{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:44:17Z","timestamp":1791438257568,"version":"4.3.3"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T00:00:00Z","timestamp":1354233600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0050976","type":"journal-article","created":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T22:44:53Z","timestamp":1354315493000},"page":"e50976","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":296,"title":["Expression of Novel Alzheimer\u2019s Disease Risk Genes in Control and Alzheimer\u2019s Disease Brains"],"prefix":"10.1371","volume":"7","author":[{"given":"Celeste M.","family":"Karch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda T.","family":"Jeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Nowotny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Cady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cruchaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison M.","family":"Goate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,11,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ajhg.2008.10.008","article-title":"Genome-wide association analysis reveals putative Alzheimer&apos;s disease susceptibility loci in addition to APOE","volume":"83","author":"L Bertram","year":"2008","journal-title":"American journal of human genetics"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4088\/JCP.v68n0419","article-title":"A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer&apos;s disease","volume":"68","author":"KD Coon","year":"2007","journal-title":"The Journal of clinical psychiatry"},{"key":"ref3","first-page":"1034","article-title":"Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage","volume":"48","author":"MA Pericak-Vance","year":"1991","journal-title":"American journal of human genetics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"9649","DOI":"10.1073\/pnas.90.20.9649","article-title":"Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease","volume":"90","author":"DE Schmechel","year":"1993","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1001\/archneurol.2010.201","article-title":"Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes","volume":"67","author":"G Jun","year":"2010","journal-title":"Archives of neurology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1001\/jama.2010.574","article-title":"Genome-wide analysis of genetic loci associated with Alzheimer disease","volume":"303","author":"S Seshadri","year":"2010","journal-title":"JAMA : the journal of the American Medical Association"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer&apos;s disease","volume":"41","author":"D Harold","year":"2009","journal-title":"Nat Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer&apos;s disease","volume":"41","author":"J-C Lambert","year":"2009","journal-title":"Nature Genetics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer&apos;s disease","volume":"43","author":"P Hollingworth","year":"2011","journal-title":"Nature genetics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer&apos;s disease","volume":"43","author":"AC Naj","year":"2011","journal-title":"Nature genetics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"H Braak","year":"1991","journal-title":"Acta neuropathologica"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"H Braak","year":"2006","journal-title":"Acta neuropathologica"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules","volume":"43","author":"JC Morris","year":"1993","journal-title":"Neurology"},{"key":"ref14","unstructured":"Muller PY, Janovjak H, Miserez AR, Dobbie Z (2002) Processing of gene expression data generated by quantitative real-time RT-PCR. BioTechniques 32: 1372\u20131374, 1376, 1378\u20131379."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/ng.2007.16","article-title":"A survey of genetic human cortical gene expression","volume":"39","author":"AJ Myers","year":"2007","journal-title":"Nature Genetics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"11590","DOI":"10.1074\/jbc.M209233200","article-title":"Synthesis and functional analyses of nuclear clusterin, a cell death protein","volume":"278","author":"KS Leskov","year":"2003","journal-title":"The Journal of biological chemistry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/25393","article-title":"Crystal structure of the ATP-binding subunit of an ABC transporter","volume":"396","author":"LW Hung","year":"1998","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0005-2736(99)00161-3","article-title":"An inventory of the human ABC proteins","volume":"1461","author":"I Klein","year":"1999","journal-title":"Biochimica et biophysica acta"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nsmb836","article-title":"The ATP switch model for ABC transporters","volume":"11","author":"CF Higgins","year":"2004","journal-title":"Nature structural & molecular biology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S1388-1981(00)00053-6","article-title":"ABC transporters in lipid transport","volume":"1486","author":"P Borst","year":"2000","journal-title":"Biochimica et biophysica acta"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1023\/A:1012823120935","article-title":"Complete characterization of the human ABC gene family","volume":"33","author":"M Dean","year":"2001","journal-title":"Journal of bioenergetics and biomembranes"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev.biochem.71.102301.093055","article-title":"Mammalian ABC transporters in health and disease","volume":"71","author":"P Borst","year":"2002","journal-title":"Annual review of biochemistry"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00795-004-0278-8","article-title":"ABC proteins: key molecules for lipid homeostasis","volume":"38","author":"K Takahashi","year":"2005","journal-title":"Medical molecular morphology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.febslet.2005.11.056","article-title":"The multidrug resistance-associated protein (MRP\/ABCC) subfamily of ATP-binding cassette transporters in plants","volume":"580","author":"M Klein","year":"2006","journal-title":"FEBS letters"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1097\/01.wnr.0000221833.41340.cd","article-title":"Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells","volume":"17","author":"WS Kim","year":"2006","journal-title":"Neuroreport"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.200601030","article-title":"ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages","volume":"174","author":"AW Jehle","year":"2006","journal-title":"The Journal of cell biology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1128\/MCB.23.12.4295-4306.2003","article-title":"Targeted disruption of the murine Bin1\/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation","volume":"23","author":"AJ Muller","year":"2003","journal-title":"Molecular and cellular biology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1101\/gad.207801","article-title":"Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila","volume":"15","author":"A Razzaq","year":"2001","journal-title":"Genes & development"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"7605","DOI":"10.1158\/0008-5472.CAN-07-1100","article-title":"Bin1 ablation increases susceptibility to cancer during aging, particularly lung cancer","volume":"67","author":"MY Chang","year":"2007","journal-title":"Cancer research"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1023\/A:1018588526788","article-title":"The potential role of sialoadhesin as a macrophage recognition molecule in health and disease","volume":"14","author":"PR Crocker","year":"1997","journal-title":"Glycoconjugate journal"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1128\/MCB.00383-07","article-title":"Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity","volume":"27","author":"H Tateno","year":"2007","journal-title":"Molecular and cellular biology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/01.wad.0000165506.60370.94","article-title":"Complement activation in very early Alzheimer disease","volume":"19","author":"H Zanjani","year":"2005","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1042\/bst0260049","article-title":"Therapeutic uses of recombinant complement receptors","volume":"26","author":"BP Morgan","year":"1998","journal-title":"Biochemical Society transactions"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"15953","DOI":"10.1021\/bi002189x","article-title":"Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state","volume":"39","author":"S Poon","year":"2000","journal-title":"Biochemistry"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1167\/iovs.05-1580","article-title":"Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material","volume":"47","author":"M Zenkel","year":"2006","journal-title":"Investigative ophthalmology & visual science"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"11030","DOI":"10.1016\/S0021-9258(18)99123-4","article-title":"Clusterin (complement lysis inhibitor) forms a high density lipoprotein complex with apolipoprotein A-I in human plasma","volume":"266","author":"DE Jenne","year":"1991","journal-title":"The Journal of biological chemistry"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/1097-0029(20000815)50:4<305::AID-JEMT10>3.0.CO;2-L","article-title":"Apolipoprotein J (clusterin) and Alzheimer&apos;s disease","volume":"50","author":"M Calero","year":"2000","journal-title":"Microscopy research and technique"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0014-5793(92)80330-J","article-title":"SP-40,40, a protein involved in the control of the complement pathway, possesses a unique array of disulphide bridges","volume":"297","author":"L Kirszbaum","year":"1992","journal-title":"FEBS letters"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jmb.2007.02.095","article-title":"The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species","volume":"369","author":"JR Kumita","year":"2007","journal-title":"Journal of molecular biology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1096\/fj.06-7986com","article-title":"The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures","volume":"21","author":"JJ Yerbury","year":"2007","journal-title":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0896-6273(03)00850-X","article-title":"ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo","volume":"41","author":"RB DeMattos","year":"2004","journal-title":"Neuron"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"10843","DOI":"10.1073\/pnas.162228299","article-title":"Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer&apos;s disease","volume":"99","author":"RB Demattos","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e9369","DOI":"10.1371\/journal.pone.0009369","article-title":"Phylogenetic analysis of the MS4A and TMEM176 gene families","volume":"5","author":"J Zuccolo","year":"2010","journal-title":"PloS one"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e15918","DOI":"10.1371\/journal.pone.0015918","article-title":"Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer&apos;s disease","volume":"6","author":"JSK Kauwe","year":"2011","journal-title":"PLoS ONE"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0092-8674(00)81608-6","article-title":"A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts","volume":"94","author":"ML Dustin","year":"1998","journal-title":"Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1128\/MCB.23.14.4917-4928.2003","article-title":"Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling","volume":"23","author":"TB Huber","year":"2003","journal-title":"Molecular and cellular biology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"37004","DOI":"10.1074\/jbc.M403534200","article-title":"A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis","volume":"279","author":"M Schiffer","year":"2004","journal-title":"The Journal of biological chemistry"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1034\/j.1600-0854.2003.40205.x","article-title":"CD2AP\/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl","volume":"4","author":"M Cormont","year":"2003","journal-title":"Traffic"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1096\/fj.03-0767fje","article-title":"The c-Cbl\/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1)","volume":"18","author":"S Kobayashi","year":"2004","journal-title":"The FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"21805","DOI":"10.1074\/jbc.M211407200","article-title":"A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton","volume":"278","author":"DK Lynch","year":"2003","journal-title":"The Journal of biological chemistry"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"10257","DOI":"10.1523\/JNEUROSCI.2471-08.2008","article-title":"Clathrin assembly protein AP180 and CALM differentially control axogenesis and dendrite outgrowth in embryonic hippocampal neurons","volume":"28","author":"I Bushlin","year":"2008","journal-title":"The Journal of neuroscience : the official journal of the Society for Neuroscience"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S1357-2725(02)00096-1","article-title":"Eph receptors and ephrins","volume":"35","author":"JP Himanen","year":"2003","journal-title":"The international journal of biochemistry & cell biology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nrm856","article-title":"Mechanisms and functions of Eph and ephrin signalling","volume":"3","author":"K Kullander","year":"2002","journal-title":"Nature reviews Molecular cell biology"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nrm1662","article-title":"Eph receptor signalling casts a wide net on cell behaviour","volume":"6","author":"EB Pasquale","year":"2005","journal-title":"Nature reviews Molecular cell biology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0074-7696(00)96005-4","article-title":"Eph receptors and ephrins: regulators of guidance and assembly","volume":"196","author":"DG Wilkinson","year":"2000","journal-title":"International review of cytology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.devcel.2004.09.006","article-title":"Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly","volume":"7","author":"A Poliakov","year":"2004","journal-title":"Developmental cell"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.cellsig.2003.10.006","article-title":"Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins","volume":"16","author":"NK Noren","year":"2004","journal-title":"Cellular signalling"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0050976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T19:42:15Z","timestamp":1643744535000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0050976"}},"subtitle":[],"editor":[{"given":"Stephen D.","family":"Ginsberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,11,30]]},"references-count":57,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,11,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0050976","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,30]]}}}