{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:45:37Z","timestamp":1792165537613,"version":"4.4.0"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T00:00:00Z","timestamp":1341792000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0040306","type":"journal-article","created":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T21:49:52Z","timestamp":1341870592000},"page":"e40306","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Gender Differences in Transcriptional Signature of Developing Rat Testes and Ovaries following Embryonic Exposure to 2,3,7,8-TCDD"],"prefix":"10.1371","volume":"7","author":[{"given":"Solange","family":"Magre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Rebourcet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ishaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Wargnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Debard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Meugnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Cohen-Tannoudji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Le Magueresse-Battistoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.pa.22.040182.002505","article-title":"2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity.","volume":"22","author":"A Poland","year":"1982","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: an Endocrine Society scientific statement.","volume":"30","author":"E Diamanti-Kandarakis","year":"2009","journal-title":"Endocr Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/toxsci\/kfn030","article-title":"Fifteen years after "Wingspread"\u2013environmental endocrine disrupters and human and wildlife health: where we are today and where we need to go.","volume":"105","author":"AK Hotchkiss","year":"2008","journal-title":"Toxicol Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/mnfr.200500247","article-title":"Risk assessments of polychlorinated dibenzo- p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in food.","volume":"50","author":"JC Larsen","year":"2006","journal-title":"Mol Nutr Food Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1289\/ehp.1002134","article-title":"Perinatal exposure to low doses of dioxin can permanently impair human semen quality.","volume":"119","author":"P Mocarelli","year":"2011","journal-title":"Environ Health Perspect"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.fct.2010.04.005","article-title":"Interpretation of studies on the developmental reproductive toxicology of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male offspring.","volume":"48","author":"DR Bell","year":"2011","journal-title":"Food Chem Toxicol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1289\/ehp.0901084","article-title":"Dioxin-induced changes in epididymal sperm count and spermatogenesis.","volume":"118","author":"WG Foster","year":"2010","journal-title":"Environ Health Perspect"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1095\/biolreprod.109.080812","article-title":"Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouse.","volume":"82","author":"S Ohsako","year":"2010","journal-title":"Biol Reprod"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/taap.1995.1153","article-title":"In utero 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters reproductive morphology and function in female rat offspring.","volume":"133","author":"LE Gray","year":"1995","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1095\/biolreprod66.6.1621","article-title":"In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran reduces growth and disrupts reproductive parameters in female rats.","volume":"66","author":"TB Salisbury","year":"2002","journal-title":"Biol Reprod"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1186\/1471-2164-12-365","article-title":"Integration of genome-wide computation DRE search, AhR ChIP-chip and gene expression analyses of TCDD-elicited responses in the mouse liver.","volume":"12","author":"E Dere","year":"2011","journal-title":"BMC Genomics"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1124\/mol.111.075952","article-title":"A novel nonconsensus xenobiotic response element capable of mediating aryl hydrocarbon receptor-dependent gene expression.","volume":"81","author":"G Huang","year":"2012","journal-title":"Mol Pharmacol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/rheumatology\/ken259","article-title":"A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis.","volume":"47","author":"S Kobayashi","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1126\/science.1925598","article-title":"Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta.","volume":"254","author":"TR Sutter","year":"1991","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/toxsci\/kfp191","article-title":"Dioxin-dependent and dioxin-independent gene batteries: comparison of liver and kidney in AHR-null mice.","volume":"112","author":"PC Boutros","year":"2009","journal-title":"Toxicol Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/humrep\/13.suppl_1.1","article-title":"Spermatogenesis.","volume":"13","author":"DM de Kretser","year":"1998","journal-title":"Hum Reprod"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1210\/endo-97-4-898","article-title":"Changes with age in levels of serum gonadotropins, prolactin and gonadal steroids in prepubertal male and female rats.","volume":"97","author":"KD Dohler","year":"1975","journal-title":"Endocrinology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1677\/joe.0.0590295","article-title":"Plasma oestradiol-17beta and its relationship to serum follicle-stimulating hormone in immature female rats.","volume":"59","author":"HM Meijs-Roelofs","year":"1973","journal-title":"J Endocrinol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1365-2605.2009.01020.x","article-title":"The effects of an in utero exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin on male reproductive function: identification of Ccl5 as a potential marker.","volume":"33","author":"D Rebourcet","year":"2010","journal-title":"Int J Androl"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1750-3639.2011.00476.x","article-title":"Integrated genomic profiling identifies loss of chromosome 11p impacting transcriptomic activity in aggressive pituitary PRL tumors.","volume":"21","author":"A Wierinckx","year":"2011","journal-title":"Brain Pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1128\/MCB.01316-10","article-title":"CCN5, a novel transcriptional repressor of the transforming growth factor beta signaling pathway.","volume":"31","author":"M Sabbah","year":"2011","journal-title":"Mol Cell Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1515\/bc.2010.128","article-title":"An introduction to the molecular basics of aryl hydrocarbon receptor biology.","volume":"391","author":"J Abel","year":"2010","journal-title":"Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1101\/gad.13.1.20","article-title":"Identification of a novel mechanism of regulation of Ah (dioxin) receptor function.","volume":"13","author":"J Mimura","year":"1999","journal-title":"Genes Dev"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1016\/j.febslet.2007.03.046","article-title":"The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein.","volume":"581","author":"R Barouki","year":"2007","journal-title":"FEBS Lett"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/faat.1995.1109","article-title":"Toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats including placental and lactational transfer to fetuses and neonates.","volume":"27","author":"X Li","year":"1995","journal-title":"Fundam Appl Toxicol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.bcp.2008.09.016","article-title":"Regulation of constitutive and inducible AHR signaling: complex interactions involving the AHR repressor.","volume":"77","author":"ME Hahn","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbrc.2004.01.028","article-title":"Primary structure and inducibility by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of aryl hydrocarbon receptor repressor in a TCDD-sensitive and a TCDD-resistant rat strain.","volume":"315","author":"M Korkalainen","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/toxsci\/68.2.479","article-title":"Effects of aryl hydrocarbon receptor null mutation and in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on prostate and seminal vesicle development in C57BL\/6 mice.","volume":"68","author":"TM Lin","year":"2002","journal-title":"Toxicol Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000117714","article-title":"Disruption of aryl hydrocarbon receptor (AhR) induces regression of the seminal vesicle in aged male mice.","volume":"2","author":"T Baba","year":"2008","journal-title":"Sex Dev"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1095\/biolreprod.104.037499","article-title":"Gene expression in rat leydig cells during development from the progenitor to adult stage: a cluster analysis.","volume":"72","author":"RS Ge","year":"2005","journal-title":"Biol Reprod"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1177\/002215540104900913","article-title":"Overexpression of NAD(P)H:quinone oxidoreductase 1 in human reproductive system.","volume":"49","author":"F Zappa","year":"2001","journal-title":"J Histochem Cytochem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0161-813X(02)00040-2","article-title":"Constitutive and TCDD-induced expression of Ah receptor-responsive genes in the pituitary.","volume":"23","author":"P Huang","year":"2002","journal-title":"Neurotoxicology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.reprotox.2009.03.004","article-title":"Effect of chronic exposure to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin in female rats on ovarian gene expression.","volume":"28","author":"KE Valdez","year":"2009","journal-title":"Reprod Toxicol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1093\/humrep\/den125","article-title":"Combination of estrogen and dioxin is involved in the pathogenesis of endometriosis by promoting chemokine secretion and invasion of endometrial stromal cells.","volume":"23","author":"J Yu","year":"2008","journal-title":"Hum Reprod"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"19906","DOI":"10.1074\/jbc.M601192200","article-title":"Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene.","volume":"281","author":"M N'Diaye","year":"2006","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.abb.2007.01.015","article-title":"Modulation of the chemokines KC and MCP-1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice.","volume":"461","author":"CF Vogel","year":"2007","journal-title":"Arch Biochem Biophys"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.bcp.2008.09.013","article-title":"Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways.","volume":"77","author":"T Haarmann-Stemmann","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"5179","DOI":"10.1073\/pnas.0507175103","article-title":"Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity.","volume":"103","author":"SG Trivedi","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1757-2215-4-3","article-title":"Hematopoietic-Prostaglandin D2 synthase through PGD2 production is involved in the adult ovarian physiology.","volume":"4","author":"A Farhat","year":"2011","journal-title":"J Ovarian Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1002\/dvdy.22726","article-title":"Hematopoietic prostaglandin D synthase (H-Pgds) is expressed in the early embryonic gonad and participates to the initial nuclear translocation of the SOX9 protein.","volume":"240","author":"B Moniot","year":"2011","journal-title":"Dev Dyn"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1046\/j.1460-9568.1998.00211.x","article-title":"Identification and characterization of a novel member of the fibroblast growth factor family.","volume":"10","author":"JM Greene","year":"1998","journal-title":"Eur J Neurosci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/jb\/mvq121","article-title":"Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease.","volume":"149","author":"N Itoh","year":"2011","journal-title":"J Biochem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/hmg\/ddi463","article-title":"Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes.","volume":"15","author":"A Beverdam","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1002\/mrd.20722","article-title":"Presumptive pre-Sertoli cells express genes involved in cell proliferation and cell signalling during a critical window in early testis differentiation.","volume":"74","author":"AT Cory","year":"2007","journal-title":"Mol Reprod Dev"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/molehr\/7.12.1133","article-title":"Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction.","volume":"7","author":"CE Hirst","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1095\/biolreprod.108.073312","article-title":"Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice.","volume":"81","author":"AN Sferruzzi-Perri","year":"2009","journal-title":"Biol Reprod"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0378-1119(01)00608-4","article-title":"Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5.","volume":"275","author":"G Glowacki","year":"2001","journal-title":"Gene"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0040306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T16:54:17Z","timestamp":1714150457000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0040306"}},"subtitle":[],"editor":[{"given":"Dmitry I.","family":"Nurminsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,9]]},"references-count":47,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0040306","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,9]]}}}