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In: Crespo Le\u00f3n F, editor. Brucelosis ovina y caprina. Paris: Office International des Epizooties. 117\u2013134."},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Madkour MM (2001) Epidemiological aspects. In: Madkour MM, editor. Madkou\u0155s Brucellosis. 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