hypertrophy and during regression in adult mice.","volume":"127","author":"N Saadane","year":"1999","journal-title":"Br J Pharmacol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1182\/blood-2007-01-065870","article-title":"A2A adenosine receptors and C\/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli.","volume":"110","author":"B Csoka","year":"2007","journal-title":"Blood"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1189\/jlb.0107060","article-title":"Adenosine A2a receptor-mediated, normoxic induction of HIF-1 through PKC and PI-3K-dependent pathways in macrophages.","volume":"82","author":"C De Ponti","year":"2007","journal-title":"J Leukoc Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1067\/mtc.2002.124886","article-title":"Adenosine A2A receptor activation decreases reperfusion injury associated with high-flow reperfusion.","volume":"124","author":"SM Fiser","year":"2002","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1161\/01.ATV.21.5.791","article-title":"Adenosine A(2A) receptor stimulation reduces inflammation and neointimal growth in a murine carotid ligation model.","volume":"21","author":"JA McPherson","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref52","first-page":"F404","article-title":"Selective A2A adenosine receptor activation reduces ischemia-reperfusion injury in rat kidney.","volume":"277","author":"MD Okusa","year":"1999","journal-title":"Am J Physiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1161\/CIRCULATIONAHA.106.622415","article-title":"Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction.","volume":"114","author":"SH Most P","year":"2006","journal-title":"Circulation"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0039919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T09:28:45Z","timestamp":1642670925000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0039919"}},"subtitle":[],"editor":[{"given":"Piero","family":"Anversa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,6]]},"references-count":54,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0039919","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,6]]}}}