{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:38:37Z","timestamp":1780569517638,"version":"3.54.1"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T00:00:00Z","timestamp":1351814400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0048973","type":"journal-article","created":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T21:04:11Z","timestamp":1351890251000},"page":"e48973","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":59,"title":["A Longitudinal Study of Atrophy in Amnestic Mild Cognitive Impairment and Normal Aging Revealed by Cortical Thickness"],"prefix":"10.1371","volume":"7","author":[{"given":"Zhijun","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanjiang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,11,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1001\/jama.288.12.1475","article-title":"Prevalence of Neuropsychiatric Symptoms in Dementia and Mild Cognitive Impairment: Results From the Cardiovascular Health Study","volume":"288","author":"CG Lyketsos","year":"2002","journal-title":"Jama-J Am Med Assoc"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/ageing\/28.6.551","article-title":"The risk of dementia and death after delirium","volume":"28","author":"K Rockwood","year":"1999","journal-title":"Age Ageing"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1159\/000256274","article-title":"Cortical Thickness Analysis to Detect Progressive Mild Cognitive Impairment: A Reference to Alzheimer&apos;s Disease","volume":"28","author":"V Julkunen","year":"2009","journal-title":"Dement Geriatr Cogn"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archneur.56.3.303","article-title":"Mild cognitive impairment: clinical characterization and outcome","volume":"56","author":"RC Petersen","year":"1999","journal-title":"Arch Neurol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild cognitive impairment as a diagnostic entity","volume":"256","author":"RC Petersen","year":"2004","journal-title":"J? Intern Med"},{"key":"ref6","first-page":"1159","article-title":"Different regional patterns of cortical thinning in Alzheimer&apos;s disease and frontotemporal dementia","volume":"130","author":"A-T Du","year":"2007","journal-title":"Brain"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/nimg.2002.1202","article-title":"Automatic Differentiation of Anatomical Patterns in the Human Brain: Validation with Studies of Degenerative Dementias","volume":"17","author":"CD Good","year":"2002","journal-title":"Neuroimage"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/hipo.20573","article-title":"Hippocampal Volume and Asymmetry in Mild Cognitive Impairment and Alzheimer&apos;s Disease: Meta-Analyses of MRI Studies","volume":"19","author":"F Shi","year":"2009","journal-title":"Hippocampus"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/nimg.2000.0582","article-title":"Voxel-Based Morphometry\u2014The Methods","volume":"11","author":"J Ashburner","year":"2000","journal-title":"Neuroimage"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jalz.2006.06.001","article-title":"Structural MRI discriminates individuals with Mild Cognitive Impairment from age-matched controls: A combined neuropsychological and voxel based morphometry study","volume":"2","author":"MA Trivedi","year":"2006","journal-title":"Alzheimers Dement"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.neuroimage.2004.07.006","article-title":"Global and local gray matter loss in mild cognitive impairment and Alzheimer&apos;s disease","volume":"23","author":"GB Karas","year":"2004","journal-title":"Neuroimage"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1212\/01.wnl.0000280575.77437.a2","article-title":"MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment","volume":"70","author":"JL Whitwell","year":"2008","journal-title":"Neurology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1212\/01.wnl.0000281688.77598.35","article-title":"Atrophy Rates Accelerate in Amnestic Mild Cognitive Impairment","volume":"70","author":"CR Jack-Jr","year":"2008","journal-title":"Neurology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1523\/JNEUROSCI.0141-08.2008","article-title":"Structural Insights into Aberrant Topological Patterns of Large-Scale Cortical Networks in Alzheimer&apos;s Disease","volume":"28","author":"Y He","year":"2008","journal-title":"J? Neurosci"},{"key":"ref15","first-page":"1","article-title":"Abnormal Cortical Networks in Mild Cognitive Impairment and Alzheimer&apos;s Disease","volume":"6","author":"ZJ Yao","year":"2010","journal-title":"PLoS Comput Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3233\/JAD-2011-101854","article-title":"Structural and Functional Network Connectivity Breakdown in Alzheimer&apos;s Disease Studied with Magnetic Resonance Imaging Techniques","volume":"24","author":"M Filippi","year":"2011","journal-title":"J? Alzheimers Dis"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Wei GX, Zhang YC, Jiang TZ, Luo J (2011) Increased Cortical Thickness in Sports Experts: A Comparison of Diving Players with the Controls. PLoS ONE 6.","DOI":"10.1371\/journal.pone.0017112"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.neulet.2008.03.032","article-title":"Variations in cortical thickness with dementia severity in Alzheimer&apos;s disease","volume":"436","author":"K Im","year":"2008","journal-title":"Neurosci Lett"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.neurobiolaging.2007.12.019","article-title":"Patterns of cortical thinning in Alzheimer&apos;s disease and frontotemporal dementia","volume":"30","author":"BA Richards","year":"2009","journal-title":"Neurobiol Aging"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.neuroimage.2007.02.042","article-title":"Cortical thickness in single-versus multiple-domain amnestic mild cognitive impairment","volume":"36","author":"SW Seo","year":"2007","journal-title":"Neuroimage"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1109\/42.668698","article-title":"A Nonparametric Method for Automatic Correction of Intensity Nonuniformity in MRI Data","volume":"17","author":"JG Sled","year":"1998","journal-title":"IEEE? T? Med Imaging"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/(SICI)1097-0193(1996)4:1<58::AID-HBM4>3.0.CO;2-O","article-title":"A Unified Statistical Approach for Determining Significant Signals in Images of Cerebral Activation","volume":"4","author":"KJ Worsley","year":"1996","journal-title":"Hum Brain Mapp"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pscychresns.2009.03.012","article-title":"Prefrontal Structural and Functional Brain Imaging findings in Antisocial, Violent, and Psychopathic Individuals: A Meta-Analysis","volume":"174","author":"YL Yang","year":"2009","journal-title":"Psychiat Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3174\/ajnr.A1484","article-title":"Alterations in Cortical Thickness and White Matter Integrity in Mild Cognitive Impairment Measured by Whole-Brain Cortical Thickness Mapping and Diffusion Tensor Imaging","volume":"30","author":"L Wang","year":"2009","journal-title":"Am? J? Neuroradiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.3233\/JAD-2010-100114","article-title":"Differences in Cortical Thickness in Healthy Controls, Subjects with Mild Cognitive Impairment, and Alzheimer&apos;s Disease Patients: A Longitudinal Study","volume":"21","author":"V Julkunen","year":"2010","journal-title":"J? Alzheimers Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1093\/brain\/awl256","article-title":"Spatial patterns of cortical thinning in mild cognitive impairment and Alzheimer&apos;s disease","volume":"129","author":"V Singh","year":"2006","journal-title":"Brain"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/13554790490896974","article-title":"Abnormal visual search in mild cognitive impairment and Alzheimer&apos;s disease","volume":"11","author":"A Tales","year":"2005","journal-title":"Neurocase"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1212\/01.WNL.0000049471.76799.DE","article-title":"A visuospatial variant of mild cognitive impairment: getting lost between aging and AD","volume":"60","author":"M Mapstone","year":"2003","journal-title":"Neurology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0197-4580(99)00107-4","article-title":"Atrophy of the medial occipitotemporal, inferior, and middle temporal gyri in non-demented elderly predict decline to Alzheimer&apos;s disease","volume":"21","author":"A Convit","year":"2000","journal-title":"Neurobiol Aging"},{"key":"ref30","first-page":"1680","article-title":"Changes in Brain Morphology in Alzheimer Disease and Normal Aging: Is Alzheimer Disease an Exaggerated Aging Process?","volume":"22","author":"T Ohnishi","year":"2001","journal-title":"Am? J? Neuroradiol"},{"key":"ref31","first-page":"209","article-title":"Analysis of Gray Matter in AD Patients and MCI Subjects Based Voxel-Based Morphometry","volume":"6889","author":"ZJ Yao","year":"2011","journal-title":"LNCS"},{"key":"ref32","first-page":"697","article-title":"A PET study of the functional neuroanatomy of writing impairment in Alzheimer&apos;s disease The role of the left supramarginal and left angular gyri Brain","volume":"118","author":"M-J Penniello","year":"1995"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.0963-7214.2004.01502009.x","article-title":"An Age-Related Deficit in Prefrontal Cortical Function Associated With Refreshing Information","volume":"15","author":"MK Johnson","year":"2004","journal-title":"Psychological Science"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1101\/lm.4.5.411","article-title":"Deficit in learning of a motor skill requiring strategy, but not of perceptuomotor recalibration, with aging","volume":"4","author":"EC McNay","year":"1998","journal-title":"Learn Memory"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1037\/0882-7974.17.1.85","article-title":"Hemispheric Asymmetry Reduction in Older Adults: The HAROLD Model","volume":"17","author":"R Cabeza","year":"2002","journal-title":"Psychology and Aging"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.neuroimage.2007.10.031","article-title":"Spatial patterns of brain atrophy in MCI patients, identified via high-dimensional pattern classification, predict subsequent cognitive decline","volume":"39","author":"Y Fan","year":"2008","journal-title":"Neuroimage"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jns.2005.05.001","article-title":"Neuroimaging as a marker of the onset and progression of Alzheimer&apos;s disease","volume":"236","author":"JC Masdeu","year":"2005","journal-title":"J? Neurol Sci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/JGP.0b013e318165dbce","article-title":"Facial Emotion Recognition Deficit in Amnestic Mild Cognitive Impairment and Alzheimer Disease","volume":"16","author":"I Spoletini","year":"2008","journal-title":"Am? J? Geriat Psychiat"},{"key":"ref39","first-page":"665","article-title":"Neuropathologic Features of Amnestic Mild Cognitive Impairment Arch Neurol","volume":"63","author":"RC Petersen","year":"2006"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1001\/archneur.1970.00480210090013","article-title":"THE APHASIC SYMPTOM-COMPLEX: A Psychological Study on an Anatomical Basis","volume":"22","author":"C Wernicke","year":"1970","journal-title":"Arch Neurol"},{"key":"ref41","first-page":"427.e415","article-title":"Discriminant analysis of longitudinal cortical thickness changes in Alzheimer&apos;s disease using dynamic and network features","volume":"33","author":"Y Li","year":"2012","journal-title":"Neurobiol Aging"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neurobiolaging.2010.02.004","article-title":"Multiple DTI index analysis in normal aging, amnestic MCI and AD. Relationship with neuropsychological performance","volume":"33","author":"B Bosch","year":"2012","journal-title":"Neurobiol Aging"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/386608a0","article-title":"Transient and sustained activity in a distributed neural system for human working memory","volume":"386","author":"SM Courtney","year":"1997","journal-title":"NATURE"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/363345a0","article-title":"A neural basis for visual search in inferior temporal cortex","volume":"363","author":"L Chelazzi","year":"1993","journal-title":"NATURE"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.jocn.2010.12.019","article-title":"Voxel-based morphometric study of brain volume changes in patients with Alzheimer&apos;s disease assessed according to the Clinical Dementia Rating score","volume":"18","author":"SY Kim","year":"2011","journal-title":"J? Clin Neurosci"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"7134","DOI":"10.1523\/JNEUROSCI.1590-05.2005","article-title":"Awareness of the functioning of one&apos;s own limbs mediated by the insular cortex?","volume":"25","author":"HO Karnath","year":"2005","journal-title":"J? Neurosci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1249\/mss.0b013e31802f04e0","article-title":"Exercise-Induced Decrease in Insular Cortex rCBF during Postexercise Hypotension","volume":"39","author":"K Lamb","year":"2007","journal-title":"Med Sci Sport Exer"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1093\/brain\/awg240","article-title":"Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula","volume":"126","author":"PJ Nestor","year":"2003","journal-title":"Brain"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1093\/brain\/awl274","article-title":"3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer&apos;s disease","volume":"129","author":"LG Apostolova","year":"2006","journal-title":"Brain"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/jnnp.71.4.441","article-title":"Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer&apos;s disease","volume":"71","author":"AT Du","year":"2001","journal-title":"J? Neurol Neurosur Ps"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/01.wad.0000213857.89613.10","article-title":"3D Mapping of Mini-mental State Examination Performance in Clinical and Preclinical Alzheimer Disease","volume":"20","author":"LG Apostolova","year":"2006","journal-title":"Alz Dis Assoc Dis"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0048973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T06:03:55Z","timestamp":1562306635000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0048973"}},"subtitle":[],"editor":[{"given":"Yong","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,2]]},"references-count":51,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0048973","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,2]]}}}