{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:45:58Z","timestamp":1791279958805,"version":"4.1.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T00:00:00Z","timestamp":1355702400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0051826","type":"journal-article","created":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T16:55:56Z","timestamp":1355763356000},"page":"e51826","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["The Spinal Muscular Atrophy Disease Protein SMN Is Linked to the Golgi Network"],"prefix":"10.1371","volume":"7","author":[{"given":"Chen-Hung","family":"Ting","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Lan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Chun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Mei","family":"Hsieh-Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Lin-Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,12,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a spinal muscular atrophy-determining gene","volume":"80","author":"S Lefebvre","year":"1995","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/hmg\/4.4.631","article-title":"Deletions in the survival motor neuron gene on 5q13 in autosomal recessive spinal muscular atrophy","volume":"4","author":"NR Rodrigues","year":"1995","journal-title":"Hum Mol Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/hmg\/6.8.1205","article-title":"The survival motor neuron protein in spinal muscular atrophy","volume":"6","author":"DD Coovert","year":"1997","journal-title":"Hum Mol Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/ng0797-265","article-title":"Correlation between severity and SMN protein level in spinal muscular atrophy","volume":"16","author":"BP Lefebvre S","year":"1997","journal-title":"Nat Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.1073\/pnas.96.11.6307","article-title":"A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy","volume":"96","author":"CL Lorson","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/hmg\/8.7.1177","article-title":"A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2","volume":"8","author":"UR Monani","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1101\/gad.1884910","article-title":"A degron created by SMN2 exon 7 skipping is a principal contributor to spinal muscular atrophy severity","volume":"24","author":"S Cho","year":"2010","journal-title":"Genes Dev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/3030","article-title":"Differential SMN2 expression associated with SMA severity","volume":"20","author":"DK Gavrilov","year":"1998","journal-title":"Nat Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/sj.ejhg.5200210","article-title":"Correlation of SMNt and SMNc gene copy number with age of onset and survival in spinal muscular atrophy","volume":"6","author":"JE Taylor","year":"1998","journal-title":"Eur J Hum Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/71709","article-title":"A mouse model for spinal muscular atrophy","volume":"24","author":"HM Hsieh-Li","year":"2000","journal-title":"Nat Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/hmg\/9.3.333","article-title":"The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(\u2212\/\u2212) mice and results in a mouse with spinal muscular atrophy","volume":"9","author":"UR Monani","year":"2000","journal-title":"Hum Mol Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0092-8674(00)80368-2","article-title":"The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis","volume":"90","author":"U Fischer","year":"1997","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0092-8674(00)80367-0","article-title":"The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins","volume":"90","author":"Q Liu","year":"1997","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1093\/hmg\/8.13.2351","article-title":"Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy","volume":"8","author":"D Buhler","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/hmg\/9.1.47","article-title":"Subcellular localization and axonal transport of the survival motor neuron (SMN) protein in the developing rat spinal cord","volume":"9","author":"S Pagliardini","year":"2000","journal-title":"Hum Mol Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.1523\/JNEUROSCI.23-16-06627.2003","article-title":"Active transport of the survival motor neuron protein and the role of exon-7 in cytoplasmic localization","volume":"23","author":"HL Zhang","year":"2003","journal-title":"J Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"8622","DOI":"10.1523\/JNEUROSCI.3967-05.2006","article-title":"Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons","volume":"26","author":"H Zhang","year":"2006","journal-title":"J Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jmb.2010.06.058","article-title":"SMN, Gemin2 and Gemin3 associate with beta-actin mRNA in the cytoplasm of neuronal cells in vitro","volume":"401","author":"AG Todd","year":"2010","journal-title":"J Mol Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1083\/jcb.200304128","article-title":"Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons","volume":"163","author":"W Rossoll","year":"2003","journal-title":"J Cell Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/hmg\/ddl482","article-title":"Stat5 constitutive activation rescues defects in spinal muscular atrophy","volume":"16","author":"CH Ting","year":"2007","journal-title":"Hum Mol Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1093\/hmg\/ddq058","article-title":"Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy","volume":"19","author":"HL Wen","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1093\/hmg\/ddr046","article-title":"The COPI vesicle complex binds and moves with survival motor neuron within axons","volume":"20","author":"CJ Peter","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/0968768031000114024","article-title":"Cisternal maturation and vesicle transport: join the band wagon! (Review)","volume":"20","author":"M Elsner","year":"2003","journal-title":"Mol Membr Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0092-8674(00)81701-8","article-title":"SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor","volume":"95","author":"T Tsukazaki","year":"1998","journal-title":"Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/aja.1001940306","article-title":"Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons","volume":"194","author":"NR Cashman","year":"1992","journal-title":"Dev Dyn"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/jnr.21507","article-title":"Characterization and use of the NSC-34 cell line for study of neurotrophin receptor trafficking","volume":"86","author":"D Matusica","year":"2008","journal-title":"J Neurosci Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/ncb1777","article-title":"Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons","volume":"10","author":"Y Zheng","year":"2008","journal-title":"Nat Cell Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/hmg\/11.1.93","article-title":"Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp\/hnRNP-Q: a role for Smn in RNA processing in motor axons?","volume":"11","author":"W Rossoll","year":"2002","journal-title":"Hum Mol Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1002\/jnr.21308","article-title":"QNQKE targeting motif for the SMN-Gemin multiprotein complexin neurons","volume":"85","author":"H Zhang","year":"2007","journal-title":"J Neurosci Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1152\/physiol.00043.2005","article-title":"Dense-core secretory granule biogenesis","volume":"21","author":"T Kim","year":"2006","journal-title":"Physiology (Bethesda)"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1074\/jbc.M707304200","article-title":"In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation protein","volume":"283","author":"N Piazzon","year":"2008","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1523\/JNEUROSCI.3631-10.2011","article-title":"The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons","volume":"31","author":"C Fallini","year":"2011","journal-title":"J Neurosci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/hmg\/ddq500","article-title":"HuD interacts with survival motor neuron protein and can rescue spinal muscular atrophy-like neuronal defects","volume":"20","author":"L Hubers","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1073\/pnas.0610660104","article-title":"Axonal-SMN (a-SMN), a protein isoform of the survival motor neuron gene, is specifically involved in axonogenesis","volume":"104","author":"V Setola","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1086\/425287","article-title":"A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis","volume":"75","author":"AL Nishimura","year":"2004","journal-title":"Am J Hum Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jns.2006.01.019","article-title":"Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death","volume":"246","author":"NK Gonatas","year":"2006","journal-title":"J Neurol Sci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0051826","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,7]],"date-time":"2019-07-07T00:32:26Z","timestamp":1562459546000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0051826"}},"subtitle":[],"editor":[{"given":"Yanmin","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,12,17]]},"references-count":36,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,12,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0051826","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,17]]}}}