{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T09:51:31Z","timestamp":1775901091940,"version":"3.50.1"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,16]],"date-time":"2012-07-16T00:00:00Z","timestamp":1342396800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0040249","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T07:40:52Z","timestamp":1342683652000},"page":"e40249","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["An Asian Validation of the TIMI Risk Score for ST-Segment Elevation Myocardial Infarction"],"prefix":"10.1371","volume":"7","author":[{"given":"Sharmini","family":"Selvarajah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan Yean Yip","family":"Fong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunavathy","family":"Selvaraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamaiyah","family":"Haniff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuno S. P. M.","family":"Uiterwaal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiel L.","family":"Bots","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,7,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1161\/01.CIR.0000030416.80014.F4","article-title":"Evidence-Based Risk Stratification to Target Therapies in Acute Coronary Syndromes.","volume":"106","author":"CP Cannon","year":"2002","journal-title":"Circulation"},{"key":"ref2","first-page":"1309","article-title":"New advances in the management of acute coronary syndromes: 1. Matching treatment to risk.","volume":"164","author":"D Fitchett","year":"2001","journal-title":"CMAJ"},{"key":"ref3","first-page":"917","article-title":"Acute Coronary Syndromes: Diagnosis and Management, Part I. Mayo Clin Proc","volume":"84","author":"A Kumar","year":"2009"},{"key":"ref4","first-page":"588","article-title":"ACC\/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction\u2013Executive Summary.","volume":"110","author":"EM Antman","year":"2004","journal-title":"Circulation"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0140-6736(03)12113-7","article-title":"Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials.","volume":"361","author":"EC Keeley","year":"2003","journal-title":"The Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1161\/01.CIR.102.17.2031","article-title":"TIMI Risk Score for ST-Elevation Myocardial Infarction: A Convenient, Bedside, Clinical Score for Risk Assessment at Presentation : An Intravenous nPA for Treatment of Infarcting Myocardium Early II Trial Substudy.","volume":"102","author":"DA Morrow","year":"2000","journal-title":"Circulation"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1001\/jama.286.11.1356","article-title":"Application of the TIMI Risk Score for ST-Elevation MI in the National Registry of Myocardial Infarction 3.","volume":"286","author":"DA Morrow","year":"2001","journal-title":"JAMA"},{"key":"ref8","first-page":"788","article-title":"TIMI Risk Score accurately predicts risk of death in 30-day and one-year follow-up in STEMI patients treated with primary percutaneous coronary interventions.","volume":"65","author":"A Kozieradzka","year":"2007","journal-title":"Kardiol Pol"},{"key":"ref9","article-title":"Annual report of the NCVD-ACS registry, Year 2007 &amp; 2008.","author":"WA Wan Ahmad","year":"2010"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.atherosclerosis.2009.03.042","article-title":"Diabetes mellitus is associated with distal embolization, impaired myocardial perfusion, and higher mortality in patients with ST-segment elevation myocardial infarction treated with primary angioplasty and glycoprotein IIb-IIIa inhibitors.","volume":"207","author":"L Giuseppe De","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref11","first-page":"493","article-title":"Elevated Admission Serum Creatinine Predicts Poor Myocardial Blood Flow and One-Year Mortality in ST-Segment Elevation Myocardial Infarction Patients undergoing Primary Percutaneous Coronary Intervention.","volume":"21","author":"L Zhao","year":"2009","journal-title":"J Invasive Cardiol"},{"key":"ref12","article-title":"Clinical Practice Guidelines - Management Of Acute ST Segment Elevation Myocardial Infarction (STEMI) 2007.","year":"2008"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1053\/euhj.2000.2498","article-title":"Intravenous NPA for the treatment of infarcting myocardium early. InTIME-II, a double-blind comparison of single-bolus lanoteplase vs accelerated alteplase for the treatment of patients with acute myocardial infarction.","volume":"21","author":"Investigators The InTIME II","year":"2000","journal-title":"Eur Heart J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.diabres.2009.04.025","article-title":"External validation of a clinical scoring system for the risk of gestational diabetes mellitus.","volume":"85","author":"M van Leeuwen","year":"2009","journal-title":"Diabetes Res Clin Prac"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1093\/eurheartj\/ehn416","article-title":"Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation.","volume":"29","author":"F Van de Werf","year":"2008","journal-title":"Eur Heart J"},{"key":"ref16","first-page":"C25","article-title":"Optimizing outcomes in patients with STEMI: mortality, bleeding, door-to-balloon times, and guidelines: the approach to regional systems for STEMI care: defining the ideal approach to reperfusion therapy based on recent trials.","author":"N Danchin","year":"2009"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.ahj.2010.11.022","article-title":"High-risk patients with ST-elevation myocardial infarction derive greatest absolute benefit from primary percutaneous coronary intervention: Results from the Primary Coronary Angioplasty Trialist versus Thrombolysis (PCAT)-2 Collaboration.","volume":"161","author":"SPM de Boer","year":"2011","journal-title":"Am Heart J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.ajem.2008.04.026","article-title":"Percutaneous coronary intervention\u2013related time delay, patient\u2019s risk profile, and survival benefits of primary angioplasty vs lytic therapy in ST-segment elevation myocardial infarction.","volume":"27","author":"G De Luca","year":"2009","journal-title":"Am J Emerg Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1253\/circj.CJ-07-0712","article-title":"Primary Percutaneous Coronary Intervention vs Conservative Treatment for Acute ST Elevation Myocardial Infarction Short- and Long-Term Follow-up According to Disease Severity.","volume":"72","author":"R Koyanagi","year":"2008","journal-title":"Circ J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.amjcard.2005.04.015","article-title":"Early Prognostic Usefulness of C-Reactive Protein Added to the Thrombolysis In Myocardial Infarction Risk Score in Acute Coronary Syndromes.","volume":"96","author":"SG Foussas","year":"2005","journal-title":"Am J Cardiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ijcard.2007.10.045","article-title":"NT-proBNP on admission for early risk stratification in STEMI patients submitted to PCI. Relation with extension of STEMI and inflammatory markers.","volume":"132","author":"S Valente","year":"2009","journal-title":"Int J Cardiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.ahj.2008.10.021","article-title":"Baseline hemoglobin concentration and creatinine clearance composite laboratory index improves risk stratification in ST-elevation myocardial infarction.","volume":"157","author":"RR Giraldez","year":"2009","journal-title":"Am Heart J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1001\/jama.291.22.2727","article-title":"A Validated Prediction Model for All Forms of Acute Coronary Syndrome.","volume":"291","author":"KA Eagle","year":"2004","journal-title":"JAMA"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/01.CIR.0000141575.92958.9C","article-title":"Platelet Function Predicts Myocardial Damage in Patients With Acute Myocardial Infarction.","volume":"110","author":"M Frossard","year":"2004","journal-title":"Circulation"},{"key":"ref25","article-title":"The Third National Health and Morbidity Survey (NHMS III) 2006. Kuala Lumpur: Institute for Public Health, Ministry of Health, Malaysia.","year":"2008"},{"key":"ref26","article-title":"Annual Report of the NCVD-ACS Registry Malaysia 2006.","author":"WA Wan Ahmad","year":"2006"},{"key":"ref27","article-title":"Access To Cardiac Care In The UK.","author":"S Green","year":"2009"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.amjcard.2008.02.088","article-title":"Comparison of the Predictive Value of Four Different Risk Scores for Outcomes of Patients With ST-Elevation Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.","volume":"102","author":"EI Lev","year":"2008","journal-title":"Am J Cardiol"},{"key":"ref29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007947","article-title":"Does simplicity compromise accuracy in ACS risk prediction? A retrospective analysis of the TIMI and GRACE risk scores.","author":"KG Aragam","year":"2009"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.ahj.2011.07.029","article-title":"Management of acute coronary syndromes in developing countries: ACute Coronary Events\u2013a multinational Survey of current management Strategies.","volume":"162","author":"Investigators The ACCESS","year":"2011","journal-title":"Am Heart J"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.jcin.2009.05.025","article-title":"Systems of Care for ST-Segment Elevation Myocardial Infarction: Impact of Different Models on Clinical Outcomes.","volume":"2","author":"N Danchin","year":"2009","journal-title":"J Am Coll Cardiol Intv"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.jclinepi.2009.12.008","article-title":"Missing covariate data in medical research: To impute is better than to ignore.","volume":"63","author":"JMJ Kristel","year":"2010","journal-title":"J Clin Epidemiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jclinepi.2009.08.028","article-title":"Unpredictable bias when using the missing indicator method or complete case analysis for missing confounder values: an empirical example.","volume":"63","author":"JK Mirjam","year":"2010","journal-title":"J Clin Epidemiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/MCA.0b013e3283487de2","article-title":"Impact of renal dysfunction on the prognostic value of the TIMI risk score in patients with non-ST elevation acute coronary syndrome.","volume":"22","author":"J Go","year":"2011","journal-title":"Coron Artery Dis"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0040249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T21:41:14Z","timestamp":1588974074000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0040249"}},"subtitle":[],"editor":[{"given":"Andrea","family":"Zuffi","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,16]]},"references-count":34,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0040249","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,16]]}}}