{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:05:51Z","timestamp":1792674351545,"version":"4.5.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T00:00:00Z","timestamp":1352937600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0049653","type":"journal-article","created":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T22:07:14Z","timestamp":1353017234000},"page":"e49653","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Evidence of Bacteroides fragilis Protection from Bartonella henselae-Induced Damage"],"prefix":"10.1371","volume":"7","author":[{"given":"Linda","family":"Sommese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Pagliuca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bice","family":"Avallone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana","family":"Ippolito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Casamassimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Colicchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimondo","family":"Cerciello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"D'Armiento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Scarpato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Giovane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabiria","family":"Pastore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Infante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Ciccodicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Fiorito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Paolo","family":"D'Armiento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Salvatore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Napoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,11,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1574-6976.2012.00336.x","article-title":"Persistent intracellular pathogens","volume":"36","author":"C Dehio","year":"2012","journal-title":"FEMS Microbiol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1574-6976.2012.00324.x","article-title":"Persistence of <italic>Bartonella<\/italic> spp. stealth pathogens: from subclinical infections to vasoproliferative tumor formation","volume":"36","author":"AT Pulliainen","year":"2012","journal-title":"FEMS Microbiol Rev"},{"key":"ref3","unstructured":"Eicher SC, Dehio C (2012) <italic>Bartonella<\/italic> entry mechanisms into mammalian host cells. Cell Microbiol. Apr 23. [Epub ahead of print]."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.clindermatol.2008.10.006","article-title":"Bartonellosis","volume":"27","author":"C Magui\u00f1a","year":"2009","journal-title":"Clin Dermatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1128\/CMR.05009-11","article-title":"Intruders below the radar: molecular pathogenesis of <italic>Bartonella spp<\/italic>","volume":"25","author":"A Harms","year":"2012","journal-title":"Clin Microbiol Rev"},{"key":"ref6","first-page":"97","article-title":"Bartonella-associated infections in HIV-infected patients","volume":"7","author":"JE Koehler","year":"1995","journal-title":"AIDS Clin Care"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"612809","DOI":"10.1155\/2012\/612809","article-title":"<italic>Bartonella<\/italic> infection in immunocompromised hosts: immunology of vascular infection and vasoproliferation","volume":"2012","author":"M Mosepele","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1371\/journal.ppat.0020115","article-title":"A translocated bacterial protein protects vascular endothelial cells from apoptosis","volume":"2(11)","author":"MC Schmid","year":"2006","journal-title":"PLoS Pathog"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"9427","DOI":"10.1073\/pnas.0803602105","article-title":"Detrimental effects of <italic>Bartonella henselae<\/italic> are counteracted by L-arginine and nitric oxide in human endothelial progenitor cells","volume":"105","author":"P Salvatore","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1182\/blood-2004-12-4670","article-title":"Infection of human CD34+ progenitor cells with <italic>Bartonella henselae<\/italic> results in intraerythrocytic presence of <italic>B. henselae<\/italic>","volume":"106","author":"T M\u00e4ndle","year":"2005","journal-title":"Blood"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/01913120701696510","article-title":"<italic>Bartonella henselae<\/italic> infects human erythrocytes","volume":"31","author":"LH Pitassi","year":"2007","journal-title":"Ultrastruct Pathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e1000946","DOI":"10.1371\/journal.ppat.1000946","article-title":"The Trw type IV secretion system of Bartonella mediates host-specific adhesion to erythrocytes","volume":"6(6)","author":"M Vayssier-Taussat","year":"2010","journal-title":"PLoS Pathog 10"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1182\/blood-2002-03-0898","article-title":"Interaction of human hematopoietic stem cells with bacterial pathogens","volume":"100","author":"A Kolb-M\u00e4urer","year":"2002","journal-title":"Blood"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1128\/JB.01559-07","article-title":"Niche-specific features of the intestinal bacteroidales","volume":"190","author":"MJ Coyne","year":"2008","journal-title":"J Bacteriol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1128\/CMR.00008-07","article-title":"Bacteroides: the good, the bad, and the nitty-gritty","volume":"20","author":"HM Wexler","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.anaerobe.2012.01.005","article-title":"In celebration of Sydney M. Finegold, M.D.: bacteroides fragilis in the colon: the good &amp; the bad","volume":"18","author":"CL Sears","year":"2012","journal-title":"Anaerobe"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2741\/3603","article-title":"Beneficial effects of <italic>Bacteroides fragilis<\/italic> polysaccharides on the immune system","volume":"15","author":"EB Troy","year":"2010","journal-title":"Front Biosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1600-065X.2011.01075.x","article-title":"The yin yang of bacterial polysaccharides: lessons learned from <italic>B. fragilis<\/italic> PSA","volume":"245","author":"NK Surana","year":"2012","journal-title":"Immunol Rev"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2005.05.007","article-title":"An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system","volume":"122","author":"SK Mazmanian","year":"2005","journal-title":"Cell"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nature07008","article-title":"A microbial symbiosis factor prevents intestinal inflammatory disease","volume":"453","author":"SK Mazmanian","year":"2008","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1073\/pnas.1010529108","article-title":"Normal gut microbiota modulates brain development and behavior","volume":"108","author":"RD Heijtz","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"11548","DOI":"10.1073\/pnas.1108924108","article-title":"Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice","volume":"108","author":"MA Kriegel","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.4049\/jimmunol.1001443","article-title":"Central nervous system demyelinating disease protection by the human commensal <italic>Bacteroides fragilis<\/italic> depends on polysaccharide A expression","volume":"185","author":"J Ochoa-Rep\u00e1raz","year":"2010","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/mi.2010.29","article-title":"A polysaccharide from the human commensal <italic>Bacteroides fragilis<\/italic> protects against CNS demyelinating disease","volume":"3","author":"J Ochoa-Rep\u00e1raz","year":"2010","journal-title":"Mucosal Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1365-2958.2003.03964.x","article-title":"The VirB type IV secretion system of <italic>Bartonella henselae<\/italic> mediates invasion, proinflammatory activation and antiapoptotic protection of endothelial cells","volume":"52","author":"MC Schmid","year":"2004","journal-title":"Mol Microbiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.1182\/blood-2010-08-300046","article-title":"Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis","volume":"117","author":"J Sumegi","year":"2011","journal-title":"Blood"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2334-12-17","article-title":"Granulomatous hepatitis due to <italic>Bartonella henselae<\/italic> infection in an immunocompetent patient","volume":"12","author":"TR VanderHeyden","year":"2012","journal-title":"BMC Infect Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5534","DOI":"10.1128\/IAI.66.11.5534-5536.1998","article-title":"Murine model of <italic>Bartonella henselae<\/italic> infection in the immunocompetent host","volume":"66","author":"T Regnath","year":"1998","journal-title":"Infect Immun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.atherosclerosis.2010.10.039","article-title":"Endothelial progenitor cells as therapeutic agents in the microcirculation: an update","volume":"215","author":"C Napoli","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1755-8794-3-40","article-title":"Impairment of circulating endothelial progenitors in Down syndrome","volume":"3","author":"V Costa","year":"2010","journal-title":"BMC Med Genomics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e1520","DOI":"10.1371\/journal.pone.0001520","article-title":"Peripheral blood endothelial progenitors as potential reservoirs of Kaposi&apos;s sarcoma-associated herpesvirus","volume":"3","author":"S Della Bella","year":"2008","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.bbrc.2004.11.085","article-title":"<italic>Bacteroides fragilis<\/italic> interferes with iNOS activity and leads to pore formation in macrophage surface","volume":"326","author":"JM Vieira","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/j.1469-0691.2008.02069.x","article-title":"Adherence and invasion of Bacteroidales isolated from the human intestinal tract","volume":"14","author":"V Nakano","year":"2008","journal-title":"Clin Microbiol Infect"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.1206095","article-title":"The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota","volume":"332","author":"JL Round","year":"2011","journal-title":"Science"},{"key":"ref35","first-page":"185","article-title":"Bacterial toxins modifying the actin cytoskeleton. Int Microbiol","volume":"2","author":"JF Richard","year":"1999"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/jb\/mvm060","article-title":"Comparison between total endothelial progenitor cell isolation versus enriched Cd133+ culture","volume":"141","author":"A Casamassimi","year":"2007","journal-title":"J Biochem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e18493","DOI":"10.1371\/journal.pone.0018493","article-title":"Massive-scale RNA-Seq analysis of non ribosomal transcriptome in human trisomy 21","volume":"6","author":"V Costa","year":"2011","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2007.07.001","article-title":"Identification and expression analysis of novel Jakmip1 transcripts","volume":"402","author":"V Costa","year":"2007","journal-title":"Gene"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1172\/JCI119813","article-title":"Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions","volume":"100","author":"C Napoli","year":"1997","journal-title":"J Clin Invest"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.3748\/wjg.v16.i23.2851","article-title":"Fixation methods for electron microscopy of human and other liver","volume":"16","author":"E Wisse","year":"2010","journal-title":"World J Gastroenterol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/jb\/mvm209","article-title":"Effect of low doses of red wine and pure resveratrol on circulating endothelial progenitor cells","volume":"143(2)","author":"ML Balestrieri","year":"2008","journal-title":"J Biochem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1080\/10715760802357057","article-title":"Antioxidants increase number of progenitor endothelial cells through multiple gene expression pathways","volume":"42","author":"C Fiorito","year":"2008","journal-title":"Free Radic Res"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Huang PH, Lin CP, Wang CH, Chiang CH, Tsai HY, <etal>et al<\/etal>.. (2012) Niacin improves ischemia-induced neovascularization in diabetic mice by enhancement of endothelial progenitor cell functions independent of changes in plasma lipids. Angiogenesis. 2012 Mar 31. [Epub ahead of print].","DOI":"10.1007\/s10456-012-9267-z"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0049653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T12:12:22Z","timestamp":1643631142000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0049653"}},"subtitle":[],"editor":[{"given":"Markus M.","family":"Heimesaat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,15]]},"references-count":43,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0049653","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,15]]}}}