{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T23:39:53Z","timestamp":1785022793755,"version":"3.55.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLOS ONE"],"DOI":"10.1371\/journal.pone.0048345","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T16:58:37Z","timestamp":1353430717000},"page":"e48345","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Rats Bred for Low Aerobic Capacity Become Promptly Fatigued and Have Slow Metabolic Recovery after Stimulated, Maximal Muscle Contractions"],"prefix":"10.1371","volume":"7","author":[{"given":"Sira","family":"Torvinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Silvennoinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Piitulainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"N\u00e4rv\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasi","family":"Tuunanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Gr\u00f6hn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren G.","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Britton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Kainulainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,11,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3389\/fphys.2012.00142","article-title":"Effects of physical activity and inactivity on muscle fatigue","volume":"3","author":"GC Bogdanis","year":"2012","journal-title":"Frontiers in Physiology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1113\/jphysiol.2002.024463","article-title":"The sites of neural adaptation induced by resistance training in humans","volume":"544","author":"TJ Carroll","year":"2002","journal-title":"The Journal of Physiology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1113\/jphysiol.1973.sp010369","article-title":"Physiological types and histochemical profiles in motor units of the cat gastrocnemius","volume":"234","author":"RE Burke","year":"1973","journal-title":"The Journal of Physiology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1136\/jnnp.31.5.424","article-title":"Histochemical composition, distribution of fibres and fatiguability of single motor units. anterior tibial muscle of the rat","volume":"31","author":"L Edstrom","year":"1968","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1046\/j.1365-201X.1998.0301f.x","article-title":"Mechanisms underlying the reduction of isometric force in skeletal muscle fatigue","volume":"162","author":"H Westerblad","year":"1998","journal-title":"Acta Physiologica Scandinavica"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.2165\/00007256-199213020-00007","article-title":"Role of excitation-contraction coupling in muscle fatigue","volume":"13","author":"DG Allen","year":"1992","journal-title":"Sports Medicine (Auckland, N.Z.)"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"C195","DOI":"10.1152\/ajpcell.1991.261.2.C195","article-title":"Cellular mechanisms of fatigue in skeletal muscle","volume":"261","author":"H Westerblad","year":"1991","journal-title":"The American Journal of Physiology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/00005768-200001000-00012","article-title":"Limiting factors for maximum oxygen uptake and determinants of endurance performance","volume":"32","author":"DR Bassett","year":"2000","journal-title":"Medicine and Science in Sports and Exercise"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1152\/jappl.1984.56.4.831","article-title":"Adaptations of skeletal muscle to endurance exercise and their metabolic consequences","volume":"56","author":"JO Holloszy","year":"1984","journal-title":"Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1152\/physiolgenomics.2001.5.1.45","article-title":"Artificial selection for intrinsic aerobic endurance running capacity in rats","volume":"5","author":"LG Koch","year":"2001","journal-title":"Physiological Genomics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"720","DOI":"10.2337\/db06-0521","article-title":"Family history of diabetes links impaired substrate switching and reduced mitochondrial content in skeletal muscle","volume":"56","author":"B Ukropcova","year":"2007","journal-title":"Diabetes"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1172\/JCI25151","article-title":"Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents","volume":"115","author":"K Morino","year":"2005","journal-title":"The Journal of Clinical Investigation"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10254-002-0004-7","article-title":"Molecular basis of skeletal muscle plasticity\u2013from gene to form and function","volume":"146","author":"M Fluck","year":"2003","journal-title":"Reviews of Physiology, Biochemistry and Pharmacology"},{"key":"ref14","first-page":"2278","article-title":"Biochemical adaptations in muscle. effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle","volume":"242","author":"JO Holloszy","year":"1967","journal-title":"The Journal of Biological Chemistry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00018-004-3345-3","article-title":"Functional investigations of exercising muscle: A noninvasive magnetic resonance spectroscopy-magnetic resonance imaging approach","volume":"61","author":"D Bendahan","year":"2004","journal-title":"Cellular and Molecular Life Sciences : CMLS"},{"key":"ref16","first-page":"43","article-title":"Quantitative interpretation of bioenergetic data from 31P and 1H magnetic resonance spectroscopic studies of skeletal muscle: An analytical review","volume":"10","author":"GJ Kemp","year":"1994","journal-title":"Magnetic Resonance Quarterly"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1469-7793.2001.00905.x","article-title":"In vivo reduction in ATP cost of contraction is not related to fatigue level in stimulated rat gastrocnemius muscle","volume":"536","author":"B Giannesini","year":"2001","journal-title":"The Journal of Physiology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/mrm.20637","article-title":"New experimental setup for studying strictly noninvasively skeletal muscle function in rat using 1H-magnetic resonance (MR) imaging and 31P-MR spectroscopy","volume":"54","author":"B Giannesini","year":"2005","journal-title":"Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine\/Society of Magnetic Resonance in Medicine"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1096\/fj.10-157313","article-title":"Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk","volume":"24","author":"R Kivel\u00e4","year":"2010","journal-title":"The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.2337\/db06-0981","article-title":"Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes","volume":"56","author":"M Mogensen","year":"2007","journal-title":"Diabetes"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/icb\/45.3.405","article-title":"Divergent selection for aerobic capacity in rats as a model for complex disease","volume":"45","author":"LG Koch","year":"2005","journal-title":"Integrative and Comparative Biology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1126\/science.1108177","article-title":"Cardiovascular risk factors emerge after artificial selection for low aerobic capacity","volume":"307","author":"U Wisloff","year":"2005","journal-title":"Science (New York, N.Y.)"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.2337\/diabetes.51.10.2944","article-title":"Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes","volume":"51","author":"DE Kelley","year":"2002","journal-title":"Diabetes"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"VK Mootha","year":"2003","journal-title":"Nature Genetics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"8466","DOI":"10.1073\/pnas.1032913100","article-title":"Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1","volume":"100","author":"ME Patti","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref26","article-title":"Intrinsic aerobic capacity sets a divide for aging and longevity","author":"LG Koch","year":"2011","journal-title":"Circulation Research"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1113\/jphysiol.1991.sp018617","article-title":"Force-velocity relations and myosin heavy chain isoform compositions of skinned fibres from rat skeletal muscle","volume":"437","author":"R Bottinelli","year":"1991","journal-title":"The Journal of Physiology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1113\/jphysiol.1994.sp020270","article-title":"Stretch activation, unloaded shortening velocity, and myosin heavy chain isoforms of rat skeletal muscle fibres","volume":"478 Pt 3","author":"S Galler","year":"1994","journal-title":"The Journal of Physiology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/jmre.1997.1244","article-title":"Improved method for accurate and efficient quantification of MRS data with use of prior knowledge","volume":"129","author":"L Vanhamme","year":"1997","journal-title":"Journal of Magnetic Resonance (San Diego, Calif.: 1997)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/mrm.1910010303","article-title":"Metabolic recovery after exercise and the assessment of mitochondrial function in vivo in human skeletal muscle by means of 31P NMR","volume":"1","author":"DL Arnold","year":"1984","journal-title":"Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine\/Society of Magnetic Resonance in Medicine"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/nbm.1940060111","article-title":"Control of phosphocreatine resynthesis during recovery from exercise in human skeletal muscle","volume":"6","author":"GJ Kemp","year":"1993","journal-title":"NMR in Biomedicine"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"R835","DOI":"10.1152\/ajpregu.00659.2010","article-title":"Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle","volume":"300","author":"DA Rivas","year":"2011","journal-title":"American Journal of Physiology.Regulatory, Integrative and Comparative Physiology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1152\/japplphysiol.01533.2005","article-title":"Enhanced mitochondrial sensitivity to creatine in rats bred for high aerobic capacity","volume":"100","author":"B Walsh","year":"2006","journal-title":"Journal of Applied Physiology (Bethesda, Md.: 1985)"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1159\/000320167","article-title":"Reduced respiratory capacity in muscle mitochondria of obese subjects","volume":"3","author":"L Bakkman","year":"2010","journal-title":"Obesity Facts"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1152\/japplphysiol.00556.2002","article-title":"Selected contribution: Skeletal muscle capillarity and enzyme activity in rats selectively bred for running endurance","volume":"94","author":"RA Howlett","year":"2003","journal-title":"Journal of Applied Physiology (Bethesda, Md.: 1985)"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF00524756","article-title":"Myosin heavy chain isoforms in histochemically defined fiber types of rat muscle","volume":"92","author":"A Termin","year":"1989","journal-title":"Histochemistry"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/39.3.1825216","article-title":"Direct correlation of parvalbumin levels with myosin isoforms and succinate dehydrogenase activity on frozen sections of rodent muscle","volume":"39","author":"EM Fuchtbauer","year":"1991","journal-title":"The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1212\/WNL.40.12.1888","article-title":"Constant relationships between force, phosphate concentration, and pH in muscles with differential fatigability","volume":"40","author":"MW Weiner","year":"1990","journal-title":"Neurology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0014-5793(01)02942-8","article-title":"Time-dependent and indirect effect of inorganic phosphate on force production in rat gastrocnemius exercising muscle determined by 31P-MRS","volume":"507","author":"B Giannesini","year":"2001","journal-title":"FEBS Letters"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1113\/jphysiol.2003.043927","article-title":"Mitochondrial and myoplasmic [Ca2+] in single fibres from mouse limb muscles during repeated tetanic contractions","volume":"551","author":"J Bruton","year":"2003","journal-title":"The Journal of Physiology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1113\/expphysiol.1991.sp003526","article-title":"Resistance to fatigue of single muscle fibres from xenopus related to succinate dehydrogenase and myofibrillar ATPase activities","volume":"76","author":"WJ van der Laarse","year":"1991","journal-title":"Experimental Physiology"},{"key":"ref42","first-page":"83","article-title":"Differences between properties of male and female motor units in the rat medial gastrocnemius muscle","volume":"57","author":"J Celichowski","year":"2006","journal-title":"Journal of Physiology and Pharmacology : An Official Journal of the Polish Physiological Society"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2337\/diacare.27.1.83","article-title":"Exercise capacity and body composition as predictors of mortality among men with diabetes","volume":"27","author":"TS Church","year":"2004","journal-title":"Diabetes Care"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1161\/01.CIR.0000091080.57509.E9","article-title":"Exercise capacity and the risk of death in women: The st james women take heart project","volume":"108","author":"M Gulati","year":"2003","journal-title":"Circulation"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJMoa011858","article-title":"Exercise capacity and mortality among men referred for exercise testing","volume":"346","author":"J Myers","year":"2002","journal-title":"The New England Journal of Medicine"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s004210050504","article-title":"Maximal and explosive force production capacity and balance performance in men of different ages","volume":"79","author":"M Izquierdo","year":"1999","journal-title":"European Journal of Applied Physiology and Occupational Physiology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1113\/jphysiol.1991.sp018833","article-title":"Effects of age on physiological, immunohistochemical and biochemical properties of fast-twitch single motor units in the rat","volume":"443","author":"L Larsson","year":"1991","journal-title":"The Journal of Physiology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/japplphysiol.00550.2007","article-title":"Age-related decline in rate of torque development is accompanied by lower maximal motor unit discharge frequency during fast contractions","volume":"104","author":"M Klass","year":"2008","journal-title":"Journal of Applied Physiology (Bethesda, Md.: 1985)"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0048345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T16:58:25Z","timestamp":1562345905000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0048345"}},"subtitle":[],"editor":[{"given":"Frank","family":"Seebacher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,20]]},"references-count":48,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0048345","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,20]]}}}