{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:11:58Z","timestamp":1773299518242,"version":"3.50.1"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,24]],"date-time":"2012-07-24T00:00:00Z","timestamp":1343088000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0041724","type":"journal-article","created":{"date-parts":[[2012,7,24]],"date-time":"2012-07-24T21:03:28Z","timestamp":1343163808000},"page":"e41724","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Salvinorin A Administration after Global Cerebral Hypoxia\/Ischemia Preserves Cerebrovascular Autoregulation via Kappa Opioid Receptor in Piglets"],"prefix":"10.1371","volume":"7","author":[{"given":"Zhenhong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Riley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Armstead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/ALN.0b013e3181dc1b84","article-title":"Preconditioning and postinsult therapies for perinatal hypoxic-ischemic injury at term.","volume":"113","author":"RD Sanders","year":"2010","journal-title":"Anesthesiology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/sj.jcbfm.9600196","article-title":"Neuroprotective effect of selective kappa opioid receptor agonist is gender specific and linked to reduced neuronal nitric oxide.","volume":"26","author":"E Zeynalov","year":"2006","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1097\/01.jnen.0000235123.05677.4b","article-title":"Opioid preconditioning induces opioid receptor-dependent delayed neuroprotection against ischemia in rats.","volume":"65","author":"P Zhao","year":"2006","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.neulet.2007.06.044","article-title":"Dose-dependent neuroprotection of delta opioid peptide [D-Ala2, D-Leu5] enkephalin in neuronal death and retarded behavior induced by forebrain ischemia in rats.","volume":"423","author":"DS Su","year":"2007","journal-title":"Neurosci Lett"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/312551a0","article-title":"Dynorphin (1\u201313) improves survival in cats with focal cerebral ischaemia.","volume":"312","author":"DS Baskin","year":"1984","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1161\/01.STR.19.8.1008","article-title":"Quantitative analysis of effects of kappa-opioid agonists on postischemic hippocampal CA1 neuronal necrosis in gerbils.","volume":"19","author":"ED Hall","year":"1988","journal-title":"Stroke"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1161\/01.STR.0000072512.30658.E7","article-title":"Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats.","volume":"34","author":"T Goyagi","year":"2003","journal-title":"Stroke"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1213\/01.ANE.0000087800.56290.2E","article-title":"Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats.","volume":"97","author":"Z Zhang","year":"2003","journal-title":"Anesth Analg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.brainres.2011.01.083","article-title":"Opioid receptor agonists reduce brain edema in stroke.","volume":"1383","author":"L Yang","year":"2011","journal-title":"Brain Research"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.physbeh.2007.10.015","article-title":"Neuroprotection and functional recovery conferred by administration of kappa- and delta 1-opioid agonists in a rat model of global ischemia.","volume":"93","author":"C Charron","year":"2008","journal-title":"Physiol behav"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1124\/mol.111.074195","article-title":"Duration of action of a broad range of selective kappa-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation.","volume":"80","author":"EJ Melief","year":"2011","journal-title":"Mol pharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/ALN.0b013e318204e029","article-title":"Salvinorin A produces cerebrovasodilation through activation of nitric oxide synthase, kappa receptor, and adenosine triphosphate-sensitive potassium channel.","volume":"114","author":"D Su","year":"2011","journal-title":"Anesthesiology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1600-0404.2011.01515.x","article-title":"Dynamic cerebral autoregulation associates with infarct size and outcome after ischemic stroke.","volume":"125","author":"M Reinhard","year":"2012","journal-title":"Acta Neurol Scand"},{"key":"ref14","first-page":"467","article-title":"Dynamic cerebral autoregulation and beat to beat blood pressure control are impaired in acute ischaemic stroke.","volume":"72","author":"PJ Eames","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000070118","article-title":"Serial changes in static and dynamic cerebral autoregulation after acute ischaemic stroke.","volume":"16","author":"SL Dawson","year":"2003","journal-title":"Cerebrovasc Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1213\/ANE.0b013e31823a5d36","article-title":"Salvinorin A Pretreatment Preserves Cerebrovascular Autoregulation After Brain Hypoxic\/Ischemic Injury via Extracellular Signal-Regulated Kinase\/Mitogen-Activated Protein Kinase in Piglets.","volume":"114","author":"D Su","year":"2012","journal-title":"Anesth Analg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1310\/CL09-U2QA-9M5A-ANG2","article-title":"Long-term functional outcome of pediatric stroke survivors.","volume":"11","author":"E Hurvitz","year":"2004","journal-title":"Top Stroke Rehabil"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1469-8749.2003.tb00337.x","article-title":"Prognosis of haemorrhagic stroke in childhood: a long-term follow-up study.","volume":"45","author":"I Blom","year":"2003","journal-title":"Dev Med Child Neurol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.thromres.2010.10.003","article-title":"New insights (and new interrogations) in perinatal arterial ischemic stroke.","volume":"127","author":"S Chabrier","year":"2011","journal-title":"Thromb Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/83358","article-title":"The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.","volume":"7","author":"O Nicole","year":"2001","journal-title":"Nat Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.brainres.2010.12.052","article-title":"tPA contributes to impairment of ATP and Ca sensitive K channel mediated cerebrovasodilation after hypoxia\/ischemia through upregulation of ERK MAPK.","volume":"1376","author":"WM Armstead","year":"2011","journal-title":"Brain Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1460-9568.1993.tb00947.x","article-title":"Neuroprotective effect of the kappa-agonist enadoline (CI-977) in rat models of focal cerebral ischaemia.","volume":"5","author":"NJ Hayward","year":"1993","journal-title":"Eur J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1161\/01.STR.0000125011.93188.c6","article-title":"Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in rats.","volume":"35","author":"TY Chen","year":"2004","journal-title":"Stroke"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"11934","DOI":"10.1073\/pnas.182234399","article-title":"Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.","volume":"99","author":"BL Roth","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1124\/mi.6.5.7","article-title":"Salvinorin A: from natural product to human therapeutics.","volume":"6","author":"TA Vortherms","year":"2006","journal-title":"Mol Interv"},{"key":"ref26","first-page":"379","article-title":"Acute physiologic and chronic histologic changes in rats and mice exposed to the unique hallucinogen salvinorin A. J Psychoactive Drugs","volume":"35","author":"M Mowry","year":"2003"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1124\/jpet.108.145342","article-title":"Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospinal fluid.","volume":"328","author":"ER Butelman","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.neuroimage.2008.03.003","article-title":"Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans.","volume":"41","author":"JM Hooker","year":"2008","journal-title":"NeuroImage"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ejpb.2009.01.002","article-title":"Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen.","volume":"72","author":"ZS Teksin","year":"2009","journal-title":"Eur J Pharm Biopharm"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1476-5381.2009.00230.x","article-title":"Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents.","volume":"157","author":"D Braida","year":"2009","journal-title":"Br J Pharmacol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1016\/j.lfs.2004.07.008","article-title":"Salvinorin A: a novel and highly selective kappa-opioid receptor agonist.","volume":"75","author":"F Yan","year":"2004","journal-title":"Life Sci"},{"key":"ref32","first-page":"H879","article-title":"Responses of cerebral arteries after ischemia and reperfusion in cats.","volume":"255","author":"WG Mayhan","year":"1988","journal-title":"Am J Physiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1097\/00004647-200009000-00007","article-title":"Activation of mitogen-activated protein kinases after permanent cerebral artery occlusion in mouse brain.","volume":"20","author":"DC Wu","year":"2000","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.brainres.2008.06.115","article-title":"uPA impairs cerebrovasodilation after hypoxia\/ischemia through LRP and ERK MAPK.","volume":"1231","author":"WM Armstead","year":"2008","journal-title":"Brain Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neuroscience.2003.08.023","article-title":"A neuroprotective role of extracellular signal-regulated kinase in N-acetyl-O-methyldopamine-treated hippocampal neurons after exposure to in vitro and in vivo ischemia.","volume":"123","author":"EM Park","year":"2004","journal-title":"Neuroscience"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1124\/jpet.102.040246","article-title":"Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis.","volume":"304","author":"X Wang","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/ANA.0b013e3182368d70","article-title":"Neuroprotective effects of remifentanil against transient focal cerebral ischemia in rats.","volume":"24","author":"S Jeong","year":"2012","journal-title":"J Neurosurg Anesthesiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/jcbfm.2010.62","article-title":"Blockade of the MEK\/ERK pathway with a raf inhibitor prevents activation of pro-inflammatory mediators in cerebral arteries and reduction in cerebral blood flow after subarachnoid hemorrhage in a rat model.","volume":"31","author":"A Maddahi","year":"2011","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"12866","DOI":"10.1073\/pnas.96.22.12866","article-title":"MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia.","volume":"96","author":"A Alessandrini","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.neuroscience.2009.12.067","article-title":"Exercise preconditioning reduces neuronal apoptosis in stroke by up-regulating heat shock protein-70 (heat shock protein-72) and extracellular-signal-regulated-kinase 1\/2.","volume":"166","author":"B Liebelt","year":"2010","journal-title":"Neuroscience"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neulet.2006.09.053","article-title":"Ischemic preconditioning-induced activation of ERK1\/2 in the rat hippocampus.","volume":"409","author":"JS Choi","year":"2006","journal-title":"Neurosci Lett"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0041724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T06:24:15Z","timestamp":1589005455000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0041724"}},"subtitle":[],"editor":[{"given":"Zhongcong","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,7,24]]},"references-count":41,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0041724","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,24]]}}}