{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:09:31Z","timestamp":1791407371233,"version":"4.3.3"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"DOI":"10.1371\/journal.pone.0050444","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T23:02:24Z","timestamp":1353538944000},"page":"e50444","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":59,"title":["Human Neural Progenitor Cell Engraftment Increases Neurogenesis and Microglial Recruitment in the Brain of Rats with Stroke"],"prefix":"10.1371","volume":"7","author":[{"given":"Zahra","family":"Hassani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"O'Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yewande","family":"Pearse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Stroemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sinden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Thuret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,11,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1161\/CIRCULATIONAHA.109.192667","article-title":"Heart disease and stroke statistics\u20132010 update: a report from the American Heart Association","volume":"121","author":"D Lloyd-Jones","year":"2010","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e478","DOI":"10.1161\/CIRCULATIONAHA.107.181486","article-title":"Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association\/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists","volume":"115","author":"HP Adams Jr","year":"2007","journal-title":"Circulation"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.expneurol.2005.12.011","article-title":"A conditionally immortal clonal stem cell line from human cortical neuroepithelium for the treatment of ischemic stroke","volume":"199","author":"K Pollock","year":"2006","journal-title":"Exp Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1177\/1545968309335978","article-title":"The neural stem cell line CTX0E03 promotes behavioral recovery and endogenous neurogenesis after experimental stroke in a dose-dependent fashion","volume":"23","author":"P Stroemer","year":"2009","journal-title":"Neurorehabil Neural Repair"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2202-10-86","article-title":"c-MycERTAM transgene silencing in a genetically modified human neural stem cell line implanted into MCAo rodent brain","volume":"10","author":"L Stevanato","year":"2009","journal-title":"BMC Neurosci"},{"key":"ref6","first-page":"464","article-title":"Release of VEGF by ReN001 cortical stem cells","volume":"17","author":"D Eve","year":"2008","journal-title":"Cell Transplantation"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0166-4328(00)00160-1","article-title":"Conditional discrimination learning in rats with global ischaemic brain damage","volume":"111","author":"M Modo","year":"2000","journal-title":"Behav Brain Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1523\/JNEUROSCI.5060-06.2007","article-title":"The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells","volume":"27","author":"TL Walker","year":"2007","journal-title":"J? Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/hipo.20550","article-title":"Hippocampus-dependent learning is associated with adult neurogenesis in MRL\/MpJ mice","volume":"19","author":"S Thuret","year":"2009","journal-title":"Hippocampus"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2818.1987.tb02837.x","article-title":"The efficiency of systematic sampling in stereology and its prediction","volume":"147","author":"HJ Gundersen","year":"1987","journal-title":"J? Microsc"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nm747","article-title":"Neuronal replacement from endogenous precursors in the adult brain after stroke","volume":"8","author":"A Arvidsson","year":"2002","journal-title":"Nat Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1634\/stemcells.2005-0281","article-title":"Persistent production of neurons from adult brain stem cells during recovery after stroke","volume":"24","author":"P Thored","year":"2006","journal-title":"Stem Cells"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1057\/biosoc.2011.6","article-title":"Reconstructing brains: A biological impossibility","volume":"6","author":"J Price","year":"2001","journal-title":"Biosocieties"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e43779","DOI":"10.1371\/journal.pone.0043779","article-title":"Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell proliferation and attenuate behavioral deficits in ischemic stroke rats","volume":"7","author":"N Tajiri","year":"2012","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e8809","DOI":"10.1371\/journal.pone.0008809","article-title":"Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years","volume":"5","author":"R Knoth","year":"2010","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.expneurol.2008.08.006","article-title":"Retinoic acid and environmental enrichment alter subventricular zone and striatal neurogenesis after stroke","volume":"214","author":"JM Plane","year":"2008","journal-title":"Exp Neurol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1523\/JNEUROSCI.4969-06.2007","article-title":"Neuroblast division during migration toward the ischemic striatum: a study of dynamic migratory and proliferative characteristics of neuroblasts from the subventricular zone","volume":"27","author":"RL Zhang","year":"2007","journal-title":"J? Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"13632","DOI":"10.1073\/pnas.2234031100","article-title":"Inflammation is detrimental for neurogenesis in adult brain","volume":"100","author":"CT Ekdahl","year":"2003","journal-title":"Proc Natl Acad Sci? U? S? A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0165-2478(91)90022-3","article-title":"The CNS acute inflammatory response to excitotoxic neuronal cell death","volume":"30","author":"PB Andersson","year":"1991","journal-title":"Immunol Lett"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1289\/ehp.6361","article-title":"Parkinson&apos;s disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation","volume":"111","author":"B Liu","year":"2003","journal-title":"Environ Health Perspect"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0301-0082(98)00034-3","article-title":"Inflammation and glial responses in ischemic brain lesions","volume":"56","author":"G Stoll","year":"1998","journal-title":"Prog Neurobiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/jnr.21585","article-title":"Inflammation: a new candidate in modulating adult neurogenesis","volume":"86","author":"S Das","year":"2008","journal-title":"J? Neurosci Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1179\/016164107X208086","article-title":"Immature and mature neurons coexist among glial scars after rat traumatic brain injury","volume":"29","author":"T Itoh","year":"2007","journal-title":"Neurol Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"6071","DOI":"10.1523\/JNEUROSCI.22-14-06071.2002","article-title":"The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury","volume":"22","author":"A Basu","year":"2002","journal-title":"J? Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.neuroscience.2008.06.052","article-title":"Brain inflammation and adult neurogenesis: the dual role of microglia","volume":"158","author":"CT Ekdahl","year":"2009","journal-title":"Neuroscience"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1161\/STROKEAHA.107.488445","article-title":"Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke","volume":"38","author":"P Thored","year":"2007","journal-title":"Stroke"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1523\/JNEUROSCI.5360-06.2007","article-title":"Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain","volume":"27","author":"M Lalancette-Hebert","year":"2007","journal-title":"J? Neurosci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e373","DOI":"10.1371\/journal.pone.0000373","article-title":"Neurosphere-derived cells exert a neuroprotective action by changing the ischemic microenvironment","volume":"2","author":"C Capone","year":"2007","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1161\/STROKEAHA.109.573691","article-title":"Human neural stem cell grafts modify microglial response and enhance axonal sprouting in neonatal hypoxic-ischemic brain injury","volume":"41","author":"MM Daadi","year":"2010","journal-title":"Stroke"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0050444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T12:15:09Z","timestamp":1589026509000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0050444"}},"subtitle":[],"editor":[{"given":"Cesar V.","family":"Borlongan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,21]]},"references-count":29,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0050444","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,21]]}}}