{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:50:33Z","timestamp":1769241033550,"version":"3.49.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T00:00:00Z","timestamp":1353024000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0049055","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T17:00:30Z","timestamp":1353085230000},"page":"e49055","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Deletion of CDKAL1 Affects High-Fat Diet\u2013Induced Fat Accumulation and Glucose-Stimulated Insulin Secretion in Mice, Indicating Relevance to Diabetes"],"prefix":"10.1371","volume":"7","author":[{"given":"Tadashi","family":"Okamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rieko","family":"Yanobu-Takanashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Isono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohito","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Qiang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Katsuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Fujioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keizo","family":"Ohnaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Takayanagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Ogihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Yamori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiro","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,11,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.1142364","article-title":"Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes","volume":"316","author":"E Zeggini","year":"2007","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/ng2043","article-title":"A variant in CDKAL1 influences insulin response and risk of type 2 diabetes","volume":"39","author":"V Steinthorsdottir","year":"2007","journal-title":"Nat Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1126\/science.1142358","article-title":"Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels","volume":"316","year":"2007","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1126\/science.1142382","article-title":"A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants","volume":"316","author":"LJ Scott","year":"2007","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.2337\/db08-1494","article-title":"Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population","volume":"58","author":"F Takeuchi","year":"2009","journal-title":"Diabetes"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.4238\/vol9-2gmr802","article-title":"CDKAL1 and type 2 diabetes: a global meta-analysis","volume":"9","author":"MA Dehwah","year":"2010","journal-title":"Genet Mol Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1007\/s00125-008-1083-z","article-title":"Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps","volume":"51","author":"MJ Groenewoud","year":"2008","journal-title":"Diabetologia"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1210\/jc.2007-2218","article-title":"Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance","volume":"93","author":"A Stanc\u00e1kov\u00e1","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.2337\/db09-0117","article-title":"Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men","volume":"58","author":"A Stanc\u00e1kov\u00e1","year":"2009","journal-title":"Diabetes"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2337\/db09-0736","article-title":"Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps","volume":"59","author":"LM 't Hart","year":"2010","journal-title":"Diabetes"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.2337\/db09-0506","article-title":"Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene","volume":"58","author":"J Zhao","year":"2009","journal-title":"Diabetes"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(98)07546-1","article-title":"The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease","volume":"353","author":"AT Hattersley","year":"1999","journal-title":"Lancet"},{"key":"ref13","first-page":"737","article-title":"Exchangeable gene trap using the Cre\/mutated lox system","volume":"45","author":"K Araki","year":"1990","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1440-169X.2005.00792.x","article-title":"Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette","volume":"47","author":"T Taniwaki","year":"2005","journal-title":"Dev Growth Differ"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1993.1458","article-title":"A novel ES cell line, TT2, with high germline-differentiating potency","volume":"214","author":"T Yagi","year":"1993","journal-title":"Anal Biochem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1210\/endo-113-6-1972","article-title":"Suppressive effect of long term sulfonylurea treatment on A, B, and D cells of normal rat pancreas","volume":"113","author":"P Filipponi","year":"1983","journal-title":"Endocrinology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.2337\/db05-1459","article-title":"Spontaneous recovery from hyperglycemia by regeneration of pancreatic beta-cells in Kir6.2G132S transgenic mice","volume":"55","author":"K Oyama","year":"2006","journal-title":"Diabetes"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.2337\/diabetes.54.4.1056","article-title":"Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility","volume":"54","author":"T Miki","year":"2005","journal-title":"Diabetes"},{"key":"ref19","first-page":"207","article-title":"Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population","volume":"32","author":"M Tsuchihashi-Makaya","year":"2009"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1093\/ajcn\/87.5.1488","article-title":"Dietary patterns and C-reactive protein in Japanese men and women","volume":"87","author":"A Nanri","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/gene.2009.51","article-title":"Differential contribution of CDKAL1 variants to psoriasis, Crohn&apos;s disease and type II diabetes","volume":"10","author":"M Quaranta","year":"2009","journal-title":"Genes Immun"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e15553","DOI":"10.1371\/journal.pone.0015553","article-title":"Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis","volume":"5","author":"M Ohara-Imaizumi","year":"2010","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000289203","article-title":"TNF-alpha and obesity","volume":"11","author":"T Tzanavari","year":"2010","journal-title":"Curr Dir Autoimmun"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.1141634","article-title":"A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity","volume":"316","author":"TM Frayling","year":"2007","journal-title":"Science"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2337\/db08-0906","article-title":"Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data","volume":"58","author":"NJ Timpson","year":"2009","journal-title":"Diabetes"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/ng.140","article-title":"Common variants near MC4R are associated with fat mass, weight and risk of obesity","volume":"40","author":"RJ Loos","year":"2008","journal-title":"Nat Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/ng.156","article-title":"Common genetic variation near MC4R is associated with waist circumference and insulin resistance","volume":"40","author":"JC Chambers","year":"2008","journal-title":"Nat Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1007\/s00125-011-2086-8","article-title":"Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals","volume":"54","author":"F Takeuchi","year":"2012","journal-title":"Diabetologia"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"532","DOI":"10.2337\/dc09-1621","article-title":"Dietary patterns and risk for diabetes: the multiethnic cohort","volume":"33","author":"E Erber","year":"2010","journal-title":"Diabetes Care"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1172\/JCI58056","article-title":"Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice","volume":"121","author":"FY Wei","year":"2012","journal-title":"J Clin Invest"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1126\/science.1071527","article-title":"Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss","volume":"297","author":"P Cohen","year":"2002","journal-title":"Science"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"37458","DOI":"10.1074\/jbc.M111.242651","article-title":"Overexpression of KLF15 transcription factor in adipocytes of mice results in down-regulation of SCD1 protein expression in adipocytes and consequent enhancement of glucose-induced insulin secretion","volume":"286","author":"T Nagare","year":"2011","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1371\/journal.pgen.0020132","article-title":"Heritability of cardiovascular and personality traits in 6,148 Sardinians","volume":"2","author":"G Pilia","year":"2006","journal-title":"PLoS Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1056\/NEJMoa062418","article-title":"TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program","volume":"355","author":"JC Florez","year":"2006","journal-title":"N Engl J Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.2337\/db06-0474","article-title":"Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes","volume":"55","author":"S Cauchi","year":"2006","journal-title":"Diabetes"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.2337\/dc09-1690","article-title":"Transcription factor 7-like 2 (TCF7L2) polymorphism and hyperglycemia in an adult Italian population-based cohort","volume":"33","author":"R Gambino","year":"2010","journal-title":"Diabetes Care"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e8541","DOI":"10.1371\/journal.pone.0008541","article-title":"Association between type 2 diabetes loci and measures of fatness","volume":"5","author":"S Pecioska","year":"2010","journal-title":"PLoS One"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2337\/db08-0906","article-title":"Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data","volume":"58","author":"NJ Timpson","year":"2009","journal-title":"Diabetes"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/oby.2007.77","article-title":"Effects of TCF7L2 polymorphisms on obesity in European populations","volume":"16","author":"S Cauchi","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"S215","DOI":"10.2337\/diabetes.53.suppl_3.S215","article-title":"The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes","volume":"53","author":"MS Winzell","year":"2004","journal-title":"Diabetes"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"E738","DOI":"10.1152\/ajpendo.00199.2002","article-title":"Insufficient islet compensation to insulin resistance vs. reduced glucose effectiveness in glucose-intolerant mice","volume":"283","author":"B Ahr\u00e9n","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.metabol.2006.09.008","article-title":"Temporal and dietary fat content-dependent islet adaptation to high-fat feeding-induced glucose intolerance in mice","volume":"56","author":"MS Winzell","year":"2007","journal-title":"Metabolism"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/ng.1086","article-title":"Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations","volume":"44","author":"Y Okada","year":"2012","journal-title":"Nat Genet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/ng.1087","article-title":"Meta-analysis identifies common variants associated with body mass index in east Asians","volume":"44","author":"W Wen","year":"2012","journal-title":"Nat Genet"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0049055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T14:30:32Z","timestamp":1562337032000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0049055"}},"subtitle":[],"editor":[{"given":"Kathrin","family":"Maedler","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,16]]},"references-count":45,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0049055","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,16]]}}}