{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:02:58Z","timestamp":1791291778609,"version":"4.1.0"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2012,6,29]],"date-time":"2012-06-29T00:00:00Z","timestamp":1340928000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0039945","type":"journal-article","created":{"date-parts":[[2012,6,29]],"date-time":"2012-06-29T21:41:31Z","timestamp":1341006091000},"page":"e39945","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":133,"title":["Cross-Talk between NFkB and the PI3-Kinase\/AKT Pathway Can Be Targeted in Primary Effusion Lymphoma (PEL) Cell Lines for Efficient Apoptosis"],"prefix":"10.1371","volume":"7","author":[{"given":"Azhar R.","family":"Hussain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeeda O.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maqbool","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar S.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Al AbdulMohsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas C.","family":"Platanias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khawla S.","family":"Al-Kuraya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahab","family":"Uddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,6,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511545313.057","article-title":"KSHV-induced oncogenesis.","author":"D Ganem","year":"2007"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-0-387-46816-7_2","article-title":"AIDS malignancies.","volume":"133","author":"A Arora","year":"2007","journal-title":"Cancer Treat Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2141.2007.06879.x","article-title":"KSHV\/HHV8-associated lymphomas.","volume":"140","author":"A Carbone","year":"2008","journal-title":"Br J Haematol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1600-6143.2007.02110.x","article-title":"Human herpesvirus-8 (HHV-8)-associated primary effusion lymphoma in two renal transplant recipients receiving rapamycin.","volume":"8","author":"E Boulanger","year":"2008","journal-title":"Am J Transplant"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1600-6143.2008.02156.x","article-title":"Pleural primary effusion lymphoma in a renal transplant recipient.","volume":"8","author":"NC Melo","year":"2008","journal-title":"Am J Transplant"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jcv.2008.08.015","article-title":"Primary effusion lymphoma in three patients with chronic hepatitis B infection.","volume":"44","author":"SJ Wu","year":"2009","journal-title":"J Clin Virol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/cncr.22691","article-title":"Primary effusion lymphoma: a series of 4 cases and review of the literature with emphasis on cytomorphologic and immunocytochemical differential diagnosis.","volume":"111","author":"F Brimo","year":"2007","journal-title":"Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1182\/blood.V97.7.2173","article-title":"Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders.","volume":"97","author":"Y Aoki","year":"2001","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1182\/blood.V94.8.2871","article-title":"Involvement of interleukin-10 (IL-10) and viral IL-6 in the spontaneous growth of Kaposi\u2019s sarcoma herpesvirus-associated infected primary effusion lymphoma cells.","volume":"94","author":"KD Jones","year":"1999","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/34193","article-title":"G-protein-coupled receptor of Kaposi\u2019s sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator.","volume":"391","author":"C Bais","year":"1998","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1038\/sj.leu.2403460","article-title":"Antitumor effects of bortezomib (PS-341) on primary effusion lymphomas.","volume":"18","author":"J An","year":"2004","journal-title":"Leukemia"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1158\/1078-0432.CCR-04-1857","article-title":"Inhibition of phosphatidylinositol 3\u2032-kinase\/AKT signaling promotes apoptosis of primary effusion lymphoma cells.","volume":"11","author":"S Uddin","year":"2005","journal-title":"Clin Cancer Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"7022","DOI":"10.1038\/sj.onc.1208864","article-title":"Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma.","volume":"24","author":"S Uddin","year":"2005","journal-title":"Oncogene"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1158\/1541-7786.MCR-07-2088","article-title":"Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis.","volume":"6","author":"G Sethi","year":"2008","journal-title":"Mol Cancer Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00428-005-1264-9","article-title":"NF-kB in development and progression of human cancer.","volume":"446","author":"X Dolcet","year":"2005","journal-title":"Virchows Arch"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"R191","DOI":"10.1016\/S0960-9822(00)00349-3","article-title":"Protein kinases: six degrees of separation?","volume":"10","author":"MP Scheid","year":"2000","journal-title":"Curr Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1080\/01635581.2010.509538","article-title":"Chemopreventive potential of natural compounds in head and neck cancer.","volume":"62","author":"MA Rahman","year":"2010","journal-title":"Nutr Cancer"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1476-4598-9-97","article-title":"NF-kappaB\/STAT3\/PI3K signaling crosstalk in iMyc E mu B lymphoma.","volume":"9","author":"SS Han","year":"2010","journal-title":"Mol Cancer"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.cellsig.2009.12.010","article-title":"Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth.","volume":"22","author":"N Ghosh-Choudhury","year":"2010","journal-title":"Cell Signal"},{"key":"ref20","first-page":"212","article-title":"Messengers of cell death: apoptotic signaling in health and disease.","volume":"88","author":"D Rossi","year":"2003","journal-title":"Haematologica"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death.","volume":"35","author":"S Elmore","year":"2007","journal-title":"Toxicol Pathol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3322\/canjclin.55.3.178","article-title":"Targeting apoptosis pathways in cancer therapy.","volume":"55","author":"IM Ghobrial","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1038\/ajg.2009.230","article-title":"High prevalence of fatty acid synthase expression in colorectal cancers in Middle Eastern patients and its potential role as a therapeutic target.","volume":"104","author":"S Uddin","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1038\/sj.leu.2403096","article-title":"Current trends in large cell lymphoma.","volume":"17","author":"RI Fisher","year":"2003","journal-title":"Leukemia"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e24703","DOI":"10.1371\/journal.pone.0024703","article-title":"Resveratrol suppresses constitutive activation of AKT via generation of ROS and induces apoptosis in diffuse large B cell lymphoma cell lines.","volume":"6","author":"AR Hussain","year":"2011","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10495-006-3392-3","article-title":"Curcumin induces apoptosis via inhibition of PI3\u2032-kinase\/AKT pathway in acute T cell leukemias.","volume":"11","author":"AR Hussain","year":"2006","journal-title":"Apoptosis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1158\/1535-7163.MCT-08-0541","article-title":"Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt\u2019s lymphoma cell lines.","volume":"7","author":"AR Hussain","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1073\/pnas.0307075101","article-title":"Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells.","volume":"101","author":"S Uddin","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bcp.2005.04.043","article-title":"Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1\/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma.","volume":"70","author":"S Shishodia","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1182\/blood-2007-05-088591","article-title":"Protein kinase C-associated kinase is required for NF-kappaB signaling and survival in diffuse large B-cell lymphoma cells.","volume":"111","author":"SW Kim","year":"2008","journal-title":"Blood"},{"key":"ref31","article-title":"Bexarotene via CBP\/p300 induces suppression of NF-kappaB-dependent cell growth and invasion in thyroid cancer.","author":"A Cras","year":"2011"},{"key":"ref32","article-title":"Modulation of NF-kappaB-dependent gene transcription using programmable DNA minor groove binders.","author":"JA Raskatov","year":"2011"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0092-8674(00)81064-8","article-title":"Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity.","volume":"84","author":"ZJ Chen","year":"1996","journal-title":"Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1182\/blood-2002-05-1320","article-title":"Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis.","volume":"101","author":"AC Bharti","year":"2003","journal-title":"Blood"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.bcp.2003.12.015","article-title":"Andrographolide suppresses endothelial cell apoptosis via activation of phosphatidyl inositol-3-kinase\/Akt pathway.","volume":"67","author":"JH Chen","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"11615","DOI":"10.1074\/jbc.M010810200","article-title":"Bax is present as a high molecular weight oligomer\/complex in the mitochondrial membrane of apoptotic cells.","volume":"276","author":"B Antonsson","year":"2001","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1158\/0008-5472.CAN-06-3764","article-title":"Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells.","volume":"67","author":"AR Hussain","year":"2007","journal-title":"Cancer Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.1210\/jc.2008-0503","article-title":"Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers.","volume":"93","author":"S Uddin","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1158\/0008-5472.CAN-07-6109","article-title":"Bortezomib (Velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer.","volume":"68","author":"S Uddin","year":"2008","journal-title":"Cancer Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1080\/10428190902951799","article-title":"Proteasome inhibitor MG-132 mediated expression of p27Kip1 via S-phase kinase protein 2 degradation induces cell cycle coupled apoptosis in primary effusion lymphoma cells.","volume":"50","author":"AR Hussain","year":"2009","journal-title":"Leuk Lymphoma"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","article-title":"Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.","volume":"22","author":"TC Chou","year":"1984","journal-title":"Adv Enzyme Regul"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1182\/blood.V96.7.2537","article-title":"Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells.","volume":"96","author":"SA Keller","year":"2000","journal-title":"Blood"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.virol.2007.12.044","article-title":"Effects of NFkappaB activation on KSHV latency and lytic reactivation are complex and context-dependent.","volume":"375","author":"C Grossmann","year":"2008","journal-title":"Virology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/sj.onc.1205018","article-title":"Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment.","volume":"21","author":"B Joseph","year":"2002","journal-title":"Oncogene"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1128\/MCB.20.3.929-935.2000","article-title":"Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane.","volume":"20","author":"R Eskes","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"19066","DOI":"10.1074\/jbc.M100614200","article-title":"Cytochrome c release occurs via Ca2+-dependent and Ca2+-independent mechanisms that are regulated by Bax.","volume":"276","author":"V Gogvadze","year":"2001","journal-title":"J Biol Chem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"11549","DOI":"10.1074\/jbc.274.17.11549","article-title":"An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9.","volume":"274","author":"H Zou","year":"1999","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"633","DOI":"10.2174\/156652411797536723","article-title":"Inhibitors of apoptosis proteins (IAPs) as potential molecular targets for therapy of hematological malignancies.","volume":"11","author":"P Smolewski","year":"2011","journal-title":"Curr Mol Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/ajcp\/105.2.221","article-title":"Primary body cavity-based AIDS-related lymphomas.","volume":"105","author":"MQ Ansari","year":"1996","journal-title":"Am J Clin Pathol"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0092484","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T00:00:00Z","timestamp":1394409600000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0039945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T07:41:51Z","timestamp":1714117311000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0039945"}},"subtitle":[],"editor":[{"given":"Ferenc","family":"Gallyas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,6,29]]},"references-count":49,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,6,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0039945","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,29]]}}}