{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:05:29Z","timestamp":1790089529497,"version":"4.0.1"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T00:00:00Z","timestamp":1354060800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0049941","type":"journal-article","created":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T21:55:49Z","timestamp":1354139749000},"page":"e49941","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Ontology-Based Combinatorial Comparative Analysis of Adverse Events Associated with Killed and Live Influenza Vaccines"],"prefix":"10.1371","volume":"7","author":[{"given":"Sirarat","family":"Sarntivijai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoshuang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerby A.","family":"Shedden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Markel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert S.","family":"Omenn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Athey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2165\/00002018-200932040-00005","article-title":"Vaccines and Guillain-Barre syndrome","volume":"32","author":"P Haber","year":"2009","journal-title":"Drug Saf"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/0264-410X(94)90315-8","article-title":"The Vaccine Adverse Event Reporting System (VAERS)","volume":"12","author":"RT Chen","year":"1994","journal-title":"Vaccine"},{"key":"ref3","first-page":"564","article-title":"Network analysis of possible anaphylaxis cases reported to the US vaccine adverse event reporting system after H1N1 influenza vaccine","volume":"169","author":"T Botsis","year":"2011","journal-title":"Studies in health technology and informatics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/amiajnl-2010-000022","article-title":"Text mining for the Vaccine Adverse Event Reporting System: medical text classification using informative feature selection","volume":"18","author":"T Botsis","year":"2011","journal-title":"Journal of the American Medical Informatics Association : JAMIA"},{"key":"ref5","first-page":"401","article-title":"A meta-analysis epidemiological assessment of neurodevelopmental disorders following vaccines administered from 1994 through 2000 in the United States","volume":"27","author":"DA Geier","year":"2006","journal-title":"Neuro endocrinology letters"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2165\/00002018-200831080-00003","article-title":"Effects of stratification on data mining in the US Vaccine Adverse Event Reporting System (VAERS)","volume":"31","author":"EJ Woo","year":"2008","journal-title":"Drug safety : an international journal of medical toxicology and drug experience"},{"key":"ref7","first-page":"749","article-title":"A case-series of adverse events, positive re-challenge of symptoms, and events in identical twins following hepatitis B vaccination: analysis of the Vaccine Adverse Event Reporting System (VAERS) database and literature review","volume":"22","author":"MR Geier","year":"2004","journal-title":"Clinical and experimental rheumatology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/00006454-200404000-00002","article-title":"Understanding vaccine safety information from the Vaccine Adverse Event Reporting System","volume":"23","author":"F Varricchio","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"ref9","article-title":"Bayesian Data Mining in Large Frequency Tables, With an Application to the FDA Spontaneous Reporting System","volume":"53","author":"W DuMouchel","year":"1999","journal-title":"The American Statistician"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s002280050466","article-title":"A Bayesian neural network method for adverse drug reaction signal generation","volume":"54","author":"A Bate","year":"1998","journal-title":"European journal of clinical pharmacology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/pds.677","article-title":"Use of proportional reporting ratios (PRRs) for signal generation from spontaneous adverse drug reaction reports","volume":"10","author":"SJ Evans","year":"2001","journal-title":"Pharmacoepidemiology and drug safety"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"901","DOI":"10.2165\/00002018-200528100-00006","article-title":"Testing and implementing signal impact analysis in a regulatory setting: results of a pilot study","volume":"28","author":"E Heeley","year":"2005","journal-title":"Drug safety : an international journal of medical toxicology and drug experience"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2165\/00002018-200225060-00010","article-title":"Use of measures of disproportionality in pharmacovigilance: three Dutch examples","volume":"25","author":"AC Egberts","year":"2002","journal-title":"Drug safety : an international journal of medical toxicology and drug experience"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2165\/00002018-200326030-00002","article-title":"Methods and pitfalls in searching drug safety databases utilising the Medical Dictionary for Regulatory Activities (MedDRA)","volume":"26","author":"EG Brown","year":"2003","journal-title":"Drug safety : an international journal of medical toxicology and drug experience"},{"key":"ref15","unstructured":"He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W (2011) AEO: A Realism-Based Biomedical Ontology for the Representation of Adverse Events. In: Smith B, editor; Buffalo, NY. pp. 309."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/1756-0500-3-175","article-title":"OntoFox: web-based support for ontology reuse","volume":"3","author":"Z Xiang","year":"2010","journal-title":"BMC Res Notes"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/nbt1346","article-title":"The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration","volume":"25","author":"B Smith","year":"2007","journal-title":"Nat Biotechnol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/pds.1107","article-title":"Comparing data mining methods on the VAERS database","volume":"14","author":"D Banks","year":"2005","journal-title":"Pharmacoepidemiology and drug safety"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1086\/603560","article-title":"\u201cPrepandemic\u201d immunization for novel influenza viruses, \u201cswine flu\u201d vaccine, Guillain-Barre syndrome, and the detection of rare severe adverse events","volume":"200","author":"D Evans","year":"2009","journal-title":"J Infect Dis"},{"key":"ref20","first-page":"295","article-title":"The Environment and Disease: Association or Causation?","volume":"58","author":"AB Hill","year":"1965","journal-title":"Proc R Soc Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.1440-1681.1999.02986.x","article-title":"Barrier mechanisms in the brain, I. Adult brain","volume":"26","author":"NR Saunders","year":"1999","journal-title":"Clinical and experimental pharmacology & physiology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.amepre.2011.04.004","article-title":"H1N1 and seasonal influenza vaccine safety in the vaccine safety datalink project","volume":"41","author":"GM Lee","year":"2011","journal-title":"American journal of preventive medicine"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jbspin.2010.02.003","article-title":"Fibromyalgia and related conditions: electromyogram profile during isometric muscle contraction","volume":"77","author":"D Maquet","year":"2010","journal-title":"Joint, bone, spine : revue du rhumatisme"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00381-010-1197-8","article-title":"Magnetic resonance imaging of childhood Guillain-Barre syndrome","volume":"26","author":"A Yikilmaz","year":"2010","journal-title":"Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/ajim.4700190412","article-title":"The association between cancer mortality and dioxin exposure: a comment on the hazard of repetition of epidemiological misinterpretation","volume":"19","author":"L Hardell","year":"1991","journal-title":"Am J Ind Med"},{"key":"ref26","article-title":"Neurologic adverse events following influenza A (H1N1) vaccinations in children","author":"SJ Lee","year":"2012","journal-title":"Pediatr Int"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.pediatrneurol.2011.02.010","article-title":"Neurologic manifestations of novel influenza A (H1N1) virus infection in childhood","volume":"45","author":"M Ozkan","year":"2011","journal-title":"Pediatr Neurol"},{"key":"ref28","first-page":"748","article-title":"Guillian-Barre syndrome","volume":"20","author":"RK Talukder","year":"2011","journal-title":"Mymensingh Med J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4103\/0972-2327.91942","article-title":"Mortality in mechanically ventilated patients of Guillain Barre Syndrome","volume":"14","author":"AB Netto","year":"2011","journal-title":"Ann Indian Acad Neurol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"6654","DOI":"10.1016\/j.vaccine.2009.08.027","article-title":"Adverse events after anthrax vaccination reported to the Vaccine Adverse Event Reporting System (VAERS), 1990\u20132007 [Vaccine 2009;27:290\u2013297]","volume":"27","author":"M Niu","year":"2009","journal-title":"Vaccine"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3185\/pathexo3182","article-title":"[Post-vaccinal adverse effects monitoring during national campaign of vaccination against measles in Cote d'Ivoire]","volume":"102","author":"H Die-Kacou","year":"2009","journal-title":"Bull Soc Pathol Exot"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5253","DOI":"10.1016\/j.vaccine.2007.03.053","article-title":"Guillain-Barre syndrome after vaccination in United States a report from the CDC\/FDA Vaccine Adverse Event Reporting System","volume":"25","author":"N Souayah","year":"2007","journal-title":"Vaccine"},{"key":"ref33","first-page":"8101","article-title":"Letter to the Editor. Guillain-Barre Syndrome(GBS) after vaccination reported to the United States Vaccine Adverse Event Reporting System(VAERS) in 2004","volume":"25","author":"P Haber","year":"2007","journal-title":"Vaccine"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/CND.0b013e3181aaa968","article-title":"Guillain-Barre syndrome after vaccination in United States: data from the Centers for Disease Control and Prevention\/Food and Drug Administration Vaccine Adverse Event Reporting System (1990\u20132005)","volume":"11","author":"N Souayah","year":"2009","journal-title":"Journal of clinical neuromuscular disease"},{"key":"ref35","article-title":"Postlicensure Safety Surveillance for High-Dose Trivalent Inactivated Influenza Vaccine in the Vaccine Adverse Event Reporting System, 1 July 2010\u201331 December 2010","author":"PL Moro","year":"2012","journal-title":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"7727","DOI":"10.1016\/j.vaccine.2011.07.129","article-title":"Serious adverse events following receipt of trivalent inactivated influenza vaccine in Korea, 2003\u20132010","volume":"29","author":"YJ Choe","year":"2011","journal-title":"Vaccine"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.amepre.2010.05.022","article-title":"Evaluation of Guillain-Barre Syndrome among recipients of influenza vaccine in 2000 and 2001","volume":"39","author":"DR Burwen","year":"2010","journal-title":"American journal of preventive medicine"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1016\/j.vaccine.2009.01.125","article-title":"Safety of trivalent inactivated influenza vaccines in adults: background for pandemic influenza vaccine safety monitoring","volume":"27","author":"C Vellozzi","year":"2009","journal-title":"Vaccine"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1001\/archinte.166.20.2217","article-title":"Guillain-Barre syndrome after influenza vaccination in adults: a population-based study","volume":"166","author":"DN Juurlink","year":"2006","journal-title":"Archives of internal medicine"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S1521-6616(03)00046-9","article-title":"Influenza vaccination and Guillain Barre syndrome small star, filled","volume":"107","author":"MR Geier","year":"2003","journal-title":"Clinical immunology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1056\/NEJM199812173392501","article-title":"The Guillain-Barre syndrome and the 1992\u20131993 and 1993\u20131994 influenza vaccines","volume":"339","author":"T Lasky","year":"1998","journal-title":"The New England journal of medicine"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1056\/NEJMoa1008553","article-title":"Safety of influenza A (H1N1) vaccine in postmarketing surveillance in China","volume":"364","author":"XF Liang","year":"2011","journal-title":"The New England journal of medicine"},{"key":"ref43","article-title":"Recurrent Guillain-Barre Syndrome Following Vaccination","author":"R Baxter","year":"2012","journal-title":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America"},{"key":"ref44","article-title":"Neurologic adverse events following influenza A (H1N1) vaccinations in children","author":"SJ Lee","year":"2012","journal-title":"Pediatrics international : official journal of the Japan Pediatric Society"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"7878","DOI":"10.1016\/j.vaccine.2011.08.069","article-title":"Guillain-Barre syndrome and H1N1 (2009) pandemic influenza vaccination using an AS03 adjuvanted vaccine in the United Kingdom: self-controlled case series","volume":"29","author":"N Andrews","year":"2011","journal-title":"Vaccine"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"d3908","DOI":"10.1136\/bmj.d3908","article-title":"Guillain-Barre syndrome and adjuvanted pandemic influenza A (H1N1) 2009 vaccine: multinational case-control study in Europe","volume":"343","author":"J Dieleman","year":"2011","journal-title":"BMJ"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s11908-011-0194-8","article-title":"Guillain-barre syndrome following influenza vaccination: causal or coincidental?","volume":"13","author":"JJ Sejvar","year":"2011","journal-title":"Current infectious disease reports"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(11)61665-6","article-title":"Guillain-Barre syndrome and H1N1 influenza vaccine in UK children","volume":"378","author":"C Verity","year":"2011","journal-title":"Lancet"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"8302","DOI":"10.1016\/j.vaccine.2011.08.093","article-title":"Causality assessment of serious neurologic adverse events following 2009 H1N1 vaccination","volume":"29","author":"SE Williams","year":"2011","journal-title":"Vaccine"},{"key":"ref50","article-title":"A cluster of nonspecific adverse events in a military reserve unit following pandemic influenza A (H1N1) 2009 vaccination-Possible stimulated reporting?","author":"MM McNeil","year":"2012","journal-title":"Vaccine"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1016\/j.vaccine.2010.09.021","article-title":"Adverse events following influenza A (H1N1) 2009 monovalent vaccines reported to the Vaccine Adverse Event Reporting System, United States, October 1, 2009\u2013January 31, 2010","volume":"28","author":"C Vellozzi","year":"2010","journal-title":"Vaccine"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1086\/603560","article-title":"\u201cPrepandemic\u201d immunization for novel influenza viruses, \u201cswine flu\u201d vaccine, Guillain-Barre syndrome, and the detection of rare severe adverse events","volume":"200","author":"D Evans","year":"2009","journal-title":"The Journal of infectious diseases"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1001\/jama.294.21.2720","article-title":"Adverse events reported following live, cold-adapted, intranasal influenza vaccine","volume":"294","author":"HS Izurieta","year":"2005","journal-title":"JAMA : the journal of the American Medical Association"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.clineuro.2003.11.002","article-title":"Guillain-Barre syndrome coexisting with pericarditis or nephrotic syndrome after influenza vaccination","volume":"106","author":"CD Kao","year":"2004","journal-title":"Clinical neurology and neurosurgery"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0049941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T23:51:01Z","timestamp":1588981861000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0049941"}},"subtitle":[],"editor":[{"given":"Gary P.","family":"Kobinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,28]]},"references-count":54,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0049941","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,28]]}}}