{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T03:32:25Z","timestamp":1777087945477,"version":"3.51.4"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T00:00:00Z","timestamp":1357689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0051799","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T00:16:37Z","timestamp":1357776997000},"page":"e51799","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":41,"title":["Expression of Chicken DEC205 Reflects the Unique Structure and Function of the Avian Immune System"],"prefix":"10.1371","volume":"8","author":[{"given":"Karen","family":"Staines","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Butter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,1,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev.iy.09.040191.001415","article-title":"The dendritic cell system and its role in immunogenicity","volume":"9","author":"RM Steinman","year":"1991","journal-title":"Annu Rev Immunol"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Kaspers B, Kothlow S, Butter C (2008) Avian Antigen Presenting Cells. In: Davison F, Kaspers B, Schat KA, editors. Avian Immunology. Ammsterdam: Academic Press. pp. 183\u2013202.","DOI":"10.1016\/B978-012370634-8.50012-3"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.imbio.2011.05.012","article-title":"Antigen presenting cells in a non-mammalian model system, the chicken","volume":"216","author":"Z Wu","year":"2011","journal-title":"Immunobiology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2567.2009.03129.x","article-title":"Generation and characterization of chicken bone marrow-derived dendritic cells","volume":"129","author":"Z Wu","year":"2010","journal-title":"Immunology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.dci.2010.12.015","article-title":"Chicken CCR6 and CCR7 are markers for immature and mature dendritic cells respectively","volume":"35","author":"Z Wu","year":"2011","journal-title":"Dev Comp Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.dci.2009.09.007","article-title":"Cloning and characterisation of the chicken orthologue of dendritic cell-lysosomal associated membrane protein (DC-LAMP)","volume":"34","author":"ZG Wu","year":"2010","journal-title":"Developmental and Comparative Immunology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.4049\/jimmunol.179.8.5117","article-title":"Unique features and distribution of the chicken CD83(+) cell","volume":"179","author":"C Hansell","year":"2007","journal-title":"Journal of Immunology"},{"key":"ref8","unstructured":"White RG (1981) The structural organisation of avian lympoid tissues. In: Rose ME, Payne, L.N. and freeman, B.M., editor. Avian Immunology. Edinburgh: British Poultry Sciences Ltd. pp. 21\u201351."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000141159","article-title":"The association of lymphoid tissue with the lymph vessels in the domestic chicken (Gallus domesticus)","volume":"29","author":"PM Biggs","year":"1957","journal-title":"Acta Anat (Basel)"},{"key":"ref10","unstructured":"Cross GM. The Avian Lymphatic System; 1988 1988. University of Sydney."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0923-2494(91)90090-6","article-title":"Structure and function of the chicken spleen","volume":"142","author":"SHM Jeurissen","year":"1991","journal-title":"Res Immunol"},{"key":"ref12","first-page":"75","article-title":"Histological and functional-differentiation of non-lymphoid cells in the chicken spleen Immunology","volume":"77","author":"SHM Jeurissen","year":"1992","journal-title":"Histological and functional-differentiation of non-lymphoid cells in the chicken spleen Immunology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3382\/ps.0350224","article-title":"The Bursa of Fabricius and Antibody Production","volume":"35","author":"B Glick","year":"1956","journal-title":"Poultry Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.dci.2005.06.018","article-title":"Antibodies, immunoglobulin genes and the bursa of Fabricius in chicken B cell development","volume":"30","author":"MJ Ratcliffe","year":"2006","journal-title":"Dev Comp Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0145-305X(79)80010-5","article-title":"Light and electron microscope structure of secretory cells in the medulla of bursal follicles of normal and cyclophosphamide treated chickens","volume":"3","author":"I Olah","year":"1979","journal-title":"Dev Comp Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1084\/jem.160.3.839","article-title":"Self-recognition specificity expressed by T cells from nude mice. Absence of detectable Ia-restricted T cells in nude mice that do exhibit self-K\/D-restricted T cell responses","volume":"160","author":"AM Kruisbeek","year":"1984","journal-title":"J Exp Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0090-1229(90)90139-H","article-title":"Ontogeny of T cell development in avian scleroderma","volume":"56","author":"J Van de Water","year":"1990","journal-title":"Clin Immunol Immunopathol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1006\/cimm.1995.1218","article-title":"DEC-205, A 205-KDA protein abundant on mouse dendritic cells and thymic epithelium that is detected by the monoclonal-antibody NLDC-145 - purification, characterization, and N-terminal amino-acid-sequence","volume":"165","author":"WJ Swiggard","year":"1995","journal-title":"Cellular Immunology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1083\/jcb.151.3.673","article-title":"The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments","volume":"151","author":"K Mahnke","year":"2000","journal-title":"Journal of Cell Biology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1182\/blood-2010-06-288068","article-title":"Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody","volume":"116","author":"C Cheong","year":"2010","journal-title":"Blood"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.molimm.2008.11.016","article-title":"CD205 (DEC-205): A recognition receptor for apoptotic and necrotic self","volume":"46","author":"RE Shrimpton","year":"2009","journal-title":"Molecular Immunology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1073\/pnas.93.6.2588","article-title":"CD14(+) blood monocytes can differentiate into functionally mature CD83(+) dendritic cells","volume":"93","author":"LJ Zhou","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/S0021-9258(18)46005-X","article-title":"Contribution to ligand-binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor","volume":"267","author":"ME Taylor","year":"1992","journal-title":"Journal of Biological Chemistry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0021-9258(18)54164-8","article-title":"Structural requirements for high-affinity binding of complex ligands by the macrophage mannose receptor","volume":"268","author":"ME Taylor","year":"1993","journal-title":"Journal of Biological Chemistry"},{"key":"ref25","first-page":"281","article-title":"Antigen-presenting cells, including Langerhans cells, veiled cells and interdigitating cells","volume":"84","author":"BM Balfour","year":"1981","journal-title":"Ciba Found Symp"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.dci.2010.02.010","article-title":"Characterization of porcine CD205","volume":"34","author":"J Hernandez","year":"2010","journal-title":"Developmental and Comparative Immunology"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Betts MJ, Russell RB (2003) Amino acid properties and consequences of subsitutions. In: Barnes MR, Gray IC, editors. Bioinformatics for Geneticists: Wiley.","DOI":"10.1002\/0470867302.ch14"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.it.2003.09.012","article-title":"Induction of tolerogenic DCs: \u2018you are what you eat\u2019","volume":"24","author":"K Mahnke","year":"2003","journal-title":"Trends in Immunology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/375151a0","article-title":"The receptor DEC-205 expressed by dendritic cells and thymic epithelial-cells is involved in antigen-processing","volume":"375","author":"WP Jiang","year":"1995","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1084\/jem.163.4.981","article-title":"Langerhans cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal-antibody","volume":"163","author":"G Kraal","year":"1986","journal-title":"Journal of Experimental Medicine"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/aja.1001650408","article-title":"Splenic White Pulp and Associated Vascular Channels in Chicken Spleen","volume":"165","author":"I Olah","year":"1982","journal-title":"American Journal of Anatomy"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/ar.1092410114","article-title":"Localization of Splenic Cells with Antigen-Transporting Capability in the Chicken","volume":"241","author":"E Delcacho","year":"1995","journal-title":"Anatomical Record"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/intimm\/dxg024","article-title":"In vitro evidence for participation of DEC-205 expressed by thymic cortical epithelial cells in clearance of apoptotic thymocytes","volume":"15","author":"M Small","year":"2003","journal-title":"International Immunology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/nature03886","article-title":"Hassall&apos;s corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus","volume":"436","author":"N Watanabe","year":"2005","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/ar.1092330115","article-title":"Differentiation of Bursal Secretory-Dendritic Cells Studied with Antivimentin Monoclonal-Antibody","volume":"233","author":"I Olah","year":"1992","journal-title":"Anatomical Record"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ar.1092320113","article-title":"Antivimentin Monoclonal-Antibody Recognizes a Cell with Dendritic Appearance in the Chickens Bursa of Fabricius","volume":"232","author":"I Olah","year":"1992","journal-title":"Anatomical Record"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1007\/BF02034727","article-title":"Secretory cell in the medulla of the bursa of Fabricius","volume":"34","author":"I Olah","year":"1978","journal-title":"Experientia"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.3382\/ps.0721262","article-title":"Bursal secretory dendritic-like cell: a microenvironment issue","volume":"72","author":"B Glick","year":"1993","journal-title":"Poult Sci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/eji.1830190527","article-title":"Emigration of B cells from chicken bursa of Fabricius","volume":"19","author":"O Lassila","year":"1989","journal-title":"Eur J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1002\/eji.1830210825","article-title":"Apoptosis is associated with the extensive B cell death in the sheep ileal Peyer&apos;s patch and the chicken bursa of Fabricius: a possible role in B cell selection","volume":"21","author":"B Motyka","year":"1991","journal-title":"Eur J Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1006\/cimm.1995.1109","article-title":"Tissue distribution of the DEC-205 protein that is detected by the monoclonal-antibody NLDC-145 : 1. Expression on dendritic cells and other subsets of mouse leukocytes","volume":"163","author":"K Inaba","year":"1995","journal-title":"Cellular Immunology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/intimm\/dxl022","article-title":"Expression of human DEC-205 (CD205) multilectin receptor on leukocytes","volume":"18","author":"M Kato","year":"2006","journal-title":"International Immunology"},{"key":"ref43","unstructured":"(1986) Guidance on the Operation of the Animals (Scientific Procedures) Act."},{"key":"ref44","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1089\/vim.2009.0047","article-title":"Early replication in pulmonary B cells after infection with Marek&apos;s disease herpesvirus by the respiratory route","volume":"22","author":"BJ Baaten","year":"2009","journal-title":"Viral Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0092-8674(81)90282-8","article-title":"SV40-transformed simian cells support the replication of early SV40 mutants","volume":"23","author":"Y Gluzman","year":"1981","journal-title":"Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1084\/jem.108.6.945","article-title":"Genetics of somatic mammalian cells","volume":"108","author":"TTC Puck","year":"1958","journal-title":"J Exp Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1073\/pnas.60.4.1275","article-title":"Genetics of somatic mammalian cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells","volume":"60","year":"1968","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/BF02602587","article-title":"Chicken B-cell marker chB6 (Bu-1) is a highly glycosylated protein of unique structure","volume":"44","author":"C Tregaskes","year":"1996","journal-title":"Immunogenetics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.dci.2004.09.001","article-title":"Conservation of biological properties of the CD40 ligand, CD154 in a non-mammalian vertebrate","volume":"29","author":"CA Tregaskes","year":"2005","journal-title":"Dev Comp Immunol"},{"key":"ref50","unstructured":"Snell D (2000) Cell-surface molecules of developing chicken B cells."},{"key":"ref51","doi-asserted-by":"crossref","first-page":"8573","DOI":"10.1073\/pnas.84.23.8573","article-title":"Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system","volume":"84","author":"A Aruffo","year":"1987","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF02900361","article-title":"The Staden sequence analysis package","volume":"5","author":"R Staden","year":"1996","journal-title":"Mol Biotechnol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1084\/jem.173.3.721","article-title":"Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation","volume":"173","author":"PS Linsley","year":"1991","journal-title":"J Exp Med"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.4049\/jimmunol.152.8.3848","article-title":"Monomeric homologue of mammalian CD28 is expressed on chicken T cells","volume":"152","author":"J Young","year":"1994","journal-title":"The Journal of Immunology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/03079450601156075","article-title":"Route of challenge is critical in determining the clinical outcome of infection with a very virulent oncogenic herpesvirus, Marek&apos;s disease virus","volume":"36","author":"C Butter","year":"2007","journal-title":"Avian Pathol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0051799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T15:16:37Z","timestamp":1687965397000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0051799"}},"subtitle":[],"editor":[{"given":"Robin Charles","family":"May","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,9]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0051799","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,9]]}}}