{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:03:11Z","timestamp":1787162591283,"version":"build-2736575974"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T00:00:00Z","timestamp":1352419200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0049250","type":"journal-article","created":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T17:10:55Z","timestamp":1352481055000},"page":"e49250","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Acupuncture Induces Divergent Alterations of Functional Connectivity within Conventional Frequency Bands: Evidence from MEG Recordings"],"prefix":"10.1371","volume":"7","author":[{"given":"Youbo","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruwei","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongguang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,11,9]]},"reference":[{"key":"ref1","unstructured":"Beijing S (1980) Nanjing colleges of traditional Chinese medicine. Essentials of Chinese acupuncture. Beijing, Foreign Language Press."},{"key":"ref2","first-page":"1518","article-title":"NIH Consensus Conference. Acupuncture","volume":"280","year":"1998","journal-title":"JAMA"},{"key":"ref3","article-title":"How Well Do Randomized Trials Inform Decision Making: Systematic Review Using Comparative Effectiveness Research Measures on Acupuncture for Back Pain","author":"CM Witt","year":"2012","journal-title":"Plos One"},{"key":"ref4","unstructured":"Nahin RL, Statistics NCfH (2009) Costs of complementary and alternative medicine (CAM) and frequency of visits to CAM practitioners: United States, 2007: US Dept. of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"374","DOI":"10.7326\/0003-4819-136-5-200203050-00010","article-title":"Acupuncture: theory, efficacy, and practice","volume":"136","author":"TJ Kaptchuk","year":"2002","journal-title":"Ann Intern Med"},{"key":"ref6","article-title":"Are acupoints specific for diseases? A systematic review of the randomized controlled trials with sham acupuncture controls","author":"H Zhang","year":"2010","journal-title":"Chin Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1073\/pnas.95.5.2670","article-title":"New findings of the correlation between acupoints and corresponding brain cortices using functional MRI","volume":"95","author":"ZH Cho","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/00001756-200304150-00002","article-title":"Visual cortical activations on fMRI upon stimulation of the vision-implicated acupoints","volume":"14","author":"G Li","year":"2003","journal-title":"Neuroreport"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/WNR.0b013e328321004d","article-title":"Acupuncture reveals no specific effect on primary auditory cortex: a functional magnetic resonance imaging study","volume":"20","author":"T Wesolowski","year":"2009","journal-title":"Neuroreport"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/hbm.20481","article-title":"Functional neuroanatomical investigation of vision-related acupuncture point specificity: A multisession fMRI study","volume":"30","author":"J Kong","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/(SICI)1097-0193(2000)9:1<13::AID-HBM2>3.0.CO;2-F","article-title":"Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjects","volume":"9","author":"KKS Hui","year":"2000","journal-title":"Hum Brain Mapp"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1002\/hbm.20769","article-title":"Time-varied characteristics of acupuncture effects in fMRI studies","volume":"30","author":"L Bai","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.1073\/pnas.89.12.5675","article-title":"Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation","volume":"89","author":"KK Kwong","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5951","DOI":"10.1073\/pnas.89.13.5951","article-title":"Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging","volume":"89","author":"S Ogawa","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","first-page":"1082","article-title":"Measuring functional connectivity using MEG: Methodology and comparison with fcMRI","volume":"56","author":"MJ Brookes","year":"2011","journal-title":"Neuro Image"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/hbm.20081","article-title":"Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI","volume":"24","author":"V Napadow","year":"2005","journal-title":"Hum Brain Mapp"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.neuroimage.2004.02.017","article-title":"Modulation of cerebellar activities by acupuncture stimulation: evidence from fMRI study","volume":"22","author":"SS Yoo","year":"2004","journal-title":"NeuroImage"},{"key":"ref18","article-title":"Differential spatial activity patterns of acupuncture by a machine learning based analysis","author":"Y You","year":"2011","journal-title":"Proc SPIE 7965, Medical Imaging 2011"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1001\/jama.1982.03320380071046","article-title":"Electric Fields of the Brain: The Neurophysics of EEG","volume":"247","author":"J Fermaglich","year":"1982","journal-title":"JAMA"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.175.4022.664","article-title":"Magnetoencephalography: detection of the brain&apos;s electrical activity with a superconducting magnetometer","volume":"175","author":"D Cohen","year":"1972","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S1364-6613(00)01549-7","article-title":"Timing of human cortical functions during cognition: role of MEG","volume":"4","author":"R Hari","year":"2000","journal-title":"Trends Cogn Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/35067550","article-title":"The brainweb: phase synchronization and large-scale integration","volume":"2","author":"F Varela","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/hbm.10022","article-title":"Detection of functional connectivity using temporal correlations in MR images","volume":"15","author":"M Hampson","year":"2002","journal-title":"Hum Brain Mapp"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1073\/pnas.98.2.694","article-title":"Dynamic imaging of coherent sources: studying neural interactions in the human brain","volume":"98","author":"J Gross","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1385\/NI:3:4:301","article-title":"Phase synchronization measurements using electroencephalographic recordings","volume":"3","author":"R Guevara","year":"2005","journal-title":"Neuroinformatics"},{"key":"ref26","article-title":"The Effect of Acupuncture at the PC-6 on the Electroencephalogram and Electrocardiogram","author":"MS Kim","year":"2008","journal-title":"Am J Chinese Med"},{"key":"ref27","article-title":"Differences in cortical response to acupressure and electroacupuncture stimuli","author":"W Thomas","year":"2011","journal-title":"BMC Neurosci"},{"key":"ref28","article-title":"Differential neural responses to acupuncture revealed by MEG using wavelet-based time-frequency analysis: A pilot study","author":"Y You","year":"2011","journal-title":"Engineering in Medicine and Biology Society, EMBC"},{"key":"ref29","first-page":"1129","article-title":"The effect of location of transcutaneous electrical nerve stimulation on postoperative opioid analgesic requirement: acupoint versus nonacupoint stimulation","volume":"87","author":"L Chen","year":"1998","journal-title":"Anesth Analg"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.pain.2010.10.012","article-title":"Acupuncture analgesia: areas of consensus and controversy","volume":"152","author":"JS Han","year":"2011","journal-title":"Pain"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1136\/aim.25.4.204-a","article-title":"Clinical introduction to medical acupuncture","volume":"25","author":"DF Mayor","year":"2007","journal-title":"Acupunct Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1136\/aim.11.2.105-a","article-title":"Chinese acupuncture and moxibustion","volume":"11","author":"F Beyens","year":"1993","journal-title":"Acupunct Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neuroimage.2005.04.037","article-title":"The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRI","volume":"27","author":"KKS Hui","year":"2005","journal-title":"NeuroImage"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1089\/acm.2007.0524","article-title":"Acupuncture de qi, from qualitative history to quantitative measurement","volume":"13","author":"J Kong","year":"2007","journal-title":"J Altern Complem Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(89)90080-8","article-title":"Conditioned response models of placebo phenomena: further support","volume":"38","author":"NJ Voudouris","year":"1989","journal-title":"Pain"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0304-3959(90)90057-K","article-title":"The role of conditioning and verbal expectancy in the placebo response","volume":"43","author":"NJ Voudouris","year":"1990","journal-title":"Pain"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/j.1532-2149.2011.00059.x","article-title":"Marathon runners&apos; reaction to potassium iontophoretic experimental pain: Pain tolerance, pain threshold, coping and self-efficacy","volume":"16","author":"M Johnson","year":"2011","journal-title":"Eur J Pain"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0006-3223(97)00394-6","article-title":"Electroacupuncture: mechanisms and clinical application","volume":"44","author":"GA Ulett","year":"1998","journal-title":"Biol Psychiat"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1093\/brain\/awm034","article-title":"Slowing of oscillatory brain activity is a stable characteristic of Parkinson&apos;s disease without dementia","volume":"130","author":"D Stoffers","year":"2007","journal-title":"Brain"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neuroscience.2010.11.039","article-title":"Cognition is related to resting-state small-world network togology: an magnetoencephalographic stduy","volume":"175","author":"L Douw","year":"2011","journal-title":"Neuroscience"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/cercor\/13.4.422","article-title":"Very slow activity fluctuations in monkey visual cortex: implications for functional brain imaging","volume":"13","author":"DA Leopold","year":"2003","journal-title":"Cereb Cortex"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neuroimage.2010.01.092","article-title":"Large-scale spontaneous fluctuations and correlations in brain electrical activity observed with magnetoencephalography","volume":"51","author":"Z Liu","year":"2010","journal-title":"Neuroimage"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1023\/B:JCNS.0000004841.66897.7d","article-title":"A novel method for the topographic analysis of neural activity reveals formation and dissolution of \u2018dynamic cell assemblies\u2019","volume":"16","author":"M Breakspear","year":"2004","journal-title":"J Comput Neurosci"},{"key":"ref44","article-title":"Synchronization tomography: a method for three-dimensional localization of phase synchronized neuronal populations in the human brain using magnetoencephalography","author":"P Tass","year":"2003","journal-title":"Phys Rev Lett"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/hbm.20153","article-title":"Parametric analysis of oscillatory activity as measured with EEG\/MEG","volume":"26","author":"SJ Kiebel","year":"2005","journal-title":"Hum Brain Mapp"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1467-9868.2010.00746.x","article-title":"Discovering the false discovery rate","volume":"72","author":"Y Benjamini","year":"2010","journal-title":"J R Statist Soc B"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"J R Statist Soc B"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Y Benjamini","year":"2001","journal-title":"Ann Stat"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.neuroimage.2006.05.033","article-title":"Magnetoencephalographic evaluation of resting-state functional connectivity in Alzheimer&apos;s disease","volume":"32","author":"C Stam","year":"2006","journal-title":"Neuroimage"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.neuroimage.2008.02.027","article-title":"Increased cortico-cortical functional connectivity in early-stage Parkinson&apos;s disease: an MEG study","volume":"41","author":"D Stoffers","year":"2008","journal-title":"Neuroimage"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.expneurol.2008.05.021","article-title":"Dopaminergic modulation of cortico-cortical functional connectivity in Parkinson&apos;s disease: An MEG study","volume":"213","author":"D Stoffers","year":"2008","journal-title":"Exp Neurol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/brain\/awn262","article-title":"Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimers disease","volume":"132","author":"CJ Stam","year":"2009","journal-title":"Brain"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/brain\/awn262","article-title":"Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer&apos;s disease","volume":"132","author":"C Stam","year":"2009","journal-title":"Brain"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.clinph.2005.01.014","article-title":"Assessing interactions of linear and nonlinear neuronal sources using MEG beamformers: a proof of concept","volume":"116","author":"A Hadjipapas","year":"2005","journal-title":"Clin Neurophysiol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1016\/j.clinph.2004.04.029","article-title":"Identifying true brain interaction from EEG data using the imaginary part of coherency","volume":"115","author":"G Nolte","year":"2004","journal-title":"Clin Neurophysiol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.clinph.2005.01.008","article-title":"Synchronization of parietal and premotor areas during preparation and execution of praxis hand movements","volume":"116","author":"LA Wheaton","year":"2005","journal-title":"Clin Neurophysiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00702-008-0132-6","article-title":"MEG resting state functional connectivity in Parkinson&apos;s disease related dementia","volume":"116","author":"JLW Bosboom","year":"2009","journal-title":"J Neural Transm"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.mri.2011.04.009","article-title":"Investigation of the large-scale functional brain networks modulated by acupuncture","volume":"29","author":"Y Feng","year":"2011","journal-title":"Magn Reson Imaging"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/jmri.22393","article-title":"Divergent neural processes specific to the acute and sustained phases of verum and SHAM acupuncture","volume":"33","author":"J Liu","year":"2011","journal-title":"J Magn Reson Imaging"},{"key":"ref60","article-title":"FMRI connectivity analysis of acupuncture effects on an amygdala-associated brain network","author":"W Qin","year":"2008","journal-title":"Mol Pain"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1385\/NI:3:4:301","article-title":"Phase synchronization measurements using electroencephalographic recordings","volume":"3","author":"R Guevara","year":"2005","journal-title":"Neuroinformatics"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/hbm.10106","article-title":"Nonlinear synchronization in EEG and whole-head MEG recordings of healthy subjects","volume":"19","author":"CJ Stam","year":"2003","journal-title":"Hum Brain Mapp"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0304-3959(86)90023-0","article-title":"Acupuncture for the treatment of pain: A review of evaluative research","volume":"24","author":"P Richardson","year":"1986","journal-title":"Pain"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0049250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T12:05:10Z","timestamp":1745150710000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0049250"}},"subtitle":[],"editor":[{"given":"Dante R.","family":"Chialvo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,9]]},"references-count":63,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0049250","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,9]]}}}