{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:53:34Z","timestamp":1790679214060,"version":"4.1.0"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0047845","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T22:04:25Z","timestamp":1351548265000},"page":"e47845","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":65,"title":["Quantitative Proteomic Analysis of Niemann-Pick Disease, Type C1 Cerebellum Identifies Protein Biomarkers and Provides Pathological Insight"],"prefix":"10.1371","volume":"7","author":[{"given":"Stephanie M.","family":"Cologna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Sheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Backlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine V. M.","family":"Cluzeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle K.","family":"Dail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Yanjanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Siebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia L.","family":"Toth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-sik","family":"Jun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Wassif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred L.","family":"Yergey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forbes D.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1034\/j.1399-0004.2003.00147.x","article-title":"Niemann-Pick disease type C","volume":"64","author":"MT Vanier","year":"2003","journal-title":"Clin Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bbalip.2004.08.014","article-title":"The pathophysiology and mechanisms of NP-C disease","volume":"1685","author":"SL Sturley","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1388-1981(00)00158-X","article-title":"Niemann-Pick type C: a disorder of cellular cholesterol trafficking","volume":"1529","author":"DS Ory","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"25517","DOI":"10.1074\/jbc.M302588200","article-title":"NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols","volume":"278","author":"A Frolov","year":"2003","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/nm.1876","article-title":"Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium","volume":"14","author":"E Lloyd-Evans","year":"2008","journal-title":"Nat Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1006\/bbrc.1994.1064","article-title":"The attenuated elevation of cytoplasmic calcium concentration following the uptake of low density lipoprotein in type C Niemann-Pick fibroblasts","volume":"198","author":"T Yamamoto","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0014-4886(03)00345-5","article-title":"Postnatal development of inflammation in a murine model of Niemann-Pick type C disease: immunohistochemical observations of microglia and astroglia","volume":"184","author":"M Baudry","year":"2003","journal-title":"Exp Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ymgme.2004.08.017","article-title":"Apoptosis accompanied by up-regulation of TNF-alpha death pathway genes in the brain of Niemann-Pick type C disease","volume":"84","author":"YP Wu","year":"2005","journal-title":"Mol Genet Metab"},{"key":"ref9","article-title":"Oxidative stress in NPC1 deficient cells: Protective effect of allopregnanolone","author":"S Zampieri","year":"2008","journal-title":"J Cell Mol Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/j.1471-4159.2006.03958.x","article-title":"Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons","volume":"98","author":"CH Koh","year":"2006","journal-title":"J Neurochem"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000019","article-title":"Clues to Neuro-Degeneration in Niemann-Pick Type C Disease from Global Gene Expression Profiling","volume":"1","author":"JV Reddy","year":"2006","journal-title":"Plos One"},{"key":"ref12","first-page":"2281","article-title":"Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking","volume":"118","author":"JR Zhang","year":"2008","journal-title":"J Clin Invest"},{"key":"ref13","article-title":"Oxidative stress in Niemann-Pick disease, type C","author":"R Fu","year":"2010","journal-title":"Molecular Genetics and Metabolism"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/ajmg.b.30969","article-title":"Linear clinical progression, independent of age of onset, in Niemann-Pick disease, type C","volume":"153B","author":"NM Yanjanin","year":"2010","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0022-3476(05)81695-6","article-title":"Niemann-Pick disease type C: diagnosis and outcome in children, with particular reference to liver disease","volume":"123","author":"DA Kelly","year":"1993","journal-title":"J Pediatr"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1474-4422(07)70194-1","article-title":"Miglustat for treatment of Niemann-Pick C disease: a randomised controlled study","volume":"6","author":"MC Patterson","year":"2007","journal-title":"Lancet Neurol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ymgme.2009.07.003","article-title":"Miglustat in patients with Niemann-Pick disease Type C (NP-C): a multicenter observational retrospective cohort study","volume":"98","author":"M Pineda","year":"2009","journal-title":"Mol Genet Metab"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1177\/0883073809344222","article-title":"Long-term miglustat therapy in children with Niemann-Pick disease type C","volume":"25","author":"MC Patterson","year":"2010","journal-title":"J Child Neurol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"9404","DOI":"10.1523\/JNEUROSCI.1317-11.2011","article-title":"Unesterified cholesterol accumulation in late endosomes\/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment","volume":"31","author":"A Aqul","year":"2011","journal-title":"J Neurosci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e6951","DOI":"10.1371\/journal.pone.0006951","article-title":"Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression","volume":"4","author":"CD Davidson","year":"2009","journal-title":"Plos One"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/00005072-198805000-00008","article-title":"Cerebellar involvement in murine sphingomyelinosis: a new model of Niemann-Pick disease","volume":"47","author":"J Tanaka","year":"1988","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s002210100870","article-title":"Neurodegeneration in Niemann-Pick type C disease mice","volume":"141","author":"WY Ong","year":"2001","journal-title":"Exp Brain Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.nbd.2011.12.027","article-title":"Early glial activation, synaptic changes and axonal pathology in the thalamocortical system of Niemann-Pick type C1 mice","volume":"45","author":"SN Pressey","year":"2012","journal-title":"Neurobiol Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1093\/hmg\/11.24.3107","article-title":"Rescue of neurodegeneration in Niemann-Pick C mice by a prion-promoter-driven Npc1 cDNA transgene","volume":"11","author":"SK Loftus","year":"2002","journal-title":"Hum Mol Genet"},{"key":"ref25","first-page":"81","article-title":"Cell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C disease","volume":"1","author":"DC Ko","year":"2005","journal-title":"PLoS Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/hmg\/ddp552","article-title":"Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration","volume":"19","author":"MJ Elrick","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.1093\/hmg\/ddr372","article-title":"Temporal and cell-specific deletion establishes that neuronal Npc1 deficiency is sufficient to mediate neurodegeneration","volume":"20","author":"T Yu","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1212\/WNL.0b013e318208f4ab","article-title":"Gamma-secretase-dependent amyloid-beta is increased in Niemann-Pick type C: a cross-sectional study","volume":"76","author":"N Mattsson","year":"2011","journal-title":"Neurology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"10314","DOI":"10.1074\/jbc.M009733200","article-title":"Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice","volume":"276","author":"N Sawamura","year":"2001","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0962-8924(01)02181-X","article-title":"Cdk5 behind the wheel: a role in trafficking and transport?","volume":"12","author":"DS Smith","year":"2002","journal-title":"Trends Cell Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"56ra81","DOI":"10.1126\/scitranslmed.3001417","article-title":"Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease","volume":"2","author":"FD Porter","year":"2010","journal-title":"Sci Transl Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1194\/jlr.D015735","article-title":"A sensitive and specific LC-MS\/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma","volume":"52","author":"X Jiang","year":"2011","journal-title":"J Lipid Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1074\/mcp.M900548-MCP200","article-title":"Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency","volume":"9","author":"XS Jiang","year":"2010","journal-title":"Mol Cell Proteomics"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1093\/hmg\/ddq011","article-title":"Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications","volume":"19","author":"XS Jiang","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.molcel.2006.06.026","article-title":"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey","volume":"23","author":"SC Kim","year":"2006","journal-title":"Mol Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1074\/mcp.M600218-MCP200","article-title":"Mitochondrial phosphoproteome revealed by an improved IMAC method and MS\/MS\/MS","volume":"6","author":"J Lee","year":"2007","journal-title":"Mol Cell Proteomics"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ymgme.2009.10.012","article-title":"L-serine synthesis in the central nervous system: a review on serine deficiency disorders","volume":"99","author":"L Tabatabaie","year":"2010","journal-title":"Mol Genet Metab"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1242\/jcs.01170","article-title":"Mammalian class E Vps proteins, SBP1 and mVps2\/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1\/Vps4B","volume":"117","author":"H Fujita","year":"2004","journal-title":"J Cell Sci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.tibs.2007.09.010","article-title":"ESCRTing proteins in the endocytic pathway","volume":"32","author":"S Saksena","year":"2007","journal-title":"Trends Biochem Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0022-510X(78)90086-2","article-title":"Multivesicular bodies in cortical dendrites of two patients with Alzheimer&apos;s disease","volume":"36","author":"MM Paula-Barbosa","year":"1978","journal-title":"J Neurol Sci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrd2589","article-title":"Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets","volume":"7","author":"M Furuhashi","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1373\/clinchem.2003.030361","article-title":"Brain- and heart-type fatty acid-binding proteins in the brain: tissue distribution and clinical utility","volume":"50","author":"MM Pelsers","year":"2004","journal-title":"Clin Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.pediatrneurol.2010.08.004","article-title":"Niemann-Pick disease type C: unique 2-deoxy-2[(1)F] fluoro-D-glucose PET abnormality","volume":"44","author":"A Kumar","year":"2011","journal-title":"Pediatr Neurol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ymgme.2009.11.007","article-title":"Clinical experience with miglustat therapy in pediatric patients with Niemann-Pick disease type C: a case series","volume":"99","author":"M Pineda","year":"2010","journal-title":"Mol Genet Metab"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/mgme.2000.3066","article-title":"Synergistic heterozygosity: disease resulting from multiple partial defects in one or more metabolic pathways","volume":"71","author":"J Vockley","year":"2000","journal-title":"Mol Genet Metab"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.nbd.2010.09.008","article-title":"Oxidative stress activates the c-Abl\/p73 proapoptotic pathway in Niemann-Pick type C neurons","volume":"41","author":"A Klein","year":"2011","journal-title":"Neurobiol Dis"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.nbd.2011.01.028","article-title":"Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis","volume":"42","author":"A Nunes","year":"2011","journal-title":"Neurobiol Dis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1093\/brain\/awl255","article-title":"Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer&apos;s disease brain, induces tau phosphorylation in neurons","volume":"129","author":"J Padmanabhan","year":"2006","journal-title":"Brain"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1126\/science.1161070","article-title":"Helical structures of ESCRT-III are disassembled by VPS4","volume":"321","author":"S Lata","year":"2008","journal-title":"Science"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"6569","DOI":"10.1523\/JNEUROSCI.5529-07.2008","article-title":"Neuronal loss of Drosophila NPC1a causes cholesterol aggregation and age-progressive neurodegeneration","volume":"28","author":"SE Phillips","year":"2008","journal-title":"J Neurosci"},{"key":"ref51","first-page":"1","article-title":"Intracellular cholesterol transport by NPC1\/NPC2: Mysteries of Niemann-Pick disease type C. In: Tate KMaS-i, editor. Functional and Structural Biology on the Lipo-network","author":"H Ninomiya","year":"2006","journal-title":"Kerala: Transworld Research Network"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature07961","article-title":"The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins","volume":"458","author":"C Raiborg","year":"2009","journal-title":"Nature"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"35428","DOI":"10.1074\/jbc.M110.126318","article-title":"Activation of human VPS4A by ESCRT-III proteins reveals ability of substrates to relieve enzyme autoinhibition","volume":"285","author":"SA Merrill","year":"2010","journal-title":"J Biol Chem"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1242\/jcs.02993","article-title":"Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1\/Vps4","volume":"119","author":"Y Ohsaki","year":"2006","journal-title":"J Cell Sci"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/ng1609","article-title":"Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia","volume":"37","author":"G Skibinski","year":"2005","journal-title":"Nat Genet"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1212\/01.wnl.0000231510.89311.8b","article-title":"ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)","volume":"67","author":"N Parkinson","year":"2006","journal-title":"Neurology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neures.2010.07.2028","article-title":"Differential expression of FABP 3, 5, 7 in infantile and adult monkey cerebellum","volume":"68","author":"NB Boneva","year":"2010","journal-title":"Neurosci Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.3233\/JAD-2010-101293","article-title":"CSF levels of heart fatty acid binding protein are altered during early phases of Alzheimer&apos;s disease","volume":"22","author":"D Chiasserini","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neulet.2004.07.061","article-title":"Heart fatty acid binding protein as a potential diagnostic marker for neurodegenerative diseases","volume":"370","author":"P Steinacker","year":"2004","journal-title":"Neurosci Lett"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.plefa.2006.07.005","article-title":"Omega-3 fatty acids and monoamine neurotransmission","volume":"75","author":"S Chalon","year":"2006","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1387\/ijdb.092976rl","article-title":"Fatty acid binding proteins in brain development and disease","volume":"54","author":"RZ Liu","year":"2010","journal-title":"Int J Dev Biol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1002\/elps.200500286","article-title":"Two-dimensional gel electrophoresis maps of the proteome and phosphoproteome of primitively cultured rat mesangial cells","volume":"26","author":"XS Jiang","year":"2005","journal-title":"Electrophoresis"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1002\/rcm.1198","article-title":"A method for reducing the time required to match protein sequences with tandem mass spectra","volume":"17","author":"R Craig","year":"2003","journal-title":"Rapid Commun Mass Spectrom"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1021\/ac025747h","article-title":"Empirical statistical model to estimate the accuracy of peptide identifications made by MS\/MS and database search","volume":"74","author":"A Keller","year":"2002","journal-title":"Anal Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/ac0341261","article-title":"A statistical model for identifying proteins by tandem mass spectrometry","volume":"75","author":"AI Nesvizhskii","year":"2003","journal-title":"Anal Chem"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"W741","DOI":"10.1093\/nar\/gki475","article-title":"WebGestalt: an integrated system for exploring gene sets in various biological contexts","volume":"33","author":"B Zhang","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref68","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-11-S4-P10","article-title":"WebGestalt2: an updated and expanded version of the Web-based Gene Set Analysis Toolkit","volume":"11","author":"D Duncan","year":"2010","journal-title":"Bmc Bioinformatics"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1182\/blood-2009-12-258491","article-title":"Lack of glucose recycling between endoplasmic reticulum and cytoplasm underlies cellular dysfunction in glucose-6-phosphatase-beta-deficient neutrophils in a congenital neutropenia syndrome","volume":"116","author":"HS Jun","year":"2010","journal-title":"Blood"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0047845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T21:34:18Z","timestamp":1714512858000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0047845"}},"subtitle":[],"editor":[{"given":"Ashley I.","family":"Bush","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,10,29]]},"references-count":69,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2012,10,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0047845","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,29]]}}}