{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:02:58Z","timestamp":1778680978627,"version":"3.51.4"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T00:00:00Z","timestamp":1341964800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0040570","type":"journal-article","created":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T20:56:49Z","timestamp":1342040209000},"page":"e40570","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Relationship between Periodontitis-Related Antibody and Frequent Exacerbations in Chronic Obstructive Pulmonary Disease"],"prefix":"10.1371","volume":"7","author":[{"given":"Tamaki","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Muro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Terada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Kiyokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuma","family":"Hoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiko","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Uno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Naruishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Takashiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiaki","family":"Mishima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,7,11]]},"reference":[{"key":"ref1","article-title":"Global strategy for diagnosis, management, and prevention of COPD updated 2010."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1056\/NEJMoa0909883","article-title":"Susceptibility to exacerbation in chronic obstructive pulmonary disease.","volume":"363","author":"JR Hurst","year":"2010","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1056\/NEJMcp012477","article-title":"Clinical practice. Acute exacerbations of chronic obstructive pulmonary disease.","volume":"346","author":"JK Stoller","year":"2002","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/thorax.55.2.114","article-title":"Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations.","volume":"55","author":"A Bhowmik","year":"2000","journal-title":"Thorax"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1136\/thorax.57.9.759","article-title":"Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations.","volume":"57","author":"IS Patel","year":"2002","journal-title":"Thorax"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/thx.2007.092858","article-title":"Impact of gastro-oesophageal reflux disease symptoms on COPD exacerbation.","volume":"63","author":"K Terada","year":"2008","journal-title":"Thorax"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1378\/chest.09-0482","article-title":"Abnormal swallowing reflex and COPD exacerbations.","volume":"137","author":"K Terada","year":"2010","journal-title":"Chest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/j.1365-2648.2010.05298.x","article-title":"Dental hygiene education for nursing staff in a nursing home for older people.","volume":"66","author":"E Kullberg","year":"2010","journal-title":"J Adv Nurs"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1365-2648.2009.05181.x","article-title":"Evaluation of dental hygiene education for nursing home staff.","volume":"66","author":"P Sjogren","year":"2010","journal-title":"J Adv Nurs"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jamda.2009.03.020","article-title":"Preventing aspiration in the nursing home: the role of biofilm and data from the ICU.","volume":"11","author":"P Drinka","year":"2010","journal-title":"J Am Med Dir Assoc"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1902\/jop.1994.65.3.260","article-title":"Assessment of risk for periodontal disease. I. Risk indicators for attachment loss.","volume":"65","author":"SG Grossi","year":"1994","journal-title":"J Periodontol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1378\/chest.124.3.832","article-title":"Immune response to Fusobacterium nucleatum and Prevotella intermedia in the sputum of patients with acute exacerbation of chronic bronchitis.","volume":"124","author":"I Brook","year":"2003","journal-title":"Chest"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.rmed.2007.12.001","article-title":"Severe chronic obstructive pulmonary disease: association with marginal bone loss in periodontitis.","volume":"102","author":"I Leuckfeld","year":"2008","journal-title":"Respir Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4103\/0970-9290.59456","article-title":"Periodontitis as a potential risk factor for chronic obstructive pulmonary disease: a retrospective study.","volume":"20","author":"V Deo","year":"2009","journal-title":"Indian J Dent Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1365-2249.2007.03450.x","article-title":"Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease.","volume":"149","author":"K Yamazaki","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1161\/01.ATV.0000072969.71452.87","article-title":"Antibodies to periodontal pathogens are associated with coronary heart disease.","volume":"23","author":"PJ Pussinen","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1177\/0022034510370817","article-title":"High antibody levels to P. gingivalis in cardiovascular disease.","volume":"89","author":"S Bohnstedt","year":"2010","journal-title":"J Dent Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"196","DOI":"10.7326\/0003-4819-106-2-196","article-title":"Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease.","volume":"106","author":"NR Anthonisen","year":"1987","journal-title":"Ann Intern Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/08959374880020022401","article-title":"Serum immunoglobulin G antibody to periodontal bacteria.","volume":"2","author":"Y Murayama","year":"1988","journal-title":"Adv Dent Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jcla.20381","article-title":"Prognosis of periodontitis recurrence after intensive periodontal treatment using examination of serum IgG antibody titer against periodontal bacteria.","volume":"25","author":"N Sugi","year":"2011","journal-title":"J Clin Lab Anal"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.","volume":"40","author":"ME Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1159\/000067462","article-title":"Factors associated with increased risk of exacerbation and hospital admission in a cohort of ambulatory COPD patients: a multiple logistic regression analysis. The EOLO Study Group.","volume":"67","author":"M Miravitlles","year":"2000","journal-title":"Respiration"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1136\/thorax.58.2.100","article-title":"Risk factors of readmission to hospital for a COPD exacerbation: a prospective study.","volume":"58","author":"J Garcia-Aymerich","year":"2003","journal-title":"Thorax"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1056\/NEJMoa0805800","article-title":"A 4-year trial of tiotropium in chronic obstructive pulmonary disease.","volume":"359","author":"DP Tashkin","year":"2008","journal-title":"N Engl J Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1056\/NEJMoa063070","article-title":"Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease.","volume":"356","author":"PM Calverley","year":"2007","journal-title":"N Engl J Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e722","DOI":"10.4317\/medoral.17032","article-title":"Periodontal disease and diabetes-Review of the Literature.","volume":"16","author":"A Bascones-Martinez","year":"2011","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1902\/jop.2006.050459","article-title":"Diabetes mellitus and periodontal diseases.","volume":"77","author":"BL Mealey","year":"2006","journal-title":"J Periodontol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/00149831-200410000-00008","article-title":"High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction.","volume":"11","author":"PJ Pussinen","year":"2004","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"ref29","article-title":"Destructive periodontal disease in relation to diabetes mellitus, cardiovascular diseases, osteoporosis and respiratory diseases.","author":"S Renvert","year":"2003"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1161\/01.STR.0000136148.29490.fe","article-title":"Antibodies to periodontal pathogens and stroke risk.","volume":"35","author":"PJ Pussinen","year":"2004","journal-title":"Stroke"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1034\/j.1399-302X.2001.160401.x","article-title":"Immunoglobulin G response of periodontitis patients to Porphyromonas gingivalis capsular carbohydrate and lipopolysaccharide antigens.","volume":"16","author":"TJ Sims","year":"2001","journal-title":"Oral Microbiol Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1600-051X.1998.tb02480.x","article-title":"Serum IgG antibody response to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis: implications for periodontal diagnosis.","volume":"25","author":"IB Lamster","year":"1998","journal-title":"J Clin Periodontol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1164\/ajrccm.157.5.9711044","article-title":"Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation.","volume":"157","author":"N Soler","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1089\/dia.2010.0178","article-title":"Increased Levels of Both Th1 and Th2 Cytokines in Subjects with Metabolic Syndrome (CURES-103).","volume":"13","author":"J Surendar","year":"2011","journal-title":"Diabetes Technology & Therapeutics"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.4049\/jimmunol.144.6.2321","article-title":"Inhibition of IgG-triggered human eosinophil function by IL-4.","volume":"144","author":"P Baskar","year":"1990","journal-title":"J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev.iy.05.040187.002241","article-title":"B-cell stimulatory factor-1\/interleukin 4.","volume":"5","author":"WE Paul","year":"1987","journal-title":"Annu Rev Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/333571a0","article-title":"Stimulation of B-cell progenitors by cloned murine interleukin-7.","volume":"333","author":"AE Namen","year":"1988","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1164\/rccm.200506-859OC","article-title":"Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations.","volume":"173","author":"A Papi","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11262-006-0064-x","article-title":"Respiratory syncytial virus (RSV) evades the human adaptive immune system by skewing the Th1\/Th2 cytokine balance toward increased levels of Th2 cytokines and IgE, markers of allergy\u2013a review.","volume":"33","author":"Y Becker","year":"2006","journal-title":"Virus Genes"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1007\/s10096-010-1027-7","article-title":"Relevance of lower airway bacterial colonization, airway inflammation, and pulmonary function in the stable stage of chronic obstructive pulmonary disease.","volume":"29","author":"M Zhang","year":"2010","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1164\/rccm.201104-0597OC","article-title":"Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers.","volume":"184","author":"M Bafadhel","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1001\/archinte.165.8.891","article-title":"Microbiologic determinants of exacerbation in chronic obstructive pulmonary disease.","volume":"165","author":"A Rosell","year":"2005","journal-title":"Arch Intern Med"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0040570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T06:58:19Z","timestamp":1687589899000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0040570"}},"subtitle":[],"editor":[{"given":"Clive M.","family":"Gray","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,11]]},"references-count":42,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0040570","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,11]]}}}