{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:50:50Z","timestamp":1773661850546,"version":"3.50.1"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T00:00:00Z","timestamp":1355788800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0052040","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T22:07:37Z","timestamp":1355868457000},"page":"e52040","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Differences between the Glycosylation Patterns of Haptoglobin Isolated from Skin Scales and Plasma of Psoriatic Patients"],"prefix":"10.1371","volume":"7","author":[{"given":"Bernardetta","family":"Maresca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Cigliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Stefania","family":"Spagnuolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Dal Piaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria M.","family":"Corsaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Balato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Nino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Balato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Ayala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Abrescia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,12,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1093\/clinchem\/42.10.1589","article-title":"Biological and clinical significance of haptoglobin polymorphism in humans","volume":"4","author":"MR Langlois","year":"1996","journal-title":"Clin Chem"},{"key":"ref2","first-page":"185","article-title":"Autoradiographic study on the site of uptake of the haptoglobin-hemoglobin complex","volume":"8","author":"T Wada","year":"1970","journal-title":"J Reticuloendothel Soc"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-1-4615-8315-8_3","article-title":"Haptoglobin: the evolutionary product of duplication, unequal crossing over, and point mutation","volume":"12","author":"BH Bowman","year":"1982","journal-title":"Adv Hum Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/BF00917353","article-title":"Extrahepatic expression of plasma protein genes during inflammation","volume":"15","author":"N Kalmovarin","year":"1991","journal-title":"Inflammation"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1096\/fj.02-0019fje","article-title":"Acute-phase protein Haptoglobin is a cell migration factor involved in arterial restructuring","volume":"16","author":"DP de Kleijn","year":"2002","journal-title":"FASEB J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1074\/jbc.M411390200","article-title":"Assignment of the binding site for haptoglobin on apolipoprotein A-I","volume":"280","author":"MS Spagnuolo","year":"2005","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6158","DOI":"10.1111\/j.1742-4658.2009.07319.x","article-title":"Haptoglobin binds the anti-atherogenic protein Apolipoprotein E: impairment of the apolipoprotein E stimulation on both the enzyme lecithin-cholesterol acyltransferase activity and cholesterol uptake by hepatocytes","volume":"276","author":"L Cigliano","year":"2009","journal-title":"FEBS J"},{"key":"ref8","first-page":"215","article-title":"Glycoprotein components of the skin under normal conditions and in several types of pathology (in Russian)","volume":"23","author":"NA Dobrotina","year":"1977","journal-title":"Vopr Med Khim"},{"key":"ref9","first-page":"647","article-title":"Biological functions of haptoglobin-new pieces to an old puzzle","volume":"35","author":"W Dobryszycka","year":"1997","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1182\/blood.V92.6.1870","article-title":"Increased susceptibility in Hp knockout mice during acute hemolysis","volume":"92","author":"SK Lim","year":"1998","journal-title":"Blood"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"L402","DOI":"10.1152\/ajplung.00115.2002","article-title":"Haptoglobin reduces lung injury associated with exposure to blood","volume":"284","author":"F Yang","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0378-1119(97)00123-6","article-title":"Tissue, temporal and inducible expression pattern of haptoglobin in mice","volume":"195","author":"J D'Armiento","year":"1997","journal-title":"Gene"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1365-2133.2005.06807.x","article-title":"Expression of haptoglobin in human keratinocytes and Langerhans cells","volume":"153","author":"H Wang","year":"2005","journal-title":"Br J Dermatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0923-1811(00)00078-5","article-title":"Haptoglobin is a natural regulator of Langerhans cell function in the skin","volume":"24","author":"Y Xie","year":"2000","journal-title":"J Dermatol Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1468-3083.2007.02444.x","article-title":"Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity","volume":"22","author":"L Cigliano","year":"2008","journal-title":"J Eur Acad Dermatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1515\/bc.2010.146","article-title":"Quantitative determination of haptoglobin glycoform variants in psoriasis","volume":"391","author":"B Maresca","year":"2010","journal-title":"Biol Chem"},{"key":"ref17","first-page":"784","article-title":"Essentials of Glycobiology","author":"A Varki","year":"2009","journal-title":"Cold Spring Harbor (NY)"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1073\/pnas.77.6.3388","article-title":"Covalent structure of human haptoglobin: a serine protease homolog","volume":"77","author":"A Kurosky","year":"1980","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0009-8981(93)90011-R","article-title":"The glycosylation of haptoglobin in rheumatoid arthritis","volume":"220","author":"S Thompson","year":"1993","journal-title":"Clin Chim Acta"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1023\/A:1022580813870","article-title":"Glycosylation and over-expression of endometriosis-associated peritoneal haptoglobin","volume":"19","author":"M Piva","year":"2002","journal-title":"Glycoconj J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0304-3835(92)90278-4","article-title":"Increased fucosylation and other carbohydrate changes in Haptoglobin in ovarian cancer","volume":"66","author":"S Thompson","year":"1992","journal-title":"Cancer Lett"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/ijc.22958","article-title":"Glycosylation status of Haptoglobin in sera of patients with prostate cancer vs benign prostate disease or normal subject","volume":"122","author":"T Fujimura","year":"2008","journal-title":"Int J Cancer"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1002\/ijc.23364","article-title":"Site-specific analysis of N-glycans on haptoglobin in sera of patients with pancreatic cancer: a novel approach for the development of tumor markers","volume":"122","author":"M Nakano","year":"2008","journal-title":"Int J Cancer"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1023\/A:1007078114674","article-title":"Haptoglobin glycoforms in a case of carbohydrate-deficient glycoprotein syndrome","volume":"16","author":"M Ferens-Sieczkowska","year":"1999","journal-title":"Glycoconj J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0009-8981(94)90136-8","article-title":"Monosaccharide composition of haptoglobin in liver diseases and alcohol abuse: large changes in glycosylation associated with alcoholic liver disease","volume":"227","author":"AC Mann","year":"1994","journal-title":"Clin Chim Acta"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1515\/bc.2011.033","article-title":"Identification of plasma haptoglobin forms which loosely bind hemoglobin","volume":"392","author":"MS Spagnuolo","year":"2011","journal-title":"Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.bbrc.2006.03.007","article-title":"HPLC analysis of discrete haptoglobin isoform N-linked oligosaccharides following 2D-PAGE isolation","volume":"343","author":"Z He","year":"2006","journal-title":"Biochem Bioph Res Com"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0009-8981(99)00248-X","article-title":"Alteration of sugar chains on alpha(1)-acid glycoprotein secreted following cytokine stimulation of HuH-7 cells in vitro","volume":"294","author":"Y Azuma","year":"2000","journal-title":"Clin Chim Acta"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10719-005-0292-7","article-title":"Regulation of sialyl-lewis x epitope expression by TNF-alpha and EGF in an airway carcinoma cell line,","volume":"22","author":"Y Ishibashi","year":"2005","journal-title":"Glycoconj J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/glycob\/cwm100","article-title":"Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG","volume":"17","author":"R Saldova","year":"2007","journal-title":"Glycobiology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1515\/CCLM.2005.066","article-title":"Fucosylation of serum glycoproteins in lung cancer patients","volume":"43","author":"B Kossowska","year":"2005","journal-title":"Clin Chem Lab Med"},{"issue":"10","key":"ref32","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1002\/ijc.26288","article-title":"\u03b11-3\/ fucosylation at Asn 241 of \u03b2-haptoglobin is a novel marker for colon cancer: A combinatorial approach for development of glycan biomarkers","volume":"130","author":"SY Park","year":"2011","journal-title":"Int J Cancer"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1021\/pr050328x","article-title":"Proteomic analysis of serum associated fucosylated glycoproteins in the development of primary hepatocellular carcinoma","volume":"5","author":"MA Comunale","year":"2006","journal-title":"J Proteome Res"},{"key":"ref34","first-page":"345","article-title":"Hemoglobin binding to deglycosylated haptoglobin","volume":"14","author":"V Kaartinen","year":"1998","journal-title":"Biochem Biophys Acta"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"7543","DOI":"10.1074\/jbc.270.13.7543","article-title":"Binding of human plasma sialoglycoproteins by the B-cell specific lectin CD-22. Selective recognition of immunoglobulin M and haptoglobin","volume":"270","author":"K Hanasaki","year":"1995","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0014-5793(95)00336-8","article-title":"Branching and elongation with lactosaminoglycan chains of N-linked oligosaccharides result in a shift toward termination with alpha 2\u2013>3-linked rather than with alpha 2\u2013>6-linked sialic acid residues","volume":"363","author":"M Nemansky","year":"1995","journal-title":"FEBS Lett"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1023\/B:GLYC.0000014072.34840.04","article-title":"Introduction to galectins","volume":"19","author":"H Leffler","year":"2004","journal-title":"Glycoconj J"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"10109","DOI":"10.1074\/jbc.M709545200","article-title":"Galectin-1, \u22122, and \u22123 exhibit differential recognition of sialylated glycans and blood group antigens","volume":"283","author":"SR Stowell","year":"2008","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/glycob\/cwn015","article-title":"Different affinity of galectins for human serum glycoproteins: Galectin-3 binds many protease inhibitors and acute phase proteins","volume":"18","author":"C Cederfur","year":"2008","journal-title":"Glycobiology"},{"key":"ref40","first-page":"741","article-title":"A circulating ligand for galectin-3 is a haptoglobin-related glycoprotein elevated in individuals with colon cancer","volume":"127","author":"RS Bresalier","year":"2004","journal-title":"Gastroenterology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1023\/B:GLYC.0000014088.21242.e0","article-title":"Galectins as inflammatory mediators","volume":"19","author":"J Almkvist","year":"2004","journal-title":"Glycoconj J"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bbagen.2005.12.020","article-title":"Galectin-3: an open-ended story","volume":"1760","author":"J Dumic","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.1074\/jbc.M410362200","article-title":"Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cells","volume":"280","author":"H Ideo","year":"2005","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-3083.2007.01986.x","article-title":"An emerging role for galectins in tuning the immune response: lessons from experimental models of inflammatory disease, autoimmunity and cancer","volume":"66","author":"GA Rabinovich","year":"2007","journal-title":"Scand J Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"35361","DOI":"10.1074\/jbc.M706923200","article-title":"Lateral compartmentalization of T cell receptor versus CD45 by Galectin-N-glycan binding and microfilaments coordinate basal and activation signalling","volume":"282","author":"IJ Chen","year":"2007","journal-title":"J Biol Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"18573","DOI":"10.1074\/jbc.M803115200","article-title":"Identification of galectin-3-binding protein as a factor secreted by tumor cells that stimulates interleukin-6 expression in the bone marrow stroma","volume":"283","author":"Y Fukaya","year":"2008","journal-title":"J Biol Chem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1038\/jid.2008.119","article-title":"Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation","volume":"128","author":"J Saegusa","year":"2008","journal-title":"J Invest Dermatol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e26560","DOI":"10.1371\/journal.pone.0026560","article-title":"Galectin-1-Binding Glycoforms of Haptoglobin with Altered Intracellular Trafficking, and Increase in Metastatic Breast Cancer Patients","volume":"6","author":"MC Carlsson","year":"2011","journal-title":"PLoS ONE"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0003-9861(03)00318-7","article-title":"Quantitative variations of the isoforms in haptoglobin 1\u20132 and 2\u20132 individual phenotypes","volume":"416","author":"L Cigliano","year":"2003","journal-title":"Arch Biochem Biophys"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0052040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T00:15:37Z","timestamp":1595117737000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0052040"}},"subtitle":[],"editor":[{"given":"Roger","family":"Chammas","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,12,18]]},"references-count":49,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,12,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0052040","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,18]]}}}