{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:30:46Z","timestamp":1791052246608,"version":"4.1.0"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T00:00:00Z","timestamp":1355961600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0052215","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T22:07:13Z","timestamp":1356041233000},"page":"e52215","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":161,"title":["Cytokine Expression Profile of Dengue Patients at Different Phases of Illness"],"prefix":"10.1371","volume":"7","author":[{"given":"Anusyah","family":"Rathakrishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok Mui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongli","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif M.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasheela","family":"Ponnampalavanar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy Chai See","family":"Lum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishya","family":"Manikam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamala Devi","family":"Sekaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,12,20]]},"reference":[{"key":"ref1","unstructured":"TDR\/WHO (2009) Dengue: guidelines for diagnosis, treatment, prevention and control; World Health O, Special Programme for R, Training in Tropical D, World Health Organization. Department of Control of Neglected Tropical D, World Health Organization E et al., editors. Geneva: World Health Organization."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S1473-3099(09)70254-3","article-title":"Progress towards a dengue vaccine","volume":"9","author":"DP Webster","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"ref3","first-page":"311","article-title":"Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered","volume":"42","author":"SB Halstead","year":"1970","journal-title":"Yale J Biol Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"638","DOI":"10.4269\/ajtmh.1980.29.638","article-title":"Enhancement of dengue virus infection in monocytes by flavivirus antisera","volume":"29","author":"SB Halstead","year":"1980","journal-title":"Am J Trop Med Hyg"},{"key":"ref5","first-page":"121","article-title":"Immunity and immunopathology in dengue virus infections","volume":"4","author":"I Kurane","year":"1992","journal-title":"Semin Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nm887","article-title":"Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever","volume":"9","author":"J Mongkolsapaya","year":"2003","journal-title":"Nat Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1600-065X.2008.00678.x","article-title":"Understanding the contribution of cellular immunity to dengue disease pathogenesis","volume":"225","author":"A Mathew","year":"2008","journal-title":"Immunol Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0162-3109(93)90025-L","article-title":"Modulation of human endothelial cell permeability by combinations of the cytokines interleukin-1 alpha\/beta, tumor necrosis factor-alpha and interferon-gamma","volume":"25","author":"A Burke-Gaffney","year":"1993","journal-title":"Immunopharmacology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1128\/JVI.71.6.4226-4232.1997","article-title":"Activation of endothelial cells via antibody-enhanced dengue virus infection of peripheral blood monocytes","volume":"71","author":"R Anderson","year":"1997","journal-title":"J Virol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1099\/vir.0.82093-0","article-title":"MCP-1, a highly expressed chemokine in dengue haemorrhagic fever\/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells","volume":"87","author":"YR Lee","year":"2006","journal-title":"J Gen Virol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1128\/JVI.76.11.5588-5597.2002","article-title":"Increased production of interleukin-8 in primary human monocytes and in human epithelial and endothelial cell lines after dengue virus challenge","volume":"76","author":"I Bosch","year":"2002","journal-title":"J Virol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1099\/vir.0.19652-0","article-title":"IL8 release, tight junction and cytoskeleton dynamic reorganization conducive to permeability increase are induced by dengue virus infection of microvascular endothelial monolayers","volume":"85","author":"D Talavera","year":"2004","journal-title":"J Gen Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"370","DOI":"10.4269\/ajtmh.2005.72.370","article-title":"Association between sex, nutritional status, severity of dengue hemorrhagic fever, and immune status in infants with dengue hemorrhagic fever","volume":"72","author":"TH Nguyen","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"ref14","first-page":"25","article-title":"Circulating levels of tumour necrosis factor-alpha &amp; interferon-gamma in patients with dengue &amp; dengue haemorrhagic fever during an outbreak","volume":"123","author":"A Chakravarti","year":"2006","journal-title":"Indian J Med Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/jmv.20080","article-title":"IL-10 levels in Dengue patients: some findings from the exceptional epidemiological conditions in Cuba","volume":"73","author":"AB Perez","year":"2004","journal-title":"J Med Virol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/jmv.21538","article-title":"Gene expression profiling of dengue infected human primary cells identifies secreted mediators in vivo","volume":"81","author":"A Becerra","year":"2009","journal-title":"J Med Virol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1574-695X.2000.tb01474.x","article-title":"Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis","volume":"28","author":"UC Chaturvedi","year":"2000","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1574-695X.2001.tb01575.x","article-title":"Elevated levels of interleukin-13 and IL-18 in patients with dengue hemorrhagic fever","volume":"30","author":"AS Mustafa","year":"2001","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref19","first-page":"1","article-title":"Shift to Th2 cytokine response in dengue haemorrhagic fever","volume":"129","author":"UC Chaturvedi","year":"2009","journal-title":"Indian J Med Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e8709","DOI":"10.1371\/journal.pone.0008709","article-title":"Clinical findings and pro-inflammatory cytokines in dengue patients in Western India: a facility-based study","volume":"5","author":"D Priyadarshini","year":"2010","journal-title":"PLoS One"},{"key":"ref21","first-page":"662","article-title":"Rapid detection and serotyping of dengue virus by multiplex RT-PCR and real-time SYBR green RT-PCR","volume":"48","author":"YK Yong","year":"2007","journal-title":"Singapore Med J"},{"key":"ref22","first-page":"532","article-title":"Detection of specific IgM in dengue infections","volume":"18","author":"SK Lam","year":"1987","journal-title":"Southeast Asian J Trop Med Pub Health"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"561","DOI":"10.4269\/ajtmh.1958.7.561","article-title":"Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses","volume":"7","author":"DH Clarke","year":"1958","journal-title":"Am J Trop Med Hyg"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1126\/science.288.5466.675","article-title":"Control of Homeostasis of CD8+ Memory T Cells by Opposing Cytokines","volume":"288","author":"CC Ku","year":"2000","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/362248a0","article-title":"Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses","volume":"362","author":"A Minty","year":"1993","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/1743-422X-5-165","article-title":"Molecular profiling of T-helper immune genes during dengue virus infection","volume":"5","author":"J Chen","year":"2008","journal-title":"Virol J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.1128\/JCM.39.12.4332-4338.2001","article-title":"Kinetics of Dengue Virus-Specific Serum Immunoglobulin Classes and Subclasses Correlate with Clinical Outcome of Infection","volume":"39","author":"P Koraka","year":"2001","journal-title":"Journal of Clinical Microbiology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1172\/JCI115457","article-title":"Activation of T lymphocytes in dengue virus infections. High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon-gamma in sera of children with dengue","volume":"88","author":"I Kurane","year":"1991","journal-title":"The Journal of Clinical Investigation"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2334-8-86","article-title":"Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity","volume":"8","author":"F Bozza","year":"2008","journal-title":"BMC Infectious Diseases"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/meth.1999.0837","article-title":"Interleukin-18","volume":"19","author":"CA Dinarello","year":"1999","journal-title":"Methods"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.4049\/jimmunol.158.4.1541","article-title":"IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12","volume":"158","author":"K Kohno","year":"1997","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/(SICI)1096-9071(199911)59:3<329::AID-JMV12>3.0.CO;2-G","article-title":"Elevated plasma interleukin-10 levels in acute dengue correlate with disease severity","volume":"59","author":"S Green","year":"1999","journal-title":"J Med Virol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1365-2249.2006.02996.x","article-title":"NK cells, displaying early activation, cytotoxicity and adhesion molecules, are associated with mild dengue disease","volume":"143","author":"EL Azeredo","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4269\/ajtmh.2006.74.142","article-title":"Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients","volume":"74","author":"LC Chen","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.4049\/jimmunol.177.3.1855","article-title":"Both CXCR3 and CXCL10\/IFN-inducible protein 10 are required for resistance to primary infection by dengue virus","volume":"177","author":"MF Hsieh","year":"2006","journal-title":"J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1084\/jem.182.1.155","article-title":"Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo","volume":"182","author":"AL Angiolillo","year":"1995","journal-title":"J Exp Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/35006097","article-title":"Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1","volume":"404","author":"L Gu","year":"2000","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/01.RES.0000078172.52740.9B","article-title":"Interleukin-1 receptor antagonist (IL-1RN) genotype modulates the replicative capacity of human endothelial cells","volume":"92","author":"RM Dewberry","year":"2003","journal-title":"Circ Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1084\/jem.179.2.751","article-title":"Monocyte chemotactic protein 3 is a most effective basophil- and eosinophil-activating chemokine","volume":"179","author":"CA Dahinden","year":"1994","journal-title":"J Exp Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cyto.2010.06.010","article-title":"MCP-1 and MIP-1alpha expression in a model resembling early immune response to dengue","volume":"52","author":"B Sierra","year":"2010","journal-title":"Cytokine"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/10623320600972135","article-title":"Evidence of vascular damage in dengue disease: demonstration of high levels of soluble cell adhesion molecules and circulating endothelial cells","volume":"13","author":"JE Cardier","year":"2006","journal-title":"Endothelium"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"186","DOI":"10.7883\/yoken.JJID.2006.186","article-title":"Serum levels of sICAM-1 and sE-selectin in patients with dengue virus infection","volume":"59","author":"A Khongphatthanayothin","year":"2006","journal-title":"Jpn J Infect Dis"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1161\/ATVBAHA.109.194134","article-title":"Eotaxin Increases Monolayer Permeability of Human Coronary Artery Endothelial Cells","volume":"29","author":"MS Jamaluddin","year":"2009","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/nm1303","article-title":"CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection","volume":"11","author":"JW Tyner","year":"2005","journal-title":"Nat Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nm848","article-title":"Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2","volume":"9","author":"R Cao","year":"2003","journal-title":"Nat Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"536","DOI":"10.4269\/ajtmh.2003.68.536","article-title":"Differentiating dengue virus infection from scrub typhus in Thai adults with fever","volume":"68","author":"G Watt","year":"2003","journal-title":"Am J Trop Med Hyg"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ijid.2004.07.012","article-title":"Classical dengue hemorrhagic fever resulting from two dengue infections spaced 20 years or more apart: Havana, Dengue 3 epidemic, 2001\u20132002","volume":"9","author":"D Gonzalez","year":"2005","journal-title":"Int J Infect Dis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/mic.10.3-4.335.350","article-title":"Platelet Chemokines and Chemokine Receptors: Linking Hemostasis, Inflammation, and Host Defense","volume":"10","author":"ARL Gear","year":"2003","journal-title":"Microcirculation"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1172\/JCI119488","article-title":"Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein","volume":"99","author":"C Gabay","year":"1997","journal-title":"The Journal of Clinical Investigation"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"360","DOI":"10.4103\/0256-4947.83215","article-title":"Relationship between circulating interleukin-10 and histological features in patients with chronic C hepatitis","volume":"31","author":"CM Bruno","year":"2011","journal-title":"Ann Saudi Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"5536","DOI":"10.4049\/jimmunol.158.11.5536","article-title":"Expression of IFN-inducible protein-10 in chronic hepatitis","volume":"158","author":"S Narumi","year":"1997","journal-title":"J Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1365-3024.2008.01061.x","article-title":"IL-4 and reactive oxygen species are elevated in Egyptian patients affected with schistosomal liver disease","volume":"30","author":"MY Elsammak","year":"2008","journal-title":"Parasite Immunology"},{"key":"ref53","first-page":"1001","article-title":"Imbalanced intrahepatic expression of interleukin 12, interferon gamma, and interleukin 10 in fulminant hepatitis B. Hepatology","volume":"36","author":"L Leifeld","year":"2002"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1726-4901(10)70004-6","article-title":"Serum Interleukin-12 Levels in Alcoholic Liver Disease","volume":"73","author":"K-H Tung","year":"2010","journal-title":"Journal of the Chinese Medical Association"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1078\/0171-9335-00113","article-title":"Vascular endothelial growth factor (VEGF) stimulates monocyte migration through endothelial monolayers via increased integrin expression","volume":"79","author":"M Heil","year":"2000","journal-title":"Eur J Cell Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/jlb.55.1.120","article-title":"Monocyte chemoattractant protein 1 (MCP-1) expression occurs in toxic rat liver injury and human liver disease","volume":"55","author":"MJ Czaja","year":"1994","journal-title":"Journal of Leukocyte Biology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1046\/j.1365-2249.2000.01392.x","article-title":"IL-10 stimulates production of platelet-activating factor by monocytes of patients with active systemic lupus erythematosus (SLE)","volume":"122","author":"B Bussolati","year":"2000","journal-title":"Clin Exp Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1442-200x.2005.02078.x","article-title":"Relationship of serum interleukin-7 concentration and the coagulation state in children with nephrotic syndrome","volume":"47","author":"A Wasilewska","year":"2005","journal-title":"Pediatrics International"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.4049\/jimmunol.157.9.4126","article-title":"Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils","volume":"157","author":"S Kishimoto","year":"1996","journal-title":"The Journal of Immunology"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"G1289","DOI":"10.1152\/ajpgi.2001.280.6.G1289","article-title":"ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice","volume":"280","author":"H Kono","year":"2001","journal-title":"American Journal of Physiology - Gastrointestinal and Liver Physiology"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0002-9440(10)65208-X","article-title":"IL-13 Activates STAT6 and Inhibits Liver Injury Induced by Ischemia\/Reperfusion","volume":"155","author":"H Yoshidome","year":"1999","journal-title":"The American Journal of Pathology"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1128\/IAI.05581-11","article-title":"Interleukin-4 (IL-4) and IL-13 Suppress Excessive Neutrophil Infiltration and Hepatocyte Damage during Acute Murine Schistosomiasis Japonica","volume":"80","author":"T Seki","year":"2012","journal-title":"Infection and Immunity"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cytogfr.2011.01.001","article-title":"Regulation of hepatocyte fate by interferon-\u03b3","volume":"22","author":"CJ Horras","year":"2011","journal-title":"Cytokine & Growth Factor Reviews"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nature04479","article-title":"Endothelial cells and VEGF in vascular development","volume":"438","author":"L Coultas","year":"2005","journal-title":"Nature"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0052215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T20:11:54Z","timestamp":1714767114000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0052215"}},"subtitle":[],"editor":[{"given":"Esper G.","family":"Kallas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,12,20]]},"references-count":64,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,12,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0052215","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,20]]}}}