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Koedel","year":"2003","journal-title":"J Immunol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1073\/pnas.0435928100","article-title":"Recognition of pneumolysin by toll-like receptor 4 confers resistance to pneumococcal infection.","volume":"100","author":"R Malley","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.163.1.1","article-title":"Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2.","volume":"163","author":"A Yoshimura","year":"1999","journal-title":"J Immunol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1128\/JB.186.5.1398-1408.2004","article-title":"Relevance of peptide uptake systems to the physiology and virulence of <italic>Streptococcus agalactiae<\/italic>.","volume":"186","author":"U Samen","year":"2004","journal-title":"J 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competence for genetic transformation in <italic>Streptococcus pneumoniae<\/italic>.","volume":"92","author":"LS Havarstein","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref78","article-title":"Molecular cloning. A laboratory manual.","author":"J Sambrook","year":"1989"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1128\/IAI.66.8.3767-3774.1998","article-title":"Molecular cloning of a 32-kilodalton lipoprotein component of a novel iron-regulated <italic>Staphylococcus epidermidis<\/italic> ABC transporter.","volume":"66","author":"A Cockayne","year":"1998","journal-title":"Infect Immun"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"6852","DOI":"10.1128\/IAI.73.10.6852-6859.2005","article-title":"Immune responses to immunisation with two iron uptake ABC transporter lipoproteins, PiaA and PiuA.","volume":"73","author":"M Jomaa","year":"2005","journal-title":"Infect Immun"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0014-5793(80)80035-4","article-title":"Absence of cytochrome b reduction in stimulated neutrophils from both female and male patients with chronic granulomatous disease.","volume":"110","author":"AW Segal","year":"1980","journal-title":"FEBS Lett"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/j.1365-2958.2004.04164.x","article-title":"Molecular analysis of the psa permease complex of <italic>Streptococcus pneumoniae<\/italic>.","volume":"53","author":"LJ McAllister","year":"2004","journal-title":"Mol Microbiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0041393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T16:57:08Z","timestamp":1687625828000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0041393"}},"subtitle":[],"editor":[{"given":"Alain","family":"Charbit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,24]]},"references-count":82,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0041393","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,24]]}}}