{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:13:08Z","timestamp":1767651188857},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T00:00:00Z","timestamp":1355097600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0049828","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T20:22:29Z","timestamp":1355257349000},"page":"e49828","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["17DD and 17D-213\/77 Yellow Fever Substrains Trigger a Balanced Cytokine Profile in Primary Vaccinated Children"],"prefix":"10.1371","volume":"7","author":[{"given":"Ana Carolina","family":"Campi-Azevedo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza Pacheco de","family":"Ara\u00fajo-Porto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Luiza-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio Azevedo","family":"Batista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Angela","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Sathler-Avelar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"da Silveira-Lemos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Antonio Bastos","family":"Camacho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinaldo","family":"de Menezes Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"de Lourdes de Sousa Maia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Henrique Guedes","family":"Farias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"da Silva Freire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Galler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Homma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Geraldo Leite","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jandira Aparecida Campos","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Auxiliadora-Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iramaya Rodrigues","family":"Caldas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana Maria","family":"El\u00f3i-Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9a","family":"Teixeira-Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olindo Assis","family":"Martins-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,12,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1586\/14760584.4.4.553","article-title":"Yellow fever vaccine","volume":"4","author":"TP Monath","year":"2005","journal-title":"Expert Rev Vaccines"},{"key":"ref2","unstructured":"World Health Organization. Global programme for vaccines and immunization (1998) Expanded programme on immunization. Yellow fever. Geneva. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/vaccines-documents\/DocsPDF\/www9842.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/vaccines-documents\/DocsPDF\/www9842.pdf<\/ext-link>. Accessed 2012 Mar 6."},{"key":"ref3","first-page":"35","article-title":"Complete nucleotide sequence of yellow fever virus vaccine strains 17DD and 17D-213","volume":"35","author":"CND Santos","year":"1995","journal-title":"V\u00edrus Res"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Fleiss JL (1986) The design and analysis of clinical experiments. New York: John Wiley &amp; Sons Inc. DOI: 10.1002\/9781118032923.","DOI":"10.1002\/9781118032923"},{"key":"ref5","unstructured":"Freestone DS (1994) Yellow fever vaccine. In: Plotkin SA, Mortimer EA, editors. Vaccines 2nd ed. Philadelphia: W.B. Saunders. pp. 741\u2013779."},{"key":"ref6","first-page":"31","article-title":"Requirements for yellow fever vaccine","volume":"872","year":"1998","journal-title":"WHO Tech Rep Ser"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"533","DOI":"10.4269\/ajtmh.2002.66.533","article-title":"Comparative safety and immunogenicity of two yellow fever 17D vaccines (ARILVAX and YF-VAX) in a phase III multicenter, double-blind clinical trial","volume":"66","author":"TP Monath","year":"2002","journal-title":"Am J Trop Med Hyg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.biologicals.2005.09.005","article-title":"Molecular and phenotypic analysis of a working seed lot of yellow fever virus 17DD vaccine strain produced from the secondary seed lot 102\/84 with an additional passage in chicken embryos","volume":"34","author":"RS Marchevsky","year":"2006","journal-title":"Biologicals"},{"key":"ref9","unstructured":"Minist\u00e9rio da Sa\u00fade (2001) Funda\u00e7\u00e3o Nacional de Sa\u00fade. Programa Nacional de Imuniza\u00e7\u00f5es. Manual de Procedimentos para Vacina\u00e7\u00e3o. 4<sup>a<\/sup> Ed. Bras\u00edlia: Funda\u00e7\u00e3o Nacional de Sa\u00fade. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dtr2001.saude.gov.br\/svs\/pub\/MPV\/mpv00.htm\" xlink:type=\"simple\">http:\/\/dtr2001.saude.gov.br\/svs\/pub\/MPV\/mpv00.htm<\/ext-link>. Accessed 2012 Mar 20."},{"key":"ref10","unstructured":"World Health Oraganization (2007) Vaccine-preventable diseases and vaccines. In: International Travel and Health. pp. 93\u2013145."},{"key":"ref11","unstructured":"Centers for Disease Control and Prevention (2011) In the News Yellow Fever in Brazil: Current Situation. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/wwwnc.cdc.gov\/travel\/notices\/in-the-news\/yellow-fever-brazil.htm\" xlink:type=\"simple\">http:\/\/wwwnc.cdc.gov\/travel\/notices\/in-the-news\/yellow-fever-brazil.htm<\/ext-link>. Accessed 2012 Feb 26."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1590\/S0034-89102004000500009","article-title":"Collaborative Group for the Study of Yellow Fever Vaccines. Immunogenicity of WHO-17D and Brazilian 17DD yellow fever vaccines: a randomized trial","volume":"38","author":"LAB Camacho","year":"2004","journal-title":"Rev Sa\u00fade P\u00fablica"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4269\/ajtmh.2005.72.189","article-title":"Randomized, double-blind, phase III, pivotal field trial of the comparative immunogenicity, safety, and tolerability of two yellow ferver 17D vaccines (Arilvax and YF-VAX) in healthy infants and children in Peru","volume":"72","author":"VE Belmusto-Worn","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1016\/j.vaccine.2007.01.053","article-title":"Randomized, double-blind, multicenter study of the immunogenicity and reactogenicity of 17DD and WHO 17D-213\/77 yellow fever vaccines in children: implications for the Brazilian National Immunization","volume":"25","year":"2007","journal-title":"Vaccine"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1590\/S0034-89102005000300012","article-title":"Collaborative Group for the Study of Yellow Fever Vaccines. Reactogenicity of yellow fever vaccines in a randomized, placebo-controlled trial","volume":"39","author":"LA Camacho","year":"2005","journal-title":"Rev Sa\u00fade P\u00fablica"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/S0264-410X(98)00320-X","article-title":"Recent immunization against measles does not interfere with the seroresponse to yellow fever vaccine","volume":"17","author":"I Stefano","year":"1999","journal-title":"Vaccine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/infdis\/jir439","article-title":"Cytokine signatures of innate and adaptive immunity in 17DD yellow fever vaccinated children and its association with the level of neutralizing antibody","volume":"15","author":"M Luiza-Silva","year":"2011","journal-title":"J Infect Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1084\/jem.20051720","article-title":"Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity","volume":"203","author":"T Querec","year":"2006","journal-title":"J Exp Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.vaccine.2007.12.035","article-title":"Innate immunity phenotypic features point toward simultaneous raise of activation and modulation events following 17DD live attenuated yellow fever first-time vaccination","volume":"26","author":"MA Martins","year":"2008","journal-title":"Vaccine"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1084\/jem.20082292","article-title":"Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses","volume":"205","author":"D Gaucher","year":"2008","journal-title":"J Exp Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.cyto.2008.02.007","article-title":"Detection of Th1\/Th2 cytokine signatures in yellow fever 17DD first-time vaccinees through ELISpot assay","volume":"42","author":"AP Santos","year":"2008","journal-title":"Cytokine"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1086\/587844","article-title":"Immune response during adverse events after 17D-derived yellow fever vaccination in Europe","volume":"197","author":"HG Bae","year":"2008","journal-title":"J Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1128\/CVI.00369-09","article-title":"Clinical and immunological insights on severe, adverse neurotropic and viscerotropic disease following 17D yellow fever vaccination","volume":"17","author":"ML Silva","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/ni.1688","article-title":"Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans","volume":"10","author":"TD Querec","year":"2009","journal-title":"Nat Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1084\/jem.20112321","article-title":"Learning vaccinology from viral infections","volume":"208","author":"R Ahmed","year":"2011","journal-title":"J Exp Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1084\/jem.20030109","article-title":"Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts","volume":"197","author":"M Wuthrich","year":"2003","journal-title":"J Exp Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.cell.2012.02.012","article-title":"Beyond Empiricism: Informing Vaccine Development through Innate Immunity Research","volume":"148","author":"SM Levitz","year":"2012","journal-title":"Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.1016\/j.vaccine.2009.07.028","article-title":"TLR expression and NK cell activation after human yellow fever vaccination","volume":"27","author":"PC Neves","year":"2009","journal-title":"Vaccine"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"7919","DOI":"10.4049\/jimmunol.0803903","article-title":"The yellow fever virus vaccine induces a broad and polyfunctional human memory CD8+ T cell response","volume":"15","author":"RS Akondy","year":"2009","journal-title":"J Immunol"},{"key":"ref30","first-page":"895","article-title":"Persistence of neutralizing antibody 30\u201335 years after immunization with 17D yellow fever vaccine","volume":"59","author":"JD Poland","year":"1981","journal-title":"Bull World Health Organ"},{"key":"ref31","first-page":"783","article-title":"Response of Volta children to jet inoculation of combined live measles, smallpox and yellow fever vaccines","volume":"30","author":"HM Meyer Jr","year":"1964","journal-title":"Bull World Health Organ"},{"key":"ref32","unstructured":"Robertson SE (1993) The Immunological Basis for Immunization. Module 8: Yellow Fever. Geneva: World Health Organization, WHO\/EPI\/GEN\/93.18. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/vaccines-documents\/DocsPDF-IBIe\/mod8_e.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/vaccines-documents\/DocsPDF-IBIe\/mod8_e.pdf<\/ext-link>. Accessed 2012 Apr 4."},{"key":"ref33","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0264-410X(85)90182-3","article-title":"Thermostability and efficacy in the field of a new, stabilized yellow fever virus vaccine","volume":"3","author":"AJ Georges","year":"1985","journal-title":"Vaccine"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0092-1157(89)90023-1","article-title":"Study of combined vaccination against yellow fever and measles in infants from six to nine months","volume":"17","author":"M Lhuillier","year":"1989","journal-title":"J Biol Stand"},{"key":"ref35","first-page":"537","article-title":"The combined measles\u2013yellow fever vaccination in African infants aged 6 to 10 months","volume":"83","author":"D Mouchon","year":"1990","journal-title":"Bull Soc Pathol Exot"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0049828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T23:08:31Z","timestamp":1562454511000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0049828"}},"subtitle":[],"editor":[{"given":"Patricia","family":"Talamas-Rohana","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,12,10]]},"references-count":35,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,12,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0049828","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,10]]}}}