{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T18:18:50Z","timestamp":1776363530143,"version":"3.51.2"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T00:00:00Z","timestamp":1352851200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0047891","type":"journal-article","created":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T22:39:08Z","timestamp":1352932748000},"page":"e47891","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":45,"title":["Antibody to Epstein-Barr Virus Deoxyuridine Triphosphate Nucleotidohydrolase and Deoxyribonucleotide Polymerase in a Chronic Fatigue Syndrome Subset"],"prefix":"10.1371","volume":"7","author":[{"given":"A. Martin","family":"Lerner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria E.","family":"Ariza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard","family":"Jason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safedin","family":"Beqaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James T.","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley","family":"Lemeshow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,11,14]]},"reference":[{"key":"ref1","first-page":"135","article-title":"An update on the management of glandular fever (infectious mononucleosis) and its sequelae caused by Epstein-Barr virus (HHV-4): new and emerging treatment strategies","volume":"2","author":"AM Lerner","year":"2010","journal-title":"Virus Adaptation and Treatment"},{"key":"ref2","first-page":"47","article-title":"Subset-directed antiviral treatment of 142 herpesvirus patients with chronic fatigue syndrome","volume":"2","author":"AM Lerner","year":"2010","journal-title":"Virus Adaptation and Treatment"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1001\/archinte.159.18.2129","article-title":"A community-based study of chronic fatigue syndrome","volume":"159","author":"LA Jason","year":"1999","journal-title":"Arch Intern Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"953","DOI":"10.7326\/0003-4819-121-12-199412150-00009","article-title":"The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group","volume":"121","author":"K Fukuda","year":"1994","journal-title":"Ann Intern Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1300\/J092v11n01_02","article-title":"Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome; Clinical Working Case Definition, Diagnostic and Treatment Protocols","volume":"11","author":"B Carruthers","year":"2003","journal-title":"Journal of Chronic Fatigue Syndrome"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1476-5918-7-6","article-title":"The economic impact of ME\/CFS: individual and societal costs","volume":"7","author":"LA Jason","year":"2008","journal-title":"Dyn Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/S1386-6532(06)70009-9","article-title":"Use of valganciclovir in patients with elevated antibody titers against Human Herpesvirus-6 (HHV-6) and Epstein-Barr Virus (EBV) who were experiencing central nervous system dysfunction including long-standing fatigue","volume":"37","author":"AM Kogelnik","year":"2006","journal-title":"J Clin Virol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1136\/bmj.2.5470.1099","article-title":"Cytomegalovirus as a possible cause of a disease resembling infectious mononucleosis","volume":"2","author":"E Klemola","year":"1965","journal-title":"Br Med J"},{"key":"ref9","first-page":"799","article-title":"Validation of the energy index point score to serially measure the degree of disability in patients with chronic fatigue syndrome","volume":"22","author":"AM Lerner","year":"2008","journal-title":"In Vivo"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbi.2004.09.001","article-title":"Stress-associated changes in the steady-state expression of latent Epstein-Barr virus: implications for chronic fatigue syndrome and cancer","volume":"19","author":"R Glaser","year":"2005","journal-title":"Brain Behav Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/jmv.20196","article-title":"Epstein-Barr virus-encoded dUTPase modulates immune function and induces sickness behavior in mice","volume":"74","author":"DA Padgett","year":"2004","journal-title":"J Med Virol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1099\/0022-1317-77-11-2795","article-title":"Cloning and expression of the Epstein-Barr virus-encoded dUTPase: patients with acute, reactivated or chronic virus infection develop antibodies against the enzyme","volume":"11)","author":"P Sommer","year":"1996","journal-title":"J Gen Virol 77 (Pt"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.virol.2005.10.034","article-title":"EBV-encoded dUTPase induces immune dysregulation: Implications for the pathophysiology of EBV-associated disease","volume":"346","author":"R Glaser","year":"2006","journal-title":"Virology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"851","DOI":"10.4049\/jimmunol.182.2.851","article-title":"The EBV-encoded dUTPase activates NF-kappa B through the TLR2 and MyD88-dependent signaling pathway","volume":"182","author":"ME Ariza","year":"2009","journal-title":"J Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1001\/archinte.1988.00380090047012","article-title":"Antibodies to Epstein-Barr virus-specific DNase and DNA polymerase in the chronic fatigue syndrome","volume":"148","author":"JF Jones","year":"1988","journal-title":"Arch Intern Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2147\/VAAT.S15105","article-title":"A paradigm linking herpesvirus immediate-early gene expression apoptosis and myalgic encephalomyelitis chronic fatigue syndrome","volume":"3","author":"AM Lerner","year":"2011","journal-title":"Virus Adaptation and Treatment"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s11926-007-0078-y","article-title":"Chronic fatigue syndrome: inflammation, immune function, and neuroendocrine interactions","volume":"9","author":"NG Klimas","year":"2007","journal-title":"Curr Rheumatol Rep"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/jcp.2007.050633","article-title":"Immunoassay with cytomegalovirus early antigens from gene products p52 and CM2 (UL44 and UL57) detects active infection in patients with chronic fatigue syndrome","volume":"61","author":"SH Beqaj","year":"2008","journal-title":"J Clin Pathol"},{"key":"ref19","first-page":"101","article-title":"IgM serum antibodies to Epstein-Barr virus are uniquely present in a subset of patients with the chronic fatigue syndrome","volume":"18","author":"AM Lerner","year":"2004","journal-title":"In Vivo"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/0042-6822(85)90341-1","article-title":"Induction of a deoxyuridine triphosphate nucleotidohydrolase activity in Epstein-Barr virus-infected cells","volume":"142","author":"MV Williams","year":"1985","journal-title":"Virology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0042-6822(80)90524-3","article-title":"Studies on the activity of DNase associated with the replication of the Epstein-Barr virus","volume":"100","author":"YC Cheng","year":"1980","journal-title":"Virology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/0042-6822(78)90058-2","article-title":"Expression of altered ribonucleotide reductase activity associated with the replication of the Epstein-Barr virus","volume":"89","author":"BE Henry","year":"1978","journal-title":"Virology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/0042-6822(77)90232-X","article-title":"Studies of an Epstein-Barr virus-induced DNA polymerase","volume":"76","author":"RL Miller","year":"1977","journal-title":"Virology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3181\/00379727-142-37176","article-title":"Thymidine kinase activity in Burkitt lymphoblastoid somatic cell hybrids after induction of the EB virus","volume":"142","author":"R Glaser","year":"1973","journal-title":"Proc Soc Exp Biol Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/310207a0","article-title":"DNA sequence and expression of the B95-8 Epstein-Barr virus genome","volume":"310","author":"R Baer","year":"1984","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"6162","DOI":"10.1073\/pnas.77.10.6162","article-title":"Frequency and levels of antibodies to Epstein-Barr virus-specific DNase are elevated in patients with nasopharyngeal carcinoma","volume":"77","author":"YC Cheng","year":"1980","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/jmv.1890280209","article-title":"Antibody against Epstein-Barr virus DNA polymerase activity in sera of patients with nasopharyngeal carcinoma","volume":"28","author":"MY Liu","year":"1989","journal-title":"J Med Virol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/ijc.2910430111","article-title":"Relationship between nasopharyngeal carcinoma and high antibody titers to Epstein-Barr virus-specific thymidine kinase","volume":"43","author":"M de Turenne-Tessier","year":"1989","journal-title":"Int J Cancer"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/ijc.2910080212","article-title":"Demonstration of two distinct components in the early antigen complex of Epstein-Barr virus-infected cells","volume":"8","author":"G Henle","year":"1971","journal-title":"Int J Cancer"},{"key":"ref30","first-page":"361","article-title":"Antibodies to Epstein-Barr virus-related antigens in nasopharyngeal carcinoma. Comparison of active cases with long-term survivors","volume":"51","author":"W Henle","year":"1973","journal-title":"J Natl Cancer Inst"},{"key":"ref31","first-page":"189","article-title":"The importance of viral markers in the study of Epstein-Barr virus-associated illness","volume":"85","author":"R Glaser","year":"1987","journal-title":"Bulletin de L'Institut Pasteur"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1016\/S0889-1591(02)00078-8","article-title":"Cytokines and depression: the need for a new paradigm","volume":"17","author":"L Capuron","year":"2003","journal-title":"Brain Behav Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2796.2004.01443.x","article-title":"Immune regulation of central nervous system functions: from sickness responses to pathological pain","volume":"257","author":"LR Watkins","year":"2005","journal-title":"J Intern Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"11108","DOI":"10.1128\/JVI.78.20.11108-11120.2004","article-title":"Lytic replication-defective Kaposi's sarcoma-associated herpesvirus: potential role in infection and malignant transformation","volume":"78","author":"JH Deng","year":"2004","journal-title":"J Virol"},{"key":"ref35","first-page":"950","article-title":"Immunosuppressive properties of a virion polypeptide, a 15,000-dalton protein, from feline leukemia virus","volume":"39","author":"LE Mathes","year":"1979","journal-title":"Cancer Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"663","DOI":"10.4049\/jimmunol.165.2.663","article-title":"Direct immunosuppressive effects of EBV-encoded latent membrane protein 1","volume":"165","author":"DF Dukers","year":"2000","journal-title":"J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1006\/jmbi.2000.3717","article-title":"Binding of the Epstein-Barr virus major envelope glycoprotein gp350 results in the upregulation of the TNF-alpha gene expression in monocytic cells via NF-kappaB involving PKC, PI3-K and tyrosine kinases","volume":"298","author":"M D'Addario","year":"2000","journal-title":"J Mol Biol"},{"key":"ref38","first-page":"1","article-title":"Benefit from B-Lymphocyte Depletion Using the Anti-CD20 rituximab in Chronic Fatigue Syndrome A Double-Blind and Placebo-Controlled Study","volume":"6","author":"O Fluge","year":"2011","journal-title":"PLoS"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e31334","DOI":"10.1371\/journal.pone.0031334","article-title":"A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome","volume":"7","author":"DR Strayer","year":"2012","journal-title":"PLoS ONE"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1084\/jem.20081761","article-title":"Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from Toll-like receptor 3","volume":"206","author":"D Iwakiri","year":"2009","journal-title":"J Exp Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/jmv.1890420109","article-title":"High titers of anti-Epstein-Barr virus DNA polymerase are found in patients with severe fatiguing illness","volume":"42","author":"BH Natelson","year":"1994","journal-title":"J Med Virol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1300\/J092v07n01_04","article-title":"Chronic Fatigue Syndrome and Cancer","volume":"7","author":"PH Levine","year":"2000","journal-title":"Journal of Chronic Fatigue Syndrome"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Chang CM, Warren JL, Engels EA (2012) Chronic Fatigue Syndrome and Subsequent Risk of Cancer Among Elderly US Adults. Cancer. doi: 10.1002\/cncr.27612.","DOI":"10.1002\/cncr.27612"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0047891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:26:18Z","timestamp":1588965978000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0047891"}},"subtitle":[],"editor":[{"given":"Ann M.","family":"Moormann","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,14]]},"references-count":43,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0047891","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,14]]}}}