{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:50:55Z","timestamp":1791258655334,"version":"4.1.0"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T00:00:00Z","timestamp":1352246400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0048775","type":"journal-article","created":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T23:29:06Z","timestamp":1352330946000},"page":"e48775","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Endogenous Thrombospondin-1 Regulates Leukocyte Recruitment and Activation and Accelerates Death from Systemic Candidiasis"],"prefix":"10.1371","volume":"7","author":[{"given":"Gema","family":"Martin-Manso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhammika H. M. L. P.","family":"Navarathna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Galli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Soto-Pantoja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana A.","family":"Kuznetsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tsokos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,11,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/1523-1747.ep12461198","article-title":"Thrombospondin in early human wound tissue","volume":"89","author":"GJ Raugi","year":"1987","journal-title":"J Invest Dermatol"},{"key":"ref2","first-page":"1851","article-title":"Thrombospondin 1 synthesis and function in wound repair","volume":"148","author":"LA DiPietro","year":"1996","journal-title":"Am J Pathol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1002\/art.1780401009","article-title":"Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium","volume":"40","author":"I Gotis-Graham","year":"1997","journal-title":"Arthritis Rheum"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1096\/fj.04-3310fje","article-title":"Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium","volume":"19","author":"NV Narizhneva","year":"2005","journal-title":"Faseb J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.4049\/jimmunol.153.9.4219","article-title":"Thrombospondin promotes chemotaxis and haptotaxis of human peripheral blood monocytes","volume":"153","author":"PJ Mansfield","year":"1994","journal-title":"J Immunol"},{"key":"ref6","unstructured":"Suchard SJ (1993) Interaction of human neutrophils and HL-60 cells with the extracellular matrix. Blood Cells 19: 197\u2013221, discussion 221\u2013193."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1083\/jcb.111.6.3077","article-title":"Thrombospondin stimulates motility of human neutrophils","volume":"111","author":"PJ Mansfield","year":"1990","journal-title":"J Cell Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nrc2561","article-title":"Regulation of nitric oxide signalling by thrombospondin 1: implications for anti-angiogenic therapies","volume":"9","author":"JS Isenberg","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e3950","DOI":"10.1371\/journal.pone.0003950","article-title":"Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in <italic>thrombospondin-1-<\/italic>deficient mice","volume":"3","author":"N Brechot","year":"2008","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1016\/j.febslet.2006.03.054","article-title":"Stable RNA interference of host thrombospondin-1 blocks <italic>Trypanosoma cruzi<\/italic> infection","volume":"580","author":"KJ Simmons","year":"2006","journal-title":"FEBS Lett"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.virol.2010.12.051","article-title":"Hepatitis C virus-induced furin and thrombospondin-1 activate TGF-beta1: role of TGF-beta1 in HCV replication","volume":"412","author":"LD Presser","year":"2011","journal-title":"Virology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1006\/bbrc.2002.6386","article-title":"Thrombospondin-1 differentially regulates release of IL-6 and IL-10 by human monocytic cell line U937","volume":"290","author":"Y Yamauchi","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0092-8674(00)81460-9","article-title":"Thrombospondin-1 is a major activator of TGF-beta1 in vivo","volume":"93","author":"SE Crawford","year":"1998","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1067\/mlc.2000.109407","article-title":"Residues F16-G33 and A784-N823 within platelet thrombospondin-1 play a major role in binding human neutrophils: evaluation by two novel binding assays","volume":"136","author":"A Majluf-Cruz","year":"2000","journal-title":"J Lab Clin Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1083\/jcb.109.3.1341","article-title":"Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11\/CD18 integrins","volume":"109","author":"C Nathan","year":"1989","journal-title":"J Cell Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"651","DOI":"10.4049\/jimmunol.147.2.651","article-title":"Activation of human neutrophils increases thrombospondin receptor expression","volume":"147","author":"SJ Suchard","year":"1991","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"7090","DOI":"10.1158\/0008-5472.CAN-08-0643","article-title":"Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells","volume":"68","author":"G Martin-Manso","year":"2008","journal-title":"Cancer Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1517\/14712598.6.9.891","article-title":"Host defence against disseminated <italic>Candida albicans<\/italic> infection and implications for antifungal immunotherapy","volume":"6","author":"AG Vonk","year":"2006","journal-title":"Expert Opin Biol Ther"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1086\/520194","article-title":"National epidemiology of mycoses survey (NEMIS): variations in rates of bloodstream infections due to <italic>Candida<\/italic> species in seven surgical intensive care units and six neonatal intensive care units","volume":"29","author":"MS Rangel-Frausto","year":"1999","journal-title":"Clin Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1567-1364.2009.00576.x","article-title":"Massive induction of innate immune response to <italic>Candida albicans<\/italic> in the kidney in a murine intravenous challenge model","volume":"9","author":"DM MacCallum","year":"2009","journal-title":"FEMS Yeast Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1086\/378745","article-title":"Attributable mortality of nosocomial candidemia, revisited","volume":"37","author":"O Gudlaugsson","year":"2003","journal-title":"Clin Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1099\/jmm.0.46740-0","article-title":"Impaired immune response to <italic>Candida albicans<\/italic> in aged mice","volume":"55","author":"C Murciano","year":"2006","journal-title":"J Med Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1099\/13500872-142-12-3487","article-title":"Neutrophil depletion increases susceptibility to systemic and vaginal candidiasis in mice, and reveals differences between brain and kidney in mechanisms of host resistance","volume":"12)","author":"A Fulurija","year":"1996","journal-title":"Microbiology 142 (Pt"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.4049\/jimmunol.152.10.5000","article-title":"Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis","volume":"152","author":"Q Qian","year":"1994","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s11908-002-0005-3","article-title":"The Pathophysiology and Treatment of <italic>Candida<\/italic> Sepsis","volume":"4","author":"B Spellberg","year":"2002","journal-title":"Curr Infect Dis Rep"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1182\/blood-2008-02-139634","article-title":"Neutrophil secretion products pave the way for inflammatory monocytes","volume":"112","author":"O Soehnlein","year":"2008","journal-title":"Blood"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Cao F, Li J, Yan X, Wu Y, Zhang D (2005) Relationship between host survival and the type of immune response in different organs during disseminated candidiasis. J Huazhong Univ Sci Technolog Med Sci 25: 141\u2013143, 184.","DOI":"10.1007\/BF02873560"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e6420","DOI":"10.1371\/journal.pone.0006420","article-title":"Early-expressed chemokines predict kidney immunopathology in experimental disseminated <italic>Candida albicans<\/italic> infections","volume":"4","author":"DM MacCallum","year":"2009","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1128\/IAI.01282-10","article-title":"Recognition and blocking of innate immunity cells by <italic>Candida albicans<\/italic> chitin","volume":"79","author":"HM Mora-Montes","year":"2011","journal-title":"Infect Immun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1189\/jlb.68.3.400","article-title":"Macrophage-derived chemokine (MDC)","volume":"68","author":"A Mantovani","year":"2000","journal-title":"J Leukoc Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1086\/430952","article-title":"Mice with disseminated candidiasis die of progressive sepsis","volume":"192","author":"B Spellberg","year":"2005","journal-title":"J Infect Dis"},{"key":"ref32","first-page":"171","article-title":"A comparative study of the cellular, exudative and histological responses to carrageenan, dextran and zymosan in the mouse","volume":"13","author":"J Dawson","year":"1991","journal-title":"Int J Tissue React"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.4049\/jimmunol.169.11.6467","article-title":"Resident cell chemokine expression serves as the major mechanism for leukocyte recruitment during local inflammation","volume":"169","author":"E Garcia-Ramallo","year":"2002","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0049-3848(99)00242-X","article-title":"Proteolysis of subendothelial adhesive glycoproteins (fibronectin, thrombospondin, and von Willebrand factor) by plasmin, leukocyte cathepsin G, and elastase","volume":"98","author":"A Bonnefoy","year":"2000","journal-title":"Thromb Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1083\/jcb.129.5.1403","article-title":"Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1","volume":"129","author":"S Godyna","year":"1995","journal-title":"J Cell Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1172\/JCI1684","article-title":"Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia","volume":"101","author":"J Lawler","year":"1998","journal-title":"J Clin Invest"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.2353\/ajpath.2008.080237","article-title":"Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury","volume":"173","author":"JS Isenberg","year":"2008","journal-title":"Am J Pathol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"A Mantovani","year":"2004","journal-title":"Trends Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.4049\/jimmunol.159.7.3595","article-title":"Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha","volume":"159","author":"PA Tessier","year":"1997","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1172\/JCI27009","article-title":"Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung","volume":"116","author":"J Reutershan","year":"2006","journal-title":"J Clin Invest"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1189\/jlb.0407247","article-title":"Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice","volume":"83","author":"JM Daley","year":"2008","journal-title":"J Leukoc Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.2741\/3542","article-title":"Neutrophils recruitment during sepsis: Critical points and crossroads","volume":"14","author":"F Pinheiro da Silva","year":"2009","journal-title":"Front Biosci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2010.02.029","article-title":"Nonresolving inflammation","volume":"140","author":"C Nathan","year":"2010","journal-title":"Cell"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/318064a0","article-title":"Thrombospondin binds falciparum malaria parasitized erythrocytes and may mediate cytoadherence","volume":"318","author":"DD Roberts","year":"1985","journal-title":"Nature"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0020-7519(89)90088-X","article-title":"In vitro adherence of bovine erythrocytes infected with <italic>Babesia bovis<\/italic> to thrombospondin and laminin","volume":"19","author":"F Parrodi","year":"1989","journal-title":"Int J Parasitol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e40614","DOI":"10.1371\/journal.pone.0040614","article-title":"Thrombospondin-1 Interacts with <italic>Trypanosoma cruzi<\/italic> Surface Calreticulin to Enhance Cellular Infection","volume":"7","author":"CA Johnson","year":"2012","journal-title":"PLoS One"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1160\/TH09-01-0049","article-title":"Pneumococcal association to platelets is mediated by soluble fibrin and supported by thrombospondin-1","volume":"102","author":"S Niemann","year":"2009","journal-title":"Thromb Haemost"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1099\/0022-1317-50-8-712","article-title":"The N-terminal of thrombospondin-1 is essential for coagulase-negative staphylococcal binding","volume":"50","author":"N Yanagisawa","year":"2001","journal-title":"J Med Microbiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1128\/IAI.59.1.279-288.1991","article-title":"Thrombospondin binds to <italic>Staphylococcus aureus<\/italic> and promotes staphylococcal adherence to surfaces","volume":"59","author":"M Herrmann","year":"1991","journal-title":"Infect Immun"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e19654","DOI":"10.1371\/journal.pone.0019654","article-title":"Thrombospondin-1 contributes to mortality in murine sepsis through effects on innate immunity","volume":"6","author":"S McMaken","year":"2011","journal-title":"PLoS One"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.4049\/jimmunol.1001296","article-title":"<italic>Escherichia coli<\/italic> K1 promotes the ligation of CD47 with thrombospondin-1 to prevent the maturation of dendritic cells in the pathogenesis of neonatal meningitis","volume":"185","author":"R Mittal","year":"2010","journal-title":"J Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1111\/j.1523-1755.2002.kid572.x","article-title":"Expression of the chemokines MCP-1\/CCL2 and RANTES\/CCL5 is differentially regulated by infiltrating inflammatory cells","volume":"62","author":"U Haberstroh","year":"2002","journal-title":"Kidney Int"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"L658","DOI":"10.1152\/ajplung.2000.279.4.L658","article-title":"Inducible lung-specific expression of RANTES: preferential recruitment of neutrophils","volume":"279","author":"ZZ Pan","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/cvr\/cvp048","article-title":"Mediators of neutrophil recruitment in human abdominal aortic aneurysms","volume":"82","author":"X Houard","year":"2009","journal-title":"Cardiovasc Res"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1128\/MCB.01304-08","article-title":"A role for a CXCR2\/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability","volume":"29","author":"J Gavard","year":"2009","journal-title":"Mol Cell Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/path.2274","article-title":"The immunology of sepsis","volume":"214","author":"S Sriskandan","year":"2008","journal-title":"J Pathol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF01540654","article-title":"Purification of Thrombospondin from human platelets","volume":"16","author":"DD Roberts","year":"1994","journal-title":"J Tissue Cult Methods"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"40938","DOI":"10.1074\/jbc.M007022200","article-title":"Physical characterization of the procollagen module of human thrombospondin 1 expressed in insect cells","volume":"275","author":"TM Misenheimer","year":"2000","journal-title":"J Biol Chem"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.freeradbiomed.2010.08.020","article-title":"<italic>Candida albicans<\/italic> heme oxygenase and its product CO contribute to pathogenesis of candidemia and alter systemic chemokine and cytokine expression","volume":"49","author":"DH Navarathna","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/infdis\/93.1.43","article-title":"Reduction of inorganic substances by yeasts. I. Extracellular reduction of sulfite by species of <italic>Candida<\/italic>","volume":"93","author":"WJ Nickerson","year":"1953","journal-title":"J Infect Dis"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Kulkarni MM (2011) Digital multiplexed gene expression analysis using the NanoString nCounter system. Curr Protoc Mol Biol Chapter 25: Unit25B 10.","DOI":"10.1002\/0471142727.mb25b10s94"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/ijc.2910170504","article-title":"Establishment and characterization of a human histiocytic lymphoma cell line (U-937)","volume":"17","author":"C Sundstrom","year":"1976","journal-title":"Int J Cancer"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0048775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T17:03:57Z","timestamp":1687799037000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0048775"}},"subtitle":[],"editor":[{"given":"Jianqing","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,7]]},"references-count":62,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0048775","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,7]]}}}