{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:45:15Z","timestamp":1767177915383,"version":"build-2238731810"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T00:00:00Z","timestamp":1343001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0041719","type":"journal-article","created":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T17:40:18Z","timestamp":1343065218000},"page":"e41719","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["IL-6 Indirectly Modulates the Induction of Glyceroneogenic Enzymes in Adipose Tissue during Exercise"],"prefix":"10.1371","volume":"7","author":[{"given":"Zhongxiao","family":"Wan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Soleil","family":"Beaudoin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Castellani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine B.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,7,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/oby.2003.121","article-title":"Metabolic partitioning of endogenous fatty acid in adipocytes.","volume":"11","author":"T Wang","year":"2003","journal-title":"Obes Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.1016\/S0021-9258(18)62651-1","article-title":"A possible physiological role for glyceroneogenesis in rat adipose tissue.","volume":"245","author":"L Reshef","year":"1970","journal-title":"J Biol Chem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"30413","DOI":"10.1074\/jbc.R300017200","article-title":"Glyceroneogenesis and the triglyceride\/fatty acid cycle.","volume":"278","author":"L Reshef","year":"2003","journal-title":"J Biol Chem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1007\/s00125-006-0560-5","article-title":"Acute and selective regulation of glyceroneogenesis and cytosolic phosphoenolpyruvate carboxykinase in adipose tissue by thiazolidinediones in type 2 diabetes.","volume":"50","author":"T Cadoudal","year":"2007","journal-title":"Diabetologia"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.2337\/db08-0477","article-title":"Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue.","volume":"57","author":"T Cadoudal","year":"2008","journal-title":"Diabetes"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"E806","DOI":"10.1152\/ajpendo.2000.279.4.E806","article-title":"Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise.","volume":"279","author":"H Pilegaard","year":"2000","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"C1162","DOI":"10.1152\/ajpcell.00188.2010","article-title":"Epinephrine-mediated regulation of PDK4 mRNA in rat adipose tissue.","volume":"299","author":"Z Wan","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1042\/BJ20082055","article-title":"AMPK and the biochemistry of exercise: implications for human health and disease.","volume":"418","author":"EA Richter","year":"2009","journal-title":"Biochem J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1073\/pnas.55.5.1148","article-title":"The balance of pyridine nucleotides and ATP in adipose tissue.","volume":"55","author":"R Rognstad","year":"1966","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1152\/physrev.90100.2007","article-title":"Muscle as an endocrine organ: focus on muscle-derived interleukin-6.","volume":"88","author":"BK Pedersen","year":"2008","journal-title":"Physiol Rev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"E155","DOI":"10.1152\/ajpendo.00257.2004","article-title":"Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro.","volume":"288","author":"EW Petersen","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.bbrc.2004.05.188","article-title":"AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise.","volume":"320","author":"M Kelly","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1210\/en.2010-0828","article-title":"Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation.","volume":"152","author":"J Zhang","year":"2011","journal-title":"Endocrinology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1194\/jlr.M000869","article-title":"Glyceroneogenesis is inhibited through HIV protease inhibitor-induced inflammation in human subcutaneous but not visceral adipose tissue.","volume":"52","author":"S Leroyer","year":"2011","journal-title":"J Lipid Res"},{"key":"ref15","article-title":"Inflammation inhibits the expression of phosphoenolpyruvate carboxykinase in liver and adipose tissue.","author":"KR Feingold","year":"2011"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"E832","DOI":"10.1152\/ajpendo.00328.2010","article-title":"IL-6 selectively stimulates fat metabolism in human skeletal muscle.","volume":"299","author":"E Wolsk","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref17","article-title":"IL-6 regulates exercise and training-induced adaptations in subcutaneous adipose tissue in mice.","author":"C Brandt","year":"2011"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"45456","DOI":"10.1074\/jbc.M104436200","article-title":"Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway.","volume":"276","author":"AS Greenberg","year":"2001","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1042\/bj3640073","article-title":"A novel pathway for adrenergic stimulation of cAMP-response-element-binding protein (CREB) phosphorylation: mediation via alpha1-adrenoceptors and protein kinase C activation.","volume":"364","author":"H Thonberg","year":"2002","journal-title":"Biochem J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1016\/j.molimm.2009.04.008","article-title":"Signaling pathways mediating beta3-adrenergic receptor-induced production of interleukin-6 in adipocytes.","volume":"46","author":"IE Tchivileva","year":"2009","journal-title":"Mol Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"16514","DOI":"10.1074\/jbc.M708177200","article-title":"AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance.","volume":"283","author":"MS Gauthier","year":"2008","journal-title":"J Biol Chem"},{"key":"ref22","article-title":"IL-6 induces lipolysis and mitochondrial dysfunction, but does not affect insulin-mediated glucose transport in 3T3-L1 adipocytes.","author":"C Ji","year":"2011"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1139\/O10-116","article-title":"Rosiglitazone regulates IL-6-stimulated lipolysis in porcine adipocytes.","volume":"88","author":"Y Yang","year":"2010","journal-title":"Biochem Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20030407","article-title":"Principles of interleukin (IL)-6-type cytokine signalling and its regulation.","volume":"374","author":"PC Heinrich","year":"2003","journal-title":"Biochem J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.it.2003.10.008","article-title":"Regulation of cytokine signaling by SOCS family molecules.","volume":"24","author":"M Fujimoto","year":"2003","journal-title":"Trends Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.regpep.2009.04.010","article-title":"Interstitial concentrations of adipokines in subcutaneous abdominal and femoral adipose tissue.","volume":"155","author":"NB Nielsen","year":"2009","journal-title":"Regul Pept"},{"key":"ref27","first-page":"889","article-title":"A trauma-like elevation of plasma cytokines in humans in response to treadmill running.","volume":"3)","author":"K Ostrowski","year":"1998","journal-title":"J Physiol 513 ( Pt"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"E1572","DOI":"10.1152\/ajpendo.00371.2007","article-title":"LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle.","volume":"293","author":"DM Thomson","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"9777","DOI":"10.1074\/jbc.M608310200","article-title":"Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase.","volume":"282","author":"Y Wu","year":"2007","journal-title":"J Biol Chem"},{"key":"ref30","first-page":"801","article-title":"Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2C alpha.","volume":"3)","author":"AE Marley","year":"1996","journal-title":"Biochem J 320 ( Pt"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"C1162","DOI":"10.1152\/ajpcell.00188.2010","article-title":"Epinephrine-mediated regulation of PDK4 mRNA in rat adipose tissue.","volume":"299","author":"Z Wan","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref32","article-title":"Epinephrine Induces PDK4 mRNA Expression in Adipose Tissue From Obese, Insulin Resistant Rats.","author":"Z Wan","year":"2011"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/(SICI)1097-4644(19970901)66:3<386::AID-JCB10>3.0.CO;2-D","article-title":"Transcriptional and posttranscriptional mechanisms of glucocorticoid-mediated repression of phosphoenolpyruvate carboxykinase gene expression in adipocytes.","volume":"66","author":"S Franckhauser-Vogel","year":"1997","journal-title":"J Cell Biochem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1113\/jphysiol.2010.200733","article-title":"Exercise-induced liver chemokine CXCL-1 expression is linked to muscle-derived interleukin-6 expression.","volume":"589","author":"L Pedersen","year":"2011","journal-title":"J Physiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"E831","DOI":"10.1152\/ajpendo.00339.2011","article-title":"Muscle-derived expression of the chemokine CXCL1 attenuates diet-induced obesity and improves fatty acid oxidation in the muscle.","volume":"302","author":"L Pedersen","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1007\/s00125-010-1754-4","article-title":"IL-6 deficiency in mice neither impairs induction of metabolic genes in the liver nor affects blood glucose levels during fasting and moderately intense exercise.","volume":"53","author":"L Fritsche","year":"2010","journal-title":"Diabetologia"},{"key":"ref37","first-page":"197","article-title":"Culture of adipose tissue and isolated adipocytes.","volume":"155","author":"SK Fried","year":"2001","journal-title":"Methods Mol Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1113\/jphysiol.2008.165464","article-title":"Exercise and adrenaline increase PGC-1{alpha} mRNA expression in rat adipose tissue.","volume":"587","author":"LN Sutherland","year":"2009","journal-title":"J Physiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"}],"updated-by":[{"DOI":"10.1371\/annotation\/3029d433-8e4e-41ca-a2da-6561aa0701bd","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T00:00:00Z","timestamp":1365552000000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0041719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T14:47:13Z","timestamp":1642862833000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0041719"}},"subtitle":[],"editor":[{"given":"Marcia B.","family":"Aguila","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,23]]},"references-count":39,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0041719","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,23]]}}}