{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:19:41Z","timestamp":1759335581866},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T00:00:00Z","timestamp":1354233600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0049850","type":"journal-article","created":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T17:48:56Z","timestamp":1354297736000},"page":"e49850","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Bioassay Studies Support the Potential for Iatrogenic Transmission of Variant Creutzfeldt Jakob Disease through Dental Procedures"],"prefix":"10.1371","volume":"7","author":[{"given":"Elizabeth","family":"Kirby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Dickinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Vassey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Dennis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Cornwall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"McLeod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip D.","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James T.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Mark","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil D. H.","family":"Raven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,11,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/39057","article-title":"Transmissions to mice indicate that \u2018new variant\u2019 CJD is caused by the BSE agent","volume":"389","author":"ME Bruce","year":"1997","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/path.1580","article-title":"Prevalence of lymphoreticular prion protein accumulation in UK tissue samples","volume":"203","author":"DA Hilton","year":"2004","journal-title":"J Pathol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"b1442","DOI":"10.1136\/bmj.b1442","article-title":"Prevalence of disease related prion protein in anonymous tonsil specimens in Britain: cross sectional opportunistic survey","volume":"338","author":"JP Clewley","year":"2009","journal-title":"BMJ"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1136\/bmj.38804.511644.55","article-title":"Variant Creutzfeldt-Jakob disease: prion protein genotype analysis of positive appendix tissue samples from a retrospective prevalence study","volume":"332","author":"JW Ironside","year":"2006","journal-title":"BMJ"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0140-6736(04)16811-6","article-title":"Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient","volume":"364","author":"AH Peden","year":"2004","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1474-4422(06)70413-6","article-title":"Predicting susceptibility and incubation time of human-to-human transmission of vCJD","volume":"5","author":"MT Bishop","year":"2006","journal-title":"Lancet Neurol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1016\/S0140-6736(06)68930-7","article-title":"Kuru in the 21st century - an acquired human prion disease with very long incubation periods","volume":"367","author":"J Collinge","year":"2006","journal-title":"Lancet"},{"key":"ref8","first-page":"1780","article-title":"Creutzfeldt-Jakob disease, prion protein gene codon 129VV, and a novel PrP<sup>Sc<\/sup> type in a young British woman Arch","volume":"64","author":"S Mead","year":"2007","journal-title":"Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0140-6736(04)15486-X","article-title":"Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion","volume":"363","author":"CA Llewelyn","year":"2004","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1099\/0022-1317-80-11-3043","article-title":"Transmission of the 263 K scrapie strain by the dental route","volume":"80","author":"L Ingrosso","year":"1999","journal-title":"J Gen. Virol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jcpa.2010.01.015","article-title":"Disease-associated prion protein in the dental tissue of mice infected with scrapie","volume":"143","author":"H Okada","year":"2010","journal-title":"J Comp. Pathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/sj.bdj.4810536","article-title":"Investigation of PrPres in dental tissues in variant CJD","volume":"195","author":"MW Head","year":"2003","journal-title":"Br Dent J"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0140-6736(01)05411-3","article-title":"Detection of variant Creutzfeldt-Jakob disease infectivity in extraneural tissues","volume":"358","author":"ME Bruce","year":"2001","journal-title":"Lancet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.bbrc.2004.03.168","article-title":"Proteolytic inactivation of the bovine spongiform encephalopathy agent Biochem","volume":"317","author":"AH McLeod","year":"2004","journal-title":"Biophys. Res. Commun"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1098\/rstb.1994.0036","article-title":"Transmission of bovine spongiform encephalopathy and scrapie to mice-strain variation and the species barrier","volume":"343","author":"M Bruce","year":"1994","journal-title":"Philosophical Transactions of the Royal Society of London B Biological Sciences"},{"key":"ref16","article-title":"Practical Statistics for Experimental Biologists","author":"AC Wardlaw","year":"1992","journal-title":"John Wiley & Sons Ltd"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1099\/0022-1317-77-8-1941","article-title":"Protease-resistant PrP deposition in brain and non-central nervous system tissues of a murine model of bovine spongiform encephalopathy","volume":"77","author":"CF Farquhar","year":"1996","journal-title":"J Gen. Virol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0140-6736(82)90421-4","article-title":"Transmission of scrapie by oral route: effect of gingival scarification","volume":"1","author":"RI Carp","year":"1982","journal-title":"Lancet"},{"key":"ref19","first-page":"1506","article-title":"High levels of disease related prion protein in the ileum in variant","volume":"54","author":"S Joiner","year":"2005","journal-title":"Creutzfeldt-Jakob disease Gut"},{"key":"ref20","first-page":"90","article-title":"Prion infectivity in variant","volume":"56","author":"JD Wadsworth","year":"2007","journal-title":"Creutzfeldt-Jakob disease rectum Gut"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/gut.2006.101964","article-title":"vCJD and the gut: implications for endoscopy","volume":"56","author":"MW Head","year":"2007","journal-title":"Gut"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"E14","DOI":"10.1038\/sj.bdj.2011.144","article-title":"A quantitative assessment of residual protein levels on dental instruments reprocessed by manual, ultrasonic and automated cleaning methods","volume":"210","author":"M Vassey","year":"2011","journal-title":"Br. Dent. J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1042\/BA20060249","article-title":"Comparative studies on the thermostability of five strains of transmissible-spongiform-encephalopathy agent Biotechnol","volume":"47","author":"K Fernie","year":"2007","journal-title":"Appl. Biochem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"E9","DOI":"10.1038\/bdj.2007.126","article-title":"Dental treatment and risk of variant CJD \u2013 a case control study","volume":"202","author":"D Everington","year":"2007","journal-title":"Br Dent J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1423-0410.2006.00833.x","article-title":"Creutzfeldt-Jakob disease and blood transfusion: results of the UK Transfusion Medicine Epidemiological Review study","volume":"91","author":"PE Hewitt","year":"2006","journal-title":"Vox Sang"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0049850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T23:07:35Z","timestamp":1539990455000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0049850"}},"subtitle":[],"editor":[{"given":"Noriyuki","family":"Nishida","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,30]]},"references-count":25,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0049850","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,30]]}}}