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Geneva: UNAIDS. 236 p."},{"key":"ref5","unstructured":"World Health Organization (2007) Maternal mortality in 2005 : estimates developed by WHO, UNICEF, UNFPA, and the World Bank. Geneva: UNAIDS. 48 p."},{"key":"ref6","unstructured":"The U.S. President\u2019s Emergency Plan for AIDS Relief (PEPFAR) (2011) PEPFAR Operational Plan. Washinghton, DC: Office of U.S. Global AIDS Coordinator. 147 p."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1001\/jama.298.16.1888","article-title":"Clinical outcomes and CD4 cell response in children receiving antiretroviral therapy at primary health care facilities in Zambia","volume":"298","author":"C Bolton-Moore","year":"2007","journal-title":"JAMA"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1001\/jama.296.7.782","article-title":"Rapid scale-up of antiretroviral therapy at primary care sites in Zambia: feasibility and early outcomes","volume":"296","author":"JS Stringer","year":"2006","journal-title":"JAMA"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"World Bank (1993) World Development Report 1993: Investing in Health. 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Oxford: Oxford Medical Publications. 305 p."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(08)60345-1","article-title":"Mortality in HIV-infected Ugandan adults receiving antiretroviral treatment and survival of their HIV-uninfected children: a prospective cohort study","volume":"371","author":"J Mermin","year":"2008","journal-title":"Lancet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF03256157","article-title":"The cost effectiveness of home-based provision of antiretroviral therapy in rural Uganda","volume":"7","author":"E Marseille","year":"2009","journal-title":"Appl Health Econ Health Policy"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Morgan MG, Henrion M (1990) Uncertainty: A Guide to Deaing with Uncertainty in Quantitative Risk and Policy Analysis. Cambridge: Cambridge University Press. 332 p.","DOI":"10.1017\/CBO9780511840609"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1097\/01.aids.0000174449.32756.c7","article-title":"Cotrimoxazole prophylaxis by HIV-infected persons in Uganda reduces morbidity and mortality among HIV-uninfected family members","volume":"19","author":"J Mermin","year":"2005","journal-title":"Aids"},{"key":"ref18","unstructured":"Kombe G, Galaty D, Gadhia R, Decker C (2005) The Human and Financial Resource Requirements for Scaling Up HIV\/AIDS Services in Ethiopia. Report by PHRplus and Abt Associates to USAID. Available: http:\/\/www.abtassociates.com\/reports\/AB_PNADC109.pdf<\/ext-link>. Accessed 2012 Nov 24."},{"key":"ref19","unstructured":"Kombe G, Smith O, Nwagbara C (2004) Scaling Up Antiretroviral Treatment in the Public Sector in Nigeria: A Comprehensive Analysis of Resource Requirements. Report issued by PHRplus and Abt Associates. Available: http:\/\/www.phrplus.org\/Pubs\/Tech037_fin.pdf<\/ext-link>. Accessed 2012 Nov 24."},{"key":"ref20","unstructured":"Kombe G, Smith O (2003) Application of the AIDSTREATCOST model to estimate the cost of ARV treatment in Zambia and Uganda. Power Point presentation produced by PHRplus, Abt Associates, and USAID."},{"key":"ref21","first-page":"811","article-title":"Exploring the costs of a limited public sector antiretroviral treatment programme in South Africa","volume":"92","author":"A Boulle","year":"2002","journal-title":"South African Medical Journal"},{"key":"ref22","unstructured":"Govender V, McIntyre D, Grimwood A, Maartens G (2000) The Costs and Perceived Quality of Care for People Living with HIV\/AIDS in the Western Cape Province in South Africa. Report from PHR and Abt Associates to USAID. Available: http:\/\/phrplus.org\/Pubs\/sar14.pdf<\/ext-link>. Accessed 2012 Nov 24."},{"key":"ref23","unstructured":"Geffen N, Nattrass N, Raubenheimer C (2003) The Cost of HIV Prevention and Treatment interventions in South Africa. Report issued by Center for Social Science Research, AIDS and Society Research Unit, University of Cape Town. Available: http:\/\/www.hst.org.za\/publications\/cost-hiv-prevention-and-treatment-interventions-south-africa-0<\/ext-link>. Accessed 2012 Nov 24."},{"key":"ref24","unstructured":"Cleary S, Jikwana S, Boulle A (2004b) Resource Requirements for Comprehensive HIV and AIDS Care, Management and Treatment in South Africa: March 2004\u2013March 2009 South African Health Review 2005. Durban: South African Health Systems Trust."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1478-7547-7-6","article-title":"Cost estimates of HIV care and treatment with and without anti-retroviral therapy at Arba Minch Hospital in southern Ethiopia","volume":"7","author":"AD Bikilla","year":"2009","journal-title":"Cost Eff Resour Alloc"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1080\/09540120701868303","article-title":"Costing universal access of highly active antiretroviral therapy in Benin","volume":"20","author":"SH Hounton","year":"2008","journal-title":"AIDS Care"},{"key":"ref27","first-page":"320","article-title":"Clinical and financial burdens of secondary level care in a public sector antiretroviral roll-out setting (G. F. Jooste Hospital)","volume":"99","author":"S Kevany","year":"2009","journal-title":"S Afr Med J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1136\/bmj.38643.368692.68","article-title":"Cost effectiveness analysis of strategies to combat HIV\/AIDS in developing countries","volume":"331","author":"DR Hogan","year":"2005","journal-title":"BMJ"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1371\/journal.pmed.0030004","article-title":"Cost-Effectiveness of Highly Active Antiretroviral Therapy in South Africa","volume":"3","author":"M Badri","year":"2005","journal-title":"PLoS Med"},{"key":"ref30","unstructured":"Cleary S, Boulle A, McIntyre D, Coetzee D (2004) Cost-effectiveness of antiretroviral treatment for HIV-positive adults in a South African township. Cape Town: M\u00e9decins Sans Fronti\u00e8res, Health Systems Trust, University of Capetown. 67 p."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1056\/NEJMsa060247","article-title":"Cost-effectiveness of HIV treatment in resource-poor settings\u2013the case of Cote d\u2019Ivoire","volume":"355","author":"SJ Goldie","year":"2006","journal-title":"N Engl J Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1056\/NEJMp0903806","article-title":"The global burden of tuberculosis\u2013combating drug resistance in difficult times","volume":"360","author":"PR Donald","year":"2009","journal-title":"N Engl J Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2165\/11318230-000000000-00000","article-title":"Cost effectiveness of facility-based care, home-based care and mobile clinics for provision of antiretroviral therapy in Uganda","volume":"27","author":"JB Babigumira","year":"2009","journal-title":"Pharmacoeconomics"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1002\/art.24567","article-title":"The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo","volume":"60","author":"JM Kremer","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0140-6736(09)60755-8","article-title":"Obama administration may flat-line funding for PEPFAR","volume":"373","author":"T Zwillich","year":"2009","journal-title":"Lancet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2165\/11586120-000000000-00000","article-title":"Unit Costs for Delivery of Antiretroviral Treatment and Prevention of Mother-to-Child Transmission of HIV: A Systematic Review for Low- and Middle-Income Countries","volume":"29","author":"O Galarraga","year":"2011","journal-title":"Pharmacoeconomics"},{"key":"ref37","unstructured":"World Health Organization (2009) Rapid advice: antiretroviral therapy for HIV infection in adults and adolescents\u2013November 2009. 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