{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:13:38Z","timestamp":1791832418211,"version":"4.3.4"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2012,10,26]],"date-time":"2012-10-26T00:00:00Z","timestamp":1351209600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0046427","type":"journal-article","created":{"date-parts":[[2012,10,26]],"date-time":"2012-10-26T16:59:04Z","timestamp":1351270744000},"page":"e46427","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":75,"title":["The Ubiquitin Ligase Nedd4-1 Participates in Denervation-Induced Skeletal Muscle Atrophy in Mice"],"prefix":"10.1371","volume":"7","author":[{"given":"Preena","family":"Nagpal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Plant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Bain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kawabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Rotin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Bain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A. E.","family":"Batt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,10,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1183\/09031936.97.10020417","article-title":"Muscle weakness is related to utilization of health care resources in COPD patients","volume":"10","author":"M Decramer","year":"1997","journal-title":"Eur Respir J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1053\/rmed.2000.0829","article-title":"Tissue depletion and health related quality of life in patients with chronic obstructive pulmonary disease","volume":"94","author":"R Mostert","year":"2000","journal-title":"Respir Med"},{"key":"ref3","first-page":"39","article-title":"Muscle wasting in cancer and ageing: cachexia versus sarcopenia","volume":"18","author":"JM Argiles","year":"2006","journal-title":"Adv Gerontol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1532-5415.2004.52014.x","article-title":"The healthcare costs of sarcopenia in the United States","volume":"52","author":"I Janssen","year":"2004","journal-title":"J Am Geriatr Soc"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1046\/j.1532-5415.2002.50216.x","article-title":"Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability","volume":"50","author":"I Janssen","year":"2002","journal-title":"J Am Geriatr Soc"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1681\/ASN.2006010083","article-title":"Protein degradation by the ubiquitin-proteasome pathway in normal and disease states","volume":"17","author":"SH Lecker","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"227S","DOI":"10.1093\/jn\/129.1.227S","article-title":"Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states","volume":"129","author":"SH Lecker","year":"1999","journal-title":"J Nutr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"26690","DOI":"10.1074\/jbc.271.43.26690","article-title":"Importance of the ATP-ubiquitin-proteasome pathway in the degradation of soluble and myofibrillar proteins in rabbit muscle extracts","volume":"271","author":"V Solomon","year":"1996","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1152\/physrev.00027.2001","article-title":"The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction","volume":"82","author":"MH Glickman","year":"2002","journal-title":"Physiol Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1073\/pnas.92.7.2563","article-title":"A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase","volume":"92","author":"JM Huibregtse","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrc3120","article-title":"RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis","volume":"11","author":"S Lipkowitz","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0962-8924(00)01834-1","article-title":"The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases","volume":"10","author":"PK Jackson","year":"2000","journal-title":"Trends Cell Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1065874","article-title":"Identification of ubiquitin ligases required for skeletal muscle atrophy","volume":"294","author":"SC Bodine","year":"2001","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1073\/pnas.251541198","article-title":"Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy","volume":"98","author":"MD Gomes","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1096\/fj.04-3640fje","article-title":"Differential gene expression profiling of short and long term denervated muscle","volume":"20","author":"J Batt","year":"2006","journal-title":"FASEB J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1096\/fj.06-6665com","article-title":"The ubiquitin-protein ligase Nedd4 targets Notch1 in skeletal muscle and distinguishes the subset of atrophies caused by reduced muscle tension","volume":"21","author":"A Koncarevic","year":"2007","journal-title":"FASEB J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1165\/rcmb.2008-0382OC","article-title":"Cellular Markers of Muscle Atrophy in Chronic Obstructive Pulmonary Disease (COPD)","volume":"42","author":"PJ Plant","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"20019","DOI":"10.1074\/jbc.M211153200","article-title":"Affinity and specificity of interactions between Nedd4 isoforms and the epithelial Na+ channel","volume":"278","author":"PC Henry","year":"2003","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"F469","DOI":"10.1152\/ajprenal.2001.281.3.F469","article-title":"Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulation","volume":"281","author":"E Kamynina","year":"2001","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1096\/fj.00-0191com","article-title":"A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel","volume":"15","author":"E Kamynina","year":"2001","journal-title":"FASEB J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/cdd.2009.84","article-title":"Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions","volume":"17","author":"B Yang","year":"2010","journal-title":"Cell Death Differ"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1128\/MCB.00463-06","article-title":"Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster","volume":"27","author":"B Ing","year":"2007","journal-title":"Mol Cell Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.neuron.2010.01.007","article-title":"Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development","volume":"65","author":"H Kawabe","year":"2010","journal-title":"Neuron"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"6770","DOI":"10.1074\/jbc.M109.082347","article-title":"The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1","volume":"285","author":"F Fouladkou","year":"2010","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ydbio.2009.03.023","article-title":"Abnormal development of the neuromuscular junction in Nedd4-deficient mice","volume":"330","author":"Y Liu","year":"2009","journal-title":"Dev Biol"},{"key":"ref26","first-page":"ra5","article-title":"Nedd4 controls animal growth by regulating IGF-1 signaling","volume":"1","author":"XR Cao","year":"2008","journal-title":"Sci Signal"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1073\/pnas.0409103102","article-title":"Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice","volume":"102","author":"S Li","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0306-4522(00)00577-7","article-title":"Improved functional recovery of denervated skeletal muscle after temporary sensory nerve innervation","volume":"103","author":"JR Bain","year":"2001","journal-title":"Neuroscience"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1534-5807(02)00254-X","article-title":"The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis","volume":"3","author":"IM Conboy","year":"2002","journal-title":"Dev Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1113\/jphysiol.2003.044701","article-title":"Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle","volume":"551","author":"EJ Stevenson","year":"2003","journal-title":"J Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1023\/A:1026127307457","article-title":"Satellite cell depletion in degenerative skeletal muscle","volume":"8","author":"SS Jejurikar","year":"2003","journal-title":"Apoptosis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1152\/physrev.00019.2003","article-title":"Cellular and molecular regulation of muscle regeneration","volume":"84","author":"SB Charge","year":"2004","journal-title":"Physiol Rev"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1177\/002215549904701104","article-title":"Satellite cells on isolated myofibers from normal and denervated adult rat muscle","volume":"47","author":"R Kuschel","year":"1999","journal-title":"J Histochem Cytochem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF00209039","article-title":"Cell proliferation in skeletal muscle following denervation or tenotomy. A series of autoradiographic studies","volume":"193","author":"J McGeachie","year":"1978","journal-title":"Cell Tissue Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1042\/BJ20081866","article-title":"The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4","volume":"419","author":"PJ Plant","year":"2009","journal-title":"Biochem J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2474-8-32","article-title":"FGFR1 inhibits skeletal muscle atrophy associated with hindlimb suspension","volume":"8","author":"J Eash","year":"2007","journal-title":"BMC Musculoskelet Disord"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"18135","DOI":"10.1073\/pnas.0404341102","article-title":"Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I","volume":"101","author":"V Kedar","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jmb.2005.05.021","article-title":"MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination","volume":"350","author":"SH Witt","year":"2005","journal-title":"J Mol Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12013-011-9175-7","article-title":"Targeting the ubiquitin E3 ligase MuRF1 to inhibit muscle atrophy","volume":"60","author":"MJ Eddins","year":"2011","journal-title":"Cell Biochem Biophys"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1074\/jbc.M411346200","article-title":"Degradation of MyoD mediated by the SCF (MAFbx) ubiquitin ligase","volume":"280","author":"LA Tintignac","year":"2005","journal-title":"J Biol Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/emboj.2008.52","article-title":"The initiation factor eIF3-f is a major target for atrogin1\/MAFbx function in skeletal muscle atrophy","volume":"27","author":"J Lagirand-Cantaloube","year":"2008","journal-title":"EMBO J"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1038\/emboj.2011.234","article-title":"Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function","volume":"30","author":"A Persaud","year":"2011","journal-title":"EMBO J"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1006\/excr.2001.5185","article-title":"FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate","volume":"265","author":"R Zhao","year":"2001","journal-title":"Exp Cell Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"R285","DOI":"10.1093\/hmg\/ddg273","article-title":"Myotubularins, a large disease-associated family of cooperating catalytically active and inactive phosphoinositides phosphatases","volume":"12 Spec No 2","author":"J Laporte","year":"2003","journal-title":"Hum Mol Genet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1091\/mbc.E08-04-0367","article-title":"Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking","volume":"19","author":"C Cao","year":"2008","journal-title":"Mol Biol Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.cell.2010.06.011","article-title":"Cell signaling by receptor tyrosine kinases","volume":"141","author":"MA Lemmon","year":"2010","journal-title":"Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1093\/hmg\/ddn112","article-title":"AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis","volume":"17","author":"A Buj-Bello","year":"2008","journal-title":"Hum Mol Genet"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1128\/MCB.01285-09","article-title":"Notch and the skeleton","volume":"30","author":"S Zanotti","year":"2010","journal-title":"Mol Cell Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.semcdb.2005.07.002","article-title":"The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis","volume":"16","author":"D Luo","year":"2005","journal-title":"Semin Cell Dev Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbrc.2011.09.048","article-title":"Nandrolone reduces activation of Notch signaling in denervated muscle associated with increased Numb expression","volume":"414","author":"XH Liu","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/(SICI)1097-0185(199707)248:3<346::AID-AR7>3.0.CO;2-N","article-title":"Quantitative study of the effects of long-term denervation on the extensor digitorum longus muscle of the rat","volume":"248","author":"CA Viguie","year":"1997","journal-title":"Anat Rec"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/00006534-200207000-00027","article-title":"Skeletal muscle denervation increases satellite cell susceptibility to apoptosis","volume":"110","author":"SS Jejurikar","year":"2002","journal-title":"Plast Reconstr Surg"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0046427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T21:44:40Z","timestamp":1562276680000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0046427"}},"subtitle":[],"editor":[{"given":"Richard Jay","family":"Smeyne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,10,26]]},"references-count":52,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2012,10,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0046427","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,26]]}}}