{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:00:16Z","timestamp":1792008016967,"version":"4.4.0"},"reference-count":81,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T00:00:00Z","timestamp":1352851200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0049180","type":"journal-article","created":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T17:49:12Z","timestamp":1352915352000},"page":"e49180","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":122,"title":["Environmental Enrichment Reduces Signs of Boredom in Caged Mink"],"prefix":"10.1371","volume":"7","author":[{"given":"Rebecca K.","family":"Meagher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia J.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,11,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.applanim.2006.01.001","article-title":"Effects of rearing and housing environment on behaviour and performance of pigs with different coping characteristics","volume":"101","author":"JE Bolhuis","year":"2006","journal-title":"Appl Anim Behav Sci"},{"key":"ref2","unstructured":"Carlstead K (1996) Effects of captivity on the behavior of wild mammals. In: Kleiman DG, Allen ME, Thompson KV, Lumpkin S, editors. Wild Mammals in Captivity. Chicago: University of Chicago Press. pp. 317\u2013333."},{"key":"ref3","unstructured":"Stevenson MF (1983) The captive environment: Its effect on exploratory and related behavioural responses in wild animals. In: Archer J, Birke LIA, editors. Exploration in animals and man. London, UK: Van Nostrand Reinhold. pp. 176\u2013197."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0304-3762(83)90142-6","article-title":"The enrichment of a bare environment for animals in confined conditions","volume":"10","author":"DGM Wood-Gush","year":"1983","journal-title":"Applied Animal Ethology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF01826929","article-title":"Exploratory behavior and the welfare of intensively kept animals","volume":"2","author":"DGM Wood-Gush","year":"1989","journal-title":"Journal of Agricultural and Environmental Ethics"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1521\/jscp.2011.30.6.647","article-title":"Boredom: An emotional experience distinct from apathy, anhedonia, or depression","volume":"30","author":"YK Goldberg","year":"2011","journal-title":"Journal of Social and Clinical Psychology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.neubiorev.2005.03.019","article-title":"Stress models of depression: Forming genetically vulnerable strains","volume":"29","author":"FA Henn","year":"2005","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.applanim.2006.05.032","article-title":"Sources of stress in captivity","volume":"102","author":"KN Morgan","year":"2007","journal-title":"Appl Anim Behav Sci"},{"key":"ref9","unstructured":"American Psychiatric Association. (2000) Diagnostic and statistical manual of mental disorders. Washington: American Psychiatric Association."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.neubiorev.2005.03.007","article-title":"Stress, depression, and anhedonia: Caveats concerning animal models","volume":"29","author":"H Anisman","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"P Willner","year":"1987","journal-title":"Psychopharmacology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0165-0327(93)90040-Q","article-title":"The sources of convergence between measures of apathy and depression","volume":"28","author":"RS Marin","year":"1993","journal-title":"J Affect Disorders"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/jts.2490050413","article-title":"Emotional numbing: A possible endorphin-mediated phenomenon associated with post-traumatic stress disorders and other allied psychopathologic states","volume":"5","author":"H Glover","year":"1992","journal-title":"J Traum Stress"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1176\/ajp.147.1.22","article-title":"Differential diagnosis and classification of apathy","volume":"147","author":"RS Marin","year":"1990","journal-title":"Am J Psychiatry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0165-1781(91)90040-V","article-title":"Reliability and validity of the apathy evaluation scale","volume":"38","author":"RS Marin","year":"1991","journal-title":"Psychiat Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/jnnp.2005.075929","article-title":"The lille apathy rating scale (LARS), a new instrument for detecting and quantifying apathy: Validation in parkinson&apos;s disease","volume":"77","author":"P Sockeel","year":"2006","journal-title":"Journal of Neurology Neurosurgery and Psychiatry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0191-8869(92)90059-X","article-title":"Sensation seeking and depressive mood","volume":"13","author":"S Carton","year":"1992","journal-title":"Personality and Individual Differences"},{"key":"ref18","unstructured":"Wemelsfelder F (1990) Boredom and laboratory animal welfare. In: Rollin BE, Kesel ML, editors. The Experimental Animal in Biomedical Research. Boca Raton, Florida: CRC-Press. pp. 243\u2013272."},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Berlyne DE (1960) Conflict, arousal, and curiosity. New York: McGraw-Hill. 350 p.","DOI":"10.1037\/11164-000"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1177\/1745691612456044","article-title":"The unengaged mind","volume":"7","author":"JD Eastwood","year":"2012","journal-title":"Perspectives on Psychological Science"},{"key":"ref21","unstructured":"Taylor L, Cohen S (1973) Psychological survival: The experience of long term imprisonment. Harmondsworth, USA: Penguin."},{"key":"ref22","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1559-1816.2000.tb02497.x","article-title":"Correlates and characteristics of boredom proneness and boredom","volume":"30","author":"MB Harris","year":"2000","journal-title":"J Appl Soc Psychol"},{"key":"ref23","first-page":"403","article-title":"Sensation seeking and anhedonia in risk taking behaviors. study in bungee jumpers","volume":"23","author":"G Michel","year":"1997","journal-title":"Encephale-Revue De Psychiatrie Clinique Biologique Et Therapeutique"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0031-9384(96)00406-4","article-title":"Food neophobia in humans: Effects of manipulated arousal and individual differences in sensation seeking","volume":"61","author":"P Pliner","year":"1997","journal-title":"Physiol Behav"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2190\/VJHU-MRAR-NLG6-1XBH","article-title":"Low self-concept as a cause of drug abuse","volume":"4","author":"DJ Samuels","year":"1974","journal-title":"Journal of Drug Education"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.1111\/j.1467-6494.1990.tb00918.x","article-title":"The psychophysiology of sensation seeking","volume":"58","author":"M Zuckerman","year":"1990","journal-title":"J Pers"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/01.fbp.0000236271.72300.0e","article-title":"Effects of environmental enrichment on extinction and reinstatement of amphetamine self-administration and sucrose-maintained responding","volume":"17","author":"DJ Stairs","year":"2006","journal-title":"Behav Pharmacol"},{"key":"ref28","article-title":"Assessing motivational strength and studies of boredom and enrichment in pigs","author":"RD Kirkden","year":"2000"},{"key":"ref29","unstructured":"Wemelsfelder F, Birke LIA (1997) Environmental challenge. In: Appleby MC, Hughes BO, editors. Animal Welfare. Wallingford, UK: CAB International. pp. 35\u201347."},{"key":"ref30","unstructured":"Russell PA (1983) Psychological studies of exploration in animals: A reappraisal. In: Archer J, Birke LIA, editors. Exploration in animals and man. London, UK: Van Nostrand Reinhold. pp. 22\u201354."},{"key":"ref31","unstructured":"Wemelsfelder F (1993) The concept of animal boredom and its relationship to stereotyped behaviour. In: Lawrence AB, Rushen J, editors. Stereotypic behavior: fundamentals and applications to animal welfare. Wallingford, UK: CAB International. pp. 95\u201396."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0168-1591(95)00627-5","article-title":"Inventory of the behavior of new-zealand white-rabbits in laboratory cages","volume":"45","author":"D Gunn","year":"1995","journal-title":"Appl Anim Behav Sci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/zoo.1430070103","article-title":"Use of novel objects to enhance environments of captive chimpanzees","volume":"7","author":"D Paquette","year":"1988","journal-title":"Zoo Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1469-8749.1977.tb07955.x","article-title":"Rhythmic habit patterns (stereotypies)","volume":"19","author":"R Mitchell","year":"1977","journal-title":"Dev Med Child Neurol"},{"key":"ref35","unstructured":"Meyer-Holzapfel M. (1968) Abnormal behavior in zoo animals. In: Fox MW, editor. Philadelphia, U.S.A.: Saunders. pp. 476\u2013503."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/sj.mp.4001032","article-title":"Organization of the stress system and its dysregulation in melancholic and atypical depression: High vs low CRH\/NE states","volume":"7","author":"PW Gold","year":"2002","journal-title":"Mol Psychiatry"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0278-5846(84)80032-9","article-title":"Learned helplessness and animal-models of depression","volume":"8","author":"SF Maier","year":"1984","journal-title":"Prog Neuro-Psychopharmacol & Biol Psychiat"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0165-0327(03)00046-6","article-title":"Early experience and depressive disorders: Human and non-human primate studies","volume":"75","author":"WS Gilmer","year":"2003","journal-title":"J Affect Disord"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1017\/S0962728600021710","article-title":"The welfare of farmed mink (<italic>Mustela vison<\/italic>) in relation to housing and management: A review","volume":"8","author":"AJ Nimon","year":"1999","journal-title":"Anim Welfare"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"363","DOI":"10.7120\/09627286.21.3.363","article-title":"The development of on-farm welfare assessment protocols for foxes and mink: The welfur project","volume":"21","author":"J Mononen","year":"2012","journal-title":"Animal Welfare"},{"key":"ref41","article-title":"Individual differences in stereotypic behaviour predict individual differences in the nature and degree of enrichment use in caged American mink","author":"JA Dallaire","journal-title":"Applied Animal Behaviour Science"},{"key":"ref42","first-page":"96","article-title":"Male mink (<italic>Mustela vison<\/italic>) from enriched cages are more successful as mates","author":"M D\u00edez-Le\u00f3n","year":"2010","journal-title":"Proc. 44th Congress ISAE"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bbr.2011.03.061","article-title":"Recurrent perseveration correlates with abnormal repetitive locomotion in adult mink but is not reduced by environmental enrichment","volume":"224","author":"JA Dallaire","year":"2011","journal-title":"Behav Brain Res"},{"key":"ref44","unstructured":"Meagher R, Mason G (2012) Identifying subtypes of inactivity that indicate poor welfare in captive mink. Proc 11th North American ISAE : 32."},{"key":"ref45","unstructured":"Russell PA (1983) Toward a cognitive theory of exploratory behaviour. In: Archer J, Birke LIA, editors. Exploration in animals and man. London, UK: Van Nostrand Reinhold. pp. 72\u2013115."},{"key":"ref46","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1037\/h0022320","article-title":"Readiness to eat and drink: Effect of stimulus conditions","volume":"60","author":"RC Bolles","year":"1965","journal-title":"J Comp Physiol Psychol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s002130050668","article-title":"Behavioral approaches to the assessment of attention in animals","volume":"138","author":"PJ Bushnell","year":"1998","journal-title":"Psychopharmacology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/dev.420150203","article-title":"Effects of early environmental enrichment upon open-field behavior and timidity in the domestic chick","volume":"15","author":"RB Jones","year":"1982","journal-title":"Dev Psychobiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0031-9384(94)90197-X","article-title":"Influence of environmental enrichment and sex on predator stress-response in rats","volume":"56","author":"SL Klein","year":"1994","journal-title":"Physiol Behav"},{"key":"ref50","unstructured":"Gray JA (1987) The psychology of fear and stress. Cambridge: Cambridge University Press."},{"key":"ref51","article-title":"Fear in farm mink (<italic>Mustela vison<\/italic>) - consequences of behavioural selection","author":"J Malmkvist","year":"2001"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1017\/S0962728600028384","article-title":"How has the risk of predation shaped the behavioural responses of sheep to fear and distress?","volume":"13","author":"CM Dwyer","year":"2004","journal-title":"Anim Welfare"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1006\/anbe.2002.3058","article-title":"Generalization of fear in farm mink, <italic>Mustela vison<\/italic>, genetically selected for behaviour towards humans","volume":"64","author":"J Malmkvist","year":"2002","journal-title":"Anim Behav"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.applanim.2011.05.009","article-title":"Who&apos;s afraid of the big bad glove? Testing for fear and its correlates in mink","volume":"133","author":"RK Meagher","year":"2011","journal-title":"Appl Anim Behav Sci"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0378-3758(99)00040-3","article-title":"A step-down multiple hypotheses testing procedure that controls the false discovery rate under independence","volume":"82","author":"Y Benjamini","year":"1999","journal-title":"Journal of Statistical Planning and Inference"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","article-title":"Controlling the false discovery rate in behavior genetics research","volume":"125","author":"Y Benjamini","year":"2001","journal-title":"Behav Brain Res"},{"key":"ref57","doi-asserted-by":"crossref","DOI":"10.1007\/BF00164184","article-title":"The costs and benefits of predator inspection behavior in Thomson gazelles","volume":"34","author":"CD Fitzgibbon","year":"1994","journal-title":"Behav Ecol Sociobiol"},{"key":"ref58","unstructured":"McFarland D (1987) Motivation. In: McFarland D, editor. The Oxford Companion to Animal Behaviour. : Oxford University Press. pp. 398."},{"key":"ref59","doi-asserted-by":"crossref","DOI":"10.1037\/h0088042","article-title":"Fighting and reinforcement in siamese fighting fish (betta splendens)","volume":"64","author":"JA Hogan","year":"1967","journal-title":"J Comp Physiol Psychol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.applanim.2007.01.014","article-title":"Novel object test can detect marginal differences in environmental enrichment in pigs","volume":"109","author":"MBM Bracke","year":"2008","journal-title":"Appl Anim Behav Sci"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1037\/0033-295X.97.3.377","article-title":"Emotion, attention, and the startle reflex","volume":"97","author":"PJ Lang","year":"1990","journal-title":"Psychol Rev"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0166-4328(02)00403-5","article-title":"Standard housed rats are more sensitive to rewards than enriched housed rats as reflected by their anticipatory behaviour","volume":"142","author":"JE van der Harst","year":"2003","journal-title":"Behav Brain Res"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Cabib S (2006) The neurobiology of stereotypy II: The role of stress. In: Mason G, Rushen J, editors. Stereotypic Animal Behaviour: Fundamentals and Applications to Welfare. Wallingford, UK: CAB International. pp. 227\u2013252.","DOI":"10.1079\/9780851990040.0227"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0168-1591(00)00204-5","article-title":"A concept of welfare based on reward evaluating mechanisms in the brain: Anticipatory behaviour as an indicator for the state of reward systems","volume":"72","author":"BM Spruijt","year":"2001","journal-title":"Appl Anim Behav Sci"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/0304-3762(80)90140-6","article-title":"Arousal and exploration in growing-pigs in different environments","volume":"6","author":"A Stolba","year":"1980","journal-title":"Applied Animal Ethology"},{"key":"ref66","first-page":"97","article-title":"Evaluation of long-term environmental enrichment in the mouse","volume":"23","author":"K Dahlborn","year":"1996","journal-title":"Scandinavian Journal of Laboratory Animal Science"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1258\/002367702320162379","article-title":"Improving housing conditions for laboratory mice: A review of \u2018environmental enrichment\u2019","volume":"36","author":"IAS Olsson","year":"2002","journal-title":"Lab Animals"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1037\/0735-7036.100.3.229","article-title":"Object interactions in juvenile rats (<italic>Rattus-norvegicus<\/italic>) - effects of different experiential histories","volume":"100","author":"MJ Renner","year":"1986","journal-title":"Journal of Comparative Psychology"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1037\/0735-7036.101.1.94","article-title":"Experience-dependent changes in exploratory-behavior in the adult-rat (<italic>Rattus-norvegicus<\/italic>) - overall activity level and interactions with objects","volume":"101","author":"MJ Renner","year":"1987","journal-title":"Journal of Comparative Psychology"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0168-1591(99)00069-6","article-title":"Increasing costs of access to resources cause re-scheduling of behaviour in American mink (<italic>Mustela vison<\/italic>): Implications for the assessment of behavioural priorities","volume":"66","author":"JJ Cooper","year":"2000","journal-title":"Appl Anim Behav Sci"},{"key":"ref71","article-title":"The response of animals to restricted environments","volume":"13","author":"D Morris","year":"1964","journal-title":"Symposia of the Zoological Society of London"},{"key":"ref72","doi-asserted-by":"crossref","DOI":"10.1017\/S0962728600020479","article-title":"Enriching the lives of zoo animals, and their welfare: Where research can be fundamental","volume":"7","author":"MH Robinson","year":"1998","journal-title":"Anim Welfare"},{"key":"ref73","first-page":"709","article-title":"Do welfare assessment results reflect the animals&apos; subjective experience?","volume":"12","author":"P Hartley","year":"2003","journal-title":"Animal Welfare"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1467-9280.2009.02283.x","article-title":"Neural correlates of emotional reactivity in sensation seeking","volume":"20","author":"JE Joseph","year":"2009","journal-title":"Psychological Science"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0092-6566(03)00067-9","article-title":"A review of behavioral and biological correlates of sensation seeking","volume":"38","author":"JW Roberti","year":"2004","journal-title":"Journal of Research in Personality"},{"key":"ref76","unstructured":"Kiley-Worthington M (1977) Behavioural problems in farm animals. Stocksfield, UK: Oriel Press Ltd."},{"key":"ref77","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1017\/S096272860001438X","article-title":"Can&apos;t stop, won&apos;t stop: Is stereotypy a reliable animal welfare indicator?","volume":"13","author":"GJ Mason","year":"2004","journal-title":"Anim Welfare"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/1469-7610.00502","article-title":"Annotation: Repetitive behaviour in autism: A review of psychological research","volume":"40","author":"M Turner","year":"1999","journal-title":"J Child Psychol Psychiat"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0149-7634(99)00026-3","article-title":"Coping styles in animals: Current status in behavior and stress-physiology","volume":"23","author":"JM Koolhaas","year":"1999","journal-title":"Neurosci Biobehav Rev"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0168-1591(95)00616-Z","article-title":"Environmental enrichment - increasing the biological relevance of captive environments","volume":"44","author":"RC Newberry","year":"1995","journal-title":"Appl Anim Behav Sci"},{"key":"ref81","unstructured":"Meagher RK (2011) The welfare significance of inactivity in captive animals, using mink as a model. Guelph, Canada: University of Guelph."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0049180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T16:03:40Z","timestamp":1687795420000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0049180"}},"subtitle":[],"editor":[{"given":"Nei","family":"Moreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,14]]},"references-count":81,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0049180","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,14]]}}}