{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:47:46Z","timestamp":1777448866736,"version":"3.51.4"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T00:00:00Z","timestamp":1353024000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0049490","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T22:21:01Z","timestamp":1353104461000},"page":"e49490","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Genetic Characterization of smg-8 Mutants Reveals No Role in C. elegans Nonsense Mediated Decay"],"prefix":"10.1371","volume":"7","author":[{"given":"Jacqueline","family":"Rosains","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E.","family":"Mango","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,11,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.biochem.76.050106.093909","article-title":"The nonsense-mediated decay RNA surveillance pathway","volume":"76","author":"YF Chang","year":"2007","journal-title":"Annu Rev Biochem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00018-009-0177-1","article-title":"Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors","volume":"67","author":"P Nicholson","year":"2010","journal-title":"Cell Mol Life Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1101\/gad.7.10.1885","article-title":"mRNA surveillance by the Caenorhabditis elegans smg genes","volume":"7","author":"R Pulak","year":"1993","journal-title":"Genes Dev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1101\/gad.819900","article-title":"Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans","volume":"14","author":"QM Mitrovich","year":"2000","journal-title":"Genes Dev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"R101","DOI":"10.1186\/gb-2009-10-9-r101","article-title":"High resolution transcriptome maps for wild-type and nonsense-mediated decay-defective Caenorhabditis elegans","volume":"10","author":"AK Ramani","year":"2009","journal-title":"Genome Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1261\/rna.1711109","article-title":"Global analysis of alternative splicing uncovers developmental regulation of nonsense-mediated decay in C. elegans","volume":"15","author":"S Barberan-Soler","year":"2009","journal-title":"RNA"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1128\/MCB.12.5.2165","article-title":"Gene products that promote mRNA turnover in Saccharomyces cerevisiae","volume":"12","author":"P Leeds","year":"1992","journal-title":"Mol Cell Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/genetics\/151.2.605","article-title":"smg-7 is required for mRNA surveillance in Caenorhabditis elegans","volume":"151","author":"BM Cali","year":"1999","journal-title":"Genetics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/genetics\/123.2.301","article-title":"A new kind of informational suppression in the nematode Caenorhabditis elegans","volume":"123","author":"J Hodgkin","year":"1989","journal-title":"Genetics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1101\/gad.417707","article-title":"Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway","volume":"21","author":"D Longman","year":"2007","journal-title":"Genes Dev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1007\/s13238-011-1119-x","article-title":"A genome-wide RNAi screen identifies genes regulating the formation of P bodies in C. elegans and their functions in NMD and RNAi","volume":"2","author":"Y Sun","year":"2011","journal-title":"Protein Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1093\/nar\/gkq1319","article-title":"Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish","volume":"39","author":"C Anastasaki","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1101\/gad.1389006","article-title":"Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay","volume":"20","author":"I Kashima","year":"2006","journal-title":"Genes Dev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S0168-9525(01)02479-9","article-title":"Stop making nonSense: the C. elegans smg genes","volume":"17","author":"SE Mango","year":"2001","journal-title":"Trends Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nsmb.1530","article-title":"SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells","volume":"16","author":"AB Eberle","year":"2009","journal-title":"Nat Struct Mol Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1261\/rna.1386208","article-title":"SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan","volume":"14","author":"E Huntzinger","year":"2008","journal-title":"RNA"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.molcel.2004.10.013","article-title":"SMG7 acts as a molecular link between mRNA surveillance and mRNA decay","volume":"16","author":"L Unterholzner","year":"2004","journal-title":"Mol Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1261\/rna.2137903","article-title":"Characterization of human Smg5\/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1","volume":"9","author":"SY Chiu","year":"2003","journal-title":"RNA"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"7483","DOI":"10.1128\/MCB.24.17.7483-7490.2004","article-title":"SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans","volume":"24","author":"A Grimson","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1101\/gad.913001","article-title":"Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay","volume":"15","author":"A Yamashita","year":"2001","journal-title":"Genes Dev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1101\/gad.1767209","article-title":"SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay","volume":"23","author":"A Yamashita","year":"2009","journal-title":"Genes Dev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1534\/genetics.111.127209","article-title":"Tissue specificity of Caenorhabditis elegans enhanced RNA interference mutants","volume":"188","author":"JJ Zhuang","year":"2011","journal-title":"Genetics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nature07274","article-title":"Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6\/7","volume":"455","author":"SE Fischer","year":"2008","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0197-4580(02)00224-5","article-title":"Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model","volume":"24","author":"CD Link","year":"2003","journal-title":"Neurobiol Aging"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"S Brenner","year":"1974","journal-title":"Genetics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1046-2023(03)00050-1","article-title":"Genome-wide RNAi screening in Caenorhabditis elegans","volume":"30","author":"RS Kamath","year":"2003","journal-title":"Methods"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2199-9-9","article-title":"Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans","volume":"9","author":"D Hoogewijs","year":"2008","journal-title":"BMC Mol Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0049490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T13:52:11Z","timestamp":1643637131000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0049490"}},"subtitle":[],"editor":[{"given":"Georg","family":"Stoecklin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,16]]},"references-count":27,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0049490","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,16]]}}}