{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T13:13:18Z","timestamp":1770901998636,"version":"3.50.1"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T00:00:00Z","timestamp":1353283200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0048997","type":"journal-article","created":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T22:14:55Z","timestamp":1353363295000},"page":"e48997","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["A Global Analysis of Tandem 3\u2032UTRs in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps"],"prefix":"10.1371","volume":"7","author":[{"given":"Peng","family":"Tian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anlong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonggui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,11,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jaci.2011.08.004","article-title":"Chronic rhinosinusitis: Epidemiology and medical management","volume":"128","author":"DL Hamilos","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.anl.2010.05.002","article-title":"A microarray study of gene expression profiles in nasal polyps","volume":"38","author":"B Rostkowska-Nadolska","year":"2011","journal-title":"Auris Nasus Larynx"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2500\/ajra.2009.23.3314","article-title":"Protein microarray analysis of nasal polyps from aspirin-sensitive and aspirin-tolerant patients with chronic rhinosinusitis E-2960-2010","volume":"23","author":"KA Zander","year":"2009","journal-title":"Am J Rhinol Allergy"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/j.1365-2222.2009.03229.x","article-title":"Gene-expression profiles in human nasal polyp tissues and identification of genetic susceptibility in aspirin-intolerant asthma C-1053-2008","volume":"39","author":"T Sekigawa","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.amjoto.2008.01.003","article-title":"Gene expression profiles of nasal polyps associated with allergic rhinitis","volume":"30","author":"W Jian","year":"2009","journal-title":"Am J Otolaryngol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1101\/gad.17268411","article-title":"Ending the message: poly(A) signals then and now","volume":"25","author":"NJ Proudfoot","year":"2011","journal-title":"Genes Dev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/nar\/gki158","article-title":"A large-scale analysis of mRNA poly(A)denylation of human and mouse genes","volume":"33","author":"B Tian","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.molcel.2011.08.017","article-title":"Mechanisms and consequences of alternative poly(A)denylation","volume":"43","author":"DC Di Giammartino","year":"2011","journal-title":"Mol Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1126\/science.1155390","article-title":"Proliferating cells express mRNAs with shortened 3\u2032 untranslated regions and fewer microRNA target sites","volume":"320","author":"R Sandberg","year":"2008","journal-title":"Science"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.cell.2009.06.016","article-title":"Widespread Shortening of 3\u2032 UTRs by Alternative Cleavage and Poly(A)denylation Activates Oncogenes in Cancer Cells","volume":"138","author":"C Mayr","year":"2009","journal-title":"CELL"},{"key":"ref11","first-page":"235","article-title":"IL-4 and TNF-alpha increased the secretion of eotaxin from cultured fibroblasts of nasal polyps with eosinophil infiltration","volume":"45","author":"K Yoshifuku","year":"2007","journal-title":"Rhinology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1101\/gr.115295.110","article-title":"Differential genome-wide profiling of tandem 3\u2032 UTRs among human breast cancer and normal cells by high-throughput sequencing","volume":"21","author":"Y Fu","year":"2011","journal-title":"Genome Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s11882-012-0249-4","article-title":"Role of innate immunity in the pathogenesis of chronic rhinosinusitis: progress and new avenues","volume":"12","author":"CM Van Drunen","year":"2012","journal-title":"Curr Allergy Asthma Rep"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jaci.2011.07.049","article-title":"Pathogenesis of chronic rhinosinusitis: Inflammation","volume":"128","author":"K Van Crombruggen","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"458427","DOI":"10.1155\/2011\/458427","article-title":"SOD1 Transcriptional and Posttranscriptional Regulation and Its Potential Implications in ALS","volume":"2011","author":"P Milani","year":"2011","journal-title":"Neurol Res Int"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1096\/fj.08-112326","article-title":"MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy","volume":"22","author":"Q Wang","year":"2008","journal-title":"FASEB J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.cell.2010.08.012","article-title":"Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses","volume":"142","author":"LF Lu","year":"2010","journal-title":"Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.4049\/jimmunol.158.8.3902","article-title":"Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia","volume":"158","author":"HU Simon","year":"1997","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/sj.onc.1206099","article-title":"DEDD and DEDD2 associate with caspase-8\/10 and signal cell death","volume":"22","author":"A Alcivar","year":"2003","journal-title":"Oncogene"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.febslet.2005.09.105","article-title":"The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis","volume":"580","author":"J Huang","year":"2006","journal-title":"FEBS Lett"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1471-2164-4-53","article-title":"TGF-beta induces the expression of SAP30L, a novel nuclear protein","volume":"4","author":"K Lindfors","year":"2003","journal-title":"BMC Genomics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"7836","DOI":"10.1073\/pnas.89.16.7836","article-title":"Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha","volume":"89","author":"C Schindler","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/MOO.0b013e3282fb2885","article-title":"The role of cytokines in chronic rhinosinusitis with nasal polyps","volume":"16","author":"BA Otto","year":"2008","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"ref24","unstructured":"Ardehali MM (2011) Histopathologic characteristics of inferior turbinate vs ethmoidal polyp in chronic rhinosinusitis. pp. 233\u2013236."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1046\/j.1398-9995.2003.00364.x","article-title":"Matrix metalloproteinases MMP-7, MMP-9 and their tissue inhibitor TIMP-1: expression in chronic sinusitis vs nasal polyposis","volume":"59","author":"JB Watelet","year":"2004","journal-title":"Allergy"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/gcc.20598","article-title":"Identification of ARHGEF17, DENND2D, FGFR3, and RBI Mutations in Melanoma by Inhibition of Nonsense-Mediated mRNA Decay E-3542-2010","volume":"47","author":"S Bloethner","year":"2008","journal-title":"Genes Chromosomes Cancer"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/sj.bjc.6604899","article-title":"The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome","volume":"100","author":"R Soong","year":"2009","journal-title":"Br J Cancer"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1134\/S0006297910120023","article-title":"The Wnt\/Frizzled GPCR signaling pathway","volume":"75","author":"VL Katanaev","year":"2010","journal-title":"Biochemistry (Mosc)"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"7028","DOI":"10.1073\/pnas.0900028106","article-title":"Progressive lengthening of 3\u2032 untranslated regions of mRNAs by alternative poly(A)denylation during mouse embryonic development","volume":"106","author":"Z Ji","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/prca.200800045","article-title":"Comparative proteome profiling of MCF10A and 184A1 human breast epithelial cells emphasized involvement of CDK4 and cyclin D3 in cell proliferation","volume":"3","author":"N Bhaskaran","year":"2009","journal-title":"Proteomics Clin Appl"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e36694","DOI":"10.1371\/journal.pone.0036694","article-title":"Cis-acting polymorphisms affect complex traits through modifications of microRNA regulation pathways","volume":"7","author":"M Arnold","year":"2012","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/wrna.47","article-title":"Alternative mRNA poly(A)denylation in eukaryotes: an effective regulator of gene expression","volume":"2","author":"CS Lutz","year":"2011","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.cell.2010.08.012","article-title":"Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses","volume":"142","author":"LF Lu","year":"2010","journal-title":"Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2500\/ajr.2008.22.3139","article-title":"Expression of survivin and enhanced polypogenesis in nasal polyps","volume":"22","author":"ZF Qiu","year":"2008","journal-title":"Am J Rhinol"},{"key":"ref35","first-page":"97","article-title":"EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists","volume":"45","author":"W Fokkens","year":"2007","journal-title":"Rhinology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/S0194-5998(97)70005-6","article-title":"Staging for rhinosinusitis","volume":"117","author":"VJ Lund","year":"1997","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref37","first-page":"50","article-title":"Measurement of asthma control according to 2006 Global Initiative on Asthma Guidelines: MAGIC Study","volume":"13","author":"JM Olaguibel","year":"2012","journal-title":"Respir Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"B Langmead","year":"2009","journal-title":"Genome Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"D613","DOI":"10.1093\/nar\/gkp939","article-title":"The UCSC Genome Browser database: update 2010","volume":"38","author":"B Rhead","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Agresti A (2002) Categorical data analysis. New York: Wiley-Interscience.","DOI":"10.1002\/0471249688"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"DW Huang","year":"2009","journal-title":"Nat Protoc"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0048997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T21:44:00Z","timestamp":1687815840000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0048997"}},"subtitle":[],"editor":[{"given":"Thomas","family":"Preiss","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,19]]},"references-count":41,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0048997","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,19]]}}}