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Bradley","year":"2001","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1128\/IAI.63.1.82-87.1995","article-title":"Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases.","volume":"63","author":"VM Gordon","year":"1995","journal-title":"Infect Immun"},{"key":"ref11","first-page":"543","article-title":"Serum protease cleavage of Bacillus anthracis protective antigen.","volume":"3)","author":"JW Ezzell Jr","year":"1992","journal-title":"J Gen Microbiol 138 (Pt"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"20607","DOI":"10.1016\/S0021-9258(17)32036-7","article-title":"Anthrax protective antigen forms oligomers during intoxication of mammalian cells.","volume":"269","author":"JC Milne","year":"1994","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.jmb.2009.07.037","article-title":"The protective 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Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"680","DOI":"10.7326\/0003-4819-125-8-199610150-00009","article-title":"Immunologic dissonance: a continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS).","volume":"125","author":"RC Bone","year":"1996","journal-title":"Ann Intern Med"},{"key":"ref47","first-page":"335","article-title":"Initial studies on the administration of C1-esterase inhibitor to patients with septic shock or with a vascular leak syndrome induced by interleukin-2 therapy.","volume":"388","author":"CE Hack","year":"1994","journal-title":"Prog Clin Biol Res"},{"year":"2010","author":"J Terra","article-title":"Characterizing the Role of Host Allelic Variation in Susceptibility to Anthrax [Thesis.","key":"ref48"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"R699","DOI":"10.1152\/ajpregu.00593.2003","article-title":"Lethality during continuous anthrax 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Medicine"},{"key":"ref56","first-page":"21","article-title":"Pulmonary capillary pressure. A review.","volume":"72","author":"CC Ganter","year":"2006","journal-title":"Minerva Anestesiologica"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/S0002-9440(10)63532-8","article-title":"Susceptibility to anthrax lethal toxin is controlled by three linked quantitative trait loci.","volume":"163","author":"RD McAllister","year":"2003","journal-title":"Am J Pathol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1046\/j.1365-2958.1998.00953.x","article-title":"Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11.","volume":"29","author":"JE Roberts","year":"1998","journal-title":"Mol Microbiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1055\/s-2006-933338","article-title":"Tissue factor in infection and severe inflammation.","volume":"32","author":"M Levi","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"ref60","first-page":"114","article-title":"New insights into pathways that determine the link between infection and thrombosis.","volume":"70","author":"M Levi","year":"2012","journal-title":"Neth J Med"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"6687","DOI":"10.1073\/pnas.85.18.6687","article-title":"Activation of factor VII bound to tissue factor: a key early step in the tissue factor pathway of blood coagulation.","volume":"85","author":"LV Rao","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1538-7836.2005.01128.x","article-title":"Initiation and propagation of coagulation from tissue factor-bearing cell monolayers to plasma: initiator cells do not regulate spatial growth rate.","volume":"3","author":"MV Ovanesov","year":"2005","journal-title":"J Thromb 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Med"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3390\/toxins3091111","article-title":"Anthrax lethal toxin-induced gene expression changes in mouse lung.","volume":"3","author":"EK Dumas","year":"2011","journal-title":"Toxins"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000068129","article-title":"Derangements of coagulation and fibrinolysis in infectious diseases.","volume":"10","author":"CE Hack","year":"2003","journal-title":"Contrib Microbiol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1152\/physiol.00059.2005","article-title":"The interaction between pathogens and the host coagulation system.","volume":"21","author":"H Sun","year":"2006","journal-title":"Physiology"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1128\/CMR.12.1.19","article-title":"Role of heat shock proteins in protection from and pathogenesis of infectious diseases.","volume":"12","author":"U Zugel","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1089\/ars.2009.2800","article-title":"HIF prolyl hydroxylase inhibitors prevent neuronal death induced by mitochondrial toxins: therapeutic implications for Huntington\u2019s disease and Alzheimer\u2019s disease.","volume":"12","author":"Z Niatsetskaya","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"e11241","DOI":"10.1371\/journal.pone.0011241","article-title":"Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1alpha in melanoma cells.","volume":"5","author":"F Spinella","year":"2010","journal-title":"PLoS ONE"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome.","volume":"440","author":"F Martinon","year":"2006","journal-title":"Nature"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"11025","DOI":"10.1128\/JVI.75.22.11025-11033.2001","article-title":"Infection and activation of monocytes by Marburg and Ebola viruses.","volume":"75","author":"U Stroher","year":"2001","journal-title":"J Virol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/bbrc.2002.6626","article-title":"TNF receptor 1, IL-1 receptor, and iNOS genetic knockout mice are not protected from anthrax infection.","volume":"292","author":"J Kalns","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1753425909347508","article-title":"Muramyldipeptide augments the actions of lipopolysaccharide in mice by stimulating macrophages to produce pro-IL-1beta and by down-regulation of the suppressor of cytokine signaling 1 (SOCS1).","volume":"17","author":"Y Shikama","year":"2011","journal-title":"Innate Immun"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/intimm\/dxp122","article-title":"IFN-gamma is a master regulator of endotoxin shock syndrome in mice primed with heat-killed Propionibacterium acnes.","volume":"22","author":"K Kawa","year":"2010","journal-title":"Internat Immunol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"678","DOI":"10.3181\/00379727-124-31823","article-title":"Effect of temperature and drug therapy on anthrax intoxications.","volume":"124","author":"F Klein","year":"1967","journal-title":"Proc Soc Exp Biol Med"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1056\/NEJMoa061592","article-title":"NALP1 in vitiligo-associated multiple autoimmune disease.","volume":"356","author":"Y Jin","year":"2007","journal-title":"New Engl J Med"},{"key":"ref79","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2008.10.039","article-title":"Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome.","author":"A Lev-Sagie","year":"2009"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/cc7702","article-title":"Bench-to-bedside review: Association of genetic variation with sepsis.","volume":"13","author":"AM Sutherland","year":"2009","journal-title":"Crit Care"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/geno.2000.6497","article-title":"Genome-tagged mice (GTM): two sets of genome-wide congenic strains.","volume":"74","author":"OA Iakoubova","year":"2001","journal-title":"Genomics"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ygeno.2007.05.009","article-title":"A genome-wide set of congenic mouse strains derived from CAST\/Ei on a C57BL\/6 background.","volume":"90","author":"RC Davis","year":"2007","journal-title":"Genomics"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"7006","DOI":"10.1128\/IAI.73.10.7006-7010.2005","article-title":"Pathophysiological manifestations in mice exposed to anthrax lethal toxin.","volume":"73","author":"NC Culley","year":"2005","journal-title":"Infect Immun"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1152\/jappl.2000.89.4.1561","article-title":"Systemic hypoxia increases leukocyte emigration and vascular permeability in conscious rats.","volume":"89","author":"JG Wood","year":"2000","journal-title":"J Appl Physiol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1152\/jappl.2001.91.3.1160","article-title":"Leukotriene B(4) promotes reactive oxidant generation and leukocyte adherence during acute hypoxia.","volume":"91","author":"DR Steiner","year":"2001","journal-title":"J Appl Physiol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1172\/JCI17129","article-title":"Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.","volume":"112","author":"RM McLoughlin","year":"2003","journal-title":"J Clin Invest"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"5018","DOI":"10.1128\/IAI.00499-07","article-title":"Role of interleukin-1beta in activating the CD11c(high) CD45RB- dendritic cell subset and priming Leishmania amazonensis-specific CD4+ T cells in vitro and in vivo.","volume":"75","author":"L Xin","year":"2007","journal-title":"Infect Immun"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nm1008","article-title":"Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways.","volume":"10","author":"H Bj\u00f6rkbacka","year":"2004","journal-title":"Nat Med"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.immuni.2006.02.004","article-title":"Critical role for NALP3\/CIAS1\/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1.","volume":"24","author":"FS Sutterwala","year":"2006","journal-title":"Immunity"},{"year":"1918","author":"H Gray","article-title":"Anatomy of the Human Body; Lewis WH, editor. Philadelphia: Lea & Febiger. Fig. 535.","key":"ref90"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jneuroim.2005.08.020","article-title":"Statistical analysis of data from studies on experimental autoimmune encephalomyelitis.","volume":"170","author":"KK Fleming","year":"2005","journal-title":"J Neuroimmunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0040126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T08:56:08Z","timestamp":1743670568000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0040126"}},"subtitle":[],"editor":[{"given":"J\u00f6rn","family":"Coers","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,5]]},"references-count":91,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0040126","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2012,7,5]]}}}