{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:35:55Z","timestamp":1770510955683,"version":"3.49.0"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T00:00:00Z","timestamp":1351641600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0048384","type":"journal-article","created":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T21:29:08Z","timestamp":1351718948000},"page":"e48384","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Repeated Abortion Affects Subsequent Pregnancy Outcomes in BALB\/c Mice"],"prefix":"10.1371","volume":"7","author":[{"given":"Fang","family":"Lv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangbo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shucheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiedong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,10,31]]},"reference":[{"key":"ref1","unstructured":"WHO (2003) Safe abortion: technical and policy guidance for health systems. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/reproductivehealth\/publications\/unsafe_abortion\/9241590343\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/reproductivehealth\/publications\/unsafe_abortion\/9241590343\/en\/<\/ext-link>. Accessed 23 June 2010."},{"key":"ref2","first-page":"142","article-title":"Gestation, birth-weight, and spontaneous abortion in pregnancy after induced abortion. Report of Collaborative Study by W.H.O. Task Force on Sequelae of Abortion","volume":"1","year":"1979","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1067\/mob.2000.107948","article-title":"Medical abortion regimens: historical context and overview","volume":"183","author":"MD Creinin","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"ref4","unstructured":"Wu S (2000) Medical abortion in China. J Am Med Womens Assoc 55: 197\u2013199, 204."},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Henshaw SK (1987) Induced abortion: a world perspective. Perspect Int Planif Fam: 12\u201316.","DOI":"10.2307\/2948102"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.2307\/2991869","article-title":"The incidence of abortion worldwide","volume":"25","author":"SK Henshaw","year":"1999","journal-title":"Int Fam Plann Persp"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1552-6909.1994.tb01921.x","article-title":"RU 486: an alternative to surgical abortion","volume":"23","author":"K Donaldson","year":"1994","journal-title":"J Obstet Gynecol Neonatal Nurs"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1089\/jwh.1998.7.991","article-title":"Update on early medical and surgical abortion","volume":"7","author":"JM Westfall","year":"1998","journal-title":"J Womens Health"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/humrep\/den426","article-title":"Mifepristone-induced abortion and placental complications in subsequent pregnancy","volume":"24","author":"QX Zhu","year":"2009","journal-title":"Hum Reprod"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.contraception.2008.03.013","article-title":"Age, parity, history of abortion and contraceptive choices affect the risk of repeat abortion","volume":"78","author":"O Heikinheimo","year":"2008","journal-title":"Contraception"},{"key":"ref11","first-page":"1","article-title":"Abortion surveillance\u2013United States, 2008","volume":"60","author":"K Pazol","year":"2011","journal-title":"MMWR Surveill Summ"},{"key":"ref12","first-page":"479","article-title":"Induced abortion in China: problems and interventions","volume":"32","author":"W Shangchun","year":"2010","journal-title":"Acta Academiae Medicinae Sinicae"},{"key":"ref13","unstructured":"Shi-qiang C, Yi-min C, Hong W, Yakun S, Yamei C, <etal>et al<\/etal>.. (2008) Study on risk factors of unwanted pregnancy again among the young abortion women in Peking. Maternal and Child Health Care of China: 1264\u20131266."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ijgo.2004.06.010","article-title":"Repeat induced abortions and contraceptive practices among unmarried young women seeking an abortion in China","volume":"87","author":"Y Cheng","year":"2004","journal-title":"Int J Gynaecol Obstet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/0002-9378(90)90713-H","article-title":"A progesterone-induced blocking factor corrects high resorption rates in mice treated with antiprogesterone","volume":"163","author":"J Szekeres-Bartho","year":"1990","journal-title":"Am J Obstet Gynecol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1006\/cimm.1997.1090","article-title":"The antiabortive effect of progesterone-induced blocking factor in mice is manifested by modulating NK activity","volume":"177","author":"J Szekeres-Bartho","year":"1997","journal-title":"Cell Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1111\/j.1471-0528.2009.02278.x","article-title":"Induced termination of pregnancy and low birthweight and preterm birth: a systematic review and meta-analyses","volume":"116","author":"PS Shah","year":"2009","journal-title":"BJOG"},{"key":"ref18","unstructured":"Junli G, Weiyue Z (2010) Influence of artificial abortion on preterm labor in a subsequent pregnancy. Chinese Journal of Obstetrics &amp; Gynecology and Pediatrics (Electronic Edition): 447\u2013451."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/ije\/dyg093","article-title":"Induced abortion and risk of subsequent miscarriage","volume":"32","author":"Y Sun","year":"2003","journal-title":"Int J Epidemiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1034\/j.1600-0412.2003.00005.x","article-title":"Are complications after an induced abortion associated with reproductive failures in a subsequent pregnancy?","volume":"82","author":"W Zhou","year":"2003","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.contraception.2011.03.013","article-title":"Mifepristone-induced abortion and vaginal bleeding in subsequent pregnancy","volume":"84","author":"H Liang","year":"2011","journal-title":"Contraception"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0897.2009.00716.x","article-title":"Epigenetics in the placenta","volume":"62","author":"MA Maccani","year":"2009","journal-title":"Am J Reprod Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1152\/physiol.00001.2005","article-title":"Development of structures and transport functions in the mouse placenta","volume":"20","author":"ED Watson","year":"2005","journal-title":"Physiology (Bethesda)"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1749-6632.2003.tb03212.x","article-title":"Chorioallantoic morphogenesis and formation of the placental villous tree","volume":"995","author":"JC Cross","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1182\/blood-2008-12-194258","article-title":"Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury","volume":"113","author":"P Redecha","year":"2009","journal-title":"Blood"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1055\/s-2006-933336","article-title":"Sources of tissue factor","volume":"32","author":"B \u00d8sterud","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1182\/blood-2007-01-070631","article-title":"Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury","volume":"110","author":"P Redecha","year":"2007","journal-title":"Blood"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1210\/en.2002-220559","article-title":"Programming of rat muscle and fat metabolism by in utero overexposure to glucocorticoids","volume":"144","author":"ME Cleasby","year":"2003","journal-title":"Endocrinology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.yhbeh.2010.06.007","article-title":"Glucocorticoids, prenatal stress and the programming of disease","volume":"58","author":"A Harris","year":"2011","journal-title":"Horm Behav"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.coph.2004.09.001","article-title":"11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action","volume":"4","author":"JR Seckl","year":"2004","journal-title":"Curr Opin Pharmacol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1210\/endo-123-5-2390","article-title":"Purification and characterization of the corticosteroid 11 beta-dehydrogenase component of the rat liver 11 beta-hydroxysteroid dehydrogenase complex","volume":"123","author":"V Lakshmi","year":"1988","journal-title":"Endocrinology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1016\/0303-7207(95)03546-J","article-title":"Detection of human 11 beta-hydroxysteroid dehydrogenase isoforms using reverse-transcriptase-polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts","volume":"110","author":"CB Whorwood","year":"1995","journal-title":"Mol Cell Endocrinol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0140-6736(93)90148-A","article-title":"Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?","volume":"341","author":"CR Edwards","year":"1993","journal-title":"Lancet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.molmed.2007.05.003","article-title":"Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health","volume":"13","author":"MJ Meaney","year":"2007","journal-title":"Trends Mol Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"E1526","DOI":"10.1152\/ajpendo.00574.2006","article-title":"Maternal stress alters endocrine function of the feto-placental unit in rats","volume":"292","author":"J Mairesse","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"5614","DOI":"10.1210\/jc.2004-0113","article-title":"Glucocorticoids stimulate the expression of 11beta-hydroxysteroid dehydrogenase type 2 in cultured human placental trophoblast cells","volume":"89","author":"JP van Beek","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"142082","DOI":"10.1155\/2008\/142082","article-title":"PPAR signaling in placental development and function","volume":"2008","author":"Y Barak","year":"2008","journal-title":"PPAR Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nm1025","article-title":"PPARs and the complex journey to obesity","volume":"10","author":"RM Evans","year":"2004","journal-title":"Nat Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1172\/JCI27913","article-title":"Going nuclear in metabolic and cardiovascular disease","volume":"116","author":"CK Glass","year":"2006","journal-title":"J Clin Invest"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"S212","DOI":"10.1016\/j.placenta.2010.12.002","article-title":"Review: effects of PPAR activation in the placenta and the fetus: implications in maternal diabetes","volume":"32","author":"A Jawerbaum","year":"2011","journal-title":"Placenta"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.cell.2010.12.008","article-title":"Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals","volume":"143","author":"BR Carone","year":"2010","journal-title":"Cell"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1101\/gad.9.13.1608","article-title":"Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation","volume":"9","author":"TJ Cole","year":"1995","journal-title":"Genes Dev"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1126\/science.1108190","article-title":"Epigenetic transgenerational actions of endocrine disruptors and male fertility","volume":"308","author":"MD Anway","year":"2005","journal-title":"Science"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/35047554","article-title":"Genomic imprinting: parental influence on the genome","volume":"2","author":"W Reik","year":"2001","journal-title":"Nat Rev Genet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/j.1939-4640.2003.tb02736.x","article-title":"Effect of transient embryonic in vivo exposure to the endocrine disruptor methoxychlor on embryonic and postnatal testis development","volume":"24","author":"AS Cupp","year":"2003","journal-title":"J Androl"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.reprotox.2004.05.008","article-title":"Effect of the anti-androgenic endocrine disruptor vinclozolin on embryonic testis cord formation and postnatal testis development and function","volume":"18","author":"M Uzumcu","year":"2004","journal-title":"Reprod Toxicol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.gde.2008.07.001","article-title":"Transgenerational epigenetic inheritance in health and disease","volume":"18","author":"NC Whitelaw","year":"2008","journal-title":"Curr Opin Genet Dev"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/ajhb.20092","article-title":"Fetal origins of developmental plasticity: animal models of induced life history variation","volume":"17","author":"TH Horton","year":"2005","journal-title":"Am J Hum Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nn1276","article-title":"Epigenetic programming by maternal behavior","volume":"7","author":"IC Weaver","year":"2004","journal-title":"Nat Neurosci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/bmb\/60.1.5","article-title":"The thrifty phenotype hypothesis","volume":"60","author":"CN Hales","year":"2001","journal-title":"Br Med Bull"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nrendo.2009.195","article-title":"Nutritional programming of the metabolic syndrome","volume":"5","author":"ME Symonds","year":"2009","journal-title":"Nat Rev Endocrinol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0008-8749(86)90306-0","article-title":"Immunogenetic studies of spontaneous abortion in mice. II. Antiabortive effects are independent of systemic regulatory mechanisms","volume":"98","author":"P Bob\u00e9","year":"1986","journal-title":"Cell Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"545","DOI":"10.4049\/jimmunol.160.2.545","article-title":"Cytokine-dependent abortion in CBA x DBA\/2 mice is mediated by the procoagulant fgl2 prothrombinase [correction of prothombinase]","volume":"160","author":"DA Clark","year":"1998","journal-title":"J Immunol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1084\/jem.20061022","article-title":"Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction","volume":"203","author":"G Girardi","year":"2006","journal-title":"J Exp Med"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1182\/blood-2009-01-199117","article-title":"Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies","volume":"114","author":"SV Seshan","year":"2009","journal-title":"Blood"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"e13663","DOI":"10.1371\/journal.pone.0013663","article-title":"A new mouse model to explore therapies for preeclampsia","volume":"5","author":"A Ahmed","year":"2010","journal-title":"PLoS One"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0048384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T13:24:55Z","timestamp":1687785895000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0048384"}},"subtitle":[],"editor":[{"given":"Gayle E.","family":"Woloschak","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,10,31]]},"references-count":56,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2012,10,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0048384","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,31]]}}}