{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:10:16Z","timestamp":1789391416492,"version":"build-2803163510"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T00:00:00Z","timestamp":1354060800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0049792","type":"journal-article","created":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T21:55:16Z","timestamp":1354139716000},"page":"e49792","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":112,"title":["Drug-Eluting Fibers for HIV-1 Inhibition and Contraception"],"prefix":"10.1371","volume":"7","author":[{"given":"Cameron","family":"Ball","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Krogstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanyanan","family":"Chaowanachan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim A.","family":"Woodrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/S0140-6736(06)69478-6","article-title":"Sexual and reproductive health: a matter of life and death","volume":"368","author":"A Glasier","year":"2006","journal-title":"The Lancet"},{"key":"ref2","unstructured":"CAMI Multipurpose Prevention Technologies for Reproductive Health: 2011 Symposium (2012) 1\u201324."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1600-0897.2010.00930.x","article-title":"Hormonal Contraception and HIV-1 Transmission","volume":"65","author":"C Blish","year":"2011","journal-title":"American Journal of Reproductive Immunology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1086\/519432","article-title":"The Influence of Hormonal Contraceptive Use on HIV-1 Transmission and Disease Progression","volume":"45","author":"JM Baeten","year":"2007","journal-title":"Clinical Infectious Diseases"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(02)11079-8","article-title":"Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial","volume":"360","author":"L Van Damme","year":"2002","journal-title":"The Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.antiviral.2010.09.005","article-title":"Combining prevention of HIV-1, other sexually transmitted infections and unintended pregnancies: Development of dual-protection technologies","volume":"88","author":"DR Friend","year":"2010","journal-title":"Antiviral Research"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/sti.2003.007153","article-title":"Effectiveness of female controlled barrier methods in preventing sexually transmitted infections and HIV: current evidence and future research directions","volume":"81","author":"A Minnis","year":"2005","journal-title":"Sexually transmitted infections"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.antiviral.2010.09.003","article-title":"Advances in microbicide vaginal rings","volume":"88","author":"RK Malcolm","year":"2010","journal-title":"Antiviral Research"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/j.antiviral.2010.09.010","article-title":"Advances in development, scale-up and manufacturing of microbicide gels, films, and tablets","volume":"88","author":"S Garg","year":"2010","journal-title":"Antiviral Research"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1126\/science.1193748","article-title":"Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women","volume":"329","author":"Q Karim","year":"2010","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1128\/AAC.01096-08","article-title":"Reverse Transcriptase Inhibitors as Potential Colorectal Microbicides","volume":"53","author":"C Herrera","year":"2009","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"5504","DOI":"10.1128\/JVI.02422-10","article-title":"The Nonnucleoside Reverse Transcriptase Inhibitor MIV-150 in Carrageenan Gel Prevents Rectal Transmission of Simian\/Human Immunodeficiency Virus Infection in Macaques","volume":"85","author":"R Singer","year":"2011","journal-title":"Journal of Virology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s13346-011-0022-6","article-title":"Development and characterization of a vaginal film containing dapivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI), for prevention of HIV-1 sexual transmission","volume":"1","author":"A Akil","year":"2011","journal-title":"Drug Delivery and Translational Research"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0168-3659(03)00260-8","article-title":"In vitro release of nonoxynol-9 from silicone matrix intravaginal rings","volume":"91","author":"K Malcolm","year":"2003","journal-title":"Journal of Controlled Release"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1093\/jac\/dki326","article-title":"Long-term, controlled release of the HIV microbicide TMC120 from silicone elastomer vaginal rings","volume":"56","author":"RK Malcolm","year":"2005","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.addr.2010.12.002","article-title":"Electrospun cellular microenvironments: Understanding controlled release and scaffold structure","volume":"63","author":"A Szentivanyi","year":"2011","journal-title":"Advanced Drug Delivery Reviews"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"013002","DOI":"10.1088\/1468-6996\/12\/1\/013002","article-title":"Technological advances in electrospinning of nanofibers","volume":"12","author":"W-E Teo","year":"2011","journal-title":"Science and Technology of Advanced Materials"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Ratner B, Hoffman A, Schoen F, Lemons J (1996) Biomaterials science: an introduction to materials in medicine. San Diego: Academic Press. 297-308 p.","DOI":"10.1016\/B978-012582460-6\/50002-5"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0169-409X(97)00048-3","article-title":"Biodegradation and biocompatibility of PLA and PLGA microspheres","volume":"28","author":"JM Anderson","year":"1997","journal-title":"Advanced Drug Delivery Reviews"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Auras RA, Lim L-T, Selke SEM, Tsuji H (2010) Poly(Lactic Acid): Synthesis, Structures, Properties, Processing, and Applications. John Wiley &amp; Sons. 356-357 p.","DOI":"10.1002\/9780470649848"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/biot.200600044","article-title":"Electrospun scaffold tailored for tissue-specific extracellular matrix","volume":"1","author":"W-E Teo","year":"2006","journal-title":"Biotechnology Journal"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1021\/ja211148a","article-title":"Superhydrophobic Materials for Tunable Drug Release: Using Displacement of Air To Control Delivery Rates","volume":"134","author":"ST Yohe","year":"2012","journal-title":"Journal of the American Chemical Society"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.contraception.2004.02.015","article-title":"Efficacy of nonhormonal vaginal contraceptives from a hydrogel delivery system","volume":"70","author":"B Saxena","year":"2004","journal-title":"Contraception"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.bbamem.2007.03.026","article-title":"Use of cyclodextrins to manipulate plasma membrane cholesterol content: evidence, misconceptions and control strategies","volume":"1768","author":"R Zidovetzki","year":"2007","journal-title":"Biochimica et biophysica acta"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1021\/bi051992u","article-title":"Glycerol Monolaurate Inhibits the Effects of Gram-Positive Select Agents on Eukaryotic Cells","volume":"45","author":"ML Peterson","year":"2006","journal-title":"Biochemistry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/nature07831","article-title":"Glycerol monolaurate prevents mucosal SIV transmission","volume":"458","author":"Q Li","year":"2009","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4721","DOI":"10.1128\/AAC.49.11.4721-4732.2005","article-title":"Maraviroc (UK-427,857), a Potent, Orally Bioavailable, and Selective Small-Molecule Inhibitor of Chemokine Receptor CCR5 with Broad-Spectrum Anti-Human Immunodeficiency Virus Type 1 Activity","volume":"49","author":"P Dorr","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1086\/338231","article-title":"Risk of Human Immunodeficiency Virus Infection in Herpes Simplex Virus Type 2\u2013Seropositive Persons: A Meta-analysis","volume":"185","author":"A Wald","year":"2002","journal-title":"The Journal of Infectious Diseases"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-0711-10-8","article-title":"The role of acidification in the inhibition of Neisseria gonorrhoeae by vaginal lactobacilli during anaerobic growth","volume":"10","author":"MA Graver","year":"2011","journal-title":"Annals of Clinical Microbiology and Antimicrobials"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ijpharm.2010.08.010","article-title":"Third generation solid dispersions of ferulic acid in electrospun composite nanofibers","volume":"400","author":"D-G Yu","year":"2010","journal-title":"International Journal of Pharmaceutics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1208\/s12249-010-9438-4","article-title":"Dissolution Improvement of Electrospun Nanofiber-Based Solid Dispersions for Acetaminophen","volume":"11","author":"D-G Yu","year":"2010","journal-title":"AAPS PharmSciTech"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1115\/1.2206198","article-title":"Squeezing Flows of Vaginal Gel Formulations Relevant to Microbicide Drug Delivery","volume":"128","author":"SL Kieweg","year":"2006","journal-title":"Journal of Biomechanical Engineering"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1021\/bm060057z","article-title":"Investigation of Drug Release and Matrix Degradation of Electrospun Poly(dl-lactide) Fibers with Paracetanol Inoculation","volume":"7","author":"W Cui","year":"2006","journal-title":"Biomacromolecules"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jconrel.2011.08.006","article-title":"Non-aqueous silicone elastomer gels as a vaginal microbicide delivery system for the HIV-1 entry inhibitor maraviroc","volume":"156","author":"CJ Forbes","year":"2011","journal-title":"Journal of Controlled Release"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1007\/s11095-008-9765-2","article-title":"Targeted Delivery of PSC-RANTES for HIV-1 Prevention using Biodegradable Nanoparticles","volume":"26","author":"A Ham","year":"2009","journal-title":"Pharmaceutical Research"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1086\/462424","article-title":"A Human Colorectal Explant Culture to Evaluate Topical Microbicides for the Prevention of HIV Infection","volume":"192","author":"SR Abner","year":"2005","journal-title":"J Infect Dis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e9310","DOI":"10.1371\/journal.pone.0009310","article-title":"In Vitro and Ex Vivo Testing of Tenofovir Shows It Is Effective As an HIV-1 Microbicide","volume":"5","author":"LC Rohan","year":"2010","journal-title":"PLoS ONE"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1128\/AAC.01129-06","article-title":"Preclinical Testing of Candidate Topical Microbicides for Anti-Human Immunodeficiency Virus Type 1 Activity and Tissue Toxicity in a Human Cervical Explant Culture","volume":"51","author":"JE Cummins","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s11095-012-0715-7","article-title":"Vaginal Film Drug Delivery of the Pyrimidinedione IQP-0528 for the Prevention of HIV Infection","volume":"29","author":"AS Ham","year":"2012","journal-title":"Pharmaceutical Research"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Fichorova RN, Tucker LD, Anderson DJ (2001) The Molecular Basis of Nonoxynol-9-Induced Vaginal Inflammation and Its Possible Relevance to Human Immunodeficiency Virus Type 1 Transmission. Journal of Infectious Diseases 184: 418 \u2013428. doi:10.1086\/322047.","DOI":"10.1086\/322047"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.contraception.2007.04.006","article-title":"Development of vaginal rings for sustained release of nonhormonal contraceptives and anti-HIV agents","volume":"76","author":"YA Han","year":"2007","journal-title":"Contraception"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/jps.20350","article-title":"Evaluation of buccal methyl-\u03b2-cyclodextrin toxicity on human oral epithelial cell culture model","volume":"94","author":"L Boulmedarat","year":"2005","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1128\/AAC.00989-08","article-title":"Glycerol monolaurate does not alter rhesus macaque (Macaca mulatta) vaginal lactobacilli and is safe for chronic use","volume":"52","author":"P Schlievert","year":"2008","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e7499","DOI":"10.1371\/journal.pone.0007499","article-title":"Glycerol Monolaurate and Dodecylglycerol Effects on Staphylococcus aureus and Toxic Shock Syndrome Toxin-1 In Vitro and In Vivo","volume":"4","author":"Y-C Lin","year":"2009","journal-title":"PLoS ONE"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1128\/AAC.49.4.1302-1305.2005","article-title":"Glycerol Monolaurate Inhibits Virulence Factor Production in Bacillus anthracis","volume":"49","author":"SM Vetter","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1128\/jb.176.14.4204-4209.1994","article-title":"Glycerol Monolaurate Inhibits the Production of Beta-Lactamase, Toxic Shock Toxin-1, and Other Staphylococcal Exoproteins by Interfering with Signal Transduction","volume":"176","author":"SJ Projan","year":"1994","journal-title":"J Bacteriol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1128\/AAC.01151-09","article-title":"Glycerol Monolaurate Inhibits Candida and Gardnerella vaginalis In Vitro and In Vivo but Not Lactobacillus","volume":"54","author":"KL Strandberg","year":"2009","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1086\/314881","article-title":"The Effects of Three Nonoxynol-9 Preparations on Vaginal Flora and Epithelium","volume":"180","author":"DH Watts","year":"1999","journal-title":"J Infect Dis"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0002-9378(99)70598-3","article-title":"Effects of multiple applications of benzalkonium chloride and nonoxynol 9 on the vaginal epithelium in the pigtailed macaque (Macaca nemestrina)","volume":"180","author":"DL Patton","year":"1999","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1186\/1471-2334-10-331","article-title":"Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse","volume":"10","author":"TR Moench","year":"2010","journal-title":"BMC Infectious Diseases"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1128\/AAC.36.3.626","article-title":"Effect of glycerol monolaurate on bacterial growth and toxin production","volume":"36","author":"PM Schlievert","year":"1992","journal-title":"Antimicrob Agents Chemother"},{"key":"ref52","first-page":"1089","article-title":"Development of a microbicide-releasing diaphragm as an HIV prevention strategy","volume":"2010","author":"I Major","year":"2010","journal-title":"Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.contraception.2007.10.003","article-title":"A phase I study of the functional performance, safety and acceptability of the BufferGel\u00ae Duet (TM)","volume":"77","author":"SA Ballagh","year":"2008","journal-title":"Contraception"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.contraception.2008.04.118","article-title":"SILCS diaphragm: postcoital testing of a new single-size contraceptive device","volume":"78","author":"JL Schwartz","year":"2008","journal-title":"Contraception"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0010-7824(96)00041-8","article-title":"Latex rubber condoms: predicting and extending shelf life","volume":"53","author":"MJ Free","year":"1996","journal-title":"Contraception"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0010-7824(99)00010-4","article-title":"A vaginal fluid simulant","volume":"59","author":"D Owen","year":"1999","journal-title":"Contraception"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/iub.181","article-title":"Simultaneous determination of maraviroc and raltegravir in human plasma by HPLC-UV","volume":"61","author":"S Notari","year":"2009","journal-title":"IUBMB Life"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"12585","DOI":"10.1128\/JVI.01726-08","article-title":"Identification of Gammaretroviruses Constitutively Released from Cell Lines Used for Human Immunodeficiency Virus Research","volume":"82","author":"Y Takeuchi","year":"2008","journal-title":"J Virol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"8358","DOI":"10.1128\/JVI.74.18.8358-8367.2000","article-title":"Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120","volume":"74","author":"CA Derdeyn","year":"2000","journal-title":"J Virol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1128\/JVI.72.4.2855-2864.1998","article-title":"Effects of CCR5 and CD4 Cell Surface Concentrations on Infections by Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1","volume":"72","author":"EJ Platt","year":"1998","journal-title":"J Virol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1128\/AAC.46.6.1896-1905.2002","article-title":"Emergence of Resistant Human Immunodeficiency Virus Type 1 in Patients Receiving Fusion Inhibitor (T-20) Monotherapy","volume":"46","author":"X Wei","year":"2002","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ref62","unstructured":"World Health Organization (2010) WHO laboratory manual for the examination and processing of human semen. Geneva: World Health Organization."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0049792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T02:31:37Z","timestamp":1594953097000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0049792"}},"subtitle":[],"editor":[{"given":"Gilda","family":"Tachedjian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,28]]},"references-count":62,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0049792","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,28]]}}}