{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:44:53Z","timestamp":1791189893813,"version":"4.1.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T00:00:00Z","timestamp":1352851200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0049996","type":"journal-article","created":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T17:31:42Z","timestamp":1352914302000},"page":"e49996","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":126,"title":["Poor Sleep in Patients with Multiple Sclerosis"],"prefix":"10.1371","volume":"7","author":[{"given":"Hanne Marie","family":"B\u00f8e Lunde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy F.","family":"Aae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Indrev\u00e5g","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Aarseth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn","family":"Bjorvatn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell-Morten","family":"Myhr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"B\u00f8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,11,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.sleep.2007.11.004","article-title":"Prevalence of \u2018poor sleep\u2019 among patients with multiple sclerosis: an independent predictor of mental and physical status","volume":"10","author":"G Merlino","year":"2009","journal-title":"Sleep Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.smrv.2009.07.005","article-title":"Sleep disorders in patients with multiple sclerosis","volume":"14","author":"SD Brass","year":"2010","journal-title":"Sleep Med Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1212\/WNL.63.11_suppl_5.S12","article-title":"A multimodal approach to managing the symptoms of multiple sclerosis","volume":"63","author":"H Crayton","year":"2004","journal-title":"Neurology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.sleep.2008.02.002","article-title":"Importance of sleep in the quality of life of multiple sclerosis patients: a long under-recognized issue","volume":"10","author":"H Attarian","year":"2009","journal-title":"Sleep Med"},{"key":"ref5","article-title":"Obstructive sleep apnea is associated with fatigue in multiple sclerosis","author":"M Kaminska","year":"2011","journal-title":"Mult Scler"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2147\/CLEP.S10425","article-title":"Beyond fatigue: Assessing variables associated with sleep problems and use of sleep medications in multiple sclerosis","volume":"2010","author":"AM Bamer","year":"2010","journal-title":"Clin Epidemiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11325-008-0202-x","article-title":"Reliability and validity of a Norwegian version of the Epworth sleepiness scale","volume":"13","author":"KK Beiske","year":"2009","journal-title":"Sleep and Breathing"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0022-3999(97)00291-2","article-title":"Fatigue in the general Norwegian population: Normative data and associations","volume":"45","author":"JH Loge","year":"1998","journal-title":"Journal of Psychosomatic Research"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1600-0404.2009.01298.x","article-title":"Psychometric properties of a Norwegian version of Multiple Sclerosis Impact Scale (MSIS-29)","volume":"122","author":"T Smedal","year":"2010","journal-title":"Acta Neurologica Scandinavica"},{"key":"ref10","first-page":"714","article-title":"Pittsburgh Sleep Quality Index","author":"S Pallesen","year":"2005","journal-title":"Tidsskrift for Norsk Psykologforening"},{"key":"ref11","unstructured":"Aasen H (2001) An empirical investigation of depression symptoms: norms, psychometric characteristics and factor structure of the Beck Depression Inventory II Bergen."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research","volume":"28","author":"DJ Buysse","year":"1989","journal-title":"Psychiatry Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s004060170045","article-title":"A double-blind, randomized and placebo-controlled study on the polysomnographic withdrawal effects of zopiclone, zolpidem and triazolam in healthy subjects","volume":"251","author":"U Voderholzer","year":"2001","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1002\/mds.23190","article-title":"Scales to assess sleep impairment in Parkinson's disease: critique and recommendations","volume":"25","author":"B Hogl","year":"2010","journal-title":"Mov Disord"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1378\/chest.11-0773","article-title":"Sleep-related problems in neurologic diseases","volume":"141","author":"ME Dyken","year":"2012","journal-title":"Chest"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"563","DOI":"10.5664\/jcsm.27351","article-title":"Relationships between the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and clinical\/polysomnographic measures in a community sample","volume":"4","author":"DJ Buysse","year":"2008","journal-title":"J Clin Sleep Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/brain\/124.5.962","article-title":"The Multiple Sclerosis Impact Scale (MSIS-29): a new patient-based outcome measure","volume":"124","author":"J Hobart","year":"2001","journal-title":"Brain"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A new method for measuring daytime sleepiness: the Epworth sleepiness scale","volume":"14","author":"MW Johns","year":"1991","journal-title":"Sleep"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0304-3959(97)00005-5","article-title":"The visual analogue pain intensity scale: what is moderate pain in millimetres","volume":"72","author":"SL Collins","year":"1997","journal-title":"Pain"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jclinepi.2004.11.017","article-title":"Visual Analog Scale pain reporting was standardized","volume":"58","author":"RL Kane","year":"2005","journal-title":"J Clin Epidemiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0022-3999(93)90081-P","article-title":"Development of a fatigue scale","volume":"37","author":"T Chalder","year":"1993","journal-title":"J Psychosom Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0165-0327(00)00242-1","article-title":"A comparison between the Beck Depression Inventory (BDI) and the self-rating version of the Montgomery Asberg Depression Rating Scale (MADRS)","volume":"64","author":"P Svanborg","year":"2001","journal-title":"J Affect Disord"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Hosmer DW LS (2000) Applied logistic regression, 2nd edn Wiley.","DOI":"10.1002\/0471722146"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1159\/000117070","article-title":"Sleep problems in multiple sclerosis","volume":"34","author":"N Tachibana","year":"1994","journal-title":"Eur Neurol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1177\/1352458508092807","article-title":"Prevalence of sleep problems in individuals with multiple sclerosis","volume":"14","author":"AM Bamer","year":"2008","journal-title":"Mult Scler"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1600-0404.2004.00257.x","article-title":"Factors influencing quality of life in multiple sclerosis patients: disability, depressive mood, fatigue and sleep quality","volume":"110","author":"IS Lobentanz","year":"2004","journal-title":"Acta Neurol Scand"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/archneur.1992.00530300077013","article-title":"Sleep disturbance, depression, and lesion site in patients with multiple sclerosis","volume":"49","author":"CM Clark","year":"1992","journal-title":"Arch Neurol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3109\/09540261003589323","article-title":"The neuropsychiatry of multiple sclerosis: focus on disorders of mood, affect and behaviour","volume":"22","author":"T Paparrigopoulos","year":"2010","journal-title":"Int Rev Psychiatry"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0301-0511(01)00090-4","article-title":"Sleep and depression\u2013results from psychobiological studies: an overview","volume":"57","author":"D Riemann","year":"2001","journal-title":"Biol Psychol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1111\/j.1468-1331.2006.01499.x","article-title":"Fatigue and sleep disturbance in multiple sclerosis","volume":"13","author":"H Kaynak","year":"2006","journal-title":"Eur J Neurol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1365-2869.2006.00508.x","article-title":"What have fatigue and sleepiness in common","volume":"15","author":"S Merkelbach","year":"2006","journal-title":"J Sleep Res"},{"key":"ref32","article-title":"Impact of sleep disorder treatment on fatigue in multiple sclerosis","author":"I Cote","year":"2012","journal-title":"Mult Scler"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.sleep.2005.05.001","article-title":"Daytime sleepiness is not increased in mild to moderate multiple sclerosis: a pupillographic study","volume":"6","author":"B Frauscher","year":"2005","journal-title":"Sleep Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2869.2005.00466.x","article-title":"Subjective fatigue and subjective sleepiness: two independent consequences of sleep disorders","volume":"14","author":"JL Hossain","year":"2005","journal-title":"J Sleep Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/BF02230913","article-title":"Acute and chronic pain syndromes in multiple sclerosis. A 5-year follow-up study","volume":"16","author":"E Stenager","year":"1995","journal-title":"Ital J Neurol Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pain.2007.08.024","article-title":"Pain associated with multiple sclerosis: systematic review and proposed classification","volume":"137","author":"AB O'Connor","year":"2008","journal-title":"Pain"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1191\/135248506ms1320oa","article-title":"Sleep and fatigue in multiple sclerosis","volume":"12","author":"BR Stanton","year":"2006","journal-title":"Mult Scler"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/JNN.0b013e3181b6be96","article-title":"The impact of pain and other symptoms on quality of life in women with relapsing-remitting multiple sclerosis","volume":"41","author":"PK Newland","year":"2009","journal-title":"J Neurosci Nurs"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.4088\/JCP.11093nr1c","article-title":"Identifying and treating pain caused by MS","volume":"73","author":"LJ Wright","year":"2012","journal-title":"J Clin Psychiatry"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1034\/j.1600-0404.2003.00166.x","article-title":"Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners","volume":"108","author":"AC Janssens","year":"2003","journal-title":"Acta Neurol Scand"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S1474-4422(05)70166-6","article-title":"Quality of life and its assessment in multiple sclerosis: integrating physical and psychological components of wellbeing","volume":"4","author":"AJ Mitchell","year":"2005","journal-title":"Lancet Neurol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jns.2011.12.013","article-title":"Polysomnographic measures of disturbed sleep are associated with reduced quality of life in multiple sclerosis","volume":"316","author":"DA Trojan","year":"2012","journal-title":"J Neurol Sci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1177\/1352458509354551","article-title":"Sleep disturbance and fatigue in mild relapsing remitting multiple sclerosis patients on chronic immunomodulant therapy: an actigraphic study","volume":"16","author":"L Mendozzi","year":"2010","journal-title":"Mult Scler"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.clineuro.2010.12.013","article-title":"Injection of interferon-beta in the morning decreases flu-like syndrome in many patients with multiple sclerosis","volume":"113","author":"Y Nadjar","year":"2011","journal-title":"Clin Neurol Neurosurg"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1212\/WNL.46.1.12","article-title":"Management of patients receiving interferon beta-1b for multiple sclerosis: report of a consensus conference","volume":"46","author":"FD Lublin","year":"1996","journal-title":"Neurology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0049996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T23:36:32Z","timestamp":1594856192000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0049996"}},"subtitle":[],"editor":[{"given":"Friedemann","family":"Paul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,14]]},"references-count":45,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0049996","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,14]]}}}