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A light microscopic and Golgi study","volume":"133","author":"L Seress","year":"1981","journal-title":"Journal of anatomy"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1523\/JNEUROSCI.5100-09.2010","article-title":"Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth","volume":"30","author":"S Rauskolb","year":"2010","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/MN:22:1-3:001","article-title":"Dendritic morphogenesis: building an arbor","volume":"22","author":"S McFarlane","year":"2000","journal-title":"Molecular neurobiology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.neuroscience.2010.02.050","article-title":"Exercise and time-dependent benefits to learning and memory","volume":"167","author":"NC Berchtold","year":"2010","journal-title":"Neuroscience"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.neuroscience.2010.03.032","article-title":"Ketamine impairs recognition memory consolidation and prevents learning-induced increase in hippocampal brain-derived neurotrophic factor levels","volume":"167","author":"BK Goulart","year":"2010","journal-title":"Neuroscience"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1055\/s-2008-1071344","article-title":"Elevated CSF glutamate in Rett syndrome","volume":"23","author":"A Hamberger","year":"1992","journal-title":"Neuropediatrics"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1017\/S0317167100052513","article-title":"Rett syndrome: review of biological abnormalities","volume":"28","author":"HG Dunn","year":"2001","journal-title":"Can J Neurol Sci"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0304-3940(89)90826-4","article-title":"Acetyl-L-carnitine enhances acetylcholine release in the striatum and hippocampus of awake freely moving rats","volume":"107","author":"A Imperato","year":"1989","journal-title":"Neuroscience letters"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/0091-3057(91)90233-R","article-title":"Cholinergic activity in the rat hippocampus, cortex and striatum correlates with locomotor activity: an in vivo microdialysis study","volume":"38","author":"J Day","year":"1991","journal-title":"Pharmacol Biochem Behav"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1101\/lm.68104","article-title":"Changes in acetylcholine extracellular levels during cognitive processes","volume":"11","author":"G Pepeu","year":"2004","journal-title":"Learn Mem"},{"key":"ref59","first-page":"401","article-title":"Cholinergic regulation of cortical development and plasticity. 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