{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:07:30Z","timestamp":1761919650927},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T00:00:00Z","timestamp":1355356800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0051645","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T22:03:28Z","timestamp":1355436208000},"page":"e51645","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Retinal Nerve Fibre Layer Thinning in Patients with Clinically Isolated Optic Neuritis and Early Treatment with Interferon-Beta"],"prefix":"10.1371","volume":"7","author":[{"given":"Kurt-Wolfram","family":"S\u00fchs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Hein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens R.","family":"Pehlke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"K\u00e4smann-Kellner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricarda","family":"Diem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,12,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1001\/archneur.62.9.1345","article-title":"Characterizing the mechanisms of progression in multiple sclerosis: evidence and new hypotheses for future directions","volume":"62","author":"EM Frohman","year":"2005","journal-title":"Arch Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/ana.20575","article-title":"Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis","volume":"58","author":"SA Trip","year":"2005","journal-title":"Ann Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s00415-007-0733-2","article-title":"Subgroups of the BENEFIT study: Risk of developing MS and treatment effect of interferon beta 1b","volume":"255","author":"CH Polman","year":"2008","journal-title":"J Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S1474-4422(09)70237-6","article-title":"Long-term effect of early treatment with interferon beta-1b after a first clinical events suggestive of multiple sclerosis: 5-year active treatment extension of the phase 3 BENEFIT trial","volume":"8","author":"L Kappos","year":"2009","journal-title":"Lancet Neurol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1056\/NEJM200009283431301","article-title":"Intramuscular interferon beta1a therapy initiated during a first demyelinating event in multiple sclerosis: CHAMPS study group","volume":"343","author":"LD Jacobs","year":"2000","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/S0140-6736(00)04725-5","article-title":"Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study","volume":"35","author":"G Comi","year":"2001","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S1474-4422(06)70573-7","article-title":"Optical coherence tomography in multiple sclerosis","volume":"5","author":"E Frohman","year":"2006","journal-title":"Lancet Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1212\/01.wnl.0000295995.46586.ae","article-title":"Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis","volume":"69","author":"E Gordon-Lipkin","year":"2007","journal-title":"Neurology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s00415-008-0985-5","article-title":"Optical coherence tomography in multiple sclerosis: Thickness of the retinal nerve fiber layer as a potential measure of axonal loss and brain atrophy","volume":"255","author":"M Siger","year":"2008","journal-title":"J Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1212\/01.wnl.0000260612.51849.ed","article-title":"Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS","volume":"68","author":"J Sepulcre","year":"2007","journal-title":"Neurology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e18132","DOI":"10.1371\/journal.pone.0018132","article-title":"Association of retinal and macular damage with brain atrophy in multiple sclerosis","volume":"6","author":"J D\u00f6rr","year":"2011","journal-title":"PLoS ONE"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jns.2009.04.010","article-title":"Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: A pilot study","volume":"282","author":"EM Frohman","year":"2009","journal-title":"J Neurol Sci"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Zimmermann H, Freing A, Kaufhold F, Gaede G, Bohn E, <etal>et al<\/etal>.. (2012) Optic neuritis interferes with optical coherence tomography and magnetic resonance imaging correlations. Mult Scler Aug 30, epub ahead of print.","DOI":"10.1177\/1352458512457844"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1093\/brain\/awq146","article-title":"A serial study of retinal changes following optic neuritis with sample size estimates for acute neuroprotection trials","volume":"133","author":"AP Henderson","year":"2010","journal-title":"Brain"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ana.23573","article-title":"A randomized, double-blind, phase II study on erythropoietin in optic neuritis","volume":"72","author":"KW S\u00fchs","year":"2012","journal-title":"Ann Neurol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/brain\/121.3.495","article-title":"The prognostic value of brain MRI in clinically isolated syndromes of the CNS: 10-year follow-up","volume":"121","author":"JI ORiordan","year":"1998","journal-title":"Brain"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1212\/01.wnl.0000280576.73609.c6","article-title":"Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis?","volume":"70","author":"M Tintore","year":"2008","journal-title":"Neurology"},{"key":"ref18","first-page":"727","article-title":"Multiple sclerosis risk after optic neuritis: final optic neuritis treatment trial follow-up","volume":"65","year":"2008","journal-title":"Arch Neurol"},{"key":"ref19","first-page":"404","article-title":"Oligoclonal bands predict multiple sclerosis after optic neuritis: a literature survey","volume":"17(4)","author":"AG Skov","year":"2010","journal-title":"Mult Scler"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0967-5868(02)00172-8","article-title":"Decreased amplitudes in multiple sclerosis patients with normal visual acuity: a VEP study","volume":"10","author":"R Diem","year":"2003","journal-title":"J Clin Neurosci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1212\/WNL.0b013e3181aaea32","article-title":"Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis","volume":"73","author":"RT Naismith","year":"2009","journal-title":"Neurology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1093\/brain\/awf235","article-title":"Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time","volume":"125","author":"T Kuhlmann","year":"2002","journal-title":"Brain"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/brain\/awp070","article-title":"The relation between inflammation and neurodegeneration in multiple sclerosis","volume":"132","author":"JM Frischer","year":"2009","journal-title":"Brain"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1046\/j.1471-4159.1997.69030939.x","article-title":"Interferon beta is a potent promoter of nerve growth factor production by astrocytes","volume":"69","author":"T Boutros","year":"1997","journal-title":"J Neurochem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1001\/archneur.62.4.563","article-title":"Interferon beta promotes nerve growth factor secretion early in the course of multiple sclerosis","volume":"62","author":"K Biernacki","year":"2005","journal-title":"Arch Neurol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.brainres.2007.08.055","article-title":"Interferon-beta is neuroprotective against the toxicity induced by activated microglia","volume":"1179","author":"S Jin","year":"2007","journal-title":"Brain Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1177\/1352458506070446","article-title":"Interferon beta-1a slows progression of brain atrophy in relapsing-remitting multiple sclerosis predominantly by reducing gray matter atrophy","volume":"13","author":"R Zivadinov","year":"2007","journal-title":"Mult Scler"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1212\/01.wnl.0000316810.01120.05","article-title":"Mechanisms of action of disease-modifying agents and brain volume changes in multiple sclerosis","volume":"71","author":"R Zivadinov","year":"2008","journal-title":"Neurology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1177\/1352458510365156","article-title":"Time domain and spectral domain optical coherence tomography in multiple sclerosis: a comparative cross-sectional study","volume":"16(7)","author":"M Bock","year":"2010","journal-title":"Mult Scler"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1177\/1352458510371640","article-title":"Reproducibility of high-resolution optical coherence tomography in multiple sclerosis","volume":"16(7)","author":"SB Syc","year":"2010","journal-title":"Mult Scler"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e22947","DOI":"10.1371\/journal.pone.0022947","article-title":"The impact of utilizing different optical coherence tomography devices for clinical purposes and in multiple sclerosis trials","volume":"6(8)","author":"CV Warner","year":"2011","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/ana.22005","article-title":"Longitudinal study of vision and retinal nerve fiber layer thickness in MS","volume":"67","author":"LS Talman","year":"2010","journal-title":"Ann Neurol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e19843","DOI":"10.1371\/journal.pone.0019843","article-title":"High resolution spectral domain optical coherence tomography (SD-OCT) in multiple sclerosis: The first follow up study over two year","volume":"6(5)","author":"N Serbecic","year":"2011","journal-title":"PLoS ONE"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/ana.22554","article-title":"Early factors associated with axonal loss after optic neuritis","volume":"70","author":"APD Henderson","year":"2011","journal-title":"Ann Neurol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1056\/NEJM199202273260901","article-title":"A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis","volume":"326","author":"RW Beck","year":"1992","journal-title":"N Eng J Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1212\/WNL.0b013e3182050388","article-title":"Treatment effects of immunomodulatory therapies at different stages of multiple sclerosis in short-term trials","volume":"76","author":"D Bates","year":"2011","journal-title":"Neurology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1523\/JNEUROSCI.5705-11.2012","article-title":"Preclinical retinal neurodegeneration in a model of multiple sclerosis","volume":"32","author":"R Fairless","year":"2012","journal-title":"J Neurosci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/brain\/awq346","article-title":"Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography","volume":"134","author":"S Saidha","year":"2011","journal-title":"Brain"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1093\/brain\/awq080","article-title":"Ocular pathology in multiple sclerosis: retinal atrophy and inflammation irrespective of disease duration","volume":"133","author":"AJ Green","year":"2010","journal-title":"Brain"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1093\/brain\/aws098","article-title":"Microcystic macular oedema in multiple sclerosis is associated with disease severity","volume":"135","author":"JM Gelfand","year":"2012","journal-title":"Brain"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0051645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T09:11:53Z","timestamp":1714727513000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0051645"}},"subtitle":[],"editor":[{"given":"Ralf Andreas","family":"Linker","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,12,13]]},"references-count":40,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,12,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0051645","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,13]]}}}