{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:14:28Z","timestamp":1764332068705},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T00:00:00Z","timestamp":1351036800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0047980","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T21:17:54Z","timestamp":1351113474000},"page":"e47980","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Transcutaneous Immunization System Using a Hydrotropic Formulation Induces a Potent Antigen-Specific Antibody Response"],"prefix":"10.1371","volume":"7","author":[{"given":"Tomoka","family":"Takatani-Nakase","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Tokuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Komai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,10,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jconrel.2010.09.018","article-title":"Advances in transcutaneous vaccine delivery: do all ways lead to Rome","volume":"148","author":"SM Bal","year":"2010","journal-title":"J Control Release"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.imbio.2007.10.017","article-title":"Mast cell functions in the innate skin immune system","volume":"213","author":"M Metz","year":"2008","journal-title":"Immunobiology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1365-2249.2006.03258.x","article-title":"Innate immunity mediated by epidermal keratinocytes promotes acquired immunity involving Langerhans cells and T cells in the skin","volume":"147","author":"K Sugita","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jconrel.2011.02.007","article-title":"Adjuvant effect of cationic liposomes and CpG depends on administration route","volume":"154","author":"B Sl\u00fctter","year":"2011","journal-title":"J Control Release"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1002\/jps.21523","article-title":"Vaccine adjuvants: current challenges and future approaches","volume":"98","author":"JH Wilson-Welder","year":"2009","journal-title":"J Pharm Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1023\/A:1016104910582","article-title":"Recent advances in vaccine adjuvants","volume":"19","author":"M Singh","year":"2002","journal-title":"Pharm Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/S0264-410X(02)00164-0","article-title":"Overview of vaccine adjuvants: present and future","volume":"20","author":"RL Hunter","year":"2002","journal-title":"Vaccine"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1016\/S0264-410X(02)00174-3","article-title":"Design and selection of vaccine adjuvants: animal models and human trials","volume":"20","author":"CR Alving","year":"2002","journal-title":"Vaccine"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0952-7915(00)00120-5","article-title":"Immunological concepts of vaccine adjuvant activity","volume":"12","author":"VE Schijns","year":"2000","journal-title":"Curr Opin Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1128\/IAI.67.3.1100-1106.1999","article-title":"Transcutaneous immunization with bacterial ADP-ribosylating exotoxins as antigens and adjuvants","volume":"67","author":"GM Glenn","year":"1999","journal-title":"Infect Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jconrel.2005.08.014","article-title":"Changes in immune responses to antigen applied to tape-stripped skin with CpG-oligodeoxynucleotide in mice","volume":"108","author":"J Inoue","year":"2005","journal-title":"J Control Release"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1172\/JCI115884","article-title":"Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice","volume":"90","author":"LC Wood","year":"1992","journal-title":"J Clin Invest"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"6179","DOI":"10.1016\/j.vaccine.2011.06.086","article-title":"Transcutaneous vaccines: novel advances in technology and delivery for overcoming the barriers","volume":"29","author":"N Li","year":"2011","journal-title":"Vaccine"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1517\/17425247.2011.574610","article-title":"Charged liposomes as carriers to enhance the permeation through the skin","volume":"8","author":"ML Gonzalez-Rodriguez","year":"2011","journal-title":"Expert Opin Drug Deliv"},{"key":"ref15","first-page":"607","article-title":"Liposomal systems as drug delivery vehicles for dermal and transdermal applications. Arch Dermatol Res","volume":"303","author":"MB Pierre","year":"2011"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jconrel.2010.05.012","article-title":"Transcutaneous vaccination using a hydrogel patch induces effective immune responses to tetanus and diphtheria toxoid in hairless rat","volume":"149","author":"K Matsuo","year":"2011","journal-title":"J Control Release"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"9086","DOI":"10.1016\/j.biomaterials.2010.08.046","article-title":"Co-administration of protein drugs with gold nanoparticles to enable percutaneous delivery","volume":"31","author":"Y Huang","year":"2010","journal-title":"Biomaterials"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11095-009-9985-0","article-title":"Efficiency of fatty acids as chemical penetration enhancers: mechanisms and structure enhancement relationship","volume":"27","author":"SA Ibrahim","year":"2010","journal-title":"Pharm Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.addr.2003.10.025","article-title":"Penetration enhancers","volume":"56","author":"AC Williams","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0168-3659(01)00359-5","article-title":"Characterization of the influence of polyol fatty acid esters on the permeation of diclofenac through rat skin","volume":"73","author":"K Takahashi","year":"2001","journal-title":"J Control Release"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"6110","DOI":"10.1016\/j.vaccine.2006.05.014","article-title":"Transcutaneous immunization with inactivated influenza virus induces protective immune responses","volume":"24","author":"I Skountzou","year":"2006","journal-title":"Vaccine"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.2042-7158.2011.01308.x","article-title":"Application of hydrotropy to transdermal formulations: hydrotropic solubilization of polyol fatty acid monoesters in water and enhancement effect on skin permeation of 5-FU","volume":"63","author":"K Takahashi","year":"2011","journal-title":"J Pharm Pharmacol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejps.2005.12.010","article-title":"Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution","volume":"28","author":"MP Evstigneev","year":"2006","journal-title":"Eur J Pharm Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijpharm.2004.01.012","article-title":"Hydrotropic solubilization of nimesulide for parenteral administration","volume":"274","author":"S Agrawal","year":"2004","journal-title":"Int J Pharm"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1021\/ie50436a012","article-title":"Use of Hydrotrope Solution in Industries","volume":"38","author":"R McKee","year":"1946","journal-title":"Ind Eng Chem"},{"key":"ref26","first-page":"107","article-title":"Hydrotropy","volume":"76","author":"C Neuberug","year":"1916","journal-title":"Biochem Z"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"16702","DOI":"10.1073\/pnas.0705974104","article-title":"Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice","volume":"104","author":"K Tsujikawa","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"MB Lutz","year":"1999","journal-title":"J Immunol Methods"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1248\/bpb.22.896","article-title":"Detection of anaphylactic reaction in the percutaneously sensitized mouse using the AW method","volume":"22","author":"H Kataoka","year":"1999","journal-title":"Biol Pharm Bull"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1248\/bpb.20.714","article-title":"A novel method for induction and detection of anaphylactic reaction using the mouse abdominal wall (AW method)","volume":"20","author":"H Kataoka","year":"1997","journal-title":"Biol Pharm Bull"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1002\/1521-4141(2000)30:8<2422::AID-IMMU2422>3.0.CO;2-H","article-title":"The enhanced antigen-specific production of cytokines induced by pertussis toxin is due to clonal expansion of T cells and not to altered effector functions of long-term memory cells","volume":"30","author":"CL Shive","year":"2000","journal-title":"Eur J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.4049\/jimmunol.162.4.2432","article-title":"Adjuvanticity of the cholera toxin A1-based gene fusion protein, CTA1-DD, is critically dependent on the ADP-ribosyltransferase and Ig-binding activity","volume":"162","author":"LC Agren","year":"1999","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0006-2952(94)90189-9","article-title":"Inhibition of neutrophil function by aspirin-like drugs (NSAIDS): requirement for assembly of heterotrimeric G proteins in bilayer phospholipid","volume":"47","author":"SB Abramson","year":"1994","journal-title":"Biochem Pharmacol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.immuni.2004.06.014","article-title":"CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions","volume":"21","author":"L Ohl","year":"2004","journal-title":"Immunity"},{"key":"ref35","first-page":"677","article-title":"Augmentation of the immune response to influenza vaccine by acetylsalicylic acid: a clinical trial in a geriatric population","volume":"16","author":"J Hsia","year":"1994","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0008-8749(89)90263-3","article-title":"The polyclonal and antigen-specific IgE and IgG subclass response of mice injected with ovalbumin in alum or complete Freund\u2019s adjuvant","volume":"123","author":"L Beck","year":"1989","journal-title":"Cell Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri2622","article-title":"Skin immune sentinels in health and disease","volume":"9","author":"FO Nestle","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/jid.2009.247","article-title":"Skin-resident T cells: the ups and downs of on site immunity","volume":"130","author":"RA Clark","year":"2010","journal-title":"J Invest Dermatol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0047980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T10:46:10Z","timestamp":1687776370000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0047980"}},"subtitle":[],"editor":[{"given":"Mauricio Martins","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,10,24]]},"references-count":38,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2012,10,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0047980","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,24]]}}}