{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:08:47Z","timestamp":1789945727581,"version":"4.0.1"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T00:00:00Z","timestamp":1341446400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0040135","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T01:11:45Z","timestamp":1341537105000},"page":"e40135","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":98,"title":["Antibacterial Activity and Mechanism of a Scorpion Venom Peptide Derivative In Vitro and In Vivo"],"prefix":"10.1371","volume":"7","author":[{"given":"Luyang","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingliang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,7,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrmicro2312","article-title":"Call of the wild: antibiotic resistance genes in natural environments.","volume":"8","author":"HK Allen","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nrmicro2319","article-title":"Antibiotic resistance and its cost: is it possible to reverse resistance?","volume":"8","author":"DI Andersson","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.idc.2010.11.006","article-title":"Common approaches to the control of multidrug-resistant organisms other than methicillin-resistant Staphylococcus aureus (MRSA).","volume":"25","author":"C Hebert","year":"2011","journal-title":"Infect Dis Clin North Am"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.ijid.2010.05.003","article-title":"Methicillin-resistant Staphylococcus aureus: the superbug.","volume":"14","author":"G Ippolito","year":"2010","journal-title":"Int J Infect Dis"},{"key":"ref5","first-page":"217","article-title":"Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?","volume":"38","author":"NK Brogden","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.resmic.2011.02.005","article-title":"Natural roles of antimicrobial peptides in microbes, plants and animals.","volume":"162","author":"G Maroti","year":"2011","journal-title":"Res Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1747-0285.2010.01067.x","article-title":"Antimicrobial beta-peptides and alpha-peptoids.","volume":"77","author":"T Godballe","year":"2011","journal-title":"Chem Biol Drug Des"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/415389a","article-title":"Antimicrobial peptides of multicellular organisms.","volume":"415","author":"M Zasloff","year":"2002","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1128\/AAC.00542-08","article-title":"Mucroporin, the first cationic host defense peptide from the venom of Lychas mucronatus.","volume":"52","author":"C Dai","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nature04051","article-title":"Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus.","volume":"437","author":"PH Mygind","year":"2005","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1128\/AAC.01436-08","article-title":"Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates.","volume":"53","author":"Z Zhao","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/bioinformatics\/btm068","article-title":"AMPer: a database and an automated discovery tool for antimicrobial peptides.","volume":"23","author":"CD Fjell","year":"2007","journal-title":"Bioinformatics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1128\/CMR.00056-05","article-title":"Peptide antimicrobial agents.","volume":"19","author":"H Jenssen","year":"2006","journal-title":"Clin Microbiol Rev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.canlet.2009.10.011","article-title":"BmKCT toxin inhibits glioma proliferation and tumor metastasis.","volume":"291","author":"S Fan","year":"2010","journal-title":"Cancer Lett"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/1471-2164-10-290","article-title":"Transcriptome analysis of the venom gland of the scorpion Scorpiops jendeki: implication for the evolution of the scorpion venom arsenal.","volume":"10","author":"Y Ma","year":"2009","journal-title":"BMC Genomics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.1046\/j.1432-1327.2000.01556.x","article-title":"Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus.","volume":"267","author":"A Torres-Larios","year":"2000","journal-title":"Eur J Biochem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0014-5793(00)01384-3","article-title":"Scorpine, an anti-malaria and anti-bacterial agent purified from scorpion venom.","volume":"471","author":"R Conde","year":"2000","journal-title":"FEBS Lett"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1046\/j.1432-1033.2002.03177.x","article-title":"Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa.","volume":"269","author":"L Moerman","year":"2002","journal-title":"Eur J Biochem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1006\/bbrc.2001.5472","article-title":"IsCT, a novel cytotoxic linear peptide from scorpion Opisthacanthus madagascariensis.","volume":"286","author":"L Dai","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.peptides.2009.10.008","article-title":"Cloning and functional characterization of a new antimicrobial peptide gene StCT1 from the venom of the scorpion Scorpiops tibetanus.","volume":"31","author":"W Yuan","year":"2010","journal-title":"Peptides"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.peptides.2003.12.003","article-title":"Identification and functional characterization of novel scorpion venom peptides with no disulfide bridge from Buthus martensii Karsch.","volume":"25","author":"XC Zeng","year":"2004","journal-title":"Peptides"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e34947","DOI":"10.1371\/journal.pone.0034947","article-title":"Anti-HIV-1 Activity of a New Scorpion Venom Peptide Derivative Kn2\u20137.","volume":"7","author":"Y Chen","year":"2012","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrd3591","article-title":"Designing antimicrobial peptides: form follows function.","volume":"11","author":"CD Fjell","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nrmicro2095","article-title":"Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations.","volume":"7","author":"MN Melo","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M111.332270","article-title":"Structure-activity analysis of the dermcidin-derived peptide DCD 1L, an anionic antimicrobial peptide present in human sweat.","author":"M Paulmann","year":"2012"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e1000190","DOI":"10.1371\/journal.ppat.1000190","article-title":"The antimicrobial peptide histatin-5 causes a spatially restricted disruption on the Candida albicans surface, allowing rapid entry of the peptide into the cytoplasm.","volume":"4","author":"AB Mochon","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nrmicro1098","article-title":"Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?","volume":"3","author":"KA Brogden","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"ref28","first-page":"203","article-title":"[Method of quantitative determination of vaccine activity against botulism of the mink].","volume":"32","author":"LV Kirillov","year":"1976","journal-title":"Dev Biol Stand"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/infdis\/jiq029","article-title":"Underlying mechanism of in vivo and in vitro activity of C-terminal-amidated thanatin against clinical isolates of extended-spectrum beta-lactamase-producing Escherichia coli.","volume":"203","author":"Z Hou","year":"2011","journal-title":"J Infect Dis"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0315211","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0040135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T04:13:16Z","timestamp":1588997596000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0040135"}},"subtitle":[],"editor":[{"given":"Paulo Lee","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,5]]},"references-count":29,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0040135","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,5]]}}}