{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:29:45Z","timestamp":1782995385290,"version":"3.54.5"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T00:00:00Z","timestamp":1354233600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0050947","type":"journal-article","created":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T22:35:35Z","timestamp":1354314935000},"page":"e50947","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Saccadic Eye Movement Characteristics in Adult Niemann-Pick Type C Disease: Relationships with Disease Severity and Brain Structural Measures"],"prefix":"10.1371","volume":"7","author":[{"given":"Larry A.","family":"Abel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Velakoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Fahey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Desmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Macfarlane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey Chee Leong","family":"Looi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Adamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Walterfang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,11,30]]},"reference":[{"key":"ref1","first-page":"120","article-title":"The adult form of Niemann\u2013Pick disease type C. Brain","volume":"130","author":"M Sevin","year":"2007"},{"key":"ref2","first-page":"1","article-title":"Niemann-Pick disease type C. Orphanet Journal of Rare Diseases","volume":"5","author":"MT Vanier","year":"2010"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1749-6632.1997.tb48641.x","article-title":"Transforming sensory perceptions into motor commands: evidence from programming of eye movements","volume":"835","author":"RJ Leigh","year":"1997","journal-title":"Annals of the New York Academy of Sciences"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1016\/S0042-6989(96)00066-1","article-title":"Evidence for independent feedback control of horizontal and vertical saccades from Niemann-Pick type C disease","volume":"37","author":"KG Rottach","year":"1997","journal-title":"Vision Research"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1196\/annals.1325.041","article-title":"Niemann-Pick Type C disease in two affected sisters: Ocular motor recordings and brain-stem neuropathology","volume":"1039","author":"D Solomon","year":"2005","journal-title":"Annals of the New York Academy of Sciences"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1109\/TBME.1985.325586","article-title":"On the identification and analysis of saccadic eye movements\u2013A quantitative study of the processing procedures","volume":"BME-32","author":"P Inchingolo","year":"1985","journal-title":"IEEE Transactions on Biomedical Engineering"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1474-4422(07)70194-1","article-title":"Miglustat for treatment of Niemann-Pick C disease: a randomised controlled study","volume":"6","author":"MC Patterson","year":"2007","journal-title":"Lancet Neurology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ymgme.2009.10.180","article-title":"Eye movement and diffusion tensor imaging analysis of treatment effects in a Niemann-Pick Type C patient","volume":"99","author":"M Sheel","year":"2010","journal-title":"Molecular Genetics and Metabolism"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1176\/jnp.2006.18.2.158","article-title":"The neuropsychiatry of Niemann-Pick Type C disease in adulthood","volume":"18","author":"M Walterfang","year":"2006","journal-title":"The Journal of Neuropsychiatry and Clinical Neurosciences"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1093\/brain\/awg148","article-title":"Decisional role of the dorsolateral prefrontal cortex in ocular motor behaviour","volume":"126","author":"C Pierrot-Deseilligny","year":"2003","journal-title":"Brain"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1196\/annals.1325.023","article-title":"The role of the human dorsolateral prefrontal cortex in ocular motor behavior","volume":"1039","author":"C Pierrot-Deseilligny","year":"2005","journal-title":"Annals of the New York Academy of Sciences"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000057702","article-title":"Effects of stimulus predictability and interstimulus gap on saccades in Alzheimer\u2019s disease","volume":"13","author":"LA Abel","year":"2002","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1068\/p230045","article-title":"Saccadic eye movements of dyslexic and normal reading children","volume":"23","author":"M Biscaldi","year":"1994","journal-title":"Perception"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1001\/archneur.1991.00530180102024","article-title":"Validation of a clinical antisaccadic eye movement test in the assessment of dementia","volume":"48","author":"J Currie","year":"1991","journal-title":"Archives of Neurology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/0006-3223(88)90050-9","article-title":"Disturbances of voluntary control of saccadic eye movements in schizophrenic patients","volume":"23","author":"J Fukushima","year":"1988","journal-title":"Biological Psychiatry"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1093\/brain\/124.10.2045","article-title":"Control of volitional and reflexive saccades in Tourette\u2019s syndrome","volume":"124","author":"LA LeVasseur","year":"2001","journal-title":"Brain"},{"key":"ref17","first-page":"32","article-title":"The antisaccade task and neuropsychological tests of prefrontal cortical integrity in schizophrenia: empirical findins and interpretative considerations","volume":"3","author":"DL Levy","year":"2004","journal-title":"World Psychiatry"},{"key":"ref18","first-page":"186","article-title":"Saccadic control and cognitive function after traumatic brain injury","volume":"4","author":"IM Williams","year":"1997","journal-title":"Journal of Clinical Neuroscience"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00019052-200402000-00005","article-title":"Eye movement control by the cerebral cortex","volume":"17","author":"C Pierrot-Deseilligny","year":"2004","journal-title":"Current Opinion in Neurology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s002210050557","article-title":"Cortical control of saccades","volume":"123","author":"B Gaymard","year":"1998","journal-title":"Experimental Brain Research"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0304-3940(02)00517-7","article-title":"Relationship between brain structure and saccadic eye movements in healthy humans","volume":"328","author":"U Ettinger","year":"2002","journal-title":"Neuroscience Letters"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1152\/jn.1998.80.4.1911","article-title":"Effects of lesions of the oculomotor vermis on eye movements in primate: Saccades","volume":"80","author":"M Takagi","year":"1998","journal-title":"Journal of Neurophysiology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/jnnp.58.1.91","article-title":"Horizontal eye movement disorders after posterior vermis infarctions","volume":"58","author":"K Vahedi","year":"1995","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1212\/01.wnl.0000345040.01917.9d","article-title":"Saccades in adult Niemann-Pick disease type C reflect frontal, brainstem, and biochemical deficits","volume":"72","author":"LA Abel","year":"2009","journal-title":"Neurology"},{"key":"ref25","first-page":"462","article-title":"Pontine-to-midbrain ratio indexes ocular-motor function and illness stage in adult Niemann\u2013Pick disease type C. European Journal of Neurology","volume":"19","author":"M Walterfang","year":"2012"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jns.2006.05.054","article-title":"Niemann-Pick C disease in Spain: Clinical spectrum and development of a disability scale","volume":"249","author":"C Iturriaga","year":"2006","journal-title":"Journal of Neurological Sciences"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1080\/j.1440-1614.2006.01923.x","article-title":"The NUCOG: validity and reliability of a brief cognitive screening tool in neuropsychiatric patients","volume":"40","author":"M Walterfang","year":"2006","journal-title":"The Australian and New Zealand journal of psychiatry"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuroimage.2009.01.045","article-title":"A probabilistic MR atlas of the human cerebellum","volume":"46","author":"J Diedrichsen","year":"2009","journal-title":"NeuroImage"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/cercor\/5.4.323","article-title":"Cytoarchitectonic Definition of Prefrontal Areas in the Normal Human Cortex: II. Variability in Locations of Areas 9 and 46 and Relationship to the Talairach Coordinate System","volume":"5","author":"G Rajkowska","year":"1995","journal-title":"Cerebral Cortex"},{"key":"ref30","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"S Holm","year":"1979","journal-title":"Scandinavian Journal of Statistics"},{"key":"ref31","first-page":"10","article-title":"What clinical disorders tell us about the neural control of saccadic eye movements","volume":"1)","author":"S Ramat","year":"2007","journal-title":"Brain 130(Pt"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1111\/j.1467-8624.2004.00745.x","article-title":"Maturation of cognitive processes from late childhood to adulthood","volume":"75","author":"B Luna","year":"2004","journal-title":"Child Development"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0925-4439(91)90069-L","article-title":"Type C Niemann-Pick disease: spectrum of phenotypic variation in disruption of intracellular LDL-derived cholesterol processing","volume":"1096","author":"MT Vanier","year":"1991","journal-title":"Biochimica et Biophysica Acta"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"56ra81","DOI":"10.1126\/scitranslmed.3001417","article-title":"Cholesterol Oxidation Products Are Sensitive and Specific Blood-Based Biomarkers for Niemann-Pick C1 Disease","volume":"2","author":"FD Porter","year":"2010","journal-title":"Science Translational Medicine"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1093\/brain\/awn047","article-title":"Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer\u2019s disease","volume":"131","author":"S Garbutt","year":"2008","journal-title":"Brain"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0050947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T08:36:40Z","timestamp":1562402200000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0050947"}},"subtitle":[],"editor":[{"given":"Susana","family":"Martinez-Conde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,30]]},"references-count":35,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0050947","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,30]]}}}