{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:29:17Z","timestamp":1792762157673,"version":"4.5.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,16]],"date-time":"2012-07-16T00:00:00Z","timestamp":1342396800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0040957","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T03:44:59Z","timestamp":1342669499000},"page":"e40957","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":119,"title":["Increased Autophagy in Placentas of Intrauterine Growth-Restricted Pregnancies"],"prefix":"10.1371","volume":"7","author":[{"given":"Tai-Ho","family":"Hung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu-Fu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Ming","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Jen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Lin","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u2019sang-T\u2019ang","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,7,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.290.5497.1717","article-title":"Autophagy as a regulated pathway of cellular degradation.","volume":"290","author":"DJ Klionsky","year":"2000","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrm2239","article-title":"Self-eating and self-killing: crosstalk between autophagy and apoptosis.","volume":"8","author":"MC Maiuri","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref3","first-page":"463","article-title":"Development by self-digestion: molecular mechanisms and biological functions of autophagy.","volume":"6","author":"B Levine","year":"2004","journal-title":"DevCell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1067\/mob.2002.127305","article-title":"The myometrial junctional zone spiral arteries in normal and abnormal pregnancies: a review of the literature.","volume":"187","author":"JJ Brosens","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1469-7580.2008.00994.x","article-title":"A stereological perspective on placental morphology in normal and complicated pregnancies.","volume":"215","author":"TM Mayhew","year":"2009","journal-title":"J Anat"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ajog.2005.07.039","article-title":"Apoptosis and its role in the trophoblast.","volume":"195","author":"B Huppertz","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.placenta.2008.03.005","article-title":"Bax, Bak and mitochondrial oxidants are involved in hypoxia-reoxygenation-induced apoptosis in human placenta.","volume":"29","author":"TH Hung","year":"2008","journal-title":"Placenta"},{"key":"ref8","first-page":"S43","article-title":"Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia.","author":"GJ Burton","year":"2009"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1113\/jphysiol.2009.173252","article-title":"Intrauterine growth restriction, human placental development and trophoblast cell death.","volume":"587","author":"CM Scifres","year":"2009","journal-title":"J Physiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.placenta.2008.07.003","article-title":"Live and let die - regulation of villous trophoblast apoptosis in normal and abnormal pregnancies.","volume":"29","author":"AE Heazell","year":"2008","journal-title":"Placenta"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10495-010-0551-3","article-title":"Intra-uterine growth restriction is associated with increased apoptosis and altered expression of proteins in the p53 pathway in villous trophoblast.","volume":"16","author":"AE Heazell","year":"2011","journal-title":"Apoptosis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1067\/mob.2002.122250","article-title":"Trophoblast apoptosis from pregnancies complicated by fetal growth restriction is associated with enhanced p53 expression.","volume":"186","author":"R Levy","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ceb.2009.12.001","article-title":"Autophagy regulation by p53.","volume":"22","author":"MC Maiuri","year":"2010","journal-title":"Curr Opin Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1016\/j.placenta.2010.12.013","article-title":"Review: Oxygen and trophoblast biology\u2013a source of controversy.","volume":"32","author":"MG Tuuli","year":"2011","journal-title":"Placenta"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.reprotox.2010.11.009","article-title":"The associations between labor and delivery mode and maternal and placental oxidative stress.","volume":"31","author":"TH Hung","year":"2011","journal-title":"Reprod Toxicol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.placenta.2011.03.005","article-title":"Autophagy in term normal human placentas.","volume":"32","author":"P Signorelli","year":"2011","journal-title":"Placenta"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1067\/mob.2000.107928","article-title":"Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy.","volume":"183","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"ref18","first-page":"25","article-title":"Nationwide singleton birth weight percentiles by gestational age in Taiwan, 1998\u20132002.","volume":"47","author":"WS Hsieh","year":"2006","journal-title":"Acta Paediatr Taiwan"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/1933719107310709","article-title":"Tumor necrosis factor-alpha converting enzyme in the human placenta throughout gestation.","volume":"15","author":"TH Hung","year":"2008","journal-title":"Reprod Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.placenta.2012.01.004","article-title":"Myeloperoxidase in the plasma and placenta of normal pregnant women and women with pregnancies complicated by preeclampsia and intrauterine growth restriction.","volume":"33","author":"TH Hung","year":"2012","journal-title":"Placenta"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e12202","DOI":"10.1371\/journal.pone.0012202","article-title":"Differential effects of concomitant use of vitamins C and E on trophoblast apoptosis and autophagy between normoxia and hypoxia-reoxygenation.","volume":"5","author":"TH Hung","year":"2010","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1101\/gad.1599207","article-title":"Autophagy: process and function.","volume":"21","author":"N Mizushima","year":"2007","journal-title":"Genes Dev"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nrm2708","article-title":"Dynamics and diversity in autophagy mechanisms: lessons from yeast.","volume":"10","author":"H Nakatogawa","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/path.2694","article-title":"Autophagy: assays and artifacts.","volume":"221","author":"S Barth","year":"2010","journal-title":"J Pathol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4161\/auto.5338","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.","volume":"4","author":"DJ Klionsky","year":"2008","journal-title":"Autophagy"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jsgi.2004.03.003","article-title":"Placental oxidative stress: from miscarriage to preeclampsia.","volume":"11","author":"GJ Burton","year":"2004","journal-title":"J Soc Gynecol Investig"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1053\/plac.2000.0616","article-title":"Expression of a cytokeratin 18 neo-epitope is a specific marker for trophoblast apoptosis in human placenta.","volume":"22","author":"M Kadyrov","year":"2001","journal-title":"Placenta"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4161\/auto.3438","article-title":"DRAM links autophagy to p53 and programmed cell death.","volume":"3","author":"D Crighton","year":"2007","journal-title":"Autophagy"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.placenta.2008.09.001","article-title":"Autophagic and apoptotic cell death in amniotic epithelial cells.","volume":"29","author":"ZY Shen","year":"2008","journal-title":"Placenta"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1177\/1933719108319159","article-title":"Autophagy-related proteins, LC3 and Beclin-1, in placentas from pregnancies complicated by preeclampsia.","volume":"15","author":"SY Oh","year":"2008","journal-title":"Reprod Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"545","DOI":"10.4161\/auto.19012","article-title":"Autophagy: A cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress.","volume":"8(4)","author":"RH Bhogal","year":"2012","journal-title":"Autophagy"},{"key":"ref32","first-page":"1292","article-title":"The rat Apg3p\/Aut1p homolog is upregulated by ischemic preconditioning in the retina.","volume":"12","author":"BX Wu","year":"2006","journal-title":"Mol Vis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"C982","DOI":"10.1152\/ajpcell.2000.278.5.C982","article-title":"Apoptosis in human cultured trophoblasts is enhanced by hypoxia and diminished by epidermal growth factor.","volume":"278","author":"R Levy","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2353\/ajpath.2008.071193","article-title":"Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction.","volume":"173","author":"HW Yung","year":"2008","journal-title":"Am J Pathol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"15237","DOI":"10.1073\/pnas.1106022108","article-title":"Placental protection of the fetal brain during short-term food deprivation.","volume":"108","author":"KD Broad","year":"2011","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0040957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T03:01:03Z","timestamp":1561950063000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0040957"}},"subtitle":[],"editor":[{"given":"Victor","family":"Sanchez-Margalet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,16]]},"references-count":35,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0040957","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,16]]}}}