{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:50:36Z","timestamp":1761630636099},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,4]],"date-time":"2013-01-04T00:00:00Z","timestamp":1357257600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0051983","type":"journal-article","created":{"date-parts":[[2013,1,4]],"date-time":"2013-01-04T22:09:44Z","timestamp":1357337384000},"page":"e51983","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Low Levels of Mannan-Binding Lectin or Ficolins Are Not Associated with an Increased Risk of Cytomegalovirus Disease in HIV-Infected Patients"],"prefix":"10.1371","volume":"8","author":[{"given":"Adrian","family":"Egli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Osthoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Thiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Mikkelsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andri","family":"Rauch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans H.","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiner C.","family":"Bucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens C.","family":"Jensenius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Battegay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marten","family":"Trendelenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Swiss HIV Cohort Study","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,1,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S1473-3099(04)01202-2","article-title":"Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments","volume":"4","author":"MK Gandhi","year":"2004","journal-title":"Lancet Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1086\/339329","article-title":"Definitions of cytomegalovirus infection and disease in transplant recipients","volume":"34","author":"P Ljungman","year":"2002","journal-title":"Clin Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S1473-3099(06)70463-7","article-title":"Immunological recovery and antiretroviral therapy in HIV-1 infection","volume":"6","author":"M Battegay","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1086\/517303","article-title":"T cell subsets and cytomegalovirus retinitis in human immunodeficiency virus-infected patients","volume":"176","year":"1997","journal-title":"J Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1086\/427828","article-title":"Dynamics of cytomegalovirus (CMV)-specific T cells in HIV-1-infected individuals progressing to AIDS with CMV end-organ disease","volume":"191","author":"C Bronke","year":"2005","journal-title":"J Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Jabs DA (2011) Cytomegalovirus retinitis and the acquired immunodeficiency syndrome\u2013bench to bedside: LXVII Edward Jackson Memorial Lecture. Am J Ophthalmol 151: 198\u2013216 e191.","DOI":"10.1016\/j.ajo.2010.10.018"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.clim.2007.04.018","article-title":"Human cytomegalovirus (CMV)-specific CD8+ T cell responses are reduced in HIV-infected individuals with a history of CMV disease despite CD4+ T cell recovery","volume":"124","author":"KP Singh","year":"2007","journal-title":"Clin Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1086\/525853","article-title":"Poor predictive value of cytomegalovirus (CMV)-specific T cell assays for the development of CMV retinitis in patients with AIDS","volume":"46","author":"MA Jacobson","year":"2008","journal-title":"Clin Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1128\/JVI.59.3.703-713.1986","article-title":"Primate cytomegalovirus glycoproteins: lectin-binding properties and sensitivities to glycosidases","volume":"59","author":"DM Benko","year":"1986","journal-title":"J Virol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s13238-010-0088-9","article-title":"Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry","volume":"1","author":"KS Brown","year":"2010","journal-title":"Protein Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1046\/j.1365-2567.1999.00781.x","article-title":"Human mannan-binding lectin inhibits the infection of influenza A virus without complement","volume":"97","author":"T Kase","year":"1999","journal-title":"Immunology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1084\/jem.169.1.185","article-title":"A human serum mannose-binding protein inhibits in vitro infection by the human immunodeficiency virus","volume":"169","author":"RA Ezekowitz","year":"1989","journal-title":"J Exp Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1086\/429631","article-title":"Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection","volume":"191","author":"WK Ip","year":"2005","journal-title":"J Infect Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.virol.2010.12.045","article-title":"Complement and viral pathogenesis","volume":"411","author":"KA Stoermer","year":"2011","journal-title":"Virology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1078\/0171-2985-00155","article-title":"Interaction of C1q and mannan-binding lectin with viruses","volume":"205","author":"NM Thielens","year":"2002","journal-title":"Immunobiology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1097\/01.tp.0000264999.71318.2b","article-title":"The influence of innate immunity gene receptors polymorphisms in renal transplant infections","volume":"83","author":"C Cervera","year":"2007","journal-title":"Transplantation"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1600-0463.2012.02880.x","article-title":"Human mannose-binding lectin inhibits human cytomegalovirus infection in human embryonic pulmonary fibroblast","volume":"120","author":"W Wu","year":"2012","journal-title":"APMIS"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1086\/314499","article-title":"Antibody-independent activation of the classical complement pathway by cytomegalovirus-infected fibroblasts","volume":"178","author":"OB Spiller","year":"1998","journal-title":"J Infect Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/sj.emboj.7601500","article-title":"Structural insights into the innate immune recognition specificities of L- and H-ficolins","volume":"26","author":"V Garlatti","year":"2007","journal-title":"EMBO J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.4049\/jimmunol.175.5.3150","article-title":"Human M-ficolin is a secretory protein that activates the lectin complement pathway","volume":"175","author":"Y Liu","year":"2005","journal-title":"J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e17377","DOI":"10.1371\/journal.pone.0017377","article-title":"A protective role for complement C3 protein during pandemic 2009 H1N1 and H5N1 influenza A virus infection","volume":"6","author":"KB O\u2019Brien","year":"2011","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.virol.2011.02.022","article-title":"N-linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement","volume":"413","author":"P Somnuke","year":"2011","journal-title":"Virology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1089\/vim.2007.0061","article-title":"Role of complement in immune regulation and its exploitation by virus","volume":"20","author":"KL Cummings","year":"2007","journal-title":"Viral Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1365-2249.2009.03929.x","article-title":"Acute-phase responsiveness of mannose-binding lectin in community-acquired pneumonia is highly dependent upon MBL2 genotypes","volume":"156","author":"BL Herpers","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1365-2249.2006.03140.x","article-title":"Mannose-binding lectin does not act as an acute-phase reactant in adults with community-acquired pneumococcal pneumonia","volume":"145","author":"M Perez-Castellano","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-2249.1992.tb05876.x","article-title":"Gene frequency and partial protein characterization of an allelic variant of mannan binding protein associated with low serum concentrations","volume":"90","author":"P Garred","year":"1992","journal-title":"Clin Exp Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/ng0992-50","article-title":"Distinct and overlapping functions of allelic forms of human mannose binding protein","volume":"2","author":"M Super","year":"1992","journal-title":"Nat Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1016\/j.molimm.2009.05.005","article-title":"MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement","volume":"46","author":"P Garred","year":"2009","journal-title":"Mol Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.jhep.2011.01.039","article-title":"Mannose-binding lectin and Ficolin-2 gene polymorphisms predispose to cytomegalovirus (re)infection after orthotopic liver transplantation","volume":"55","author":"BJ de Rooij","year":"2011","journal-title":"J Hepatol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1365-2249.2004.02616.x","article-title":"Mannan-binding lectin modulates the response to HSV-2 infection","volume":"138","author":"M Gadjeva","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/01.tp.0000251721.90688.c2","article-title":"Association between mannose-binding lectin deficiency and cytomegalovirus infection after kidney transplantation","volume":"83","author":"O Manuel","year":"2007","journal-title":"Transplantation"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.3324\/haematol.2009.017863","article-title":"Mannose-binding lectin levels and major infections in a cohort of very long-term survivors after allogeneic stem cell transplantation","volume":"95","author":"M Osthoff","year":"2010","journal-title":"Haematologica"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.humimm.2009.01.022","article-title":"Mannose-binding lectin 2 gene polymorphism in recurrent herpes simplex virus 2 infection","volume":"70","author":"M Seppanen","year":"2009","journal-title":"Hum Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/j.transproceed.2009.06.056","article-title":"Influence of mannose-binding lectin gene polymorphisms on the invasiveness of cytomegalovirus disease after solid organ transplantation","volume":"41","author":"C Cervera","year":"2009","journal-title":"Transplant Proc"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1093\/ndt\/gfn355","article-title":"Impact of the complement lectin pathway on cytomegalovirus disease early after kidney transplantation","volume":"23","author":"S Sagedal","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/ije\/dyp321","article-title":"Cohort profile: the Swiss HIV Cohort study","volume":"39","author":"F Schoeni-Affolter","year":"2010","journal-title":"Int J Epidemiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2307\/2530744","article-title":"Biased selection of controls for case-control analyses of cohort studies","volume":"40","author":"JH Lubin","year":"1984","journal-title":"Biometrics"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000218324","article-title":"Characteristics and biological variations of M-ficolin, a pattern recognition molecule, in plasma","volume":"2","author":"T Wittenborn","year":"2010","journal-title":"J Innate Immun"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Henckaerts L, Nielsen KR, Steffensen R, Van Steen K, Mathieu C, <etal>et al<\/etal>.. (2009) Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit. Crit Care Med 37: 192\u2013201, e191\u2013193.","DOI":"10.1097\/CCM.0b013e31819263d8"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2307\/2530047","article-title":"Covariance adjustment of relative-risk estimates in matched studies","volume":"38","author":"N Breslow","year":"1982","journal-title":"Biometrics"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1002\/sim.3057","article-title":"Sample size evaluation for a multiply matched case-control study using the score test from a conditional logistic (discrete Cox PH) regression model","volume":"27","author":"JM Lachin","year":"2008","journal-title":"Stat Med"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Sarkar N (2008) Lattice: Multivariate Data Visualization with R. New York: Springer.","DOI":"10.1007\/978-0-387-75969-2"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1089\/vim.2009.0109","article-title":"Association between mannose-binding lectin gene polymorphism and pediatric cytomegalovirus infection","volume":"23","author":"Y Hu","year":"2010","journal-title":"Viral Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1016\/j.molimm.2011.06.220","article-title":"Mannan-binding lectin-2 (MBL2) gene polymorphisms in prenatal and perinatal cytomegalovirus infections","volume":"48","author":"A Szala","year":"2011","journal-title":"Mol Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1365-2249.2011.04436.x","article-title":"Mannose-binding lectin deficiency linked to cytomegalovirus (CMV) reactivation and survival in lung transplantation","volume":"165","author":"JM Kwakkel-van Erp","year":"2011","journal-title":"Clin Exp Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1086\/596313","article-title":"Donor mannose-binding lectin deficiency increases the likelihood of clinically significant infection after liver transplantation","volume":"48","author":"DL Worthley","year":"2009","journal-title":"Clin Infect Dis"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.gastro.2005.06.049","article-title":"Mannose binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation","volume":"129","author":"LH Bouwman","year":"2005","journal-title":"Gastroenterology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1093\/eurheartj\/ehi198","article-title":"Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischaemia, and rejection after human heart transplantation","volume":"26","author":"AE Fiane","year":"2005","journal-title":"Eur Heart J"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1399-3062.2007.00285.x","article-title":"Cytomegalovirus-associated chorioretinitis after liver transplantation: case report and review of the literature","volume":"10","author":"A Egli","year":"2008","journal-title":"Transpl Infect Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/j.1442-9071.2011.02572.x","article-title":"Mannose-binding lectin as part of the complement pathway: characterization in non-inflamed and inflamed human eyes","volume":"39","author":"SP Chow","year":"2011","journal-title":"Clin Experiment Ophthalmol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1136\/sti.76.5.342","article-title":"Is cytomegalovirus viraemia a useful tool in managing CMV disease?","volume":"76","author":"JR Deayton","year":"2000","journal-title":"Sex Transm Infect"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1590\/S0036-46652011000200005","article-title":"Evaluation of glycoprotein B genotypes and load of CMV infecting blood leukocytes on prognosis of AIDS patients","volume":"53","author":"AA Cunha","year":"2011","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1471-2334-7-127","article-title":"CMV quantitative PCR in the diagnosis of CMV disease in patients with HIV-infection - a retrospective autopsy based study","volume":"7","author":"AB Brantsaeter","year":"2007","journal-title":"BMC Infect Dis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1016\/j.ophtha.2012.03.032","article-title":"Risk factors for cytomegalovirus retinitis in patients with cytomegalovirus viremia after hematopoietic stem cell transplantation","volume":"119","author":"S Jeon","year":"2012","journal-title":"Ophthalmology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1093\/cid\/cis818","article-title":"State-of-the-art on Monitoring of Cytomegalovirus-Specific Cell Mediated Immunity after Organ Transplant: A Primer for the Clinician","volume":"55(12)","author":"A Egli","year":"2012","journal-title":"Clin Infect Dis"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0051983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T21:57:50Z","timestamp":1595195870000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0051983"}},"subtitle":[],"editor":[{"given":"Niels","family":"Bovenschen","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,4]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0051983","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2013,1,4]]}}}