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(2012) Specific versus non-specific immune responses in an invertebrate species evidenced by a comparative de novo sequencing study. PLoS One 7. doi:10.1371\/journal.pone.0032512.","DOI":"10.1371\/journal.pone.0032512"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"e550","DOI":"10.1371\/journal.pntd.0000550","article-title":"Role of the endogenous antioxidant system in the protection of <italic>Schistosoma mansoni<\/italic> primary sporocysts against exogenous oxidative stress","volume":"3","author":"M Mourao","year":"2009","journal-title":"PLoS neglected tropical diseases"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.gene.2004.05.019","article-title":"Discovery of genes expressed in response to <italic>Perkinsus marinus<\/italic> challenge in Eastern (<italic>Crassostrea virginica<\/italic>) and Pacific (<italic>C. gigas<\/italic>) oysters","volume":"338","author":"A Tanguy","year":"2004","journal-title":"Gene"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-3305-4-203","article-title":"Insights into the functional biology of schistosomes","volume":"4","author":"A Walker","year":"2011","journal-title":"Parasites & Vectors"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0051102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,7]],"date-time":"2019-07-07T12:03:11Z","timestamp":1562500991000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0051102"}},"subtitle":[],"editor":[{"given":"Geoffrey N.","family":"Gobert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,12,26]]},"references-count":73,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,12,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0051102","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,26]]}}}