{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:30:03Z","timestamp":1791286203115,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T00:00:00Z","timestamp":1354060800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0050208","type":"journal-article","created":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T21:55:58Z","timestamp":1354139758000},"page":"e50208","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":71,"title":["Placental Growth Factor for the Prediction of Adverse Outcomes in Patients with Suspected Preeclampsia or Intrauterine Growth Restriction"],"prefix":"10.1371","volume":"7","author":[{"given":"Jeanne","family":"Sibiude","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Guibourdenche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Danielle","family":"Dionne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Le Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Anselem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Serreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Goffinet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis","family":"Tsatsaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/j.semperi.2009.02.010","article-title":"The global impact of pre-eclampsia and eclampsia","volume":"33","author":"L Duley","year":"2009","journal-title":"Semin Perinatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/ajh.2008.20","article-title":"Secular trends in the rates of preeclampsia, eclampsia, and gestational hypertension, United States, 1987\u20132004","volume":"21","author":"AB Wallis","year":"2008","journal-title":"Am J Hypertens"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0140-6736(06)68397-9","article-title":"WHO analysis of causes of maternal death: a systematic review","volume":"367","author":"KS Khan","year":"2006","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0140-6736(00)03599-6","article-title":"Primary, secondary, and tertiary prevention of pre-eclampsia","volume":"357","author":"G Dekker","year":"2001","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"465 e461","DOI":"10.1016\/j.ajog.2011.06.062","article-title":"Benefits and risks of expectant management of severe preeclampsia at less than 26 weeks gestation: the impact of gestational age and severe fetal growth restriction","volume":"205","author":"J Belghiti","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1053\/j.semperi.2009.02.002","article-title":"Expectant management in pregnancies with severe pre-eclampsia","volume":"33","author":"B Haddad","year":"2009","journal-title":"Semin Perinatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ajog.2006.02.012","article-title":"Prediction of maternal complications and adverse infant outcome at admission for temporizing management of early-onset severe hypertensive disorders of pregnancy","volume":"195","author":"W Ganzevoort","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"ref8","first-page":"1070","article-title":"Aggressive or expectant management for patients with severe preeclampsia between 28\u201334 weeks' gestation: a randomized controlled trial","volume":"76","author":"HJ Odendaal","year":"1990","journal-title":"Obstet Gynecol"},{"key":"ref9","first-page":"181","article-title":"Diagnosis and management of gestational hypertension and preeclampsia","volume":"102","author":"BM Sibai","year":"2003","journal-title":"Obstet Gynecol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ajog.2011.07.017","article-title":"Evaluation and management of severe preeclampsia before 34 weeks' gestation","volume":"205","author":"BM Sibai","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1471-0528.2006.00908.x","article-title":"Accuracy of serum uric acid in predicting complications of pre-eclampsia: a systematic review","volume":"113","author":"S Thangaratinam","year":"2006","journal-title":"Bjog"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1741-7015-7-10","article-title":"Estimation of proteinuria as a predictor of complications of pre-eclampsia: a systematic review","volume":"7","author":"S Thangaratinam","year":"2009","journal-title":"BMC Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1471-0528.2000.tb11690.x","article-title":"How useful is uterine artery Doppler flow velocimetry in the prediction of pre-eclampsia, intrauterine growth retardation and perinatal death? An overview","volume":"107","author":"PF Chien","year":"2000","journal-title":"Bjog"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"326 e321","DOI":"10.1016\/j.ajog.2006.11.002","article-title":"Identification of patients at risk for early onset and\/or severe preeclampsia with the use of uterine artery Doppler velocimetry and placental growth factor","volume":"196","author":"J Espinoza","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/GRF.0b013e3181fbb5f5","article-title":"Evidence-based approach to umbilical artery Doppler fetal surveillance in high-risk pregnancies: an update","volume":"53","author":"D Maulik","year":"2010","journal-title":"Clin Obstet Gynecol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1067\/mob.2000.103890","article-title":"Can antenatal clinical and biochemical markers predict the development of severe preeclampsia?","volume":"182","author":"DM Stamilio","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(10)61351-7","article-title":"Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model","volume":"377","author":"P von Dadelszen","year":"2011","journal-title":"Lancet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/j.1471-0528.2000.tb11617.x","article-title":"Expectant management of early onset, severe pre-eclampsia: perinatal outcome","volume":"107","author":"DR Hall","year":"2000","journal-title":"Bjog"},{"key":"ref19","article-title":"Admission uric acid levels and length of expectant management in preterm preeclampsia","author":"AC Urato","year":"2011","journal-title":"J Perinatol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)71003-5","article-title":"Pre-eclampsia","volume":"365","author":"B Sibai","year":"2005","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1210\/jc.2003-030528","article-title":"Overexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: pathophysiological consequences","volume":"88","author":"V Tsatsaris","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/10641950802419895","article-title":"Serum sFlt1:PlGF ratio, PlGF, and soluble endoglin levels in gestational proteinuria","volume":"28","author":"A Ohkuchi","year":"2009","journal-title":"Hypertens Pregnancy"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1210\/jc.2004-1955","article-title":"Soluble fms-like tyrosine kinase 1 is increased in preeclampsia but not in normotensive pregnancies with small-for-gestational-age neonates: relationship to circulating placental growth factor","volume":"90","author":"E Shibata","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"RJ Levine","year":"2004","journal-title":"N Engl J Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/CIRCULATIONAHA.111.054361","article-title":"Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia","volume":"125","author":"S Rana","year":"2012","journal-title":"Circulation"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1471-0528.1994.tb13007.x","article-title":"Charts of fetal size: 2. Head measurements","volume":"101","author":"LS Chitty","year":"1994","journal-title":"Br J Obstet Gynaecol"},{"key":"ref27","first-page":"159","article-title":"Diagnosis and management of preeclampsia and eclampsia","volume":"99","year":"2002","journal-title":"Obstet Gynecol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1542\/peds.32.5.793","article-title":"Intrauterine Growth as Estimated from Liveborn Birth-Weight Data at 24 to 42 Weeks of Gestation","volume":"32","author":"LO Lubchenco","year":"1963","journal-title":"Pediatrics"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.preghy.2011.08.117","article-title":"A single rapid point-of-care placental growth factor determination as an aid in the diagnosis of preeclampsia","volume":"2","author":"U Knudsen","year":"2012","journal-title":"Pregnancy Hypertension"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1111\/j.1600-0412.2011.01186.x","article-title":"A longitudinal study of plasma levels of soluble fms-like tyrosine kinase 1 (sFlt1), placental growth factor (PlGF), sFlt1: PlGF ratio and vascular endothelial growth factor (VEGF-A) in normal pregnancy","volume":"90","author":"M Palm","year":"2011","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref31","unstructured":"StataCorporation. (2009) Stata 11.0 for Windows. . College Station, Texas : Stata Corporation."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/14767050802034545","article-title":"The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age","volume":"21","author":"O Erez","year":"2008","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref33","article-title":"Angiogenic Factors and Pregnant Woman with New Onset Seizures","author":"H Quant","year":"2012","journal-title":"Hypertens Pregnancy"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ajog.2005.08.034","article-title":"Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis","volume":"194","author":"H Masuyama","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3109\/14767050903184207","article-title":"The use of angiogenic biomarkers to differentiate non-HELLP related thrombocytopenia from HELLP syndrome","volume":"23","author":"B Young","year":"2011","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/uog.7628","article-title":"Hypertensive disorders in pregnancy: screening by biophysical and biochemical markers at 11\u201313 weeks","volume":"35","author":"LC Poon","year":"2010","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3109\/14767050902994754","article-title":"A prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia","volume":"22","author":"JP Kusanovic","year":"2009","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1161\/HYPERTENSIONAHA.111.179069","article-title":"Midgestation maternal serum 25-hydroxyvitamin D level and soluble fms-like tyrosine kinase 1\/placental growth factor ratio as predictors of severe preeclampsia","volume":"58","author":"PC Woodham","year":"2011","journal-title":"Hypertension"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1161\/CIRCULATIONAHA.109.895458","article-title":"Prospective study of placental angiogenic factors and maternal vascular function before and after preeclampsia and gestational hypertension","volume":"122","author":"M Noori","year":"2010","journal-title":"Circulation"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/00016340903289892","article-title":"Maternal serum placental growth factor and soluble fms-like tyrosine kinase 1 as early predictors of preeclampsia","volume":"89","author":"M Shokry","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/14767050701830480","article-title":"A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate","volume":"21","author":"R Romero","year":"2008","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.3109\/14767058.2011.589932","article-title":"Maternal plasma concentrations of angiogenic\/anti-angiogenic factors are of prognostic value in patients presenting to the obstetrical triage area with the suspicion of preeclampsia","volume":"24","author":"T Chaiworapongsa","year":"2011","journal-title":"J Matern Fetal Neonatal Med"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0050208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T03:34:06Z","timestamp":1714620846000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0050208"}},"subtitle":[],"editor":[{"given":"Cees","family":"Oudejans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,28]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0050208","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,28]]}}}