{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:24:44Z","timestamp":1782458684174,"version":"3.54.5"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,16]],"date-time":"2012-07-16T00:00:00Z","timestamp":1342396800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0040764","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T07:53:33Z","timestamp":1342684413000},"page":"e40764","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Targeted Inactivation of GPR26 Leads to Hyperphagia and Adiposity by Activating AMPK in the Hypothalamus"],"prefix":"10.1371","volume":"7","author":[{"given":"Daohong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,7,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1056\/NEJMoa1110294","article-title":"Lifestyle change and mobility in obese adults with type 2 diabetes.","volume":"366","author":"WJ Rejeski","year":"2012","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1210\/jc.2004-0288","article-title":"The epidemic of obesity.","volume":"89","author":"CJ Stein","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1172\/JCI10842","article-title":"Obesity and insulin resistance.","volume":"106","author":"BB Kahn","year":"2000","journal-title":"J Clin Invest"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nrd781","article-title":"Obesity market overview.","volume":"1","author":"C Farrigan","year":"2002","journal-title":"Nat Rev Drug Discov"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S1359-6446(04)03244-1","article-title":"Pharmaceutical approaches to the treatment of obesity.","volume":"9","author":"RJ Jandacek","year":"2004","journal-title":"Drug Discov Today"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2006.02.004","article-title":"Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents.","volume":"3","author":"HA Overton","year":"2006","journal-title":"Cell Metab"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1073\/pnas.0230374100","article-title":"The G protein-coupled receptor repertoires of human and mouse.","volume":"100","author":"DK Vassilatis","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ejphar.2004.07.029","article-title":"Orphan G protein-coupled receptors and obesity.","volume":"500","author":"YL Xu","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0167-4781(99)00241-9","article-title":"Cloning and characterization of additional members of the G protein-coupled receptor family.","volume":"1490","author":"DK Lee","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1089\/15406580360545053","article-title":"Identification of signal transduction pathways used by orphan g protein-coupled receptors.","volume":"1","author":"JN Bresnick","year":"2003","journal-title":"Assay Drug Dev Technol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nature01279","article-title":"Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes.","volume":"421","author":"K Ashrafi","year":"2003","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2337\/diabetes.50.4.707","article-title":"Circulating ghrelin levels are decreased in human obesity.","volume":"50","author":"M Tschop","year":"2001","journal-title":"Diabetes"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.tem.2010.08.002","article-title":"Obesity and leptin resistance: distinguishing cause from effect.","volume":"21","author":"MG Myers","year":"2010","journal-title":"Trends Endocrinol Metab"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1172\/JCI29126","article-title":"Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.","volume":"116","author":"T Kadowaki","year":"2006","journal-title":"J Clin Invest"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cmet.2007.10.001","article-title":"AMPK and SNF1: Snuffing Out Stress.","volume":"6","author":"DG Hardie","year":"2007","journal-title":"Cell Metab"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cmet.2009.03.012","article-title":"AMPK: an emerging drug target for diabetes and the metabolic syndrome.","volume":"9","author":"BB Zhang","year":"2009","journal-title":"Cell Metab"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1074\/jbc.C300557200","article-title":"AMP-activated protein kinase plays a role in the control of food intake.","volume":"279","author":"U Andersson","year":"2004","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/j.1365-2826.2008.01745.x","article-title":"Role of AMP-activated protein kinase in the control of appetite.","volume":"20","author":"B Kola","year":"2008","journal-title":"J Neuroendocrinol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/sj.emboj.7600110","article-title":"LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK\/PAR-1.","volume":"23","author":"JM Lizcano","year":"2004","journal-title":"EMBO Journal"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI13505","article-title":"Role of AMP-activated protein kinase in mechanism of metformin action.","volume":"108","author":"G Zhou","year":"2001","journal-title":"J Clin Invest"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1086\/345648","article-title":"Interacting genetic loci on chromosomes 20 and 10 influence extreme human obesity.","volume":"72","author":"C Dong","year":"2003","journal-title":"Am J Hum Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1210\/endo.143.7.8903","article-title":"Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity.","volume":"143","author":"Y Chen","year":"2002","journal-title":"Endocrinology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.cmet.2010.07.003","article-title":"Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity.","volume":"12","author":"J Li","year":"2010","journal-title":"Cell Metab"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1371\/journal.pgen.0020081","article-title":"Changes in gene expression foreshadow diet-induced obesity in genetically identical mice.","volume":"2","author":"RA Koza","year":"2006","journal-title":"PLoS Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2004.12.003","article-title":"AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.","volume":"1","author":"BB Kahn","year":"2005","journal-title":"Cell Metab"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1113\/jphysiol.2006.113217","article-title":"AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues.","volume":"574","author":"B Xue","year":"2006","journal-title":"J Physiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nature02440","article-title":"AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.","volume":"428","author":"Y Minokoshi","year":"2004","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.2337\/db10-0221","article-title":"Hypothalamic AMP-activated protein kinase regulates glucose production.","volume":"59","author":"CS Yang","year":"2010","journal-title":"Diabetes"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"32182","DOI":"10.1074\/jbc.M110.134890","article-title":"AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner.","volume":"285","author":"JM Lee","year":"2010","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1126\/science.1120781","article-title":"The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.","volume":"310","author":"RJ Shaw","year":"2005","journal-title":"Science"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cmet.2011.03.009","article-title":"AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.","volume":"13","author":"Y Li","year":"2011","journal-title":"Cell Metab"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"36662","DOI":"10.1074\/jbc.M606676200","article-title":"Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP.","volume":"281","author":"RL Hurley","year":"2006","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/nrd2874","article-title":"Targeting the CNS to treat type 2 diabetes.","volume":"8","author":"DA Sandoval","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMoa044537","article-title":"Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia.","volume":"353","author":"JP Despres","year":"2005","journal-title":"N Engl J Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"25196","DOI":"10.1074\/jbc.C500175200","article-title":"Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase.","volume":"280","author":"B Kola","year":"2005","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrendo.2009.197","article-title":"CB1 antagonists for obesity\u2013what lessons have we learned from rimonabant?","volume":"5","author":"V Di Marzo","year":"2009","journal-title":"Nat Rev Endocrinol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/nrcardio.2010.148","article-title":"Prevention: Neuropsychiatric adverse effects signal the end of the line for rimonabant.","volume":"7","author":"A King","year":"2010","journal-title":"Nat Rev Cardiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neuroscience.2011.08.069","article-title":"GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala.","volume":"196","author":"LL Zhang","year":"2011","journal-title":"Neuroscience"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"b3868","DOI":"10.1136\/bmj.b3868","article-title":"Obesity and depression or anxiety.","volume":"339","author":"E Atlantis","year":"2009","journal-title":"BMJ"}],"updated-by":[{"DOI":"10.1371\/annotation\/3629b4c2-4810-4bbd-ae13-53d3d01bce60","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T00:00:00Z","timestamp":1344470400000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0040764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T04:17:31Z","timestamp":1540527451000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0040764"}},"subtitle":[],"editor":[{"given":"Jianping","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,16]]},"references-count":39,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0040764","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/3629b4c2-4810-4bbd-ae13-53d3d01bce60","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,16]]}}}