{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:16:27Z","timestamp":1791400587646,"version":"4.3.3"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T00:00:00Z","timestamp":1357171200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0051253","type":"journal-article","created":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T19:54:28Z","timestamp":1357242868000},"page":"e51253","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":172,"title":["Intranasal Mesenchymal Stem Cell Treatment for Neonatal Brain Damage: Long-Term Cognitive and Sensorimotor Improvement"],"prefix":"10.1371","volume":"8","author":[{"given":"Vanessa","family":"Donega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy T. J.","family":"van Velthoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora H.","family":"Nijboer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"van Bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martien J. H.","family":"Kas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke","family":"Kavelaars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cobi J.","family":"Heijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,1,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1203\/PDR.0b013e318223f38d","article-title":"Neonatal encephalopathy or hypoxic ischemic encephalopathy? Appropriate terminology matters","volume":"70","author":"O Dammann","year":"2011","journal-title":"Pediatr Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1467-7687.2006.00499.x","article-title":"Brain and cognitive-behavioural development after asphyxia at term birth","volume":"9","author":"M De Haan","year":"2006","journal-title":"Dev Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1056\/NEJMra041996","article-title":"Neonatal brain injury","volume":"351","author":"DM Ferriero","year":"2004","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ajog.2008.06.094","article-title":"A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy","volume":"199","author":"EM Graham","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00431-007-0437-8","article-title":"Long-term cognitive and behavioural consequences of neonatal encephalopathy following perinatal asphyxia: a review","volume":"166","author":"M van Handel","year":"2007","journal-title":"Eur J Pediatr"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/1098-2779(200102)7:1<56::AID-MRDD1008>3.0.CO;2-A","article-title":"Perinatal brain injury: from pathogenesis to neuroprotection","volume":"7","author":"JJ Volpe","year":"2001","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"c363","DOI":"10.1136\/bmj.c363","article-title":"Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data","volume":"340","author":"AD Edwards","year":"2010","journal-title":"BMJ"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","article-title":"Moderate hypothermia to treat perinatal asphyxial encephalopathy","volume":"361","author":"DV Azzopardi","year":"2009","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1203\/PDR.0b013e31821d0d00","article-title":"Baby STEPS: A giant leap for cell therapy in neonatal brain injury","volume":"70","author":"CV Borlongan","year":"2011","journal-title":"Pediatr Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1203\/PDR.0b013e3181bf594b","article-title":"Mesenchymal stem-cell transplantation for hypoxic-ischemic brain injury in neonatal rat model","volume":"67","author":"JA Lee","year":"2010","journal-title":"Pediatr Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1089\/scd.2009.0403","article-title":"Cell therapy for neonatal hypoxic-ischemic encephalopathy","volume":"19","author":"PM Pimentel-Coelho","year":"2010","journal-title":"Stem Cells Dev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/ana.22518","article-title":"Stem cell therapy for neonatal brain injury: perspectives and challenges","volume":"70","author":"L Titomanlio","year":"2011","journal-title":"Ann of Neurol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/pr.2011.64","article-title":"Mesenchymal stem cells as a treatment for neonatal ischemic brain damage","volume":"71","author":"CT van Velthoven","year":"2012","journal-title":"Pediatr Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbi.2009.10.017","article-title":"Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration","volume":"24","author":"CT van Velthoven","year":"2010","journal-title":"Brain Behav Immun"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"9603","DOI":"10.1523\/JNEUROSCI.1835-10.2010","article-title":"Repeated mesenchymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendrocytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function","volume":"30","author":"CT van Velthoven","year":"2010","journal-title":"J Neurosci"},{"key":"ref16","first-page":"419","article-title":"Nasal administration of stem cells: a promising novel route to treat neonatal ischemic brain damage","volume":"68","author":"CT van Velthoven","year":"2010","journal-title":"Pediatr Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3727\/000000006783982034","article-title":"Behavioral and histological characterization of intrahippocampal grafts of human bone marrow-derived multipotent progenitor cells in neonatal rats with hypoxic-ischemic injury","volume":"15","author":"T Yasuhara","year":"2006","journal-title":"Cell Transplant"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1038\/jcbfm.2008.68","article-title":"Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic-ischemic rats","volume":"28","author":"T Yasuhara","year":"2008","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1601-183X.2004.00071.x","article-title":"Automated apparatus for quantitation of social approach behaviors in mice","volume":"3","author":"JJ Nadler","year":"2004","journal-title":"Genes Brain Behav"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1523\/JNEUROSCI.4769-07.2008","article-title":"Low endogenous G-protein-coupled receptor kinase 2 sensitizes the immature brain to hypoxia-ischemia-induced gray and white matter damage","volume":"28","author":"CH Nijboer","year":"2008","journal-title":"J Neurosci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/0145-2126(93)90153-C","article-title":"A novel approach to the measurement of different in vitro leukaemic cell growth parameters: The use of PKH GL fluorescent probes","volume":"17","author":"DM Ashley","year":"1993","journal-title":"Leuk Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1365-2826.2005.01400.x","article-title":"Progesterone Treatment of Adult Male Rats Suppresses Arginine Vasopressin Expression in the Bed Nucleus of the Stria Terminalis and the Centromedial Amygdala","volume":"18","author":"CJ Auger","year":"2005","journal-title":"J of Neuroendoc"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1006\/frne.2002.0229","article-title":"The neuroendocrine basis of social recognition","volume":"23","author":"JN Ferguson","year":"2002","journal-title":"Front Neuroendocrinol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuroscience.2010.12.056","article-title":"Learning and memory consolidation: Linking molecular and behavioural data","volume":"176","author":"I Morgado-Bernal","year":"2011","journal-title":"Neurosci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0051253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T18:20:34Z","timestamp":1540232434000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0051253"}},"subtitle":[],"editor":[{"given":"Olivier","family":"Baud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,3]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0051253","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,3]]}}}