{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T19:40:30Z","timestamp":1783712430716,"version":"3.55.0"},"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,16]],"date-time":"2012-07-16T00:00:00Z","timestamp":1342396800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0040996","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T07:42:24Z","timestamp":1342683744000},"page":"e40996","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Constructing Endophenotypes of Complex Diseases Using Non-Negative Matrix Factorization and Adjusted Rand Index"],"prefix":"10.1371","volume":"7","author":[{"given":"Hui-Min","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Lin","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Ru","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy S. J.","family":"Fann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,7,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1176\/appi.ajp.160.4.636","article-title":"The endophenotype concept in psychiatry: Etymology and strategic intentions.","volume":"160","author":"II Gottesman","year":"2003","journal-title":"American Journal of Psychiatry"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001195","article-title":"Subclass Mapping: Identifying Common Subtypes in Independent Disease Data Sets.","author":"Y Hoshida","year":"2007"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/bioinformatics\/bti738","article-title":"A method for predicting disease subtypes in presence of misclassification among training samples using gene expression: application to human breast cancer.","volume":"22","author":"WS Zhang","year":"2006","journal-title":"Bioinformatics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1158\/1078-0432.CCR-10-0151","article-title":"Integrative Genomics Analyses Reveal Molecularly Distinct Subgroups of B-Cell Chronic Lymphocytic Leukemia Patients with 13q14 Deletion.","volume":"16","author":"L Mosca","year":"2010","journal-title":"Clinical Cancer Research"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.plefa.2007.08.006","article-title":"Endophenotype properties of niacin sensitivity as marker of impaired prostaglandin signalling in Schizophrenia.","volume":"77","author":"S Smesny","year":"2007","journal-title":"Prostaglandins Leukotrienes and Essential Fatty Acids"},{"key":"ref6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005134","article-title":"Molecular Phenotypes Distinguish Patients with Relatively Stable from Progressive Idiopathic Pulmonary Fibrosis (IPF).","author":"K Boon","year":"2009"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.semradonc.2009.05.004","article-title":"Breast Cancer Molecular Subtypes in Patients With Locally Advanced Disease: Impact on Prognosis, Patterns of Recurrence, and Response to Therapy.","volume":"19","author":"KE Huber","year":"2009","journal-title":"Seminars in Radiation Oncology"},{"key":"ref8","article-title":"Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms.","author":"T Sorlie","year":"2006"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1080\/07853890600989211","article-title":"Complex disease, gender and epigenetics.","volume":"38","author":"Z Kaminsky","year":"2006","journal-title":"Annals of Medicine"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1200\/JCO.2008.19.1916","article-title":"Gene Expression Profiles of Tumor Biology Provide a Novel Approach to Prognosis and May Guide the Selection of Therapeutic Targets in Multiple Myeloma.","volume":"27","author":"A Anguiano","year":"2009","journal-title":"Journal of Clinical Oncology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nature02797","article-title":"Genetic analysis of genome-wide variation in human gene expression.","volume":"430","author":"M Morley","year":"2004","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/nature04244","article-title":"Mapping determinants of human gene expression by regional and genome-wide association.","volume":"437","author":"VG Cheung","year":"2005","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1212\/WNL.0b013e3181d07654","article-title":"Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease.","volume":"74","author":"F Zou","year":"2010","journal-title":"Neurology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/bioinformatics\/btp106","article-title":"A neural network model for constructing endophenotypes of common complex diseases: an application to male young-onset hypertension microarray data.","volume":"25","author":"KS Lynn","year":"2009","journal-title":"Bioinformatics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/gepi.20136","article-title":"Using endophenotypes for pathway clusters to map complex disease genes.","volume":"30","author":"WH Pan","year":"2006","journal-title":"Genetic Epidemiology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/bioinformatics\/17.9.763","article-title":"Principal component analysis for clustering gene expression data.","volume":"17","author":"KY Yeung","year":"2001","journal-title":"Bioinformatics"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"10101","DOI":"10.1073\/pnas.97.18.10101","article-title":"Singular value decomposition for genome-wide expression data processing and modeling.","volume":"97","author":"O Alter","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.2144\/000112950","article-title":"A review of independent component analysis application to microarray gene expression data.","author":"W Kong","year":"2008"},{"key":"ref19","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-7-78","article-title":"Biclustering of gene expression data by non-smooth non-negative matrix factorization.","author":"P Carmona-Saez","year":"2006"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/44565","article-title":"Learning the parts of objects by non-negative matrix factorization.","volume":"401","author":"DD Lee","year":"1999","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1158\/1078-0432.CCR-08-1791","article-title":"Molecular Characterization of Breast Cancer with High-Resolution Oligonucleotide Comparative Genomic Hybridization Array.","volume":"15","author":"F Andre","year":"2009","journal-title":"Clinical Cancer Research"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.neuroimage.2007.05.031","article-title":"Using non-negative matrix factorization for single-trial analysis of fMRI data.","volume":"37","author":"G Lohmann","year":"2007","journal-title":"Neuroimage"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/j.1349-7006.2009.01204.x","article-title":"Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2 in tumor progression and prognosis.","volume":"100","author":"K Yoshihara","year":"2009","journal-title":"Cancer Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1073\/pnas.0308531101","article-title":"Metagenes and molecular pattern discovery using matrix factorization.","volume":"101","author":"JP Brunet","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jbi.2007.12.003","article-title":"Reducing microarray data via nonnegative matrix factorization for visualization and clustering analysis.","volume":"41","author":"WX Liu","year":"2008","journal-title":"Journal of Biomedical Informatics"},{"key":"ref26","first-page":"2369","article-title":"Learning parts-based representations of data.","volume":"7","author":"DA Ross","year":"2006","journal-title":"Journal of Machine Learning Research"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ajhg.2009.03.011","article-title":"Genetic Control of Human Brain Transcript Expression in Alzheimer Disease.","volume":"84","author":"JA Webster","year":"2009","journal-title":"American Journal of Human Genetics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/A:1023949509487","article-title":"Consensus clustering: A resampling-based method for class discovery and visualization of gene expression microarray data.","volume":"52","author":"S Monti","year":"2003","journal-title":"Machine Learning"},{"key":"ref29","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-11-367","article-title":"A flexible R package for nonnegative matrix factorization.","author":"R Gaujoux","year":"2010"},{"key":"ref30","first-page":"319","article-title":"Pathway mapping tools for analysis of high content data.","volume":"356","author":"S Ekins","year":"2007","journal-title":"Methods Mol Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.toxlet.2005.02.004","article-title":"A novel method for generation of signature networks as biomarkers from complex high throughput data.","volume":"158","author":"Y Nikolsky","year":"2005","journal-title":"Toxicology Letters"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/bib\/bbq090","article-title":"Principal component analysis based methods in bioinformatics studies.","volume":"12","author":"SG Ma","year":"2011","journal-title":"Briefings in Bioinformatics"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/bioinformatics\/btl550","article-title":"Inferential, robust non-negative matrix factorization analysis of microarray data.","volume":"23","author":"P Fogel","year":"2007","journal-title":"Bioinformatics"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-9473(01)00046-9","article-title":"A mixture model approach for the analysis of microarray gene expression data.","volume":"39","author":"DB Allison","year":"2002","journal-title":"Computational Statistics & Data Analysis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s10709-010-9480-x","article-title":"Systems genetics, bioinformatics and eQTL mapping.","volume":"138","author":"H Li","year":"2010","journal-title":"Genetica"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ymeth.2009.03.004","article-title":"Detection and interpretation of expression quantitative trait loci (eQTL).","volume":"48","author":"JJ Michaelson","year":"2009","journal-title":"Methods"},{"key":"ref37","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-11-502","article-title":"Data-driven assessment of eQTL mapping methods.","author":"JJ Michaelson","year":"2010"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1101\/gr.6981507","article-title":"The influence of genetic variation on gene expression.","volume":"17","author":"RBH Williams","year":"2007","journal-title":"Genome Research"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"E515","DOI":"10.1208\/aapsj080361","article-title":"Searching for polymorphisms that affect gene expression and mRNA processing: Example ABCB1 (MDR1).","volume":"8","author":"DX Wang","year":"2006","journal-title":"Aaps Journal"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/ng2142","article-title":"Population genomics of human gene expression.","volume":"39","author":"BE Stranger","year":"2007","journal-title":"Nature Genetics"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nature06757","article-title":"Variations in DNA elucidate molecular networks that cause disease.","volume":"452","author":"YQ Chen","year":"2008","journal-title":"Nature"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1093\/bioinformatics\/btm134","article-title":"Sparse non-negative matrix factorizations via alternating non-negativity-constrained least squares for microarray data analysis.","volume":"23","author":"H Kim","year":"2007","journal-title":"Bioinformatics"},{"key":"ref43","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis.","author":"P Langfelder","year":"2008"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1093\/hmg\/ddn298","article-title":"Genome-wide association studies: past, present and future.","volume":"17","author":"MI McCarthy","year":"2008","journal-title":"Hum Mol Genet"},{"key":"ref45","article-title":"The Framingham Heart Study 100 K SNP genome-wide association study resource: overview of 17 phenotype working group reports.","author":"LA Cupples","year":"2007"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"A94","DOI":"10.2337\/db07-0451","article-title":"Genome-wide association with diabetes-related traits in the Framingham heart study.","volume":"56","author":"JC Florez","year":"2007","journal-title":"Diabetes"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1186\/1753-6561-3-S7-S41","article-title":"The effect of minor allele frequency on the likelihood of obtaining false positives.","volume":"3","author":"ME Tabangin","year":"2009","journal-title":"BMC Proc"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ajhg.2009.01.005","article-title":"A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals.","volume":"84","author":"BL Browning","year":"2009","journal-title":"American Journal of Human Genetics"},{"key":"ref49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000029","article-title":"Nonnegative Matrix Factorization: An Analytical and Interpretive Tool in Computational Biology.","author":"K Devarajan","year":"2008"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.canlet.2005.06.025","article-title":"Gastrin and cancer: a review.","volume":"238","author":"A Ferrand","year":"2006","journal-title":"Cancer Lett"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1152\/physrev.00014.2005","article-title":"Cholecystokinin and gastrin receptors.","volume":"86","author":"M Dufresne","year":"2006","journal-title":"Physiol Rev"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2007.06.017","article-title":"Role of gastrin peptides in carcinogenesis.","volume":"257","author":"AM Grabowska","year":"2007","journal-title":"Cancer Lett"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/physrev.1998.78.1.189","article-title":"Dopamine receptors: from structure to function.","volume":"78","author":"C Missale","year":"1998","journal-title":"Physiol Rev"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1523\/JNEUROSCI.3609-11.2012","article-title":"Suppression of a MEF2-KLF6 Survival Pathway by PKA Signaling Promotes Apoptosis in Embryonic Hippocampal Neurons.","volume":"32","author":"J Salma","year":"2012","journal-title":"Journal of Neuroscience"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1385\/MN:29:2:155","article-title":"Myocyte enhancer factor-2 transcription factors in neuronal differentiation and survival.","volume":"29","author":"KA Heidenreich","year":"2004","journal-title":"Molecular Neurobiology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.molmed.2004.07.001","article-title":"Cdk5 deregulation in the pathogenesis of Alzheimer&apos;s disease.","volume":"10","author":"JC Cruz","year":"2004","journal-title":"Trends in Molecular Medicine"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1182\/blood.V96.3.823","article-title":"Erythropoietin, iron, and erythropoiesis.","volume":"96","author":"LT Goodnough","year":"2000","journal-title":"Blood"},{"key":"ref58","first-page":"521","article-title":"Erythropoietin, the biology of erythropoiesis and epoetin alfa - An overview.","volume":"46","author":"E Bieber","year":"2001","journal-title":"Journal of Reproductive Medicine"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1038\/sj.cdd.4401450","article-title":"Erythropoietin as an antiapoptotic, tissue-protective cytokine.","volume":"11","author":"P Ghezzi","year":"2004","journal-title":"Cell Death and Differentiation"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng1934","article-title":"Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.","volume":"39","author":"L Bertram","year":"2007","journal-title":"Nature Genetics"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1046\/j.1529-8817.2004.00110.x","article-title":"Molecular genetics of late-onset Alzheimer&apos;s disease.","volume":"68","author":"MI Kamboh","year":"2004","journal-title":"Ann Hum Genet"},{"key":"ref62","article-title":"Genome-wide association study of Alzheimer&apos;s disease with psychotic symptoms.","author":"P Hollingworth","year":"2011"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4088\/JCP.v68n0419","article-title":"A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer&apos;s disease.","volume":"68","author":"KD Coon","year":"2007","journal-title":"J Clin Psychiatry"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer.","volume":"112","author":"J Cohen","year":"1992","journal-title":"Psychol Bull"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrg1749","article-title":"Microarray data analysis: from disarray to consolidation and consensus.","volume":"7","author":"DB Allison","year":"2006","journal-title":"Nat Rev Genet"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00439-011-1001-1","article-title":"Genomic medicine and neurological disease.","volume":"130","author":"PM Boone","year":"2011","journal-title":"Hum Genet"},{"key":"ref67","article-title":"Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics.","author":"G Jonsson","year":"2010"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1093\/bioinformatics\/bti653","article-title":"Improving molecular cancer class discovery through sparse non-negative matrix factorization.","volume":"21","author":"Y Gao","year":"2005","journal-title":"Bioinformatics"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ccr.2006.03.019","article-title":"High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients.","volume":"9","author":"DR Carrasco","year":"2006","journal-title":"Cancer Cell"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1566524053152861","article-title":"The transcriptome in blood: Challenges and solutions for robust expression profiling.","volume":"5","author":"HT Fan","year":"2005","journal-title":"Current Molecular Medicine"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"R129","DOI":"10.1093\/hmg\/ddn285","article-title":"Using gene expression to investigate the genetic basis of complex disorders.","volume":"17","author":"AC Nica","year":"2008","journal-title":"Hum Mol Genet"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1111\/j.1471-4159.2006.04064.x","article-title":"D2-class dopamine receptor inhibition of NMDA currents in prefrontal cortical neurons is platelet-derived growth factor receptor-dependent.","volume":"98","author":"MA Beazely","year":"2006","journal-title":"J Neurochem"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2174\/157488907780832742","article-title":"The gastrin-releasing peptide receptor as a therapeutic target in central nervous system disorders.","volume":"2","author":"R Roesler","year":"2007","journal-title":"Recent Pat CNS Drug Discov"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"24546","DOI":"10.1074\/jbc.M201098200","article-title":"Suppression of death receptor signaling in cerebellar Purkinje neurons protects neighboring granule neurons from apoptosis via an insulin-like growth factor I-dependent mechanism.","volume":"277","author":"DA Linseman","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1006\/bbrc.2000.3926","article-title":"Erythropoietin inhibits calcium-induced neurotransmitter release from clonal neuronal cells.","volume":"279","author":"M Kawakami","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"ref76","article-title":"a language and environment for statistical computing, R Foundation for Statistical Computing, Vienna, Austria.","year":"2011"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0040996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T03:46:19Z","timestamp":1642823179000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0040996"}},"subtitle":[],"editor":[{"given":"Frank","family":"Emmert-Streib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,16]]},"references-count":76,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0040996","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,16]]}}}